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Trabalhos Originais
Evaluation of Proliferative Activity in the Mammary Epithelium Adjacent to Fibroadenoma in Women Treated with Tamoxifen
Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(7):429-433
10-06-2000
Summary
Trabalhos OriginaisEvaluation of Proliferative Activity in the Mammary Epithelium Adjacent to Fibroadenoma in Women Treated with Tamoxifen
Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(7):429-433
10-06-2000DOI 10.1590/S0100-72032000000700005
Views117See morePurpose: to study the monoclonal antibody MIB-1 in the normal breast epithelium adjacent to a fibroadenoma in women in the luteal phase of the menstrual cycle treated with tamoxifen. Patients and methods: the proliferative activity of the mammary epithelium adjacent to the fibroadenoma was studied by immunohistochemistry based on immunoexpression of the monoclonal antibody MIB-1. The study was randomized and double blind and was conducted on 44 women with fibroadenomas, divided into 3 groups: A (n = 16; placebo), B (n = 15; tamoxifen, 10 mg), and C (n = 13; tamoxifen, 20 mg). Tamoxifen was administered for 22 days starting on the 2nd day of the menstrual cycle and a biopsy was taken on the 23rd day. Results: the mean percentage of stained nuclei per 1000 cells was 9.2 in group A, 4.5 in group B, and 3.2 in group C. Fisher’s test revealed that tamoxifen significantly reduced the immunoexpression of MIB-1 at the doses of 10 and 20 mg compared to the placebo group (p<0.0001), with no significant differences between doses in terms of proliferative activity (p = 0.21). Conclusion: we conclude that tamoxifen significantly reduced the proliferative activity of the mammary epithelium at the doses of 10 and 20 mg/day.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Trabalhos Originais
Natural Triplet Pregnancies: Maternal Complications and Perinatal Results
Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(7):413-419
10-06-2000
Summary
Trabalhos OriginaisNatural Triplet Pregnancies: Maternal Complications and Perinatal Results
Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(7):413-419
10-06-2000DOI 10.1590/S0100-72032000000700003
Views109See morePurpose: to analyze maternal complications and perinatal results of triplet pregnancies. Method: retrospective study of maternal and perinatal data on all triplets weighing >500 g delivered in a period of 8 years at Maternidade Escola de Vila Nova Cachoeirinha. Results: between 1990-1998, 18 women gave birth to triplets, representing 1 in every 2,060 deliveries. The main complications were preterm delivery (94.4%) and preeclampsia (44.4%) and 83.3% of these patients needed hospitalization before delivery, for 1-50 days, most in order to inhibit preterm labor. Cesarean section was performed in 88.9%, the mean gestational age at birth was 34.2 weeks (+ 1.8), mean weight 1,827 g (+ 421), 20.4% weighed <1,500 g and 75.9% weighed 1,500-2,499 g. Birth weight discrepancy (> 25%) occurred in 38.9% of these pregnancies and 35.2% of the 54 fetuses were small for gestational age. Eighty-six percent of live-born infants had neonatal morbidity and 3.7% had evident congenital anomalies. Perinatal mortality was 16.7%, 7.4% due to intrauterine demise and 9.3% due to neonatal death. The mean duration of hospitalization in the neonatal ward was 18.5 days; late neonatal sepsis was the main cause of death. Conclusion: triplet pregnancies had high a incidence of obstetric complications, demanded prolonged maternal hospitalization and ended almost always in surgical delivery. Intrauterine and neonatal death rates were high, neonatal morbidity was detected in almost all live-born infants and their hospitalization was long, exposing these prematures to infection, their main cause of death. Triplet pregnancies carry high maternal and fetal risks and should be managed at tertiary facilities.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Trabalhos Originais
The Relationship between White’s Classification and the Histopathological Changes in the Placentas of Diabetic Pregnant Women
Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(7):401-411
10-06-2000
Summary
Trabalhos OriginaisThe Relationship between White’s Classification and the Histopathological Changes in the Placentas of Diabetic Pregnant Women
Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(7):401-411
10-06-2000DOI 10.1590/S0100-72032000000700002
Views54See morePurpose: to analyze the relationship between White’s classification and the histopathological, changes occurring in the placentas of diabetic pregnant women, performing a qualitative comparison of histopathological changes in the placentas of nondiabetic pregnant women with those in diabetic ones (classes A and A/B), clinical, short duration (classes B and C), and clinical with vasculopathy (classes D to FRH), studying the influence of the quality of glycemic control and of gestational age on placental changes in the three groups of diabetic pregnant women. Patients and methods: specimens of placentas were collected from all diabetic pregnant women seen between 1991 and 1996 in the Maternity Section of the Hospital das Clínicas, Faculdade de Medicina de Botucatu, stained using the hematoxylin-eosin technique, and submitted to a histopathological examination. The quality of glycemic control was analyzed by the glycemia average of gestation and classified as adequate or inadequate, with a limit of 120 mg/dl. Gestational age was individualized as term and preterm. Results: forty-two newborns (43.3%) were born at term and the remaining were preterm (56.7%). The prematurity rate was higher for women with clinical diabetes (classes B and C; D to FRH). Some histopathological alterations were observed only in placentas from diabetic pregnant women: cystoid degeneration, chorial edema, intima edema, dysmaturity, Hofbauer cell hyperplasia, villitis, ghost cells, two vessels in the umbilical cord, and endarteritis. Conclusions: histopathological changes in the placentas of pregnant women with gestational diabetes (classes A and A/B), clinical, short duration (classes B and C), and clinical with vasculopathy (classes D to FRH) were similar to those in the nondiabetic ones, and, therefore, were independent of White’s clinical classification. The histopathological changes in the placentas of pregnant women with gestational diabetes (classes A and A and B), clinical, short duration (classes B and C), and clinical with vasculopathy (classes D to FRH) were not related to gestational age at birth and to the quality of glycemic control of the mother. The comparison between histopathological changes and the increased number of preterm newborns in clinical diabetes, class D to FRH, suggest early placental ageing in clinical diabetes patients.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Resumos de Teses
Avaliação da Quantidade do Colágeno da Pele de Ratas Castradas após o Uso de Estrogênio, Progestagênio e Tamoxifeno
Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(7):462-462
10-03-2000
Summary
Resumos de TesesAvaliação da Quantidade do Colágeno da Pele de Ratas Castradas após o Uso de Estrogênio, Progestagênio e Tamoxifeno
Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(7):462-462
10-03-2000DOI 10.1590/S0100-72032000000700016
Views49Avaliação da Quantidade do Colágeno da Pele de Ratas Castradas após o Uso de Estrogênio, Progestagênio e Tamoxifeno[…]See moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Resumos de Teses
Estudo Comparativo de Sistemas de Graduação em Preparados Citológicos e Histológicos para Carcinoma Infiltrante de Ductos Mamários. Avaliação da Concordância Cito-Histológica
Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(7):461-462
10-03-2000
Summary
Resumos de TesesEstudo Comparativo de Sistemas de Graduação em Preparados Citológicos e Histológicos para Carcinoma Infiltrante de Ductos Mamários. Avaliação da Concordância Cito-Histológica
Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(7):461-462
10-03-2000DOI 10.1590/S0100-72032000000700015
Views52Estudo Comparativo de Sistemas de Graduação em Preparados Citológicos e Histológicos para Carcinoma Infiltrante de Ductos Mamários. Avaliação da Concordância Cito-Histológica[…]See moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Resumos de Teses
Misoprostol como Indutor do Trabalho de Parto em Gestantes com Feto Vivo a Termo
Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(7):460-460
10-03-2000
Summary
Resumos de TesesMisoprostol como Indutor do Trabalho de Parto em Gestantes com Feto Vivo a Termo
Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(7):460-460
10-03-2000This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Resumos de Teses
Estudo Comparativo entre a Punção Aspirativa por Agulha Fina e a Biópsia de Fragmento Guiadas por Ultra-som no Diagnóstico de Lesões Mamárias Suspeitas de Malignidade
Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(7):460-460
10-03-2000
Summary
Resumos de TesesEstudo Comparativo entre a Punção Aspirativa por Agulha Fina e a Biópsia de Fragmento Guiadas por Ultra-som no Diagnóstico de Lesões Mamárias Suspeitas de Malignidade
Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(7):460-460
10-03-2000DOI 10.1590/S0100-72032000000700013
Views33Estudo Comparativo entre a Punção Aspirativa por Agulha Fina e a Biópsia de Fragmento Guiadas por Ultra-som no Diagnóstico de Lesões Mamárias Suspeitas de Malignidade[…]See moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Resumos de Teses
Estudo de Fatores Relacionados com a Violência Sexual contra Crianças, Adolescentes e Mulheres Adultas
Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(7):459-459
10-03-2000
Summary
Resumos de TesesEstudo de Fatores Relacionados com a Violência Sexual contra Crianças, Adolescentes e Mulheres Adultas
Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(7):459-459
10-03-2000DOI 10.1590/S0100-72032000000700011
Views40Estudo de Fatores Relacionados com a Violência Sexual contra Crianças, Adolescentes e Mulheres Adultas[…]See moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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