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Review Article
Efficacy, Safety, and Acceptability of Misoprostol in the Treatment of Incomplete Miscarriage: A Systematic Review and Meta-analysis
Rev Bras Ginecol Obstet. 2023;45(12):808-817
Summary
Review ArticleEfficacy, Safety, and Acceptability of Misoprostol in the Treatment of Incomplete Miscarriage: A Systematic Review and Meta-analysis
Rev Bras Ginecol Obstet. 2023;45(12):808-817
Views67See moreAbstract
Objective
To assess the efficacy, safety, and acceptability of misoprostol in the treatment of incomplete miscarriage.
Data sources
The PubMed, Scopus, Embase, Web of Science, Cochrane Library, and Clinical Trials databases (clinicaltrials.gov) were searched for the relevant articles, and search strategies were developed using a combination of thematic Medical Subject Headings terms and text words. The last search was conducted on July 4, 2022. No language restrictions were applied.
Selection of studies
Randomized clinical trials with patients of gestational age up to 6/7 weeks with a diagnosis of incomplete abortion and who were managed with at least 1 of the 3 types of treatment studied were included. A total of 8,087 studies were screened.
Data collection
Data were synthesized using the statistical package Review Manager V.5.1 (The Cochrane Collaboration, Oxford, United Kingdom). For dichotomous outcomes, the odds ratio (OR) and 95% confidence interval (CI) were derived for each study. Heterogeneity between the trial results was evaluated using the standard test, I2 statistic.
Data synthesis
When comparing misoprostol with medical vacuum aspiration (MVA), the rate of complete abortion was higher in the MVA group (OR = 0.16; 95%CI = 0.07–0.36). Hemorrhage or heavy bleeding was more common in the misoprostol group (OR = 3.00; 95%CI = 1.96–4.59), but pain after treatment was more common in patients treated with MVA (OR = 0.65; 95%CI = 0.52–0.80). No statistically significant differences were observed in the general acceptability of the treatments.
Conclusion
Misoprostol has been determined as a safe option with good acceptance by patients.
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Febrasgo Position Statement
Misoprostol use in obstetrics: Number 6 – June 2023
Rev Bras Ginecol Obstet. 2023;45(6):356-367
Summary
Febrasgo Position StatementMisoprostol use in obstetrics: Number 6 – June 2023
Rev Bras Ginecol Obstet. 2023;45(6):356-367
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Febrasgo Position Statement
Guidelines for care in sexual violence: the role of medical training – Number 4 – April 2021
Rev Bras Ginecol Obstet. 2021;43(4):341-346
Summary
Febrasgo Position StatementGuidelines for care in sexual violence: the role of medical training – Number 4 – April 2021
Rev Bras Ginecol Obstet. 2021;43(4):341-346
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Original Article
Impact of sexual and reproductive health theme insertion in the undergraduate medical
Rev Bras Ginecol Obstet. 2014;36(3):107-112
Summary
Original ArticleImpact of sexual and reproductive health theme insertion in the undergraduate medical
Rev Bras Ginecol Obstet. 2014;36(3):107-112
DOI 10.1590/S0100-72032014000300003
Views1See morePURPOSE:
To evaluate the impact of sexual and reproductive health theme insertion in the undergraduate medical curriculum at a Brazilian public university.
METHODS:
We developed an instrument for cognitive assessment in sexual and reproductive health based on the subjects addressed in the optional curriculum component Reproductive Health, resulting in an objective multiple choice test containing 27 items. The selected topics were: human, sexual and reproductive rights (HSRR), sexuality, institutional violence, gender, sexual violence, conception, contraception, abortion/legal interruption of pregnancy, maternal mortality and sexually transmitted infections (STIs) – HIV/AIDS. The subjects were grouped into three dimensions of knowledge: HSRR, legal/institutional and biomedical. Two multivariate models were adjusted in the analysis of covariance.
RESULTS:
The study included 183 students, 127 of the group who took the elective curriculum course reproductive health (RH Group) and 56 who did not (Non-RH Group). Ninety-six students (52.5%) were males and 87 (47.5%) were females. Mean age was 24.7±1.9 years for the RH Group and 24.4±2.6 for the Non-RH Group. The average performance of the SR Group was higher than that of Non-RH subjects regarding the following subjects: HSRR, sexuality, institutional violence, sexual violence, abortion/legal interruption, and STDs – HIV/AIDS. There was no gender difference in performance, except for the theme maternal mortality, in which males scored worse than females (6.9±0.2 and 7.8±0.2, respectively; p<0.05).
CONCLUSIONS:
The participation of students in the elective curriculum component Reproductive Health was associated with better performance in some dimensions of cognitive assessment, suggesting a positive impact of this initiative on general medical education.
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Original Article
Opinion of Medical and Law students of Federal University of Rio Grande do Norte about abortion in Brazil
Rev Bras Ginecol Obstet. 2012;34(1):16-21
Summary
Original ArticleOpinion of Medical and Law students of Federal University of Rio Grande do Norte about abortion in Brazil
Rev Bras Ginecol Obstet. 2012;34(1):16-21
DOI 10.1590/S0100-72032012000100004
Views4See morePURPOSE: To analyze and compare the knowledge and opinions of Law and Medical students regarding the issue of abortion in Brazil. METHODS: This was a cross-sectional study involving 125 graduate students from the class of 2010. Of these, 52 were medical students (MED group) and 73 law students (LAW group). A questionnaire was applied based on published research about the topic. Dependent variables were: monitoring the abortion debate, knowledge concerning situations where abortion is permitted under Brazilian law, opinion about situations that agree with extending legal permission to terminate pregnancy and prior knowledge of someone who has undergone induced abortion. Independent variables were: sex, age, household income and graduation course. Statistical analysis: χ² and Fisher’s exact tests, with the level of significance set at 5%. RESULTS: Most interviewees reported monitoring the debate on abortion in Brazil (67.3% of the MED group and 70.2% of the LAW group, p>0.05). When assessing knowledge on the subject, medical students had a significantly higher percentage of correct answers than law students (100.0 and 87.5%, respectively; p=0.005) regarding the legality of abortion for pregnancies resulting from rape. Elevated percentages of correct responses were also recorded for both groups in relation to pregnancies that threaten the life of the mother (94.2 and 87.5% for MED and LAW groups, respectively), but without statistical significance. A significant percentage of respondents declared they were in favor of extending legal abortion to other situations, primarily in cases of anencephaly (68%), pregnancy severely harming the mother’s physical health (42.1%) or that of the fetus in cases of severe congenital malformation (33.7%). CONCLUSION: Results showed a satisfactory knowledge on the part of law and medical school graduate students regarding the legality of abortion in Brazil, combined with a favorable trend towards extending legal permission to other situations not covered by the law. It is important to underscore the inclusion of this topic in the undergraduate curriculum and the development of inter-professional teaching strategies.
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