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Trabalhos Originais
Effects of chronic amprenavir treatment on rat pregnancy
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(3):207-211
07-05-2004
Summary
Trabalhos OriginaisEffects of chronic amprenavir treatment on rat pregnancy
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(3):207-211
07-05-2004DOI 10.1590/S0100-72032004000300006
Views114See moreOBJECTIVE: to evaluate the chronic effects of amprenavir on implantations, reabsorptions, fetuses, placentae, and maternal and fetal mortality in the albino rat. METHODS: five groups of EPM-1 Wistar pregnant rats were used: two controls: Contr1 (control of stress) and Contr2 (drug vehicle control), and 3 experimental groups that were treated once a day throughout gestation with 46mg/kg (Exper1), 138mg/kg (Exper2) and 414mg/kg (Exper3) of oral solution of amprenavir. The drug and the vehicle (propyleneglycol) were administered by gavage. The evaluations included maternal body weight gain, number of implantations, reabsorptions, fetuses, placentae and of intrauterine deaths as well as fetal and placental mean weight and major malformations. Fragments of lungs, kidneys, liver and intestines were collected and prepared for histopathological evaluation. RESULTS: Exper3 group tended to show lesser maternal body weight gain during gestation (P = 0.07), but amprenavir did not affect the intrauterine contents. The cytotoxic effect of the drug was observed with regard to the histopathological analyses of pregnant rat viscerae and to the maternal mortality rate: 50% in Exper1 and Exper2 groups, and 70% in Exper3 group. CONCLUSION: amprenavir exerted adverse side effects on maternal lung, gut, kidney and liver, and significantly increased maternal mortality rates in all administered doses and especially at 414 mg/kg.
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Trabalhos OriginaisEffects of chronic amprenavir treatment on rat pregnancy
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(3):207-211
07-05-2004DOI 10.1590/S0100-72032004000300006
Views114See moreOBJECTIVE: to evaluate the chronic effects of amprenavir on implantations, reabsorptions, fetuses, placentae, and maternal and fetal mortality in the albino rat. METHODS: five groups of EPM-1 Wistar pregnant rats were used: two controls: Contr1 (control of stress) and Contr2 (drug vehicle control), and 3 experimental groups that were treated once a day throughout gestation with 46mg/kg (Exper1), 138mg/kg (Exper2) and 414mg/kg (Exper3) of oral solution of amprenavir. The drug and the vehicle (propyleneglycol) were administered by gavage. The evaluations included maternal body weight gain, number of implantations, reabsorptions, fetuses, placentae and of intrauterine deaths as well as fetal and placental mean weight and major malformations. Fragments of lungs, kidneys, liver and intestines were collected and prepared for histopathological evaluation. RESULTS: Exper3 group tended to show lesser maternal body weight gain during gestation (P = 0.07), but amprenavir did not affect the intrauterine contents. The cytotoxic effect of the drug was observed with regard to the histopathological analyses of pregnant rat viscerae and to the maternal mortality rate: 50% in Exper1 and Exper2 groups, and 70% in Exper3 group. CONCLUSION: amprenavir exerted adverse side effects on maternal lung, gut, kidney and liver, and significantly increased maternal mortality rates in all administered doses and especially at 414 mg/kg.
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Trabalhos Originais
Mobiluncus sp morphotype counts and leukocyte concentrations in vaginal smears of patients with bacterial vaginosis
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(3):221-225
07-05-2004
Summary
Trabalhos OriginaisMobiluncus sp morphotype counts and leukocyte concentrations in vaginal smears of patients with bacterial vaginosis
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(3):221-225
07-05-2004DOI 10.1590/S0100-72032004000300008
Views50See moreOBJECTIVE: to evaluate the presence of curved rods, suggesting Mobiluncus sp, and leukocytosis on Gram and Papanicolaou-stained vaginal smears in cases of bacterial vaginosis. METHODS: two hundred and five vaginal smears were studied by the Papanicolaou's method and other 205 vaginal smears, in the same patients, were evaluated by Gram staining. The diagnosis of bacterial vaginosis was made clinically by one of the authors (J.E.J.) using Amsel's criteria. In the Gram method stained smears the Nugent's score was calculated and the presence of curved rods was evaluated. In Papanicolaou's smears curved rods were searched as well the presence of leukocytes. The data were analyzed by Prism 3.0® with confidence interval of 95% using the Fisher exact test with modified Wald's method. RESULTS: on Pap smears the curved rods were present in 51.7% of the cases. The number of leukocytes varied, although the leukopenia was more frequent. In Gram-stained smears the curved rods were present in 46.8% of the cases and the Nugent's score was 8 in 48.3% of the cases. The finding of Mobiluncus sp in both methods occurred in 82%. When curved rods were observed leukocytosis occurred in 57.5% (p < 0.0001). In the same way, leukocytosis was more frequent in Nugent's scores 9 and 10. CONCLUSION: curved rods were observed in about 52% of bacterial vaginosis. Leukocytosis in Pap smears was more frequent when Mobiluncus sp were found with higher Nugent's scores.
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Trabalhos OriginaisMobiluncus sp morphotype counts and leukocyte concentrations in vaginal smears of patients with bacterial vaginosis
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(3):221-225
07-05-2004DOI 10.1590/S0100-72032004000300008
Views50See moreOBJECTIVE: to evaluate the presence of curved rods, suggesting Mobiluncus sp, and leukocytosis on Gram and Papanicolaou-stained vaginal smears in cases of bacterial vaginosis. METHODS: two hundred and five vaginal smears were studied by the Papanicolaou's method and other 205 vaginal smears, in the same patients, were evaluated by Gram staining. The diagnosis of bacterial vaginosis was made clinically by one of the authors (J.E.J.) using Amsel's criteria. In the Gram method stained smears the Nugent's score was calculated and the presence of curved rods was evaluated. In Papanicolaou's smears curved rods were searched as well the presence of leukocytes. The data were analyzed by Prism 3.0® with confidence interval of 95% using the Fisher exact test with modified Wald's method. RESULTS: on Pap smears the curved rods were present in 51.7% of the cases. The number of leukocytes varied, although the leukopenia was more frequent. In Gram-stained smears the curved rods were present in 46.8% of the cases and the Nugent's score was 8 in 48.3% of the cases. The finding of Mobiluncus sp in both methods occurred in 82%. When curved rods were observed leukocytosis occurred in 57.5% (p < 0.0001). In the same way, leukocytosis was more frequent in Nugent's scores 9 and 10. CONCLUSION: curved rods were observed in about 52% of bacterial vaginosis. Leukocytosis in Pap smears was more frequent when Mobiluncus sp were found with higher Nugent's scores.
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Trabalhos Originais
Risk factors for wound infection in operated breast cancer patients
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(3):227-232
07-05-2004
Summary
Trabalhos OriginaisRisk factors for wound infection in operated breast cancer patients
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(3):227-232
07-05-2004DOI 10.1590/S0100-72032004000300009
Views68See morePURPOSE: to identify the risk factors associated with the occurrence of surgical site infection (SSI) in surgeries for the treatment of breast cancer. METHODS: the study was conducted on 140 women submitted to treatment of invasive breast cancer during the period from January 2001 to December 2002. SSI was defined as infection occurring up to 30 days after surgery and was related to the operation, according to the standard criteria adopted by the Centers for Disease Control and Prevention (CDC), USA. SSI were considered to be superficial when they involved only the skin and subcutaneous tissue and deep when they involved deep tissues at the site of incision, such as fascia and muscles. The risk factors related to patient were age, hormonal status, staging, body mass index (BMI) and hemoglobin, and the factors related to surgery were type of operation, time of hospitalization, duration of surgery, and formation of seroma and hematoma. Data concerning numerical nonparametric variables were analyzed by the Mann-Whitney test and quantitative variables were analyzed by the Fisher exact test. RESULTS: of the 140 patients studied, 29 (20.7%) presented SSI, which were superficial in 19 (13.6%) and deep in 10 (71%); 111 patients did not present SSI and represented the control group. The risk factors associated with the patient and the disease were locally advanced stage (odds ratio = 27; 95% CI: 1.1-6.5) and obesity, represented by a mean BMI of 32.2 kg/m² in the patients with SSI and a mean BMI of 27.2 kg/m² in the control group (p<0.0001). The factors related to treatment of the disease were the use of neoadjuvant chemotherapy (odds ratio = 2.7 (95% CI: 1.1-6.5), the duration of surgery, whose median value was 165 minutes for the patients who developed the infection and 137 minutes for the control group (p=0.02), and the number of days of use of the postoperative drain, whose median value was 6 days for the patients with SSI and 5 days for the control group (p=0.048). CONCLUSION: on the basis of the identification of risk factors such as advanced stage, neoadjuvant chemotherapy and obesity, preoperative care for these patients should be emphasized. The use of an accurate surgical technique may reduce the impact of other factors such as surgical time and time of use of the drain.
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Trabalhos OriginaisRisk factors for wound infection in operated breast cancer patients
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(3):227-232
07-05-2004DOI 10.1590/S0100-72032004000300009
Views68See morePURPOSE: to identify the risk factors associated with the occurrence of surgical site infection (SSI) in surgeries for the treatment of breast cancer. METHODS: the study was conducted on 140 women submitted to treatment of invasive breast cancer during the period from January 2001 to December 2002. SSI was defined as infection occurring up to 30 days after surgery and was related to the operation, according to the standard criteria adopted by the Centers for Disease Control and Prevention (CDC), USA. SSI were considered to be superficial when they involved only the skin and subcutaneous tissue and deep when they involved deep tissues at the site of incision, such as fascia and muscles. The risk factors related to patient were age, hormonal status, staging, body mass index (BMI) and hemoglobin, and the factors related to surgery were type of operation, time of hospitalization, duration of surgery, and formation of seroma and hematoma. Data concerning numerical nonparametric variables were analyzed by the Mann-Whitney test and quantitative variables were analyzed by the Fisher exact test. RESULTS: of the 140 patients studied, 29 (20.7%) presented SSI, which were superficial in 19 (13.6%) and deep in 10 (71%); 111 patients did not present SSI and represented the control group. The risk factors associated with the patient and the disease were locally advanced stage (odds ratio = 27; 95% CI: 1.1-6.5) and obesity, represented by a mean BMI of 32.2 kg/m² in the patients with SSI and a mean BMI of 27.2 kg/m² in the control group (p<0.0001). The factors related to treatment of the disease were the use of neoadjuvant chemotherapy (odds ratio = 2.7 (95% CI: 1.1-6.5), the duration of surgery, whose median value was 165 minutes for the patients who developed the infection and 137 minutes for the control group (p=0.02), and the number of days of use of the postoperative drain, whose median value was 6 days for the patients with SSI and 5 days for the control group (p=0.048). CONCLUSION: on the basis of the identification of risk factors such as advanced stage, neoadjuvant chemotherapy and obesity, preoperative care for these patients should be emphasized. The use of an accurate surgical technique may reduce the impact of other factors such as surgical time and time of use of the drain.
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Trabalhos Originais
Histoarchitecture, endocrine function and pregnancy rate after orthotopic intact and sliced ovarian autologous transplantation in the rabbit
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(2):117-123
05-10-2004
Summary
Trabalhos OriginaisHistoarchitecture, endocrine function and pregnancy rate after orthotopic intact and sliced ovarian autologous transplantation in the rabbit
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(2):117-123
05-10-2004DOI 10.1590/S0100-72032004000200006
Views60See morePURPOSE: to assess the natural pregnancy rates in rabbits submitted to bilateral oophorectomy and orthotopic autologous (both intact and sliced) ovarian transplantation without vascular pedicle and to verify the morphofunctional aspects of reimplanted ovaries. METHOD: thirty-two female New Zealand White rabbits were studied. The ovaries were removed and orthotopically replaced without vascular anastomosis. In the control group (GC) (n=8), only laparotomy was carried out. In the RI group (n=8) intact ovaries were reimplanted in both sides. In the RF group (n=8) the ovaries were sliced and orthotopically reimplanted. In the RIF group (n=8), in one side the intact ovary and in the other side the sliced ovary was reimplanted.Three months later, the animals were paired with sexually mature males for copulation. Estradiol, progesterone, follicle stimulating hormone and luteinizing hormone levels were assessed nine months after surgery. Histologic study of the transplanted ovaries, tubes and uteri was carried out, and the number of pregnancies and animals per litter in each group was taken into account as well. The chi² test compared the pregnancy and the litters between the groups. Student's t test compared the hormone determinations. Significance was set at p<0.05. RESULTS: pregnancies occurred in all rabbits of the GC, between the second and third months after copulation, with 6 to 10 animals per litter for animal. In the other groups, the pregnancies occurred between the fifth and eighth postoperative month. Pregnancies occurred in 37.5% of rabbits in group RI, and in 50% of the RF and RIF groups. There was no difference between the number of animals per litter in the reimplanted groups, with 1 to 4 animals per litter for each animal. Hormone levels and histology confirmed the vitality of all ovaries. CONCLUSIONS: intact or sliced orthotopic autologous ovarian transplantation without vascular pedicle is viable in rabbits, and preserves the hormonal and fertile functions.
Views60This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Trabalhos OriginaisHistoarchitecture, endocrine function and pregnancy rate after orthotopic intact and sliced ovarian autologous transplantation in the rabbit
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(2):117-123
05-10-2004DOI 10.1590/S0100-72032004000200006
Views60See morePURPOSE: to assess the natural pregnancy rates in rabbits submitted to bilateral oophorectomy and orthotopic autologous (both intact and sliced) ovarian transplantation without vascular pedicle and to verify the morphofunctional aspects of reimplanted ovaries. METHOD: thirty-two female New Zealand White rabbits were studied. The ovaries were removed and orthotopically replaced without vascular anastomosis. In the control group (GC) (n=8), only laparotomy was carried out. In the RI group (n=8) intact ovaries were reimplanted in both sides. In the RF group (n=8) the ovaries were sliced and orthotopically reimplanted. In the RIF group (n=8), in one side the intact ovary and in the other side the sliced ovary was reimplanted.Three months later, the animals were paired with sexually mature males for copulation. Estradiol, progesterone, follicle stimulating hormone and luteinizing hormone levels were assessed nine months after surgery. Histologic study of the transplanted ovaries, tubes and uteri was carried out, and the number of pregnancies and animals per litter in each group was taken into account as well. The chi² test compared the pregnancy and the litters between the groups. Student's t test compared the hormone determinations. Significance was set at p<0.05. RESULTS: pregnancies occurred in all rabbits of the GC, between the second and third months after copulation, with 6 to 10 animals per litter for animal. In the other groups, the pregnancies occurred between the fifth and eighth postoperative month. Pregnancies occurred in 37.5% of rabbits in group RI, and in 50% of the RF and RIF groups. There was no difference between the number of animals per litter in the reimplanted groups, with 1 to 4 animals per litter for each animal. Hormone levels and histology confirmed the vitality of all ovaries. CONCLUSIONS: intact or sliced orthotopic autologous ovarian transplantation without vascular pedicle is viable in rabbits, and preserves the hormonal and fertile functions.
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Trabalhos Originais
Contact with paternal antigens in oral and vaginal mucosa and recurrent abortion
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(2):139-146
05-10-2004
Summary
Trabalhos OriginaisContact with paternal antigens in oral and vaginal mucosa and recurrent abortion
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(2):139-146
05-10-2004DOI 10.1590/S0100-72032004000200009
Views61See morePURPOSE: to evaluate whether oral and vaginal sex practice, with or without exposure to semen, decrease the occurrence of recurrent spontaneous abortion. METHOD: this was a case-control study carried out between May 2000 and April 2003. A questionnaire was applied analyzing the clinical, obstetric and sexual history of women, who were divided into two groups: a case group comprised 116 patients with a history of at least two spontaneous abortions, without previous pregnancy longer than 22 weeks, and a control group that included 241 women with history of one or more term pregnancies with live birth and no miscarriage. The analyzed variables included the number of sexual partners, condom use, oral sex practice, and the exposure of female oral mucosa to semen. RESULTS: in the control group 38.8%, and in the patients group 35.7% of the women had only one partner. In both groups about 75% of the women reported that the partners did not use condom. Approximately 55% of the women of both groups referred oral sex practice, and 13.8% of those with recurrent abortion and 20.3% with a history of successful pregnancies had oral mucosa exposed to semen. There was no difference between the patients with recurrent abortion and women with successful pregnancies regarding number of sexual partners, use of condom, practice of oral sex, and exposure of oral mucosa to the partner's semen. CONCLUSION: our results did not confirm the hypothesis that sexual behavior influences the occurrence of spontaneous abortion.
Views61This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Trabalhos OriginaisContact with paternal antigens in oral and vaginal mucosa and recurrent abortion
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(2):139-146
05-10-2004DOI 10.1590/S0100-72032004000200009
Views61See morePURPOSE: to evaluate whether oral and vaginal sex practice, with or without exposure to semen, decrease the occurrence of recurrent spontaneous abortion. METHOD: this was a case-control study carried out between May 2000 and April 2003. A questionnaire was applied analyzing the clinical, obstetric and sexual history of women, who were divided into two groups: a case group comprised 116 patients with a history of at least two spontaneous abortions, without previous pregnancy longer than 22 weeks, and a control group that included 241 women with history of one or more term pregnancies with live birth and no miscarriage. The analyzed variables included the number of sexual partners, condom use, oral sex practice, and the exposure of female oral mucosa to semen. RESULTS: in the control group 38.8%, and in the patients group 35.7% of the women had only one partner. In both groups about 75% of the women reported that the partners did not use condom. Approximately 55% of the women of both groups referred oral sex practice, and 13.8% of those with recurrent abortion and 20.3% with a history of successful pregnancies had oral mucosa exposed to semen. There was no difference between the patients with recurrent abortion and women with successful pregnancies regarding number of sexual partners, use of condom, practice of oral sex, and exposure of oral mucosa to the partner's semen. CONCLUSION: our results did not confirm the hypothesis that sexual behavior influences the occurrence of spontaneous abortion.
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Trabalhos Originais
Knowledge, opinion and attitudes of Brazilian gynecologists and obstetricians regarding induction of abortion
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(2):89-96
05-07-2004
Summary
Trabalhos OriginaisKnowledge, opinion and attitudes of Brazilian gynecologists and obstetricians regarding induction of abortion
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(2):89-96
05-07-2004DOI 10.1590/S0100-72032004000200002
Views80See morePURPOSE: to evaluate knowledge, opinion and practice of gynecologists/obstetricians regarding induction of abortion. Method: a pretested, structured questionnaire was sent to gynecologists/obstetricians affiliated to FEBRASGO. They were asked to answer and return the questionnaire in a self-addressed, prepaid envelope, without identification of the respondent so as to preserve anonymity. Knowledge about the legal situation of abortion in Brazil, opinion about it and practice if confronted with abortion requests were questioned. RESULTS: approximately 90% of the respondents believed that abortion is legal for pregnancy resulting from rape or in case of risk to a woman's life and for 31.8% in case of severe fetal malformation. In their opinion abortion should be permitted in the case that pregnancy is a risk for a woman's life (79.3%), fetal malformation (77.0%) and after rape (76.6%), added to 9.9% who expressed that abortion should be permitted in all circumstances. Two thirds wrongly thought that a judicial order is required to practice a legal abortion and only 27.4% knew that a written request by the woman is required. Confronted with unwanted pregnancy, 77.6% of female gynecologists/obstetricians and 79.9% of partners of male respondents had an abortion, 40% would help a client and 48.5% a relative in the same situation. CONCLUSION: gynecologists/obstetricians lack knowledge on the legal situation of abortion although their opinion and practice are favorable.
Views80This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Trabalhos OriginaisKnowledge, opinion and attitudes of Brazilian gynecologists and obstetricians regarding induction of abortion
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(2):89-96
05-07-2004DOI 10.1590/S0100-72032004000200002
Views80See morePURPOSE: to evaluate knowledge, opinion and practice of gynecologists/obstetricians regarding induction of abortion. Method: a pretested, structured questionnaire was sent to gynecologists/obstetricians affiliated to FEBRASGO. They were asked to answer and return the questionnaire in a self-addressed, prepaid envelope, without identification of the respondent so as to preserve anonymity. Knowledge about the legal situation of abortion in Brazil, opinion about it and practice if confronted with abortion requests were questioned. RESULTS: approximately 90% of the respondents believed that abortion is legal for pregnancy resulting from rape or in case of risk to a woman's life and for 31.8% in case of severe fetal malformation. In their opinion abortion should be permitted in the case that pregnancy is a risk for a woman's life (79.3%), fetal malformation (77.0%) and after rape (76.6%), added to 9.9% who expressed that abortion should be permitted in all circumstances. Two thirds wrongly thought that a judicial order is required to practice a legal abortion and only 27.4% knew that a written request by the woman is required. Confronted with unwanted pregnancy, 77.6% of female gynecologists/obstetricians and 79.9% of partners of male respondents had an abortion, 40% would help a client and 48.5% a relative in the same situation. CONCLUSION: gynecologists/obstetricians lack knowledge on the legal situation of abortion although their opinion and practice are favorable.
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Trabalhos Originais
Association of cervical intraepithelial neoplasia with CD4 T cell counts and viral load in HIV-infected women
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(2):97-102
05-07-2004
Summary
Trabalhos OriginaisAssociation of cervical intraepithelial neoplasia with CD4 T cell counts and viral load in HIV-infected women
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(2):97-102
05-07-2004DOI 10.1590/S0100-72032004000200003
Views86See morePURPOSE: to correlate the type of cervical lesion diagnosed by Pap smear with CD4 cell counts and HIV-RNA viral load in HIV-positive patients. METHODS: one hundred and fifteen HIV patients were evaluated retrospectively in the present study, during the period from January 2002 to April 2003, at a university hospital. Eighty-three patients presented cervical intraepithelial neoplasia (CIN) in Pap smear, in comparison with thirty-two with no lesions. Patients were divided into three groups, according to CD4 counts: CD4 more than 500 cells/mm³, between 200 and 500 cells/mm³, and less than 200 cells/mm³, and other three groups, according to HIV viral load: less than 10,000 HIV-RNA copies/mL, between 10,000 and 100,000 HIV-RNA copies/mL, or more than 100,000 HIV-RNA copies/mL. Correlation was investigated by the Fisher test. RESULTS: of the eighty-three patients with CIN, 73% presented CD4 counts less than 500 cells/mm³. In all CD4 groups, more than 50% of the patients presented CIN. According to the viral load, 71.7% of the patients with less than 10,000 HIV-RNA copies/mL presented CIN I, compared with 11.3% that showed CIN III. In the group with higher viral load (>100.000 HIV-RNA copies/mL), 61.5% showed CIN I and 30.8% presented CIN III. CONCLUSION: association between viral load and CIN was established (p=0.013), which was not observed with CD4 cell counts and CIN. Concomitant cervicovaginal infection was considered a potential confounding factor.
Views86This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Trabalhos OriginaisAssociation of cervical intraepithelial neoplasia with CD4 T cell counts and viral load in HIV-infected women
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(2):97-102
05-07-2004DOI 10.1590/S0100-72032004000200003
Views86See morePURPOSE: to correlate the type of cervical lesion diagnosed by Pap smear with CD4 cell counts and HIV-RNA viral load in HIV-positive patients. METHODS: one hundred and fifteen HIV patients were evaluated retrospectively in the present study, during the period from January 2002 to April 2003, at a university hospital. Eighty-three patients presented cervical intraepithelial neoplasia (CIN) in Pap smear, in comparison with thirty-two with no lesions. Patients were divided into three groups, according to CD4 counts: CD4 more than 500 cells/mm³, between 200 and 500 cells/mm³, and less than 200 cells/mm³, and other three groups, according to HIV viral load: less than 10,000 HIV-RNA copies/mL, between 10,000 and 100,000 HIV-RNA copies/mL, or more than 100,000 HIV-RNA copies/mL. Correlation was investigated by the Fisher test. RESULTS: of the eighty-three patients with CIN, 73% presented CD4 counts less than 500 cells/mm³. In all CD4 groups, more than 50% of the patients presented CIN. According to the viral load, 71.7% of the patients with less than 10,000 HIV-RNA copies/mL presented CIN I, compared with 11.3% that showed CIN III. In the group with higher viral load (>100.000 HIV-RNA copies/mL), 61.5% showed CIN I and 30.8% presented CIN III. CONCLUSION: association between viral load and CIN was established (p=0.013), which was not observed with CD4 cell counts and CIN. Concomitant cervicovaginal infection was considered a potential confounding factor.
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Trabalhos Originais
Detection rate of human papillomavirus by hybrid capture II in women with cervical intraepithelial neoplasia
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(2):105-110
05-07-2004
Summary
Trabalhos OriginaisDetection rate of human papillomavirus by hybrid capture II in women with cervical intraepithelial neoplasia
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(2):105-110
05-07-2004DOI 10.1590/S0100-72032004000200004
Views94See morePURPOSE: to evaluate the high-risk oncogenic human papillomavirus (HPV) detection rate of patients with cervical intraepithelial neoplasia (CIN), checking the association between high-risk HPV, viral load and severity of the lesion, as well as the best viral load cutoff to predict lesion severity. METHODS: this is a cross-sectional study. One hundred and ten patients were selected by cytology and/or biopsy with CIN diagnosis. All of them were submitted to a new oncologic cytology, hybrid capture II (HC II), colposcopy, and loop electrosurgical excision and fulguration procedures (LEEP). RESULTS: the global detection rate of high-risk oncogenic HPV in these women was 77.3%. Eighty-one women (73.7%) had CIN with a detection rate of HPV-DNA of 87.6%. In women with CIN 2 or 3 the detection rate was 85.9%. HC II had a sensitivity of 87.8%, specificity of 56.0%, predictive positive value of 86.6% and predictive negative value of 58.3%, with an odds ratio of 7.76 (2.47 < OR < 25.15) for CIN 2 or 3 diagnosis. Using a receiver operator characteristic curve a viral load cutoff was set at 20 pg/mL in this population, with a predictive positive value of 81.3%. CONCLUSIONS: HPV DNA detection rate of patients with CIN was 77.3%. In women with CIN 2/3 it was 85.9%. The best viral load cutoff to predict cervical lesion severity was 20 pg/ml. Above this level the probability of high-risk oncogenic HPV detection is greater than 80%.
Views94This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Trabalhos OriginaisDetection rate of human papillomavirus by hybrid capture II in women with cervical intraepithelial neoplasia
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(2):105-110
05-07-2004DOI 10.1590/S0100-72032004000200004
Views94See morePURPOSE: to evaluate the high-risk oncogenic human papillomavirus (HPV) detection rate of patients with cervical intraepithelial neoplasia (CIN), checking the association between high-risk HPV, viral load and severity of the lesion, as well as the best viral load cutoff to predict lesion severity. METHODS: this is a cross-sectional study. One hundred and ten patients were selected by cytology and/or biopsy with CIN diagnosis. All of them were submitted to a new oncologic cytology, hybrid capture II (HC II), colposcopy, and loop electrosurgical excision and fulguration procedures (LEEP). RESULTS: the global detection rate of high-risk oncogenic HPV in these women was 77.3%. Eighty-one women (73.7%) had CIN with a detection rate of HPV-DNA of 87.6%. In women with CIN 2 or 3 the detection rate was 85.9%. HC II had a sensitivity of 87.8%, specificity of 56.0%, predictive positive value of 86.6% and predictive negative value of 58.3%, with an odds ratio of 7.76 (2.47 < OR < 25.15) for CIN 2 or 3 diagnosis. Using a receiver operator characteristic curve a viral load cutoff was set at 20 pg/mL in this population, with a predictive positive value of 81.3%. CONCLUSIONS: HPV DNA detection rate of patients with CIN was 77.3%. In women with CIN 2/3 it was 85.9%. The best viral load cutoff to predict cervical lesion severity was 20 pg/ml. Above this level the probability of high-risk oncogenic HPV detection is greater than 80%.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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