Early and late-onset preeclampsia: effects of DDAH2 polymorphisms on ADMA levels and association with DDAH2 haplotypes - Revista Brasileira de Ginecologia e Obstetrícia
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Early and late-onset preeclampsia: effects of DDAH2 polymorphisms on ADMA levels and association with DDAH2 haplotypes
To examine whether the DDAH2 promoter polymorphisms -1415G/A (rs2272592), -1151A/C (rs805304) and -449G/C (rs805305), and their haplotypes, are associated with PE compared with normotensive pregnant women, and whether they affect ADMA levels in these groups.
Methods:
A total of 208 pregnant women were included in the study and classified as early-onset (N=57) or late-onset PE (N =49), and as normotensive pregnant women (N = 102).
Results:
Pregnant with early-onset PE carrying the GC and GG genotypes for the DDAH2 -449G/C polymorphism had increased ADMA levels (P=0.01). No association of DDAH2 polymorphisms with PE in single-locus analysis was found. However, the G-C-G haplotype was associated with the risk for late-onset PE.
Conclusion:
It is suggested that DDAH2 polymorphisms could affect ADMA levels in PE, and that DDAH2 haplotypes may affect the risk for PE.
Mendes FS, Luizon MR, Lopes ACS, Pereira DA, Evangelista FCG, Godoi LC, Dusse LM, et al. Early and late-onset preeclampsia: effects of DDAH2 polymorphisms on ADMA levels and association with DDAH2 haplotypes. Rev Bras Ginecol Obstet 2024;46:e-rbgo19.
Electronic Document Format (ABNT)
Mendes, Fernanda Santos; Luizon, Marcelo Rizzatti; Lopes, Ana Cristina dos Santos; Pereira, Daniela Alves; Evangelista, Fernanda Cristina Gontijo; Godoi, Lara Carvalho; Dusse, Luci Maria; Alpoim, Patrícia Nessralla. Early and late-onset preeclampsia: effects of DDAH2 polymorphisms on ADMA levels and association with DDAH2 haplotypes. Rev Bras Ginecol Obstet, v. 46, e-rbgo19, Mar. 2024.
Electronic Document Format (APA)
Mendes, F. S., Luizon, M. R., Lopes, A. C. S., Pereira, D. A., Evangelista, F. C. G., Godoi, L. C., Dusse, L. M., & Alpoim, P. N. (2024). Early and late-onset preeclampsia: effects of DDAH2 polymorphisms on ADMA levels and association with DDAH2 haplotypes. Rev Bras Ginecol Obstet, 46, e-rbgo19.
Electronic Document Format (ISO)
Mendes, Fernanda Santos and Luizon, Marcelo Rizzatti and Lopes, Ana Cristina dos Santos and Pereira, Daniela Alves and Evangelista, Fernanda Cristina Gontijo and Godoi, Lara Carvalho and Dusse, Luci Maria and Alpoim, Patrícia Nessralla. Early and late-onset preeclampsia: effects of DDAH2 polymorphisms on ADMA levels and association with DDAH2 haplotypes. Rev Bras Ginecol Obstet [online]. 2024, vol. 46, [cited 2024-05-12], e-rbgo19. Available from: <https://journalrbgo.org/article/early-and-late-onset-preeclampsia-effects-of-ddah2-polymorphisms-on-adma-levels-and-association-with-ddah2-haplotypes/>.
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