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Trabalhos Originais
The effects of nomegestrol acetate subdermal implant on carbohydrate metabolism, serum lipoproteins and on hepatic function
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(6):309-313
04-11-1998
Summary
Trabalhos OriginaisThe effects of nomegestrol acetate subdermal implant on carbohydrate metabolism, serum lipoproteins and on hepatic function
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(6):309-313
04-11-1998DOI 10.1590/S0100-72031998000600003
Views99Objective: to evaluate variations in body weight, arterial blood pressure, fasting glucose, HbA1C, insulin, total cholesterol, HDL-C, LDL-C, triglycerides, Sgot, SGPT, GGT and bilirubin in women bearing a single subdermal Silastic implant containing 55 mg (+ 10%) of nomegestrol acetate during two years. Methods: eighteen healthy volunteers of reproductive age who desired to use anticonceptive drugs and who did not present contraindications to hormonal contraception participated in the study. All women were investigated before starting treatment and were followed-up for two years. At the end of the first year the capsules were inserted. Results: body weight increased from 54.9 + 1.5 kg at admission to 55.3 + 2.0 kg at 12 months of use (p<0.05) and from 56.0 + 2.7 kg at 24 months of use. There was a slight increase in arterial blood pressure, both systolic and diastolic, at month 12 (p<0.01). At month 24, the arterial blood pressure was not significantly different from the values at admission. All values were within the normal range. Insulin, HbA1C, LDL-C and GGT remained unchanged during the use of the implant. A significant decrease in total cholesterol (p<0.05) was observed in the third month and of HDL-C (p<0.01) in the sixth month. All lipoprotein alterations were inconsistent and values were within the normal range. Significant increases in fast glucose (p<0.05 and p<0.01) were observed in the third and sixth months, respectively. Significant SGOT decreases (p<0.05, p<0.01 and p<0.05) were observed in months 6, 18 and 24, respectively, and of SGPT (p<0.05) in month 18. Significant bilirubin increase (p<0.05) was observed only in the third month of implant use. All these variations remained within the normal range. Conclusions: these results show that, within the normal range, fasting glucose variations do not correlate with alterations in insulin levels. The slight serum lipoprotein, SGTO, SGPT and insulin alterations were transient. No clinical effects could be observed regarding lipoproteins, carbohydrate metabolism, insulin levels and liver function among the users during the two years.
Key-words ContraceptionCorbohydrate metabolismInjectable contraceptive drugsLiver functionProgesteroneSee more
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Trabalhos Originais
Mammographic density variation in users and nonusers of hormonal replacement therapy
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(6):303-308
04-11-1998
Summary
Trabalhos OriginaisMammographic density variation in users and nonusers of hormonal replacement therapy
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(6):303-308
04-11-1998DOI 10.1590/S0100-72031998000600002
Views67See moreObjective: to compare mammographic density changes, case by case, according to image digitization in three consecutive evaluations of users or nonusers of hormonal replacement therapy (HRT). Methods: 59 postmenopausal women were evaluated, 43 being users of cyclic or continuous estro-progestin hormonal replacement therapy, and 16 nonusers. The criteria of inclusion were: amenorrhea for at least 12 months, a normal mammographic examination at the beginning of the HRT (users) or the clinical follow-up without HRT (nonusers), at two incidences (mediolateral and craniocaudal). The following variables were used for the evaluation of mammary density: initial change – the difference between the first mammography after HRT performed in 12 ± 3 months and the mammography performed before HRT-and final change – the difference between the second mammography after HRT performed in 24 ± 3 months and the mammography performed before HRT. Wilcoxon and c² tests were used in order to evaluate the differences in mammographic density changes. Results: more than half (56.3%) of the women, HRT users with initial increase in mammographic density remained with the increase after the final evaluation. This finding was not significant (p=0.617). In the same group, the initial nonincrease was significantly associated with the final nonincrease (p=0.017). Among the nonusers, all breasts that were not totally fat at the initial evaluation presented a mammographic density decrease at the final evaluation. Conclusions: the majority of HRT users presenting mammographic density increase at the first evaluation, after approximately one year of use, remained with the increase at a second evaluation. After some time, the nonusers tended to present a significant mammographic density decrease (p=0.003).
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Editorial
A FEBRASGO e as ações voltadas para a promoção da saúde
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(6):301-301
04-11-1998
Summary
EditorialA FEBRASGO e as ações voltadas para a promoção da saúde
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(6):301-301
04-11-1998This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Resumos de Teses
Avaliação longitudinal de aspectos imunológicos e virológicos durante a gravidez e puerpério em mulheres portadoras do vírus da imunodeficiência humana tipo 1 (HIV-1)
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):170-170
04-10-1998
Summary
Resumos de TesesAvaliação longitudinal de aspectos imunológicos e virológicos durante a gravidez e puerpério em mulheres portadoras do vírus da imunodeficiência humana tipo 1 (HIV-1)
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):170-170
04-10-1998DOI 10.1590/S0100-72031998000300011
Views61Avaliação Longitudinal de Aspectos Imunológicos e Virológicos Durante a Gravidez e Puerpério em Mulheres Portadoras do Vírus da Imunodeficiência Humana Tipo 1 (HIV-1)[…]See moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Resumos de Teses
A dopplervelocimetria com mapeamento em cores dos ramos intramiometriais da artéria uterina de mulheres na pós-menopausa, com e sem carcinoma de endométrio
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):169-170
04-10-1998
Summary
Resumos de TesesA dopplervelocimetria com mapeamento em cores dos ramos intramiometriais da artéria uterina de mulheres na pós-menopausa, com e sem carcinoma de endométrio
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):169-170
04-10-1998DOI 10.1590/S0100-72031998000300010
Views48A Dopplervelocimetria com Mapeamento em Cores dos Ramos Intramiometriais da Artéria Uterina de Mulheres na Pós-Menopausa, com e sem Carcinoma de Endométrio[…]See moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Resumos de Teses
Avaliação da esteroidogênese das supra-renais em mulheres normais por meio dos testes de ACTH simples de depósito
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):169-169
04-10-1998
Summary
Resumos de TesesAvaliação da esteroidogênese das supra-renais em mulheres normais por meio dos testes de ACTH simples de depósito
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):169-169
04-10-1998DOI 10.1590/S0100-72031998000300009
Views46Avaliação da Esteroidogênese das Supra-Renais em Mulheres Normais por Meio dos Testes de ACTH Simples de Depósito[…]See moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Relatos de Casos
Recurrent HELLP syndrome: report on two cases
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):165-167
04-10-1998
Summary
Relatos de CasosRecurrent HELLP syndrome: report on two cases
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):165-167
04-10-1998DOI 10.1590/S0100-72031998000300008
Views58See moreHELLP syndrome is a severe complication of preeclampsia that increases maternal and perinatal morbidity and mortality. Two cases of recurrent HELLP syndrome are described, maternal death occurring in one of the cases. This study is a warning about the increased risk of HELLP syndrome in the next pregnancy.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Relatos de Casos
Fetal reanimation: a case report
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):161-163
04-10-1998
Summary
Relatos de CasosFetal reanimation: a case report
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):161-163
04-10-1998DOI 10.1590/S0100-72031998000300007
Views54See moreA tocolytic treatment is described with the use of terbutaline in a case of cardiotocographic prolonged deceleration of fetal heart rate with successful outcome.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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