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Review Article
Online scientific research on placentophagy: a bibliometric analysis
- Paloma Elisama de Oliveira Morais
, - Melissa Santos Nassif ,
- Andreia Cristina Barbosa Costa ,
- Patrícia Scotini Freitas ,
- Rômulo Severo Sampaio , [ ... ],
- Isabelle Cristinne Pinto Costa
03-14-2024
Summary
Review ArticleOnline scientific research on placentophagy: a bibliometric analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo4
03-14-2024- Paloma Elisama de Oliveira Morais ,
- Melissa Santos Nassif ,
- Andreia Cristina Barbosa Costa ,
- Patrícia Scotini Freitas ,
- Rômulo Severo Sampaio ,
- Isabelle Cristinne Pinto Costa
Views224See moreAbstract
Objective:
To classify the bibliometric indicators of online scientific research on placentophagy.
Methods:
A bibliometric study was conducted to quantify the scientific production of authors and institutions with the aim of highlighting the growth and impact of these publications nationally and internationally. The Bradford Law, network maps, and textual statistics were used, with searches conducted in libraries and databases in October 2021.
Results:
The sample consisted of 64 articles, whose primary authors were associated with 49 institutions, and mostly with degrees in anthropology. The United States of America was the country that published the most papers on the theme, and most studies were reviews with individual production. Through the term analysis, it was found that the predominant themes regarding placentophagy were the following: Alternative therapy for women's health, methodologies used for research in this area, period of placenta ingestion (postpartum period), and its benefits.
Conclusion:
The bibliometric indicators found are essential for the development of future research.
Views224
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Review ArticleOnline scientific research on placentophagy: a bibliometric analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo4
03-14-2024- Paloma Elisama de Oliveira Morais ,
- Melissa Santos Nassif ,
- Andreia Cristina Barbosa Costa ,
- Patrícia Scotini Freitas ,
- Rômulo Severo Sampaio ,
- Isabelle Cristinne Pinto Costa
Views224See moreAbstract
Objective:
To classify the bibliometric indicators of online scientific research on placentophagy.
Methods:
A bibliometric study was conducted to quantify the scientific production of authors and institutions with the aim of highlighting the growth and impact of these publications nationally and internationally. The Bradford Law, network maps, and textual statistics were used, with searches conducted in libraries and databases in October 2021.
Results:
The sample consisted of 64 articles, whose primary authors were associated with 49 institutions, and mostly with degrees in anthropology. The United States of America was the country that published the most papers on the theme, and most studies were reviews with individual production. Through the term analysis, it was found that the predominant themes regarding placentophagy were the following: Alternative therapy for women's health, methodologies used for research in this area, period of placenta ingestion (postpartum period), and its benefits.
Conclusion:
The bibliometric indicators found are essential for the development of future research.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Paloma Elisama de Oliveira Morais
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Review Article
Breast Imaging Reporting and Data System (BI-RADS®): a success history and particularities of its use in Brazil
- Vanessa Merjane ,
- Douglas Marcel Puricelli Perin ,
- Patrícia Martins Gomes El Bacha ,
- Beatriz Medicis Maranhão Miranda ,
- Almir Galvão Vieira Bitencourt , [ ... ],
- Wagner Iared
03-14-2024
Summary
Review ArticleBreast Imaging Reporting and Data System (BI-RADS®): a success history and particularities of its use in Brazil
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo6
03-14-2024- Vanessa Merjane ,
- Douglas Marcel Puricelli Perin ,
- Patrícia Martins Gomes El Bacha ,
- Beatriz Medicis Maranhão Miranda ,
- Almir Galvão Vieira Bitencourt ,
- Wagner Iared
Views258See moreAbstract
BI-RADS® is a standardization system for breast imaging reports and results created by the American College of Radiology to initially address the lack of uniformity in mammography reporting. The system consists of a lexicon of descriptors, a reporting structure with final categories and recommended management, and a structure for data collection and auditing. It is accepted worldwide by all specialties involved in the care of breast diseases. Its implementation is related to the Mammography Quality Standards Act initiative in the United States (1992) and breast cancer screening. After its initial creation in 1993, four additional editions were published in 1995, 1998, 2003 and 2013. It is adopted in several countries around the world and has been translated into 6 languages. Successful breast cancer screening programs in high-income countries can be attributed in part to the widespread use of BI-RADS®. This success led to the development of similar classification systems for other organs (e.g., lung, liver, thyroid, ovaries, colon). In 1998, the structured report model was adopted in Brazil. This article highlights the pioneering and successful role of BI-RADS®, created by ACR 30 years ago, on the eve of publishing its sixth edition, which has evolved into a comprehensive quality assurance tool for multiple imaging modalities. And, especially, it contextualizes the importance of recognizing how we are using BI-RADS® in Brazil, from its implementation to the present day, with a focus on breast cancer screening.
Views258This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Review ArticleBreast Imaging Reporting and Data System (BI-RADS®): a success history and particularities of its use in Brazil
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo6
03-14-2024- Vanessa Merjane ,
- Douglas Marcel Puricelli Perin ,
- Patrícia Martins Gomes El Bacha ,
- Beatriz Medicis Maranhão Miranda ,
- Almir Galvão Vieira Bitencourt ,
- Wagner Iared
Views258See moreAbstract
BI-RADS® is a standardization system for breast imaging reports and results created by the American College of Radiology to initially address the lack of uniformity in mammography reporting. The system consists of a lexicon of descriptors, a reporting structure with final categories and recommended management, and a structure for data collection and auditing. It is accepted worldwide by all specialties involved in the care of breast diseases. Its implementation is related to the Mammography Quality Standards Act initiative in the United States (1992) and breast cancer screening. After its initial creation in 1993, four additional editions were published in 1995, 1998, 2003 and 2013. It is adopted in several countries around the world and has been translated into 6 languages. Successful breast cancer screening programs in high-income countries can be attributed in part to the widespread use of BI-RADS®. This success led to the development of similar classification systems for other organs (e.g., lung, liver, thyroid, ovaries, colon). In 1998, the structured report model was adopted in Brazil. This article highlights the pioneering and successful role of BI-RADS®, created by ACR 30 years ago, on the eve of publishing its sixth edition, which has evolved into a comprehensive quality assurance tool for multiple imaging modalities. And, especially, it contextualizes the importance of recognizing how we are using BI-RADS® in Brazil, from its implementation to the present day, with a focus on breast cancer screening.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Vanessa Merjane
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Review Article
Non-RhD alloimmunization in pregnancy: an updated review
- Sabrina Menes Ares ,
- Luciano Marcondes Machado Nardozza ,
- Edward Araujo Júnior ,
- Eduardo Félix Martins Santana
00-00-2024
Summary
Review ArticleNon-RhD alloimmunization in pregnancy: an updated review
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo22
00-00-2024- Sabrina Menes Ares ,
- Luciano Marcondes Machado Nardozza ,
- Edward Araujo Júnior ,
- Eduardo Félix Martins Santana
Views445Abstract
RhD alloimmunization in pregnancy is still the main cause of hemolytic disease of the fetus and neonate (HDFN). Nevertheless, there are other antigens that may be associated with the occurrence of this phenomenon and that have been growing in proportion, given that current prevention strategies focus only on anti-RhD antibodies. Although not widespread, the screening and diagnostic management of the disease caused by these antibodies has recommendations in the literature. For this reason, the following review was carried out with the objective of listing the main red blood cell antigen groups described — such as Rh, ABO, Kell, MNS, Duffy, Kidd, among others — addressing the clinical importance of each one, prevalence in different countries, and recommended management when detecting such antibodies during pregnancy.
Key-words Blood group antigensErythroblastosisfetalFetal diseasesNon-Rh alloimmunizationPregnancyPrevalenceRh isoimmunizationSee moreViews445This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Review ArticleNon-RhD alloimmunization in pregnancy: an updated review
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo22
00-00-2024- Sabrina Menes Ares ,
- Luciano Marcondes Machado Nardozza ,
- Edward Araujo Júnior ,
- Eduardo Félix Martins Santana
Views445Abstract
RhD alloimmunization in pregnancy is still the main cause of hemolytic disease of the fetus and neonate (HDFN). Nevertheless, there are other antigens that may be associated with the occurrence of this phenomenon and that have been growing in proportion, given that current prevention strategies focus only on anti-RhD antibodies. Although not widespread, the screening and diagnostic management of the disease caused by these antibodies has recommendations in the literature. For this reason, the following review was carried out with the objective of listing the main red blood cell antigen groups described — such as Rh, ABO, Kell, MNS, Duffy, Kidd, among others — addressing the clinical importance of each one, prevalence in different countries, and recommended management when detecting such antibodies during pregnancy.
Key-words Blood group antigensErythroblastosisfetalFetal diseasesNon-Rh alloimmunizationPregnancyPrevalenceRh isoimmunizationSee moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Sabrina Menes Ares
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Review Article
Incidence and Outcomes Associated with Menopausal Status in COVID-19 Patients: A Systematic Review and Meta-analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2023;45(12):796-807
01-11-2023
Summary
Review ArticleIncidence and Outcomes Associated with Menopausal Status in COVID-19 Patients: A Systematic Review and Meta-analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2023;45(12):796-807
01-11-2023Views159See moreAbstract
Objective
Menopause causes several changes in the body that may affect the response to COVID-19. We aimed to investigate the possible association between menopausal status and incidence and outcomes in COVID-19 patients.
Methods
Combinations of keywordsCOVID-19, menopause, and estrogen were used to search the PubMed, Embase, Web-of-Science, and Scopus databases for articles reporting the incidence and outcomes of COVID-19 (discharge, length-of-admission, intensive care, or mortality) in premenopausal women, available through December 29, 2022. Data from studies comparing the incidence of COVID-19 infection with the age-matched male population were pooled and meta-analyzed using a random-effects model.
Results
Overall, 1,564 studies were retrieved, of which 12 were finally included in the systematic review to compare disease outcomes, and 6 were meta-analyzed for the incidence of COVID-19 in premenopausal and postmenopausal women. All studies reported better COVID-19-associated outcomes in premenopausal women compared with postmenopausal women. After adjusting for confounding factors, three studies found better outcomes in postmenopausal women, and two found no association between menopausal status and COVID-19 outcomes. Our meta-analysis found a higher incidence of COVID-19 infection among premenopausal women than postmenopausal women, when compared with age-matched men (odds ratio = 1.270; 95% confidence interval: 1.086–1.486; p = 0.003).
Conclusion
The incidence of COVID-19 was significantly higher in premenopausal women than in postmenopausal women when compared with age-matched men. Although premenopausal women may have more favorable COVID-19-associated outcomes, the presumed preventive effect of estrogens on the incidence and related outcomes of COVID-19 in premenopausal women cannot be proven at present. Further longitudinal studies comparing pre- and post-menopausal women are required to provide further insight into this matter.
Views159This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Review ArticleIncidence and Outcomes Associated with Menopausal Status in COVID-19 Patients: A Systematic Review and Meta-analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2023;45(12):796-807
01-11-2023Views159See moreAbstract
Objective
Menopause causes several changes in the body that may affect the response to COVID-19. We aimed to investigate the possible association between menopausal status and incidence and outcomes in COVID-19 patients.
Methods
Combinations of keywordsCOVID-19, menopause, and estrogen were used to search the PubMed, Embase, Web-of-Science, and Scopus databases for articles reporting the incidence and outcomes of COVID-19 (discharge, length-of-admission, intensive care, or mortality) in premenopausal women, available through December 29, 2022. Data from studies comparing the incidence of COVID-19 infection with the age-matched male population were pooled and meta-analyzed using a random-effects model.
Results
Overall, 1,564 studies were retrieved, of which 12 were finally included in the systematic review to compare disease outcomes, and 6 were meta-analyzed for the incidence of COVID-19 in premenopausal and postmenopausal women. All studies reported better COVID-19-associated outcomes in premenopausal women compared with postmenopausal women. After adjusting for confounding factors, three studies found better outcomes in postmenopausal women, and two found no association between menopausal status and COVID-19 outcomes. Our meta-analysis found a higher incidence of COVID-19 infection among premenopausal women than postmenopausal women, when compared with age-matched men (odds ratio = 1.270; 95% confidence interval: 1.086–1.486; p = 0.003).
Conclusion
The incidence of COVID-19 was significantly higher in premenopausal women than in postmenopausal women when compared with age-matched men. Although premenopausal women may have more favorable COVID-19-associated outcomes, the presumed preventive effect of estrogens on the incidence and related outcomes of COVID-19 in premenopausal women cannot be proven at present. Further longitudinal studies comparing pre- and post-menopausal women are required to provide further insight into this matter.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 
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Review Article
Efficacy, Safety, and Acceptability of Misoprostol in the Treatment of Incomplete Miscarriage: A Systematic Review and Meta-analysis
- Thiago Menezes da Silva ,
- Moema Alves Guerra de Araujo ,
- Ana Carolina Zimmermann Simões ,
- Ronnier de Oliveira ,
- Kleyton Santos de Medeiros , [ ... ],
- Ana Katherine Gonçalves
01-11-2023
Summary
Review ArticleEfficacy, Safety, and Acceptability of Misoprostol in the Treatment of Incomplete Miscarriage: A Systematic Review and Meta-analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2023;45(12):808-817
01-11-2023- Thiago Menezes da Silva ,
- Moema Alves Guerra de Araujo ,
- Ana Carolina Zimmermann Simões ,
- Ronnier de Oliveira ,
- Kleyton Santos de Medeiros ,
- Ayane Cristine Sarmento ,
- Robinson Dias de Medeiros ,
- Ana Paula Ferreira Costa ,
- Ana Katherine Gonçalves
Views268See moreAbstract
Objective
To assess the efficacy, safety, and acceptability of misoprostol in the treatment of incomplete miscarriage.
Data sources
The PubMed, Scopus, Embase, Web of Science, Cochrane Library, and Clinical Trials databases (clinicaltrials.gov) were searched for the relevant articles, and search strategies were developed using a combination of thematic Medical Subject Headings terms and text words. The last search was conducted on July 4, 2022. No language restrictions were applied.
Selection of studies
Randomized clinical trials with patients of gestational age up to 6/7 weeks with a diagnosis of incomplete abortion and who were managed with at least 1 of the 3 types of treatment studied were included. A total of 8,087 studies were screened.
Data collection
Data were synthesized using the statistical package Review Manager V.5.1 (The Cochrane Collaboration, Oxford, United Kingdom). For dichotomous outcomes, the odds ratio (OR) and 95% confidence interval (CI) were derived for each study. Heterogeneity between the trial results was evaluated using the standard test, I2 statistic.
Data synthesis
When comparing misoprostol with medical vacuum aspiration (MVA), the rate of complete abortion was higher in the MVA group (OR = 0.16; 95%CI = 0.07–0.36). Hemorrhage or heavy bleeding was more common in the misoprostol group (OR = 3.00; 95%CI = 1.96–4.59), but pain after treatment was more common in patients treated with MVA (OR = 0.65; 95%CI = 0.52–0.80). No statistically significant differences were observed in the general acceptability of the treatments.
Conclusion
Misoprostol has been determined as a safe option with good acceptance by patients.
Views268This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Review ArticleEfficacy, Safety, and Acceptability of Misoprostol in the Treatment of Incomplete Miscarriage: A Systematic Review and Meta-analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2023;45(12):808-817
01-11-2023- Thiago Menezes da Silva ,
- Moema Alves Guerra de Araujo ,
- Ana Carolina Zimmermann Simões ,
- Ronnier de Oliveira ,
- Kleyton Santos de Medeiros ,
- Ayane Cristine Sarmento ,
- Robinson Dias de Medeiros ,
- Ana Paula Ferreira Costa ,
- Ana Katherine Gonçalves
Views268See moreAbstract
Objective
To assess the efficacy, safety, and acceptability of misoprostol in the treatment of incomplete miscarriage.
Data sources
The PubMed, Scopus, Embase, Web of Science, Cochrane Library, and Clinical Trials databases (clinicaltrials.gov) were searched for the relevant articles, and search strategies were developed using a combination of thematic Medical Subject Headings terms and text words. The last search was conducted on July 4, 2022. No language restrictions were applied.
Selection of studies
Randomized clinical trials with patients of gestational age up to 6/7 weeks with a diagnosis of incomplete abortion and who were managed with at least 1 of the 3 types of treatment studied were included. A total of 8,087 studies were screened.
Data collection
Data were synthesized using the statistical package Review Manager V.5.1 (The Cochrane Collaboration, Oxford, United Kingdom). For dichotomous outcomes, the odds ratio (OR) and 95% confidence interval (CI) were derived for each study. Heterogeneity between the trial results was evaluated using the standard test, I2 statistic.
Data synthesis
When comparing misoprostol with medical vacuum aspiration (MVA), the rate of complete abortion was higher in the MVA group (OR = 0.16; 95%CI = 0.07–0.36). Hemorrhage or heavy bleeding was more common in the misoprostol group (OR = 3.00; 95%CI = 1.96–4.59), but pain after treatment was more common in patients treated with MVA (OR = 0.65; 95%CI = 0.52–0.80). No statistically significant differences were observed in the general acceptability of the treatments.
Conclusion
Misoprostol has been determined as a safe option with good acceptance by patients.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 
- Thiago Menezes da Silva
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Review Article
Combined Oral Contraceptive Use and the Risk of Cervical Cancer: Literature Review
- Adriane Cristina Bovo ,
- Priscila Grecca Pedrão ,
- Yasmin Medeiros Guimarães ,
- Luani Rezende Godoy ,
- Júlio César Possati Resende , [ ... ],
- Ricardo dos Reis
01-11-2023
Summary
Review ArticleCombined Oral Contraceptive Use and the Risk of Cervical Cancer: Literature Review
Revista Brasileira de Ginecologia e Obstetrícia. 2023;45(12):818-823
01-11-2023- Adriane Cristina Bovo ,
- Priscila Grecca Pedrão ,
- Yasmin Medeiros Guimarães ,
- Luani Rezende Godoy ,
- Júlio César Possati Resende ,
- Adhemar Longatto Filho ,
- Ricardo dos Reis
Views229See moreAbstract
Cervical cancer (CC) is caused by persistent infection of human papillomavirus of high oncogenic risk (hr-HPV); however, several cofactors are important in its carcinogenesis, such as smoking, multiparity, and prolonged use of oral hormonal contraceptives (COCs). Worldwide, 16% of women use COCs, whereas in Brazil this rate is of ~ 30%. The safety and adverse effects of COCs are widely discussed in the literature, including the increase in carcinogenic risk. Due to the existence of several drugs, combinations, and dosages of COCs, it is hard to have uniform information in epidemiological studies. Our objective was to perform a narrative review on the role of COCs use in the carcinogenesis of cervical cancer. Several populational studies have suggested an increase in the incidence of cervical cancer for those who have used COCs for > 5 years, but other available studies reach controversial and contradictory results regarding the action of COCs in the development of CC.
Views229This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Review ArticleCombined Oral Contraceptive Use and the Risk of Cervical Cancer: Literature Review
Revista Brasileira de Ginecologia e Obstetrícia. 2023;45(12):818-823
01-11-2023- Adriane Cristina Bovo ,
- Priscila Grecca Pedrão ,
- Yasmin Medeiros Guimarães ,
- Luani Rezende Godoy ,
- Júlio César Possati Resende ,
- Adhemar Longatto Filho ,
- Ricardo dos Reis
Views229See moreAbstract
Cervical cancer (CC) is caused by persistent infection of human papillomavirus of high oncogenic risk (hr-HPV); however, several cofactors are important in its carcinogenesis, such as smoking, multiparity, and prolonged use of oral hormonal contraceptives (COCs). Worldwide, 16% of women use COCs, whereas in Brazil this rate is of ~ 30%. The safety and adverse effects of COCs are widely discussed in the literature, including the increase in carcinogenic risk. Due to the existence of several drugs, combinations, and dosages of COCs, it is hard to have uniform information in epidemiological studies. Our objective was to perform a narrative review on the role of COCs use in the carcinogenesis of cervical cancer. Several populational studies have suggested an increase in the incidence of cervical cancer for those who have used COCs for > 5 years, but other available studies reach controversial and contradictory results regarding the action of COCs in the development of CC.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Adriane Cristina Bovo
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Review Article
Prognostic Impact of AGR3 Protein Expression in Breast Cancer: A Systematic Review and Meta-analysis
- Carolina Leão de Moraes ,
- Carolina Rodrigues Mendonça ,
- Natália Cruz e Melo ,
- Fernanda Sardinha de Abreu Tacon ,
- Jair Pereira de Melo Junior , [ ... ],
- Waldemar Naves do Amaral
12-11-2023
Summary
Review ArticlePrognostic Impact of AGR3 Protein Expression in Breast Cancer: A Systematic Review and Meta-analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2023;45(10):609-619
12-11-2023- Carolina Leão de Moraes ,
- Carolina Rodrigues Mendonça ,
- Natália Cruz e Melo ,
- Fernanda Sardinha de Abreu Tacon ,
- Jair Pereira de Melo Junior ,
- Waldemar Naves do Amaral
Views145See moreAbstract
Objective
To investigate the clinicopathological significance and prognosis of the expression of the anterior gradient 3 (AGR3) protein in women with breast cancer.
Data Sources
The PubMed, CINAHL, EMBASE, Scopus, and Web of Science databases were searched for studies published in English and without restrictions regarding the year of publication. The search terms were: breast cancer AND anterior gradient 3 OR AGR3 expression.
Study Selection
We included observational or interventional studies, studies on AGR3 protein expression by immunohistochemistry, and studies on invasive breast cancer. Case reports, studies with animals, and reviews were excluded. In total, 4 studies were included, containing 713 cases of breast cancer.
Data Collection
Data were extracted on clinicopathological characteristics and survival. A meta-analysis of the prevalence of AGR3 expression was performed according to the clinicopathological characteristics, hazard ratios (HRs), and overall survival and disease-free survival.
Data Synthesis
The expression of AGR3 was found in 62% of the cases, and it was associated with histological grade II, positivity of estrogen and progesterone receptors, low expression of ki67, recurrence or distant metastasis, and lumen subtypes. In patients with low and intermediate histological grades, AGR3 expression was associated with worse overall survival (HR: 2.39; 95% confidence interval [95%CI]: 0.628–4.159; p = 0.008) and worse disease-free survival (HR: 3.856; 95%CI: 1.026–6.686; p = 0.008).
Conclusion
The AGR3 protein may be a biomarker for the early detection of breast cancer and predict prognosis in luminal subtypes. In addition, in patients with low and intermediate histological grades, AGR3 protein expression may indicate an unfavorable prognosis in relation to survival.
Views145This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Review ArticlePrognostic Impact of AGR3 Protein Expression in Breast Cancer: A Systematic Review and Meta-analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2023;45(10):609-619
12-11-2023- Carolina Leão de Moraes ,
- Carolina Rodrigues Mendonça ,
- Natália Cruz e Melo ,
- Fernanda Sardinha de Abreu Tacon ,
- Jair Pereira de Melo Junior ,
- Waldemar Naves do Amaral
Views145See moreAbstract
Objective
To investigate the clinicopathological significance and prognosis of the expression of the anterior gradient 3 (AGR3) protein in women with breast cancer.
Data Sources
The PubMed, CINAHL, EMBASE, Scopus, and Web of Science databases were searched for studies published in English and without restrictions regarding the year of publication. The search terms were: breast cancer AND anterior gradient 3 OR AGR3 expression.
Study Selection
We included observational or interventional studies, studies on AGR3 protein expression by immunohistochemistry, and studies on invasive breast cancer. Case reports, studies with animals, and reviews were excluded. In total, 4 studies were included, containing 713 cases of breast cancer.
Data Collection
Data were extracted on clinicopathological characteristics and survival. A meta-analysis of the prevalence of AGR3 expression was performed according to the clinicopathological characteristics, hazard ratios (HRs), and overall survival and disease-free survival.
Data Synthesis
The expression of AGR3 was found in 62% of the cases, and it was associated with histological grade II, positivity of estrogen and progesterone receptors, low expression of ki67, recurrence or distant metastasis, and lumen subtypes. In patients with low and intermediate histological grades, AGR3 expression was associated with worse overall survival (HR: 2.39; 95% confidence interval [95%CI]: 0.628–4.159; p = 0.008) and worse disease-free survival (HR: 3.856; 95%CI: 1.026–6.686; p = 0.008).
Conclusion
The AGR3 protein may be a biomarker for the early detection of breast cancer and predict prognosis in luminal subtypes. In addition, in patients with low and intermediate histological grades, AGR3 protein expression may indicate an unfavorable prognosis in relation to survival.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 
- Carolina Leão de Moraes
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Review Article
Fetal Macrosomia and Postpartum Hemorrhage in Latin American and Caribbean Region: Systematic Review and Meta-analysis
- Araceli Quezada-Robles ,
- Fiorella Quispe-Sarmiento ,
- Guido Bendezu-Quispe ,
- Rodrigo Vargas-Fernández
12-05-2023
Summary
Review ArticleFetal Macrosomia and Postpartum Hemorrhage in Latin American and Caribbean Region: Systematic Review and Meta-analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2023;45(11):706-723
12-05-2023- Araceli Quezada-Robles ,
- Fiorella Quispe-Sarmiento ,
- Guido Bendezu-Quispe ,
- Rodrigo Vargas-Fernández
Views170See moreAbstract
Objective
To determine the association between fetal macrosomia (FM) and postpartum hemorrhage (PPH) in Latin American and Caribbean (LAC) women.
Data Sources
Studies evaluating the association between FM and PPH (≥ 500 ml) and severe PPH (≥ 1,000 ml) until November 4, 2021, indexed in CINHAL, Scopus, Embase, Cochrane Library, MEDLINE, LILACS, and SciELO.
Selection of Studies
Inclusion criteria were cohort and case-control studies that provided the number of PPH and FM cases. Exclusion criteria were studies lacking information about the number of cases, with a population of women who were not from LAC; published in a language other than English, Spanish, or Portuguese, and with a different design.
Data Collection
Data extraction was performed independently by two authors, and discrepancies were resolved with a third author. Data regarding FM and PPH cases were retrieved.
Data Synthesis
Of the 1,044 articles evaluated, 5 studies were included, from 6 different countries: Argentina and Uruguay (multi-country), West Indies, Antigua and Barbuda, French Guyana, and Suriname. The pooled odds ratio (OR) for FM and PPH in the meta-analysis (five studies) was 2.10 (95% confidence interval [CI]: 1.79–2.47; I2: 0%), with estimates within this 95% CI in the sensitivity analysis. The combined OR for severe PPH (3 studies) was 1.61 (95% CI: 0.40–6.48; I2: 91.89%), showing high heterogeneity.
Conclusion
There was a positive association between FM and PPH in the LAC, increasing the risk of the presence of this event 2-fold. The high heterogeneity of the studies that measured severe PPH does not allow drawing conclusions about the estimates obtained.
Views170This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Review ArticleFetal Macrosomia and Postpartum Hemorrhage in Latin American and Caribbean Region: Systematic Review and Meta-analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2023;45(11):706-723
12-05-2023- Araceli Quezada-Robles ,
- Fiorella Quispe-Sarmiento ,
- Guido Bendezu-Quispe ,
- Rodrigo Vargas-Fernández
Views170See moreAbstract
Objective
To determine the association between fetal macrosomia (FM) and postpartum hemorrhage (PPH) in Latin American and Caribbean (LAC) women.
Data Sources
Studies evaluating the association between FM and PPH (≥ 500 ml) and severe PPH (≥ 1,000 ml) until November 4, 2021, indexed in CINHAL, Scopus, Embase, Cochrane Library, MEDLINE, LILACS, and SciELO.
Selection of Studies
Inclusion criteria were cohort and case-control studies that provided the number of PPH and FM cases. Exclusion criteria were studies lacking information about the number of cases, with a population of women who were not from LAC; published in a language other than English, Spanish, or Portuguese, and with a different design.
Data Collection
Data extraction was performed independently by two authors, and discrepancies were resolved with a third author. Data regarding FM and PPH cases were retrieved.
Data Synthesis
Of the 1,044 articles evaluated, 5 studies were included, from 6 different countries: Argentina and Uruguay (multi-country), West Indies, Antigua and Barbuda, French Guyana, and Suriname. The pooled odds ratio (OR) for FM and PPH in the meta-analysis (five studies) was 2.10 (95% confidence interval [CI]: 1.79–2.47; I2: 0%), with estimates within this 95% CI in the sensitivity analysis. The combined OR for severe PPH (3 studies) was 1.61 (95% CI: 0.40–6.48; I2: 91.89%), showing high heterogeneity.
Conclusion
There was a positive association between FM and PPH in the LAC, increasing the risk of the presence of this event 2-fold. The high heterogeneity of the studies that measured severe PPH does not allow drawing conclusions about the estimates obtained.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 
- Araceli Quezada-Robles
Review Article Archives - Page 7 of 16 - Revista Brasileira de Ginecologia e Obstetrícia
