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Review Article
Monkeypox infection and pregnancy in lower and middle-income countries: Precautions & recommendations
- Omar Abu-Azzam
, - Mohammad Abu-Jeyyab ,
- Mohammad Daradkeh ,
- Sadeen Zein Eldeen ,
- Saja Zuaiter , [ ... ],
- Eman Alshdaifat
06-27-2024
Summary
Review ArticleMonkeypox infection and pregnancy in lower and middle-income countries: Precautions & recommendations
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo54
06-27-2024- Omar Abu-Azzam ,
- Mohammad Abu-Jeyyab ,
- Mohammad Daradkeh ,
- Sadeen Zein Eldeen ,
- Saja Zuaiter ,
- Mohammad Al-Mseadeen ,
- Amer Sindiani ,
- Eman Alshdaifat
Views140See moreAbstract
Monkeypox (MPX), an orthopoxviral disease endemic in Africa, is now a public health emergency of international concern (PHEIC) as declared by the World Health Organization in July 2023. Although it is generally mild, the overall case fatality rate was reported to be 3%, and the basic reproduction number (R0) is > 1 in men who have sex with men (MSM, i.e., Portugal (1.4), the United Kingdom (1.6), and Spain (1.8)). However, R0 is < 1 in other settings. In concordance with the smallpox virus, it is also expected to increase the risk of adverse outcomes for both the mother and the fetus. The outcomes of the disease in an immunocompromised state of pregnancy are scary, showing high mortality and morbidity of both mother and fetus, with up to a 75% risk of fetal side effects and a 25% risk of severe maternal diseases. Therefore, it warrants timely diagnosis and intervention. The reverse transcription polymerase chain reaction (RT PCR) test is the standard approach to diagnosis. We summarized the recent findings of MPX on pregnancy, and the associated risk factors. We also give recommendations for active fetal surveillance, perinatal care, and good reporting to improve outcomes. The available vaccines have shown promise for primary disease prevention.
Views140
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Review ArticleMonkeypox infection and pregnancy in lower and middle-income countries: Precautions & recommendations
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo54
06-27-2024- Omar Abu-Azzam ,
- Mohammad Abu-Jeyyab ,
- Mohammad Daradkeh ,
- Sadeen Zein Eldeen ,
- Saja Zuaiter ,
- Mohammad Al-Mseadeen ,
- Amer Sindiani ,
- Eman Alshdaifat
Views140See moreAbstract
Monkeypox (MPX), an orthopoxviral disease endemic in Africa, is now a public health emergency of international concern (PHEIC) as declared by the World Health Organization in July 2023. Although it is generally mild, the overall case fatality rate was reported to be 3%, and the basic reproduction number (R0) is > 1 in men who have sex with men (MSM, i.e., Portugal (1.4), the United Kingdom (1.6), and Spain (1.8)). However, R0 is < 1 in other settings. In concordance with the smallpox virus, it is also expected to increase the risk of adverse outcomes for both the mother and the fetus. The outcomes of the disease in an immunocompromised state of pregnancy are scary, showing high mortality and morbidity of both mother and fetus, with up to a 75% risk of fetal side effects and a 25% risk of severe maternal diseases. Therefore, it warrants timely diagnosis and intervention. The reverse transcription polymerase chain reaction (RT PCR) test is the standard approach to diagnosis. We summarized the recent findings of MPX on pregnancy, and the associated risk factors. We also give recommendations for active fetal surveillance, perinatal care, and good reporting to improve outcomes. The available vaccines have shown promise for primary disease prevention.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Omar Abu-Azzam
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Review Article
Prevention, diagnosis, and treatment protocol of dengue during pregnancy and the postpartum period
- Geraldo Duarte ,
- Antonio Rodrigues Braga Neto ,
- Regis Kreitchmann ,
- Maria Luiza Bezerra Menezes ,
- Angélica Espinosa Barbosa Miranda , [ ... ],
- Maria Celeste Osório Wender
06-27-2024
Summary
Review ArticlePrevention, diagnosis, and treatment protocol of dengue during pregnancy and the postpartum period
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo73
06-27-2024- Geraldo Duarte ,
- Antonio Rodrigues Braga Neto ,
- Regis Kreitchmann ,
- Maria Luiza Bezerra Menezes ,
- Angélica Espinosa Barbosa Miranda ,
- Ana Gabriela Alvares Travassos ,
- Patrícia Pereira dos Santos Melli ,
- Roseli Mieko Yamamoto Nomura ,
- Agnaldo Lopes da Silva Filho ,
- Maria Celeste Osório Wender
Views182Introduction Over the last few decades, Brazil has faced significant challenges related to infection by the dengue virus (DENV) transmitted by the Aedes aegypti mosquito. Dengue is endemic in many tropical and subtropical regions of the planet, often leading to epidemic outbreaks of varying intensity and frequency, influenced by factors such as rising temperatures, catastrophic […]See moreViews182This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Review ArticlePrevention, diagnosis, and treatment protocol of dengue during pregnancy and the postpartum period
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo73
06-27-2024- Geraldo Duarte ,
- Antonio Rodrigues Braga Neto ,
- Regis Kreitchmann ,
- Maria Luiza Bezerra Menezes ,
- Angélica Espinosa Barbosa Miranda ,
- Ana Gabriela Alvares Travassos ,
- Patrícia Pereira dos Santos Melli ,
- Roseli Mieko Yamamoto Nomura ,
- Agnaldo Lopes da Silva Filho ,
- Maria Celeste Osório Wender
Views182Introduction Over the last few decades, Brazil has faced significant challenges related to infection by the dengue virus (DENV) transmitted by the Aedes aegypti mosquito. Dengue is endemic in many tropical and subtropical regions of the planet, often leading to epidemic outbreaks of varying intensity and frequency, influenced by factors such as rising temperatures, catastrophic […]See moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Geraldo Duarte
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Review Article
Laser therapy for genitourinary syndrome of menopause: systematic review and meta-analysis of randomized controlled trial
- Lisieux de Lourdes Martins Nóbrega Pessoa ,
- Amaxsell Thiago Barros de Souza ,
- Ayane Cristine Alves Sarmento ,
- Ana Paula Ferreira Costa ,
- Isis Kelly dos Santos , [ ... ],
- Ricardo Ney Cobucci
06-03-2024
Summary
Review ArticleLaser therapy for genitourinary syndrome of menopause: systematic review and meta-analysis of randomized controlled trial
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo38
06-03-2024- Lisieux de Lourdes Martins Nóbrega Pessoa ,
- Amaxsell Thiago Barros de Souza ,
- Ayane Cristine Alves Sarmento ,
- Ana Paula Ferreira Costa ,
- Isis Kelly dos Santos ,
- Eduardo Pereira de Azevedo ,
- Kleyton Santos de Medeiros ,
- Ana Katherine Gonçalves ,
- Ricardo Ney Cobucci
Views189See moreAbstract
Objective:
This meta-analysis of randomized controlled trials (RCTs) aimed to update evidence on the effectiveness and safety of laser therapy for treating genitourinary syndrome of menopause (GSM).
Data sources:
Manuscripts published until May 2023 were systematically searched in PubMed; Embase; Scopus; Web of Science; CENTRAL; CINAHL; and clinical trial databases (www.trialscentral.org, www.controlled-trials.com, and clinicaltrials.gov), with no language and year of publication restriction.
Studies selection:
RCTs with women diagnosed with GSM, and the intervention was vaginal laser therapy (CO2-laser or Er: YAG-laser) comparing with placebo (sham therapy), no treatment or vaginal estrogen therapy.
Data collection:
Two authors evaluated the publications for inclusion based on the title and abstract, followed by reviewing the relevant full-text articles. Disagreements during the review process were addressed by consensus, with the involvement of a third author.
Data synthesis:
Twelve RCTs, representing a total of 5147 participants, were included in this review. Vaginal health index (VHI) significantly improved in the carbon dioxide laser (CO2-laser) therapy group (MD=2.21; 95% CI=1.25 to 3.16), while dyspareunia (MD=−0.85; 95% CI=−1.59 to −0.10), dryness (MD=−0.62; 95% CI=−1.12 to −0.12) and burning (MD= −0.64; 95% CI=−1.28 to −0.01) decreased. No serious adverse effects were reported.
Conclusion:
CO2-laser increases VHI score and decreases dyspareunia, dryness and burning, especially when compared to sham-laser. However, the certainty of the evidence is low, thus preventing the recommendation of laser therapy for GSM management.
Views189This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Review ArticleLaser therapy for genitourinary syndrome of menopause: systematic review and meta-analysis of randomized controlled trial
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo38
06-03-2024- Lisieux de Lourdes Martins Nóbrega Pessoa ,
- Amaxsell Thiago Barros de Souza ,
- Ayane Cristine Alves Sarmento ,
- Ana Paula Ferreira Costa ,
- Isis Kelly dos Santos ,
- Eduardo Pereira de Azevedo ,
- Kleyton Santos de Medeiros ,
- Ana Katherine Gonçalves ,
- Ricardo Ney Cobucci
Views189See moreAbstract
Objective:
This meta-analysis of randomized controlled trials (RCTs) aimed to update evidence on the effectiveness and safety of laser therapy for treating genitourinary syndrome of menopause (GSM).
Data sources:
Manuscripts published until May 2023 were systematically searched in PubMed; Embase; Scopus; Web of Science; CENTRAL; CINAHL; and clinical trial databases (www.trialscentral.org, www.controlled-trials.com, and clinicaltrials.gov), with no language and year of publication restriction.
Studies selection:
RCTs with women diagnosed with GSM, and the intervention was vaginal laser therapy (CO2-laser or Er: YAG-laser) comparing with placebo (sham therapy), no treatment or vaginal estrogen therapy.
Data collection:
Two authors evaluated the publications for inclusion based on the title and abstract, followed by reviewing the relevant full-text articles. Disagreements during the review process were addressed by consensus, with the involvement of a third author.
Data synthesis:
Twelve RCTs, representing a total of 5147 participants, were included in this review. Vaginal health index (VHI) significantly improved in the carbon dioxide laser (CO2-laser) therapy group (MD=2.21; 95% CI=1.25 to 3.16), while dyspareunia (MD=−0.85; 95% CI=−1.59 to −0.10), dryness (MD=−0.62; 95% CI=−1.12 to −0.12) and burning (MD= −0.64; 95% CI=−1.28 to −0.01) decreased. No serious adverse effects were reported.
Conclusion:
CO2-laser increases VHI score and decreases dyspareunia, dryness and burning, especially when compared to sham-laser. However, the certainty of the evidence is low, thus preventing the recommendation of laser therapy for GSM management.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Lisieux de Lourdes Martins Nóbrega Pessoa
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Review Article
Prevalence of syphilis and associated factors among pregnant women in Brazil: systematic review and meta-analysis
- Iana Mundim de Oliveira ,
- Regilane Cordeiro dos Santos ,
- Renan Alves Silva ,
- Rosane Ribeiro Figueiredo Alves ,
- Bruno César Teodoro Martins , [ ... ],
- Leonardo Ribeiro Soares
06-03-2024
Summary
Review ArticlePrevalence of syphilis and associated factors among pregnant women in Brazil: systematic review and meta-analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo28
06-03-2024- Iana Mundim de Oliveira ,
- Regilane Cordeiro dos Santos ,
- Renan Alves Silva ,
- Rosane Ribeiro Figueiredo Alves ,
- Bruno César Teodoro Martins ,
- Leonardo Ribeiro Soares
Views194See moreAbstract
Objective:
This systematic review accompanied by a meta-analysis aimed to estimate the prevalence of syphilis in pregnant women in Brazil and describe its associated factors.
Methods:
Following the establishment the search strategies and the registration of the review protocol in PROSPERO, we conducted a search for relevant articles in the Pubmed, LILACS, Science Direct, SciELO and Web of Science databases. Our inclusion criteria were cross-sectional studies published between 2005 and 2023, with no language restrictions. The combined prevalence of syphilis infection was estimated using the random effects model in the R Software with a 95% confidence interval (95% CI) and p < 0.01 as statistically significant.
Results:
A total of 24 articles were recruited, which together investigated 221,884 women. The combined prevalence of syphilis in pregnant women in Brazil was 1.79% (95% CI: 1.24-2.57%), and the main factors associated with its occurrence were black and brown skin color, low education and factors related to the partner.
Conclusion:
There was a high prevalence of syphilis in pregnancy in Brazil, mainly associated with socioeconomic factors.
Views194This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Review ArticlePrevalence of syphilis and associated factors among pregnant women in Brazil: systematic review and meta-analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo28
06-03-2024- Iana Mundim de Oliveira ,
- Regilane Cordeiro dos Santos ,
- Renan Alves Silva ,
- Rosane Ribeiro Figueiredo Alves ,
- Bruno César Teodoro Martins ,
- Leonardo Ribeiro Soares
Views194See moreAbstract
Objective:
This systematic review accompanied by a meta-analysis aimed to estimate the prevalence of syphilis in pregnant women in Brazil and describe its associated factors.
Methods:
Following the establishment the search strategies and the registration of the review protocol in PROSPERO, we conducted a search for relevant articles in the Pubmed, LILACS, Science Direct, SciELO and Web of Science databases. Our inclusion criteria were cross-sectional studies published between 2005 and 2023, with no language restrictions. The combined prevalence of syphilis infection was estimated using the random effects model in the R Software with a 95% confidence interval (95% CI) and p < 0.01 as statistically significant.
Results:
A total of 24 articles were recruited, which together investigated 221,884 women. The combined prevalence of syphilis in pregnant women in Brazil was 1.79% (95% CI: 1.24-2.57%), and the main factors associated with its occurrence were black and brown skin color, low education and factors related to the partner.
Conclusion:
There was a high prevalence of syphilis in pregnancy in Brazil, mainly associated with socioeconomic factors.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Iana Mundim de Oliveira
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Review Article
How can we reduce maternal mortality due to preeclampsia? The 4P rule
- Henri Augusto Korkes ,
- Ricardo Carvalho Cavalli ,
- Leandro Gustavo De Oliveira ,
- José Geraldo Lopes Ramos ,
- Sérgio Hofmeister de Almeida Martins Costa , [ ... ],
- Maria Laura Costa
06-03-2024
Summary
Review ArticleHow can we reduce maternal mortality due to preeclampsia? The 4P rule
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo43
06-03-2024- Henri Augusto Korkes ,
- Ricardo Carvalho Cavalli ,
- Leandro Gustavo De Oliveira ,
- José Geraldo Lopes Ramos ,
- Sérgio Hofmeister de Almeida Martins Costa ,
- Francisco Lázaro Pereira de Sousa ,
- Edson Vieira da Cunha Filho ,
- Maria Rita de Souza Mesquita ,
- Mário Dias Corrêa Júnior ,
- Ana Cristina Pinheiro Fernandes Araújo ,
- Alberto Carlos Moreno Zaconeta ,
- Carlos Henrique Esteves Freire ,
- Carlos Eduardo Poli de Figueiredo ,
- Edilberto Alves Pereira da Rocha Filho ,
- Nelson Sass ,
- José Carlos Peraçoli ,
- Maria Laura Costa
Views234See moreAbstract
In low and middle-income countries such as Brazil, most maternal deaths are related to hypertensive complications. Preeclampsia is the leading cause of maternal mortality and morbidity. Significant proportion is associated with the following factors: lack of identification of high-risk women, lack of adequate prevention, difficulty in maintaining a high-risk prenatal follow-up, delayed diagnosis, insecurity and low use of magnesium sulphate, delayed pregnancy interruption and lack of postpartum follow-up of these high-risk cases. Four major actions are proposed to minimize this alarming clinical picture and reduce the mortality rates due to preeclampsia, called the "4 P Rule" (Adequate Prevention – Vigilant Prenatal Care – Timely Delivery (Parturition) – Safe Postpartum). From this simple "rule" we can open a range of important processes and reminders that may help in the guidance of preeclampsia management.
Views234This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Review ArticleHow can we reduce maternal mortality due to preeclampsia? The 4P rule
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo43
06-03-2024- Henri Augusto Korkes ,
- Ricardo Carvalho Cavalli ,
- Leandro Gustavo De Oliveira ,
- José Geraldo Lopes Ramos ,
- Sérgio Hofmeister de Almeida Martins Costa ,
- Francisco Lázaro Pereira de Sousa ,
- Edson Vieira da Cunha Filho ,
- Maria Rita de Souza Mesquita ,
- Mário Dias Corrêa Júnior ,
- Ana Cristina Pinheiro Fernandes Araújo ,
- Alberto Carlos Moreno Zaconeta ,
- Carlos Henrique Esteves Freire ,
- Carlos Eduardo Poli de Figueiredo ,
- Edilberto Alves Pereira da Rocha Filho ,
- Nelson Sass ,
- José Carlos Peraçoli ,
- Maria Laura Costa
Views234See moreAbstract
In low and middle-income countries such as Brazil, most maternal deaths are related to hypertensive complications. Preeclampsia is the leading cause of maternal mortality and morbidity. Significant proportion is associated with the following factors: lack of identification of high-risk women, lack of adequate prevention, difficulty in maintaining a high-risk prenatal follow-up, delayed diagnosis, insecurity and low use of magnesium sulphate, delayed pregnancy interruption and lack of postpartum follow-up of these high-risk cases. Four major actions are proposed to minimize this alarming clinical picture and reduce the mortality rates due to preeclampsia, called the "4 P Rule" (Adequate Prevention – Vigilant Prenatal Care – Timely Delivery (Parturition) – Safe Postpartum). From this simple "rule" we can open a range of important processes and reminders that may help in the guidance of preeclampsia management.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Henri Augusto Korkes
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Review Article
Patient positioning in minimally invasive gynecologic surgery: strategies to prevent injuries and improve outcomes
- Agnaldo Lopes da Silva Filho ,
- Matheus Eduardo Soares Pinhati ,
- Gabriel Lage Neves ,
- Eduarda Naves Gonçalves de Almeida ,
- Teresa Lamaita Lopes , [ ... ],
- Eduardo Batista Cândido
06-03-2024
Summary
Review ArticlePatient positioning in minimally invasive gynecologic surgery: strategies to prevent injuries and improve outcomes
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo46
06-03-2024- Agnaldo Lopes da Silva Filho ,
- Matheus Eduardo Soares Pinhati ,
- Gabriel Lage Neves ,
- Eduarda Naves Gonçalves de Almeida ,
- Teresa Lamaita Lopes ,
- Rívia Mara Lamaita ,
- Eduardo Batista Cândido
Views169Abstract
Effective patient positioning is a critical factor influencing surgical outcomes, mainly in minimally invasive gynecologic surgery (MIGS) where precise positioning facilitates optimal access to the surgical field. This paper provides a comprehensive exploration of the significance of strategic patient placement in MIGS, emphasizing its role in preventing intraoperative injuries and enhancing overall surgical success. The manuscript addresses potential complications arising from suboptimal positioning and highlights the essential key points for appropriate patient positioning during MIGS, encompassing what the surgical team should or shouldn't do. In this perspective, the risk factors associated with nerve injuries, sliding, compartment syndrome, and pressure ulcers are outlined to guide clinical practice. Overall, this paper underscores the critical role of precise patient positioning in achieving successful MIGS procedures and highlights key principles for the gynecological team to ensure optimal patient outcomes.
Key-words Compartment syndromeGynecologic surgical proceduresIntraoperative complicationsMinimally invasive surgical proceduresNerve injuryPatient positioningpatient safetyPressure ulcerRisk factorsTreatment outcomeSee moreViews169This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Review ArticlePatient positioning in minimally invasive gynecologic surgery: strategies to prevent injuries and improve outcomes
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo46
06-03-2024- Agnaldo Lopes da Silva Filho ,
- Matheus Eduardo Soares Pinhati ,
- Gabriel Lage Neves ,
- Eduarda Naves Gonçalves de Almeida ,
- Teresa Lamaita Lopes ,
- Rívia Mara Lamaita ,
- Eduardo Batista Cândido
Views169Abstract
Effective patient positioning is a critical factor influencing surgical outcomes, mainly in minimally invasive gynecologic surgery (MIGS) where precise positioning facilitates optimal access to the surgical field. This paper provides a comprehensive exploration of the significance of strategic patient placement in MIGS, emphasizing its role in preventing intraoperative injuries and enhancing overall surgical success. The manuscript addresses potential complications arising from suboptimal positioning and highlights the essential key points for appropriate patient positioning during MIGS, encompassing what the surgical team should or shouldn't do. In this perspective, the risk factors associated with nerve injuries, sliding, compartment syndrome, and pressure ulcers are outlined to guide clinical practice. Overall, this paper underscores the critical role of precise patient positioning in achieving successful MIGS procedures and highlights key principles for the gynecological team to ensure optimal patient outcomes.
Key-words Compartment syndromeGynecologic surgical proceduresIntraoperative complicationsMinimally invasive surgical proceduresNerve injuryPatient positioningpatient safetyPressure ulcerRisk factorsTreatment outcomeSee moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Agnaldo Lopes da Silva Filho
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Review Article
Timing of semen cryopreservation: before or after processing?
- Ana Paula de Souza Kussler ,
- Ivan Cunha Bustamante Filho ,
- Elisa Negri ,
- Edison Capp ,
- Helena von Eye Corleta
04-09-2024
Summary
Review ArticleTiming of semen cryopreservation: before or after processing?
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo36
04-09-2024- Ana Paula de Souza Kussler ,
- Ivan Cunha Bustamante Filho ,
- Elisa Negri ,
- Edison Capp ,
- Helena von Eye Corleta
Views336Abstract
Objective:
Seminal cryopreservation causes significant damage to the sperm; therefore, different methods of cryopreservation have been studied. The aim of the study was to compare the effects of density gradient processing and washing/centrifugation with seminal plasma removal for cryopreservation in semen parameters.
Methods:
Seminal samples of 26 normozoospermic patients were divided into 3 parts: with seminal plasma; after washing/centrifugation; and after selection through density gradient. The samples were cryopreserved for at least two weeks. Motility, sperm count, morphology and viability were evaluated before cryopreservation and after thawing.
Results:
Density gradient processing selected motile and viable sperm with normal morphology in fresh samples (p<0.05). Cryopreservation negatively affected all sperm parameters regardless of the processing performed, and even if the sperm recovery was lower in the density gradient after the thawing, progressive motility, total motility, viability and morphology remained higher (p<0.05).
Conclusion:
Cryopreservation significantly compromises sperm parameters (motility, morphology, viability). In normozoospermic patients, the density gradients select better quality spermatozoa compared to other processing methods; this benefit was kept after thawing.
Key-words CentrifugationCryopreservationDensity gradientSemenSeminal plasmaSperm countSperm washSpermatozoaSee moreViews336This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Review ArticleTiming of semen cryopreservation: before or after processing?
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo36
04-09-2024- Ana Paula de Souza Kussler ,
- Ivan Cunha Bustamante Filho ,
- Elisa Negri ,
- Edison Capp ,
- Helena von Eye Corleta
Views336Abstract
Objective:
Seminal cryopreservation causes significant damage to the sperm; therefore, different methods of cryopreservation have been studied. The aim of the study was to compare the effects of density gradient processing and washing/centrifugation with seminal plasma removal for cryopreservation in semen parameters.
Methods:
Seminal samples of 26 normozoospermic patients were divided into 3 parts: with seminal plasma; after washing/centrifugation; and after selection through density gradient. The samples were cryopreserved for at least two weeks. Motility, sperm count, morphology and viability were evaluated before cryopreservation and after thawing.
Results:
Density gradient processing selected motile and viable sperm with normal morphology in fresh samples (p<0.05). Cryopreservation negatively affected all sperm parameters regardless of the processing performed, and even if the sperm recovery was lower in the density gradient after the thawing, progressive motility, total motility, viability and morphology remained higher (p<0.05).
Conclusion:
Cryopreservation significantly compromises sperm parameters (motility, morphology, viability). In normozoospermic patients, the density gradients select better quality spermatozoa compared to other processing methods; this benefit was kept after thawing.
Key-words CentrifugationCryopreservationDensity gradientSemenSeminal plasmaSperm countSperm washSpermatozoaSee moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Ana Paula de Souza Kussler
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Review Article
A meta-analysis of ferric carboxymaltose versus other intravenous iron preparations for the management of iron deficiency anemia during pregnancy
- Sanjay Gupte ,
- Ashis Mukhopadhyay ,
- Manju Puri ,
- P. M. Gopinath ,
- Reena Wani , [ ... ],
- Onkar C. Swami
03-15-2024
Summary
Review ArticleA meta-analysis of ferric carboxymaltose versus other intravenous iron preparations for the management of iron deficiency anemia during pregnancy
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo21
03-15-2024- Sanjay Gupte ,
- Ashis Mukhopadhyay ,
- Manju Puri ,
- P. M. Gopinath ,
- Reena Wani ,
- J. B. Sharma ,
- Onkar C. Swami
Views459Abstract
Objective:
We conducted a meta-analysis of randomized clinical trials evaluating the clinical effects of ferric carboxymaltose therapy compared to other intravenous iron in improving hemoglobin and serum ferritin in pregnant women. We also assessed the safety of ferric carboxymaltose vs. other intravenous iron.
Data source:
EMBASE, PubMed, and Web of Science were searched for trials related to ferric carboxymaltose in pregnant women, published between 2005 and 2021. We also reviewed articles from google scholar. The keywords "ferric carboxymaltose," "FCM," "intravenous," "randomized," "pregnancy," "quality of life," and "neonatal outcomes" were used to search the literature. The search was limited to pregnant women.
Selection of studies:
Studies related to ferric carboxymaltose in pregnancy were scanned. Observational studies, review articles, and case reports were excluded. Randomized studies in pregnant women involving ferric carboxymaltose and other intravenous iron formulations were shortlisted. Of 256 studies, nine randomized control trials were selected.
Data collection:
Two reviewers independently extracted data from nine selected trials
Data synthesis:
The final effect size for increase in hemoglobin after treatment was significant for ferric carboxymaltose vs. iron sucrose/iron polymaltose (standard mean difference 0.89g/dl [95% confidence interval 0.27,1.51]). The final effect size for the increase in ferritin after treatment was more for ferric carboxymaltose vs. iron sucrose/iron polymaltose (standard mean difference 22.53µg/L [-7.26, 52.33]). No serious adverse events were reported with ferric carboxymaltose or other intravenous iron.
Conclusion:
Ferric carboxymaltose demonstrated better efficacy than other intravenous iron in increasing hemoglobin and ferritin levels in treating iron deficiency anemia in pregnant women.
Key-words AnemiaFerric carboximaltoseFerric oxideferritinhemoglobinIntravenous ironIron polymaltoseIron sucroseIron-deficiency anemiaPregnancysaccharatedSee moreViews459This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Review ArticleA meta-analysis of ferric carboxymaltose versus other intravenous iron preparations for the management of iron deficiency anemia during pregnancy
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo21
03-15-2024- Sanjay Gupte ,
- Ashis Mukhopadhyay ,
- Manju Puri ,
- P. M. Gopinath ,
- Reena Wani ,
- J. B. Sharma ,
- Onkar C. Swami
Views459Abstract
Objective:
We conducted a meta-analysis of randomized clinical trials evaluating the clinical effects of ferric carboxymaltose therapy compared to other intravenous iron in improving hemoglobin and serum ferritin in pregnant women. We also assessed the safety of ferric carboxymaltose vs. other intravenous iron.
Data source:
EMBASE, PubMed, and Web of Science were searched for trials related to ferric carboxymaltose in pregnant women, published between 2005 and 2021. We also reviewed articles from google scholar. The keywords "ferric carboxymaltose," "FCM," "intravenous," "randomized," "pregnancy," "quality of life," and "neonatal outcomes" were used to search the literature. The search was limited to pregnant women.
Selection of studies:
Studies related to ferric carboxymaltose in pregnancy were scanned. Observational studies, review articles, and case reports were excluded. Randomized studies in pregnant women involving ferric carboxymaltose and other intravenous iron formulations were shortlisted. Of 256 studies, nine randomized control trials were selected.
Data collection:
Two reviewers independently extracted data from nine selected trials
Data synthesis:
The final effect size for increase in hemoglobin after treatment was significant for ferric carboxymaltose vs. iron sucrose/iron polymaltose (standard mean difference 0.89g/dl [95% confidence interval 0.27,1.51]). The final effect size for the increase in ferritin after treatment was more for ferric carboxymaltose vs. iron sucrose/iron polymaltose (standard mean difference 22.53µg/L [-7.26, 52.33]). No serious adverse events were reported with ferric carboxymaltose or other intravenous iron.
Conclusion:
Ferric carboxymaltose demonstrated better efficacy than other intravenous iron in increasing hemoglobin and ferritin levels in treating iron deficiency anemia in pregnant women.
Key-words AnemiaFerric carboximaltoseFerric oxideferritinhemoglobinIntravenous ironIron polymaltoseIron sucroseIron-deficiency anemiaPregnancysaccharatedSee moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Sanjay Gupte
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