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Review Article
Biochemical markers for prediction of the first half pregnancy losses: a review
- Meruyet Kuspanova
, - Andrey Gaiday ,
- Nurzhamal Dzhardemaliyeva ,
- Maxat Tuganbayev ,
- Maksym Gorobeiko , [ … ],
- Akylbek Tussupkaliyev
09-06-2024
Views157
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Review ArticleBiochemical markers for prediction of the first half pregnancy losses: a review
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo72
09-06-2024- Meruyet Kuspanova ,
- Andrey Gaiday ,
- Nurzhamal Dzhardemaliyeva ,
- Maxat Tuganbayev ,
- Maksym Gorobeiko ,
- Andrii Dinets ,
- Saule Bermagambetova ,
- Zhanna Amirbekova ,
- Gulshat Oraltayeva ,
- Dinara Omertayeva ,
- Akylbek Tussupkaliyev
Views157Abstract
Objective
26% of all pregnancies end in miscarriage, and up to 10% of clinically diagnosed pregnancies, and recurrent pregnancy loss is 5% among couples of childbearing ages. Although there are several known causes of pregnancy loss in the first half, including recurrent pregnancy loss, including parental chromosomal abnormalities, uterine malformations, endocrinological disorders, and immunological abnormalities, about half of the cases of pregnancy loss in its first half remain unexplained.
Methods
The review includes observational controlled studies (case-control or cohort, longitudinal studies, reviews, meta-analyses), which include the study of biochemical factors for predicting pregnancy losses in the first half, in singlet pregnancy. The Newcastle-Ottawa Scale (NOS) was used to assess the research quality.
Results
Finally, 27 studies were included in the review, which has 134904 examined patients. The results of the review include estimates of β-human chorionic gonadotropin, progesterone, pregnancy-associated protein – A, angiogenic vascular factors, estradiol, α-fetoprotein, homocysteine and CA-125 as a predictors or markers of the first half pregnancy losses.
Conclusion
It may be concluded that to date, research data indicate the unavailability of any reliable biochemical marker for predicting pregnancy losses in its first half and require either a combination of them or comparison with clinical evidence. A fairly new model shall be considered for the assessment of α-fetoprotein in vaginal blood, which may have great prospects in predicting spontaneous miscarriages.
Key-words Biochemical markerLaboratory markerMiscarriagemissed abortionpredictionPregnancySpontaneous abortionSee moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Meruyet Kuspanova
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Original Article
Association between dietary patterns and infant birth weight in brazilian pregnancy women with gestational diabetes: a cross-sectional study
- Luciana da Cunha Bernardes Argenta ,
- Nadya Helena Alves dos Santos ,
- Cláudia Saunders ,
- Joana Dias da Costa ,
- Letícia Victoria Souza da Cunha , [ … ],
- Patricia de Carvalho Padilha
09-06-2024
Summary
Original ArticleAssociation between dietary patterns and infant birth weight in brazilian pregnancy women with gestational diabetes: a cross-sectional study
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo68
09-06-2024- Luciana da Cunha Bernardes Argenta ,
- Nadya Helena Alves dos Santos ,
- Cláudia Saunders ,
- Joana Dias da Costa ,
- Letícia Victoria Souza da Cunha ,
- Pamela Melo Krok Fedeszen ,
- Patricia de Carvalho Padilha
Views143See moreAbstract
Objective
To evaluate the association between the dietary patterns (DPs) of pregnant women with GDM (gestational diabetes mellitus) and the birth weight (BW) of the infants.
Methods
Cross-sectional study with 187 adult pregnant women with GDM attended at a maternity in Rio de Janeiro from 2011 to 2014. Dietary intake was assessed in the third trimester using a semiquantitative food frequency questionnaire (FFQ). The outcomes were BW and weight adequacy for gestational age (GA). Reduced Rank Regression (RRR) was used to explain the following response variables: density of carbohydrates, fibres, and saturated fatty acids. Statistical analyzes included multinomial logistic regression models.
Results
The mean BW was 3261.9 (± 424.5) g. Three DPs were identified, with DP 3 (high consumption of refined carbohydrates, fast foods/snacks, whole milk, sugars/sweets, and soft drinks and low consumption of beans, vegetables, and low-fat milk and derivatives) being the main pattern, explaining 48.37% of the response variables. In the multinomial logistic regression analysis no statistically significant association was found between the tertiles of DPs and BW or the adequacy of weight for GA, even after adjustments of confounding covariates.
Conclusion
No significant associations were found between maternal DPs in the third trimester of pregnancy and infant BW or adequacy of weight for GA.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Luciana da Cunha Bernardes Argenta
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Review Article
Relationship between early age at menarche, older age at menopause and subtypes of breast cancer: a scoping review
- Lucas Casagrande Passoni Lopes ,
- Gabriel Araújo Medeiros ,
- Igor José Nogueira Gualberto ,
- Thales Baptista Gut ,
- Rafael Vasconcelos Silva Ferrazini , [ … ],
- Carlos Antonio Negrato
09-06-2024
Summary
Review ArticleRelationship between early age at menarche, older age at menopause and subtypes of breast cancer: a scoping review
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo50
09-06-2024- Lucas Casagrande Passoni Lopes ,
- Gabriel Araújo Medeiros ,
- Igor José Nogueira Gualberto ,
- Thales Baptista Gut ,
- Rafael Vasconcelos Silva Ferrazini ,
- Carlos Antonio Negrato
Views150See moreAbstract
Objective
To determine the relationship between early age at menarche, late age at menopause with specific subtypes of breast cancer (BC).
Methods
A literature search was conducted in Embase, Lilacs, PubMed, Scopus, and Scielo databases, following the Joanna Briggs Institute scoping review protocol and answering the question “How early age at menarche or late age at menopause are related to different breast cancer subtypes?”.
Results
A number of 4,003 studies were identified, of which 17 were selected. Most of the included articles found a clear relationship between early menarche, late menopause and some subtypes of BC, mainly, PR+, ER+, luminal, and HER-2 tumors. However, some studies have found a contradictory relationship and one study didn’t find any relationship between them.
Conclusion
A relationship between early age at menarche and advanced age at menopause was observed with some subtypes of breast cancer, since other factors must be considered in its understanding.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Lucas Casagrande Passoni Lopes
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Original Article
A new screening of preterm birth in gestation with short cervix after pessary plus progesterone
- Marcelo Santucci França ,
- Valter Lacerda de Andrade Jr. ,
- Alan Roberto Hatanaka ,
- Roberto Santos ,
- Francisco Herlanio Costa Carvalho , [ … ],
- Rodolfo de Carvalho Pacagnella
09-06-2024
Summary
Original ArticleA new screening of preterm birth in gestation with short cervix after pessary plus progesterone
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo39i
09-06-2024- Marcelo Santucci França ,
- Valter Lacerda de Andrade Jr. ,
- Alan Roberto Hatanaka ,
- Roberto Santos ,
- Francisco Herlanio Costa Carvalho ,
- Maria Laura Costa ,
- Gabriela Ubeda Santucci França ,
- Rosiane Mattar ,
- Ben Willem Mol ,
- Antonio Fernandes Moron ,
- Rodolfo de Carvalho Pacagnella
Views133See moreAbstract
Objective
This study aims to create a new screening for preterm birth < 34 weeks after gestation with a cervical length (CL) ≤ 30 mm, based on clinical, demographic, and sonographic characteristics.
Methods
This is a post hoc analysis of a randomized clinical trial (RCT), which included pregnancies, in middle-gestation, screened with transvaginal ultrasound. After observing inclusion criteria, the patient was invited to compare pessary plus progesterone (PP) versus progesterone only (P) (1:1). The objective was to determine which variables were associated with severe preterm birth using logistic regression (LR). The area under the curve (AUC), sensitivity, specificity, and positive predictive value (PPV) and negative predictive value (NPV) were calculated for both groups after applying LR, with a false positive rate (FPR) set at 10%.
Results
The RCT included 936 patients, 475 in PP and 461 in P. The LR selected: ethnics white, absence of previous curettage, previous preterm birth, singleton gestation, precocious identification of short cervix, CL < 14.7 mm, CL in curve > 21.0 mm. The AUC (CI95%), sensitivity, specificity, PPV, and PNV, with 10% of FPR, were respectively 0.978 (0.961-0.995), 83.4%, 98.1%, 83.4% and 98.1% for PP < 34 weeks; and 0.765 (0.665-0.864), 38.7%, 92.1%, 26.1% and 95.4%, for P < 28 weeks.
Conclusion
Logistic regression can be effective to screen preterm birth < 34 weeks in patients in the PP Group and all pregnancies with CL ≤ 30 mm.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Marcelo Santucci França
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Editorial
The importance of the quadrivalent HPV vaccine in the elimination of cervical cancer in Brazil
- Cecília Martins Roteli-Martins ,
- Ana Goretti Kalume Maranhão ,
- Susana Cristina Aidé Viviani Fialho ,
- Agnaldo Lopes da Silva-Filho
09-06-2024
Summary
EditorialThe importance of the quadrivalent HPV vaccine in the elimination of cervical cancer in Brazil
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgoedt4
09-06-2024- Cecília Martins Roteli-Martins ,
- Ana Goretti Kalume Maranhão ,
- Susana Cristina Aidé Viviani Fialho ,
- Agnaldo Lopes da Silva-Filho
Views145HPV vaccination program in BrazilThe introduction of the quadrivalent HPV vaccine Gardasil 4V into the Brazilian National Immunization Schedule was approved by the National Committee for Technology Incorporation into the Unified Health System (Conitec) and incorporated into the National Immunization Schedule in 2014. This decision was based on a previous cost-effectiveness study that analyzed different […]See moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Cecília Martins Roteli-Martins
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Review Article
Artificial intelligence in mammography: a systematic review of the external validation
- Paulo Eduardo Souza Castelo Branco ,
- Adriane Helena Silva Franco ,
- Amanda Prates de Oliveira ,
- Isabela Maurício Costa Carneiro ,
- Luciana Maurício Costa de Carvalho , [ … ],
- Eduardo Batista Cândido
09-04-2024
Summary
Review ArticleArtificial intelligence in mammography: a systematic review of the external validation
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo71
09-04-2024- Paulo Eduardo Souza Castelo Branco ,
- Adriane Helena Silva Franco ,
- Amanda Prates de Oliveira ,
- Isabela Maurício Costa Carneiro ,
- Luciana Maurício Costa de Carvalho ,
- Jonathan Igor Nunes de Souza ,
- Danniel Rodrigo Leandro ,
- Eduardo Batista Cândido
Views189See moreAbstract
Objective
To conduct a systematic review of external validation studies on the use of different Artificial Intelligence algorithms in breast cancer screening with mammography.
Data source
Our systematic review was conducted and reported following the PRISMA statement, using the PubMed, EMBASE, and Cochrane databases with the search terms “Artificial Intelligence,” “Mammography,” and their respective MeSH terms. We filtered publications from the past ten years (2014 – 2024) and in English.
Study selection
A total of 1,878 articles were found in the databases used in the research. After removing duplicates (373) and excluding those that did not address our PICO question (1,475), 30 studies were included in this work.
Data collection
The data from the studies were collected independently by five authors, and it was subsequently synthesized based on sample data, location, year, and their main results in terms of AUC, sensitivity, and specificity.
Data synthesis
It was demonstrated that the Area Under the ROC Curve (AUC) and sensitivity were similar to those of radiologists when using independent Artificial Intelligence. When used in conjunction with radiologists, statistically higher accuracy in mammogram evaluation was reported compared to the assessment by radiologists alone.
Conclusion
AI algorithms have emerged as a means to complement and enhance the performance and accuracy of radiologists. They also assist less experienced professionals in detecting possible lesions. Furthermore, this tool can be used to complement and improve the analyses conducted by medical professionals.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Paulo Eduardo Souza Castelo Branco
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FEBRASGO POSITION STATEMENT
Difficult fetal extraction in cesarean section: Number 8 – 2024
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-FPS08
08-15-2024
Summary
FEBRASGO POSITION STATEMENTDifficult fetal extraction in cesarean section: Number 8 – 2024
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-FPS08
08-15-2024This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Letter to the Editor
Comment on: Prediction and secondary prevention of preeclampsia from the perspective of public health management – the initiative of the State of Rio de Janeiro
- Karina Bilda de Castro Rezende ,
- Danielle Sodré Barmpas ,
- Heron Werner ,
- Daniel Lorber Rolnik ,
- Fabricio da Silva Costa , [ … ],
- Renato Augusto Moreira de Sá
08-05-2024
Summary
Letter to the EditorComment on: Prediction and secondary prevention of preeclampsia from the perspective of public health management – the initiative of the State of Rio de Janeiro
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo80
08-05-2024- Karina Bilda de Castro Rezende ,
- Danielle Sodré Barmpas ,
- Heron Werner ,
- Daniel Lorber Rolnik ,
- Fabricio da Silva Costa ,
- Liona Poon ,
- Marianna Amaral Pedroso ,
- Lisandra Stein Bernardes ,
- Juliana Costa Rezende ,
- Conrado Sávio Ragazini ,
- Rita Guérios Bornia ,
- David Wright ,
- Kypros Nicolaides ,
- Cristos Pritsivelis ,
- Renato Augusto Moreira de Sá
Views111Dear Editor,We read with interest the article “Prediction and secondary prevention of preeclampsia from the perspective of public health management—the initiative of the State of Rio de Janeiro,” published by Braga and colleagues.() The authors recommend universal treatment (for all pregnant women) with elemental calcium at 1500 mg per day and identification of women at […]See moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Karina Bilda de Castro Rezende
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