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Original Article04-11-1998
Prenatal diagnosis of fetal lung maturity in high-risk pregnancies
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(6):315-321
Abstract
Original ArticlePrenatal diagnosis of fetal lung maturity in high-risk pregnancies
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(6):315-321
DOI 10.1590/S0100-72031998000600004
Views79See moreThe objective was to evaluate the accuracy of the foam stability test, lecithin/sphingomyelin (LS) ratio, presence of phosphatidylglycerol (PG) and lung profile (L/S ratio > 1.7 and PG present simultaneously) in 121 consecutive high-risk gestations at the São Paulo Hospital from January 1990 to January 1995. Delivery occurred within 3 days of fetal lung maturation testing. This is a prospective study in which the sensitivity, specificity, positive (PPV) and negative predictive value (NPV) of all the tests were determined. Neonatal respiratory outcome and amniocentesis results were stratified by gestational age for comparison. The distribution of the studied population according to maternal pathology was diabetes mellitus (48), hypertensive disorders (41), Rh isoimmunization (14) and miscellaneous (18). Respiratory distress (RD) was present in 33 infants (27.2%), mainly in the diabetic group. There was no false negative using lung profile (all patients) and foam stability tests among hypertensive pregnancies (specificity 100%), but there were about 20% to 50% false positives in the other tests. Overall, all four tests had a low PPV: 23% for foam test, 51% for L/S ratio, 63% for PG, 61% for lung profile, and high NPV: 92% for foam test, 88% for L/S ratio, 89% for PG and 100% for lung profile. All tests had less accuracy in the diabetic pregnant women. This study shows that the presence of PG and L/S ratio > 1.7 in the amniotic fluid of high-risk pregnancies confirms maturity with a very low risk to develop RD and that the foam stability test was useful as a first-line test to predict the absence of surfactant-deficient respiratory distress syndrome, particularly in hypertensive pregnant women.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Original Article04-11-1998
The effects of nomegestrol acetate subdermal implant on carbohydrate metabolism, serum lipoproteins and on hepatic function
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(6):309-313
Abstract
Original ArticleThe effects of nomegestrol acetate subdermal implant on carbohydrate metabolism, serum lipoproteins and on hepatic function
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(6):309-313
DOI 10.1590/S0100-72031998000600003
Views108Objective: to evaluate variations in body weight, arterial blood pressure, fasting glucose, HbA1C, insulin, total cholesterol, HDL-C, LDL-C, triglycerides, Sgot, SGPT, GGT and bilirubin in women bearing a single subdermal Silastic implant containing 55 mg (+ 10%) of nomegestrol acetate during two years. Methods: eighteen healthy volunteers of reproductive age who desired to use anticonceptive drugs and who did not present contraindications to hormonal contraception participated in the study. All women were investigated before starting treatment and were followed-up for two years. At the end of the first year the capsules were inserted. Results: body weight increased from 54.9 + 1.5 kg at admission to 55.3 + 2.0 kg at 12 months of use (p<0.05) and from 56.0 + 2.7 kg at 24 months of use. There was a slight increase in arterial blood pressure, both systolic and diastolic, at month 12 (p<0.01). At month 24, the arterial blood pressure was not significantly different from the values at admission. All values were within the normal range. Insulin, HbA1C, LDL-C and GGT remained unchanged during the use of the implant. A significant decrease in total cholesterol (p<0.05) was observed in the third month and of HDL-C (p<0.01) in the sixth month. All lipoprotein alterations were inconsistent and values were within the normal range. Significant increases in fast glucose (p<0.05 and p<0.01) were observed in the third and sixth months, respectively. Significant SGOT decreases (p<0.05, p<0.01 and p<0.05) were observed in months 6, 18 and 24, respectively, and of SGPT (p<0.05) in month 18. Significant bilirubin increase (p<0.05) was observed only in the third month of implant use. All these variations remained within the normal range. Conclusions: these results show that, within the normal range, fasting glucose variations do not correlate with alterations in insulin levels. The slight serum lipoprotein, SGTO, SGPT and insulin alterations were transient. No clinical effects could be observed regarding lipoproteins, carbohydrate metabolism, insulin levels and liver function among the users during the two years.
Key-words ContraceptionCorbohydrate metabolismInjectable contraceptive drugsLiver functionProgesteroneSee moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Original Article04-11-1998
Mammographic density variation in users and nonusers of hormonal replacement therapy
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(6):303-308
Abstract
Original ArticleMammographic density variation in users and nonusers of hormonal replacement therapy
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(6):303-308
DOI 10.1590/S0100-72031998000600002
Views87See moreObjective: to compare mammographic density changes, case by case, according to image digitization in three consecutive evaluations of users or nonusers of hormonal replacement therapy (HRT). Methods: 59 postmenopausal women were evaluated, 43 being users of cyclic or continuous estro-progestin hormonal replacement therapy, and 16 nonusers. The criteria of inclusion were: amenorrhea for at least 12 months, a normal mammographic examination at the beginning of the HRT (users) or the clinical follow-up without HRT (nonusers), at two incidences (mediolateral and craniocaudal). The following variables were used for the evaluation of mammary density: initial change – the difference between the first mammography after HRT performed in 12 ± 3 months and the mammography performed before HRT-and final change – the difference between the second mammography after HRT performed in 24 ± 3 months and the mammography performed before HRT. Wilcoxon and c² tests were used in order to evaluate the differences in mammographic density changes. Results: more than half (56.3%) of the women, HRT users with initial increase in mammographic density remained with the increase after the final evaluation. This finding was not significant (p=0.617). In the same group, the initial nonincrease was significantly associated with the final nonincrease (p=0.017). Among the nonusers, all breasts that were not totally fat at the initial evaluation presented a mammographic density decrease at the final evaluation. Conclusions: the majority of HRT users presenting mammographic density increase at the first evaluation, after approximately one year of use, remained with the increase at a second evaluation. After some time, the nonusers tended to present a significant mammographic density decrease (p=0.003).
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
04-11-1998
A FEBRASGO e as ações voltadas para a promoção da saúde
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(6):301-301
Abstract
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
04-10-1998
Avaliação longitudinal de aspectos imunológicos e virológicos durante a gravidez e puerpério em mulheres portadoras do vírus da imunodeficiência humana tipo 1 (HIV-1)
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):170-170
Abstract
Avaliação longitudinal de aspectos imunológicos e virológicos durante a gravidez e puerpério em mulheres portadoras do vírus da imunodeficiência humana tipo 1 (HIV-1)
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):170-170
DOI 10.1590/S0100-72031998000300011
Views87Avaliação Longitudinal de Aspectos Imunológicos e Virológicos Durante a Gravidez e Puerpério em Mulheres Portadoras do Vírus da Imunodeficiência Humana Tipo 1 (HIV-1)[…]See moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
04-10-1998
A dopplervelocimetria com mapeamento em cores dos ramos intramiometriais da artéria uterina de mulheres na pós-menopausa, com e sem carcinoma de endométrio
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):169-170
Abstract
A dopplervelocimetria com mapeamento em cores dos ramos intramiometriais da artéria uterina de mulheres na pós-menopausa, com e sem carcinoma de endométrio
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):169-170
DOI 10.1590/S0100-72031998000300010
Views72A Dopplervelocimetria com Mapeamento em Cores dos Ramos Intramiometriais da Artéria Uterina de Mulheres na Pós-Menopausa, com e sem Carcinoma de Endométrio[…]See moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
04-10-1998
Avaliação da esteroidogênese das supra-renais em mulheres normais por meio dos testes de ACTH simples de depósito
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):169-169
Abstract
Avaliação da esteroidogênese das supra-renais em mulheres normais por meio dos testes de ACTH simples de depósito
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):169-169
DOI 10.1590/S0100-72031998000300009
Views70Avaliação da Esteroidogênese das Supra-Renais em Mulheres Normais por Meio dos Testes de ACTH Simples de Depósito[…]See moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Case Report04-10-1998
Recurrent HELLP syndrome: report on two cases
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):165-167
Abstract
Case ReportRecurrent HELLP syndrome: report on two cases
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):165-167
DOI 10.1590/S0100-72031998000300008
Views73See moreHELLP syndrome is a severe complication of preeclampsia that increases maternal and perinatal morbidity and mortality. Two cases of recurrent HELLP syndrome are described, maternal death occurring in one of the cases. This study is a warning about the increased risk of HELLP syndrome in the next pregnancy.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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