-
Original Article
Early and late-onset preeclampsia: effects of DDAH2 polymorphisms on ADMA levels and association with DDAH2 haplotypes
- Fernanda Santos Mendes
, - Marcelo Rizzatti Luizon ,
- Ana Cristina dos Santos Lopes ,
- Daniela Alves Pereira ,
- Fernanda Cristina Gontijo Evangelista , [ ... ],
- Patrícia Nessralla Alpoim
00-00-2024
Summary
Original ArticleEarly and late-onset preeclampsia: effects of DDAH2 polymorphisms on ADMA levels and association with DDAH2 haplotypes
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo19
00-00-2024- Fernanda Santos Mendes ,
- Marcelo Rizzatti Luizon ,
- Ana Cristina dos Santos Lopes ,
- Daniela Alves Pereira ,
- Fernanda Cristina Gontijo Evangelista ,
- Lara Carvalho Godoi ,
- Luci Maria Dusse ,
- Patrícia Nessralla Alpoim
Views536Abstract
Objective:
To examine whether the DDAH2 promoter polymorphisms -1415G/A (rs2272592), -1151A/C (rs805304) and -449G/C (rs805305), and their haplotypes, are associated with PE compared with normotensive pregnant women, and whether they affect ADMA levels in these groups.
Methods:
A total of 208 pregnant women were included in the study and classified as early-onset (N=57) or late-onset PE (N =49), and as normotensive pregnant women (N = 102).
Results:
Pregnant with early-onset PE carrying the GC and GG genotypes for the DDAH2 -449G/C polymorphism had increased ADMA levels (P=0.01). No association of DDAH2 polymorphisms with PE in single-locus analysis was found. However, the G-C-G haplotype was associated with the risk for late-onset PE.
Conclusion:
It is suggested that DDAH2 polymorphisms could affect ADMA levels in PE, and that DDAH2 haplotypes may affect the risk for PE.
Key-words Asymmetric dimethylarginineDimethylarginine dimethylaminohydrolase 2 geneGenotypeHaplotypesNitric Oxide SynthaseNitric Oxide Synthase Type III/ geneticsPolymorphism, geneticPre-eclampsiaPregnant womenSee moreViews536
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Original ArticleEarly and late-onset preeclampsia: effects of DDAH2 polymorphisms on ADMA levels and association with DDAH2 haplotypes
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo19
00-00-2024- Fernanda Santos Mendes ,
- Marcelo Rizzatti Luizon ,
- Ana Cristina dos Santos Lopes ,
- Daniela Alves Pereira ,
- Fernanda Cristina Gontijo Evangelista ,
- Lara Carvalho Godoi ,
- Luci Maria Dusse ,
- Patrícia Nessralla Alpoim
Views536Abstract
Objective:
To examine whether the DDAH2 promoter polymorphisms -1415G/A (rs2272592), -1151A/C (rs805304) and -449G/C (rs805305), and their haplotypes, are associated with PE compared with normotensive pregnant women, and whether they affect ADMA levels in these groups.
Methods:
A total of 208 pregnant women were included in the study and classified as early-onset (N=57) or late-onset PE (N =49), and as normotensive pregnant women (N = 102).
Results:
Pregnant with early-onset PE carrying the GC and GG genotypes for the DDAH2 -449G/C polymorphism had increased ADMA levels (P=0.01). No association of DDAH2 polymorphisms with PE in single-locus analysis was found. However, the G-C-G haplotype was associated with the risk for late-onset PE.
Conclusion:
It is suggested that DDAH2 polymorphisms could affect ADMA levels in PE, and that DDAH2 haplotypes may affect the risk for PE.
Key-words Asymmetric dimethylarginineDimethylarginine dimethylaminohydrolase 2 geneGenotypeHaplotypesNitric Oxide SynthaseNitric Oxide Synthase Type III/ geneticsPolymorphism, geneticPre-eclampsiaPregnant womenSee moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Fernanda Santos Mendes
Asymmetric dimethylarginine Archives - Revista Brasileira de Ginecologia e Obstetrícia
