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Trabalhos Originais
In vitro fertilization with low-cost programmed cycles – first outcome in a teaching hospital
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(9):679-686
01-19-2003
Summary
Trabalhos OriginaisIn vitro fertilization with low-cost programmed cycles – first outcome in a teaching hospital
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(9):679-686
01-19-2003DOI 10.1590/S0100-72032003000900010
Views37See morePURPOSE: to evaluate the first in vitro fertilization results at a medical university using low-cost programmed cycles. METHODS: from May to December 2002, 66 programmed cycles of in vitro fertilization were carried out using norethisterone acetate, clomiphene citrate and human chorionic gonadotrophin (hCG). The ovarian follicle aspiration was guided by ultrasonography, 34 to 36 h after the administration of hCG, and the embryo transfer, 48 h after puncturing. The diagnosis of clinical pregnancy was defined when a pulsating heart was detected by transvaginal ultrasonography. RESULTS: the cycle cancelation rate was 21.2%. An average of 2.8 follicles and 1.7 oocytes were obtained per puncture. In 79.6% of the punctured cycles it was possible to retrieve oocytes and 69% of them were fertilized. The number of embryos per transfer was 1.5. Some level of difficulty occurred in 10.2% of the aspiration procedures and 32.4% in the embryo transfer. The obtained pregnancy rate was 10,8% per transfer; however, the drug cost per transferred embryo was only R$ 96,00. CONCLUSION: the difficulty to begin an in vitro fertilization program in a medical school, not aiming at profits and to help a population without financial possibilities, became evident. After progressive experience, the cumulative pregnancy rate tends to be similar to that of reference centers, but with significantly lower costs and incidence of complications.
Views37
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Trabalhos OriginaisIn vitro fertilization with low-cost programmed cycles – first outcome in a teaching hospital
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(9):679-686
01-19-2003DOI 10.1590/S0100-72032003000900010
Views37See morePURPOSE: to evaluate the first in vitro fertilization results at a medical university using low-cost programmed cycles. METHODS: from May to December 2002, 66 programmed cycles of in vitro fertilization were carried out using norethisterone acetate, clomiphene citrate and human chorionic gonadotrophin (hCG). The ovarian follicle aspiration was guided by ultrasonography, 34 to 36 h after the administration of hCG, and the embryo transfer, 48 h after puncturing. The diagnosis of clinical pregnancy was defined when a pulsating heart was detected by transvaginal ultrasonography. RESULTS: the cycle cancelation rate was 21.2%. An average of 2.8 follicles and 1.7 oocytes were obtained per puncture. In 79.6% of the punctured cycles it was possible to retrieve oocytes and 69% of them were fertilized. The number of embryos per transfer was 1.5. Some level of difficulty occurred in 10.2% of the aspiration procedures and 32.4% in the embryo transfer. The obtained pregnancy rate was 10,8% per transfer; however, the drug cost per transferred embryo was only R$ 96,00. CONCLUSION: the difficulty to begin an in vitro fertilization program in a medical school, not aiming at profits and to help a population without financial possibilities, became evident. After progressive experience, the cumulative pregnancy rate tends to be similar to that of reference centers, but with significantly lower costs and incidence of complications.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Trabalhos Originais
The influence of the nutritional status of pregnant adolescents on parturition and the newborn’s weight
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(9):625-630
01-19-2003
Summary
Trabalhos OriginaisThe influence of the nutritional status of pregnant adolescents on parturition and the newborn’s weight
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(9):625-630
01-19-2003DOI 10.1590/S0100-72032003000900002
Views90See morePURPOSE: to evaluate the nutritional condition of pregnant adolescents using the pregestational body mass index (BMI) and the BMI at the end of pregnancy and to establish a possible association with the type of delivery and weight of the newborn child. METHODS: in a descriptive retrospective observational study 558 pregnant teenagers as well as their newborns were evaluated in the Obstetrics outpatient clinic of the Universidade Federal de São Paulo, Brazil (UNIFESP-EPM), from January 1998 to December 2000. The sample consisted of pregnant girls who were between 10 and 19 years old at the time of the first prenatal examination, excluding the teenagers who had preexistent disease and those with incomplete data in their records. Thus, the sample consisted of 300 pregnant teenagers. Qualitative variables are presented as absolute and relative frequency and quantitative variables as mean, standard deviation and range. The correlation between maternal variables (pre-pregnancy BMI and final BMI) and parameters of the newborn (type of delivery and weight) was determined by the c² test and the differences were identified by partitioning of the c² values, with the level of significance set at p < 0.05 (a = 0.05). RESULTS: nutritional deviation was detected in 34.7% of the girls, at the beginning of pregnancy. Of these adolescents, 27.7% presented malnutrition, 4% were overweight and 3% were obese. By the end of the gestational period, BMI of 54.3% of them was normal, 1.3% correponded to malnutrition, 27% to overweight and 17.3% to obesity. The mother's nutritional condition (malnutrition, normal, overweight and obesity) did not affect the method of delivery, either vaginal (80.3%) or cesarean section (19.7%). The patients who reached end of pregnancy with BMI corresponding to malnutrition had 75% of neonates under 2.500 g. CONCLUSIONS: the mother's nutritional status was not related to the type of delivery. BMI corresponding to malnutrition at the end of pregnancy was significantly related to more cases of newborn babies under 2.500 g.
Views90This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Trabalhos OriginaisThe influence of the nutritional status of pregnant adolescents on parturition and the newborn’s weight
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(9):625-630
01-19-2003DOI 10.1590/S0100-72032003000900002
Views90See morePURPOSE: to evaluate the nutritional condition of pregnant adolescents using the pregestational body mass index (BMI) and the BMI at the end of pregnancy and to establish a possible association with the type of delivery and weight of the newborn child. METHODS: in a descriptive retrospective observational study 558 pregnant teenagers as well as their newborns were evaluated in the Obstetrics outpatient clinic of the Universidade Federal de São Paulo, Brazil (UNIFESP-EPM), from January 1998 to December 2000. The sample consisted of pregnant girls who were between 10 and 19 years old at the time of the first prenatal examination, excluding the teenagers who had preexistent disease and those with incomplete data in their records. Thus, the sample consisted of 300 pregnant teenagers. Qualitative variables are presented as absolute and relative frequency and quantitative variables as mean, standard deviation and range. The correlation between maternal variables (pre-pregnancy BMI and final BMI) and parameters of the newborn (type of delivery and weight) was determined by the c² test and the differences were identified by partitioning of the c² values, with the level of significance set at p < 0.05 (a = 0.05). RESULTS: nutritional deviation was detected in 34.7% of the girls, at the beginning of pregnancy. Of these adolescents, 27.7% presented malnutrition, 4% were overweight and 3% were obese. By the end of the gestational period, BMI of 54.3% of them was normal, 1.3% correponded to malnutrition, 27% to overweight and 17.3% to obesity. The mother's nutritional condition (malnutrition, normal, overweight and obesity) did not affect the method of delivery, either vaginal (80.3%) or cesarean section (19.7%). The patients who reached end of pregnancy with BMI corresponding to malnutrition had 75% of neonates under 2.500 g. CONCLUSIONS: the mother's nutritional status was not related to the type of delivery. BMI corresponding to malnutrition at the end of pregnancy was significantly related to more cases of newborn babies under 2.500 g.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Trabalhos Originais
Maternal age as a risk factor for pregnancy-induced hypertension: multivariate analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(9):631-635
01-19-2003
Summary
Trabalhos OriginaisMaternal age as a risk factor for pregnancy-induced hypertension: multivariate analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(9):631-635
01-19-2003DOI 10.1590/S0100-72032003000900003
Views41See morePURPOSE: to evaluate maternal age of 40 and older as an independent risk factor for pregnancy-induced hypertension (PIH). METHOD: we conducted a retrospective cohort study involving analysis of medical records of 2047 women in labor, divided into groups of 298 aged 40 and older and 1749 aged under 40. A multiple logistic regression was done to evaluate the association of maternal age with the occurrence of PIH adjusted by parity, chronic arterial hypertension, diabetes and twin pregnancy. RESULTS: the incidence of PIH in patients aged 40 and over was 22.1% (66/298), higher than in patients aged under 40 (16%, 286/1463). PIH was diagnosed in 27.2% of primiparous (174/640), 47.6% of chronic hypertensive (30/66) and 27.1% of diabetic patients (13/48). Advancing maternal age, primiparity and chronic arterial hypertension were associated with the occurrence of PIH in univariate analysis (OR = 1.46, 2.58 and 4.69, respectively). There was no significant association with diabetes. After the adjustment we observed an increase in the strength of the association between maternal age and PIH (adjusted OR = 1.69), as well as parity and chronic arterial hypertension. CONCLUSION: maternal age of 40 and older was a risk factor for the occurrence of PIH independent of parity, chronic arterial hypertension and diabetes.
Views41This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Trabalhos OriginaisMaternal age as a risk factor for pregnancy-induced hypertension: multivariate analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(9):631-635
01-19-2003DOI 10.1590/S0100-72032003000900003
Views41See morePURPOSE: to evaluate maternal age of 40 and older as an independent risk factor for pregnancy-induced hypertension (PIH). METHOD: we conducted a retrospective cohort study involving analysis of medical records of 2047 women in labor, divided into groups of 298 aged 40 and older and 1749 aged under 40. A multiple logistic regression was done to evaluate the association of maternal age with the occurrence of PIH adjusted by parity, chronic arterial hypertension, diabetes and twin pregnancy. RESULTS: the incidence of PIH in patients aged 40 and over was 22.1% (66/298), higher than in patients aged under 40 (16%, 286/1463). PIH was diagnosed in 27.2% of primiparous (174/640), 47.6% of chronic hypertensive (30/66) and 27.1% of diabetic patients (13/48). Advancing maternal age, primiparity and chronic arterial hypertension were associated with the occurrence of PIH in univariate analysis (OR = 1.46, 2.58 and 4.69, respectively). There was no significant association with diabetes. After the adjustment we observed an increase in the strength of the association between maternal age and PIH (adjusted OR = 1.69), as well as parity and chronic arterial hypertension. CONCLUSION: maternal age of 40 and older was a risk factor for the occurrence of PIH independent of parity, chronic arterial hypertension and diabetes.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Trabalhos Originais
Variability of amniotic fluid volume with gestational age according to some sociodemographic and obstetrical variables among low-risk pregnancies
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(9):639-646
01-19-2003
Summary
Trabalhos OriginaisVariability of amniotic fluid volume with gestational age according to some sociodemographic and obstetrical variables among low-risk pregnancies
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(9):639-646
01-19-2003DOI 10.1590/S0100-72032003000900004
Views91See morePURPOSE: to evaluate the association between the variability of amniotic fluid index (AFI) values with gestational age and some sociodemographic and obstetric variables among low-risk pregnant women. METHOD: a comparative study was carried out including 2868 low-risk pregnant women who had routine obstetric ultrasound examination, including fetal biometry and the measurement of AFI, from 20 to 42 weeks of gestation. The data were analyzed using Student's t test, analysis of variance of mean AFI values along gestational ages, according to other control variables, and also by multiple linear regression analysis. RESULTS: there was no significant variation of mean AFI values during the time of pregnancy neither when separately evaluating its association with maternal age, color, education, smoking habit, parity, and the presence of previous cesarean section scars, nor when the evaluation was performed through multivariate analysis. In this situation only the increase in gestational age showed to be associated with the decrease of AFI. Generally speaking, the mean AFI values fluctuated between 140 and 180 mm between the 20th and the 36th week, then showing values below 140 mm in a progressive decrease after this limit of gestational age. CONCLUSIONS: AFI values do not show a significant variation during pregnancy regarding the studied sociodemographic and obstetric variables.
Views91This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Trabalhos OriginaisVariability of amniotic fluid volume with gestational age according to some sociodemographic and obstetrical variables among low-risk pregnancies
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(9):639-646
01-19-2003DOI 10.1590/S0100-72032003000900004
Views91See morePURPOSE: to evaluate the association between the variability of amniotic fluid index (AFI) values with gestational age and some sociodemographic and obstetric variables among low-risk pregnant women. METHOD: a comparative study was carried out including 2868 low-risk pregnant women who had routine obstetric ultrasound examination, including fetal biometry and the measurement of AFI, from 20 to 42 weeks of gestation. The data were analyzed using Student's t test, analysis of variance of mean AFI values along gestational ages, according to other control variables, and also by multiple linear regression analysis. RESULTS: there was no significant variation of mean AFI values during the time of pregnancy neither when separately evaluating its association with maternal age, color, education, smoking habit, parity, and the presence of previous cesarean section scars, nor when the evaluation was performed through multivariate analysis. In this situation only the increase in gestational age showed to be associated with the decrease of AFI. Generally speaking, the mean AFI values fluctuated between 140 and 180 mm between the 20th and the 36th week, then showing values below 140 mm in a progressive decrease after this limit of gestational age. CONCLUSIONS: AFI values do not show a significant variation during pregnancy regarding the studied sociodemographic and obstetric variables.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Trabalhos Originais
Effect of physiotherapeutic techniques on musculoskeletal discomforts in pregnancy
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(9):647-654
01-19-2003
Summary
Trabalhos OriginaisEffect of physiotherapeutic techniques on musculoskeletal discomforts in pregnancy
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(9):647-654
01-19-2003DOI 10.1590/S0100-72032003000900005
Views80See morePURPOSE: to study the effects of physiotherapeutic techniques applied by the Multidisciplinary Program of Preparation for the Childbirth and Maternity on musculoskeletal discomforts during pregnancy. METHODS: prospective cohort study, with 71 low-risk nulliparous women, distributed according to participation (study: n=38) or not (control; n=33). The Multidisciplinary Program of Preparation for Childbirh and Maternity had 10 meetings (18th to 38th week), with educational, physiotherapeutic, and interaction activities. Occurrence, characteristics, and evolution of musculoskeletal discomforts were compared by means of a specific questionnaire, both at the beginning and at the end of the program. The average of results of the initial assessment was compared through analysis of variance (ANOVA) followed by the F test. For the study between proportions in the beginning and at the end of the program the c² was used. The statistical significance was determined at 5% of limit (p<0.05). RESULTS: at the beginning of the program, 63.6% of the pregnant women of the control group and 84.2% of the study group reported musculoskeletal symptoms (p=0.05), characterized by back and posterior pelvic pain. In the control group, light intensity (18.2%) and serious intensity pain (18.4) were predominant, while in the study group, the serious was 36.8%, and the isolated or associated was 31.6%. At the end, the control group showed symptoms of serious intensity (60.6%), with daily frequency (42.4%) and length of more than 3 h (69.7%; p<0.05). The study group reported light intensity (57.9%) and bimonthly frequency (50.0%) with a maximum length of one hour (55.3%) (p<0.05). Symptom evolution was also differentiated and there were worsening in 63.6% of pregnant women of the control group and improvement in 65.8% of participants of the program (p<0.05). CONCLUSIONS: the physiotherapeutic techniques of the Multidisciplinary Program of Preparation for Childbirth and Maternity were related to a decrease in intensity, frequency and length and to a better evolution of musculoskeletal discomforts during pregnancy.
Views80This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Trabalhos OriginaisEffect of physiotherapeutic techniques on musculoskeletal discomforts in pregnancy
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(9):647-654
01-19-2003DOI 10.1590/S0100-72032003000900005
Views80See morePURPOSE: to study the effects of physiotherapeutic techniques applied by the Multidisciplinary Program of Preparation for the Childbirth and Maternity on musculoskeletal discomforts during pregnancy. METHODS: prospective cohort study, with 71 low-risk nulliparous women, distributed according to participation (study: n=38) or not (control; n=33). The Multidisciplinary Program of Preparation for Childbirh and Maternity had 10 meetings (18th to 38th week), with educational, physiotherapeutic, and interaction activities. Occurrence, characteristics, and evolution of musculoskeletal discomforts were compared by means of a specific questionnaire, both at the beginning and at the end of the program. The average of results of the initial assessment was compared through analysis of variance (ANOVA) followed by the F test. For the study between proportions in the beginning and at the end of the program the c² was used. The statistical significance was determined at 5% of limit (p<0.05). RESULTS: at the beginning of the program, 63.6% of the pregnant women of the control group and 84.2% of the study group reported musculoskeletal symptoms (p=0.05), characterized by back and posterior pelvic pain. In the control group, light intensity (18.2%) and serious intensity pain (18.4) were predominant, while in the study group, the serious was 36.8%, and the isolated or associated was 31.6%. At the end, the control group showed symptoms of serious intensity (60.6%), with daily frequency (42.4%) and length of more than 3 h (69.7%; p<0.05). The study group reported light intensity (57.9%) and bimonthly frequency (50.0%) with a maximum length of one hour (55.3%) (p<0.05). Symptom evolution was also differentiated and there were worsening in 63.6% of pregnant women of the control group and improvement in 65.8% of participants of the program (p<0.05). CONCLUSIONS: the physiotherapeutic techniques of the Multidisciplinary Program of Preparation for Childbirth and Maternity were related to a decrease in intensity, frequency and length and to a better evolution of musculoskeletal discomforts during pregnancy.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Trabalhos Originais
Prevalence of hepatitis B in parturients and perinatal serologic profile
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(8):571-576
12-15-2003
Summary
Trabalhos OriginaisPrevalence of hepatitis B in parturients and perinatal serologic profile
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(8):571-576
12-15-2003DOI 10.1590/S0100-72032003000800005
Views50See morePURPOSE: to estimate the prevalence of the hepatitis B surface antigen (HBsAg) in parturients admitted to the "Instituto Materno-Infantil de Pernambuco (IMIP)", Recife-PE, and to determine the serologic profile of the positive ones. METHODS: this is a prospective cross-sectional study where the VIDAS and VIDAS HBs systems were used for detection and confirmation of HBsAg, respectively. The parturients were randomly selected. In HBsAg+ patients, the other serologic markers were tested by the use of the AxSYM automated system. The newborn babies of HBsAg+ mothers were vaccinated with the Engerix B vaccine. RESULTS: among 1584 parturients, there were 9 (0.6%) HBsAg positive. None of them had anti-HBc IgM, thus they were all prevalent cases. In 1/9 (11.1%) of the HBsAg+ mothers, HBeAg was isolated and in 4/9 (44.4%), this antigen circulated along with its antibody, hence the importance of establishing the different magnitudes of risk of vertical transmission. Except for two newborn babies from a twin pregnancy (one with low birth weight), all presented seroconversion to anti-HBs with 3 doses of the vaccine. The premature twin babies showed seroconvertion only after the fourth dose of the vaccine. CONCLUSIONS: the prevalence of hepatitis B among parturients at IMIP is relatively low and all patients diagnosed had the chronic form of the infection.
Views50This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Trabalhos OriginaisPrevalence of hepatitis B in parturients and perinatal serologic profile
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(8):571-576
12-15-2003DOI 10.1590/S0100-72032003000800005
Views50See morePURPOSE: to estimate the prevalence of the hepatitis B surface antigen (HBsAg) in parturients admitted to the "Instituto Materno-Infantil de Pernambuco (IMIP)", Recife-PE, and to determine the serologic profile of the positive ones. METHODS: this is a prospective cross-sectional study where the VIDAS and VIDAS HBs systems were used for detection and confirmation of HBsAg, respectively. The parturients were randomly selected. In HBsAg+ patients, the other serologic markers were tested by the use of the AxSYM automated system. The newborn babies of HBsAg+ mothers were vaccinated with the Engerix B vaccine. RESULTS: among 1584 parturients, there were 9 (0.6%) HBsAg positive. None of them had anti-HBc IgM, thus they were all prevalent cases. In 1/9 (11.1%) of the HBsAg+ mothers, HBeAg was isolated and in 4/9 (44.4%), this antigen circulated along with its antibody, hence the importance of establishing the different magnitudes of risk of vertical transmission. Except for two newborn babies from a twin pregnancy (one with low birth weight), all presented seroconversion to anti-HBs with 3 doses of the vaccine. The premature twin babies showed seroconvertion only after the fourth dose of the vaccine. CONCLUSIONS: the prevalence of hepatitis B among parturients at IMIP is relatively low and all patients diagnosed had the chronic form of the infection.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Trabalhos Originais
The placental bed in abruptio placentae
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(8):585-591
12-15-2003
Summary
Trabalhos OriginaisThe placental bed in abruptio placentae
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(8):585-591
12-15-2003DOI 10.1590/S0100-72032003000800007
Views75See morePURPOSE: to analyze the histopathological patterns of the placental bed arteries in pregnancies complicated by abruptio placentae (AP) and compare them with the normal vascular histology of the placental bed. METHODS: placental bed biopsy was performed in 23 pregnant women with a diagnosis of abruptio placentae associated with high blood pressure (G/HBP) disorders, with gestational age of 28 weeks or more, submitted to cesarean section. The control group (CG) consisted of 30 patients without disease, submitted to cesarean section for obstetric reasons. The selected histological variables were: unaltered pattern, physiological changes, medial layer disorganization, hyperplastic changes, acute necrosis and atherosis. RESULTS: in patients with AP associated with HBP there was a significant predominance of medial layer disorganization and hyperplastic changes, compared to CG, while physiological changes in spiral arteries were statistically more common in CG. Findings of acute necrosis and atherosis were observed in a low number of G/HBP, with no statistical significance. CONCLUSIONS: in pregnant women with AP associated with HBP the predominant vascular histological findings were medial layer disorganization and hyperplastic changes. The presence of histopathological features was significantly higher in G/HBP, with prevalence of medial layer disorganization. Normal histological pattern, i.e., physiological changes, were more prevalent in CG.
Views75This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Trabalhos OriginaisThe placental bed in abruptio placentae
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(8):585-591
12-15-2003DOI 10.1590/S0100-72032003000800007
Views75See morePURPOSE: to analyze the histopathological patterns of the placental bed arteries in pregnancies complicated by abruptio placentae (AP) and compare them with the normal vascular histology of the placental bed. METHODS: placental bed biopsy was performed in 23 pregnant women with a diagnosis of abruptio placentae associated with high blood pressure (G/HBP) disorders, with gestational age of 28 weeks or more, submitted to cesarean section. The control group (CG) consisted of 30 patients without disease, submitted to cesarean section for obstetric reasons. The selected histological variables were: unaltered pattern, physiological changes, medial layer disorganization, hyperplastic changes, acute necrosis and atherosis. RESULTS: in patients with AP associated with HBP there was a significant predominance of medial layer disorganization and hyperplastic changes, compared to CG, while physiological changes in spiral arteries were statistically more common in CG. Findings of acute necrosis and atherosis were observed in a low number of G/HBP, with no statistical significance. CONCLUSIONS: in pregnant women with AP associated with HBP the predominant vascular histological findings were medial layer disorganization and hyperplastic changes. The presence of histopathological features was significantly higher in G/HBP, with prevalence of medial layer disorganization. Normal histological pattern, i.e., physiological changes, were more prevalent in CG.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Trabalhos Originais
Do antiretroviral agents modify lipid profile in pregnant women?
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(8):593-598
12-15-2003
Summary
Trabalhos OriginaisDo antiretroviral agents modify lipid profile in pregnant women?
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(8):593-598
12-15-2003DOI 10.1590/S0100-72032003000800008
Views74See morePURPOSE: to investigate the effect of antiretroviral drugs on the lipid metabolism in HIV-infected pregnant women. METHODS: a prospective study was conducted on 57 pregnant women. The women were divided into three groups: ZDV group, consisting of 20 HIV-infected women taking ZDV; TT group, consisting of 25 HIV-1-infected women on triple antiretroviral treatment (ZDV + 3TC + NFV), and control group, consisting of 12 pregnant women considered to be normal from a clinical and laboratory viewpoint. Demographic and anthropometric data were homogeneous. Patients with a personal and family history of hyperlipidemia were excluded. Blood samples were obtained for the determination of fasting lipids (total cholesterol, LDL and HDL, and triglycerides) at four periods during pregnancy (1st = 14-20 weeks; 2nd = 21-26 weeks; 3rd = 27-32 weeks and 4th = 33-38 weeks). Data were analyzed statistically using the nonparametric chi², Friedman and Kruskal-Wallis tests . RESULTS: the use of antiretroviral drugs during pregnancy induced no difference in total or HDL cholesterol but caused an increase from 76.5 and 84 mg/dL to 96 and 105 mg/dL in the concentration of the LDL fraction along gestation in ZDV and TT groups, respectively (p<0.01). A positive significant association was observed between triglycerides and viral burden in the ZDV group (r: 0.534; p=0.015). CONCLUSION: Antiretroviral agents during pregnancy increase serum LDL-colesterol levels. The risk of pregnancy regarding potentiation of long-term antiretroviral effects on lipid metabolism, remains to be established.
Views74This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Trabalhos OriginaisDo antiretroviral agents modify lipid profile in pregnant women?
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(8):593-598
12-15-2003DOI 10.1590/S0100-72032003000800008
Views74See morePURPOSE: to investigate the effect of antiretroviral drugs on the lipid metabolism in HIV-infected pregnant women. METHODS: a prospective study was conducted on 57 pregnant women. The women were divided into three groups: ZDV group, consisting of 20 HIV-infected women taking ZDV; TT group, consisting of 25 HIV-1-infected women on triple antiretroviral treatment (ZDV + 3TC + NFV), and control group, consisting of 12 pregnant women considered to be normal from a clinical and laboratory viewpoint. Demographic and anthropometric data were homogeneous. Patients with a personal and family history of hyperlipidemia were excluded. Blood samples were obtained for the determination of fasting lipids (total cholesterol, LDL and HDL, and triglycerides) at four periods during pregnancy (1st = 14-20 weeks; 2nd = 21-26 weeks; 3rd = 27-32 weeks and 4th = 33-38 weeks). Data were analyzed statistically using the nonparametric chi², Friedman and Kruskal-Wallis tests . RESULTS: the use of antiretroviral drugs during pregnancy induced no difference in total or HDL cholesterol but caused an increase from 76.5 and 84 mg/dL to 96 and 105 mg/dL in the concentration of the LDL fraction along gestation in ZDV and TT groups, respectively (p<0.01). A positive significant association was observed between triglycerides and viral burden in the ZDV group (r: 0.534; p=0.015). CONCLUSION: Antiretroviral agents during pregnancy increase serum LDL-colesterol levels. The risk of pregnancy regarding potentiation of long-term antiretroviral effects on lipid metabolism, remains to be established.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Trabalhos Originais Archives - Page 4 of 51 - Revista Brasileira de Ginecologia e Obstetrícia
