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Review Article
Analysis of the Role of Female Hormones During Infection by COVID-19
- David Balbino Pascoal
, - Isabela Macêdo de Araujo ,
- Lorenna Peixoto Lopes ,
- Cristiane Monteiro da Cruz
01-24-2021
Summary
Review ArticleAnalysis of the Role of Female Hormones During Infection by COVID-19
Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(12):940-948
01-24-2021- David Balbino Pascoal ,
- Isabela Macêdo de Araujo ,
- Lorenna Peixoto Lopes ,
- Cristiane Monteiro da Cruz
Views116See moreAbstract
Women have metabolic, immunological, and genetic variables that ensure more protection from coronavirus infection. However, the indication of treatment for several pathologies and contraception is determined by hormones that have adverse effects and raise doubts about their use during the COVID-19 pandemic. Therefore, the present study searches women specificities and the relation between female sexual hormones and COVID-19, and reports the main recommendations in this background. To this end, a review of the literature was conducted in the main databases, auxiliary data sources, and official websites. Therefore, considering the hypercoagulability status of COVID-19, the debate about the use of contraceptives due to the relative risk of thromboembolic effects that they impose arises. However, the current available evidence, as well as the recommendations of main health organs around the world, demonstrate that the use of hormonal contraceptives must be maintained during the pandemic.
Views116
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Review ArticleAnalysis of the Role of Female Hormones During Infection by COVID-19
Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(12):940-948
01-24-2021- David Balbino Pascoal ,
- Isabela Macêdo de Araujo ,
- Lorenna Peixoto Lopes ,
- Cristiane Monteiro da Cruz
Views116See moreAbstract
Women have metabolic, immunological, and genetic variables that ensure more protection from coronavirus infection. However, the indication of treatment for several pathologies and contraception is determined by hormones that have adverse effects and raise doubts about their use during the COVID-19 pandemic. Therefore, the present study searches women specificities and the relation between female sexual hormones and COVID-19, and reports the main recommendations in this background. To this end, a review of the literature was conducted in the main databases, auxiliary data sources, and official websites. Therefore, considering the hypercoagulability status of COVID-19, the debate about the use of contraceptives due to the relative risk of thromboembolic effects that they impose arises. However, the current available evidence, as well as the recommendations of main health organs around the world, demonstrate that the use of hormonal contraceptives must be maintained during the pandemic.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 
- David Balbino Pascoal
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Review Article
Clinical and Obstetric Aspects of Pregnant Women with COVID-19: A Systematic Review
- Sarah Nilkece Mesquita Araújo Nogueira Bastos ,
- Bárbara Louise Freire Barbosa ,
- Larisse Giselle Barbosa Cruz ,
- Rayza Pereira de Souza ,
- Simone Santos e Silva Melo , [ ... ],
- Caroline Camargo Bandeira da Silveira Luz
01-24-2021
Summary
Review ArticleClinical and Obstetric Aspects of Pregnant Women with COVID-19: A Systematic Review
Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(12):949-960
01-24-2021- Sarah Nilkece Mesquita Araújo Nogueira Bastos ,
- Bárbara Louise Freire Barbosa ,
- Larisse Giselle Barbosa Cruz ,
- Rayza Pereira de Souza ,
- Simone Santos e Silva Melo ,
- Caroline Camargo Bandeira da Silveira Luz
Views187See moreAbstract
Objective
To analyze the clinical and obstetric aspects of pregnant women with COVID-19.
Methods
A systematic literature review in the MEDLINE/PubMed, LILACS, SCIELO, and CNKI databases was performed from March to May 2020, with the descriptors: Pregnancy; 2019-nCov; Coronavirus; SARS-Cov-2, Covid-19. Of those chosen were original titles, without language and period restriction and that addressed pregnant women with a clinical and/or laboratory diagnosis of COVID-19. Revisions, editorials, and duplicate titles were excluded. The Newcastle-Ottawa (NOS) and Murad et al. scales were used to assess the quality of the studies.
Results
We included 34 articles with 412 pregnant women infected with severe acute respiratory syndrome (SARS-Cov-2), with an average age of 27.5 years of age and 36.0 gestational weeks. The most common symptom was fever (205 [49.7%]), and 89 (21.6%) pregnant women progressed to severe viral pneumonia. Laboratory tests showed an increase in C-reactive protein (154 [37.8%]), and radiological tests showed pneumonia with peripheral ground-glass pattern (172 [51.4%]). Emergency cesarean delivery was indicated for most pregnant women, and the most common gestational complication was premature rupture of ovarian membranes (14 [3.4%;]). We detected 2 (0.5%) neonatal deaths, 2 (0.5%) stillbirths, and 1 (0.2%) maternal death.
Conclusion
Pregnant women with COVID-19 presented a clinical picture similar to that of non-infected pregnant women, with few obstetric or neonatal repercussions. There was a greater indication of cesarean deliveries before the disease aggravated, and there was no evidence of vertical transmission of the infection.
Views187This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Review ArticleClinical and Obstetric Aspects of Pregnant Women with COVID-19: A Systematic Review
Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(12):949-960
01-24-2021- Sarah Nilkece Mesquita Araújo Nogueira Bastos ,
- Bárbara Louise Freire Barbosa ,
- Larisse Giselle Barbosa Cruz ,
- Rayza Pereira de Souza ,
- Simone Santos e Silva Melo ,
- Caroline Camargo Bandeira da Silveira Luz
Views187See moreAbstract
Objective
To analyze the clinical and obstetric aspects of pregnant women with COVID-19.
Methods
A systematic literature review in the MEDLINE/PubMed, LILACS, SCIELO, and CNKI databases was performed from March to May 2020, with the descriptors: Pregnancy; 2019-nCov; Coronavirus; SARS-Cov-2, Covid-19. Of those chosen were original titles, without language and period restriction and that addressed pregnant women with a clinical and/or laboratory diagnosis of COVID-19. Revisions, editorials, and duplicate titles were excluded. The Newcastle-Ottawa (NOS) and Murad et al. scales were used to assess the quality of the studies.
Results
We included 34 articles with 412 pregnant women infected with severe acute respiratory syndrome (SARS-Cov-2), with an average age of 27.5 years of age and 36.0 gestational weeks. The most common symptom was fever (205 [49.7%]), and 89 (21.6%) pregnant women progressed to severe viral pneumonia. Laboratory tests showed an increase in C-reactive protein (154 [37.8%]), and radiological tests showed pneumonia with peripheral ground-glass pattern (172 [51.4%]). Emergency cesarean delivery was indicated for most pregnant women, and the most common gestational complication was premature rupture of ovarian membranes (14 [3.4%;]). We detected 2 (0.5%) neonatal deaths, 2 (0.5%) stillbirths, and 1 (0.2%) maternal death.
Conclusion
Pregnant women with COVID-19 presented a clinical picture similar to that of non-infected pregnant women, with few obstetric or neonatal repercussions. There was a greater indication of cesarean deliveries before the disease aggravated, and there was no evidence of vertical transmission of the infection.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 
- Sarah Nilkece Mesquita Araújo Nogueira Bastos
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Review Article
Intermittent versus Continuous Catheterization and Differences in the Evolution of Labor: Systematic Review and Meta-analysis
- Inês Reis ,
- Sara Cunha ,
- Matilde Martins ,
- Luísa Sousa ,
- Adérito Seixas , [ ... ],
- Cátia Rasteiro
01-24-2021
Summary
Review ArticleIntermittent versus Continuous Catheterization and Differences in the Evolution of Labor: Systematic Review and Meta-analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(12):961-967
01-24-2021Views197See moreAbstract
Objective
To evaluate the differences between bladder emptying options (permanent catheterization and intermittent bladder emptying/spontaneous urination) regarding the effects on labor length, need of operative vaginal deliveries, and cesarean section rate.
Data Sources
The search was conducted in MEDLINE, Scopus, Web of Science, and The Cochrane Central Register of Controlled Trials databases.
Selection of Studies
The survey returned 964 studies. A total of 719 studies were evaluated by title and abstract, of which 4 were selected for inclusion.
Data Collection
All references were inserted in the Rayyan QCRI tool (Rayyan Systems Inc., Cambridge, MA, USA). The full text of the selected articles was obtained so we could later decide whether or not to include them in this systematic review.
Data Synthesis
No differences were found in the number of instrumented deliveries or in cesarean section rate between groups.
Conclusions
After evaluating the studies performed on the topic, we concluded that there is no clear advantage to either method, although continuous catheterization was associated with a greater occurrence of eutocic births. In the remaining outcomes, there were no differences between catheterization types.
Views197This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Review ArticleIntermittent versus Continuous Catheterization and Differences in the Evolution of Labor: Systematic Review and Meta-analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(12):961-967
01-24-2021Views197See moreAbstract
Objective
To evaluate the differences between bladder emptying options (permanent catheterization and intermittent bladder emptying/spontaneous urination) regarding the effects on labor length, need of operative vaginal deliveries, and cesarean section rate.
Data Sources
The search was conducted in MEDLINE, Scopus, Web of Science, and The Cochrane Central Register of Controlled Trials databases.
Selection of Studies
The survey returned 964 studies. A total of 719 studies were evaluated by title and abstract, of which 4 were selected for inclusion.
Data Collection
All references were inserted in the Rayyan QCRI tool (Rayyan Systems Inc., Cambridge, MA, USA). The full text of the selected articles was obtained so we could later decide whether or not to include them in this systematic review.
Data Synthesis
No differences were found in the number of instrumented deliveries or in cesarean section rate between groups.
Conclusions
After evaluating the studies performed on the topic, we concluded that there is no clear advantage to either method, although continuous catheterization was associated with a greater occurrence of eutocic births. In the remaining outcomes, there were no differences between catheterization types.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 
- Inês Reis
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Review Article
The Effect of Aromatherapy Alone or in Combination with Massage on Dysmenorrhea: A Systematic Review and Meta-analysis
- Mona Najaf Najafi ,
- Neshat Najaf Najafi ,
- Farzaneh Rashidi Fakari ,
- Somayeh Moeindarbary ,
- Fatemeh Abdi , [ ... ],
- Masumeh Ghazanfarpour
01-24-2021
Summary
Review ArticleThe Effect of Aromatherapy Alone or in Combination with Massage on Dysmenorrhea: A Systematic Review and Meta-analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(12):968-979
01-24-2021- Mona Najaf Najafi ,
- Neshat Najaf Najafi ,
- Farzaneh Rashidi Fakari ,
- Somayeh Moeindarbary ,
- Fatemeh Abdi ,
- Zeinab Sadat Hoseini ,
- Masumeh Ghazanfarpour
Views261See moreAbstract
Objective
The aim of the present systematic review meta-analysis is to assess the effect of olfactory stimulation on reducing dysmenorrhea.
Methods
Systematic search was conducted in several databases, such as PubMed, Web of Science, Cochrane, and Scopus, to identify relevant research up to October 26, 2019. The identified studies were evaluated based on a modified Jadad scale. The intervention involves aromatherapy alone or in combination with essential oils. There was no restriction for the control group such as a placebo group or other common treatments. The Comprehensive Meta-Analysis Version 2 (Bio stat, Englewood, NJ, USA) was used for meta-analysis. Cochran’s Q and I2 tests were utilized.
Results
The findings of our meta-analysis, which contained 13 trials (15 data), showed that dysmenorrhea decreased significantly in the group receiving aromatherapy with herbal compared with the control group (standardized mean difference [SMD] =-0.795; 95% confidence interval [CI]: -0.922 to- 0.667; 17 trials O < 0.001); heterogeneity; I2 = 19.47%; p = 0.236). In addition, four studies with insufficient data were not included in our meta-analysis. The results of all studies suggested that aromatherapy with herbal medicine group compared with control group is effective.
Conclusion
Aromatherapy with herbal medicine decreased dysmenorrhea. This treatment was particularly effective when aroma oil was combined with massage or when a mixture of aroma oil was used for the treatment of dysmenorrhea.
Views261This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Review ArticleThe Effect of Aromatherapy Alone or in Combination with Massage on Dysmenorrhea: A Systematic Review and Meta-analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(12):968-979
01-24-2021- Mona Najaf Najafi ,
- Neshat Najaf Najafi ,
- Farzaneh Rashidi Fakari ,
- Somayeh Moeindarbary ,
- Fatemeh Abdi ,
- Zeinab Sadat Hoseini ,
- Masumeh Ghazanfarpour
Views261See moreAbstract
Objective
The aim of the present systematic review meta-analysis is to assess the effect of olfactory stimulation on reducing dysmenorrhea.
Methods
Systematic search was conducted in several databases, such as PubMed, Web of Science, Cochrane, and Scopus, to identify relevant research up to October 26, 2019. The identified studies were evaluated based on a modified Jadad scale. The intervention involves aromatherapy alone or in combination with essential oils. There was no restriction for the control group such as a placebo group or other common treatments. The Comprehensive Meta-Analysis Version 2 (Bio stat, Englewood, NJ, USA) was used for meta-analysis. Cochran’s Q and I2 tests were utilized.
Results
The findings of our meta-analysis, which contained 13 trials (15 data), showed that dysmenorrhea decreased significantly in the group receiving aromatherapy with herbal compared with the control group (standardized mean difference [SMD] =-0.795; 95% confidence interval [CI]: -0.922 to- 0.667; 17 trials O < 0.001); heterogeneity; I2 = 19.47%; p = 0.236). In addition, four studies with insufficient data were not included in our meta-analysis. The results of all studies suggested that aromatherapy with herbal medicine group compared with control group is effective.
Conclusion
Aromatherapy with herbal medicine decreased dysmenorrhea. This treatment was particularly effective when aroma oil was combined with massage or when a mixture of aroma oil was used for the treatment of dysmenorrhea.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 
- Mona Najaf Najafi
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Review Article
Dyspnea and COVID-19: A Review of Confounding Diagnoses during the Postpartum Period
Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(11):862-869
01-12-2021
Summary
Review ArticleDyspnea and COVID-19: A Review of Confounding Diagnoses during the Postpartum Period
Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(11):862-869
01-12-2021Views167See moreAbstract
The puerperium is a complex period that begins with placental delivery and lasts for 6 weeks, during which readaptation of the female organism and redistribution of blood volume occur. This period is conducive to the occurrence of thromboembolic events. In the context of the SARS-CoV-2 pandemic, the virus responsible for COVID-19, the attention of the scientific community and health professionals has been focused on obtaining insights on different aspects of this disease, including etiology, transmission, diagnosis, and treatment. Regarding the pregnancy-postpartum cycle, it is opportune to review the clinical conditions that can occur during this period and to investigate dyspnea as a postpartum symptom in order to avoid its immediate association with COVID-19 without further investigation, which can lead to overlooking the diagnosis of other important and occasionally fatal conditions.
Views167This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Review ArticleDyspnea and COVID-19: A Review of Confounding Diagnoses during the Postpartum Period
Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(11):862-869
01-12-2021Views167See moreAbstract
The puerperium is a complex period that begins with placental delivery and lasts for 6 weeks, during which readaptation of the female organism and redistribution of blood volume occur. This period is conducive to the occurrence of thromboembolic events. In the context of the SARS-CoV-2 pandemic, the virus responsible for COVID-19, the attention of the scientific community and health professionals has been focused on obtaining insights on different aspects of this disease, including etiology, transmission, diagnosis, and treatment. Regarding the pregnancy-postpartum cycle, it is opportune to review the clinical conditions that can occur during this period and to investigate dyspnea as a postpartum symptom in order to avoid its immediate association with COVID-19 without further investigation, which can lead to overlooking the diagnosis of other important and occasionally fatal conditions.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Review Article
Can Prenatal and Postnatal Cell Phone Exposure Increase Adverse Maternal, Infant and Child Outcomes?
- Farzaneh Ashrafinia ,
- Somayeh Moeindarbari ,
- Parisa Razmjouei ,
- Masumeh Ghazanfarpour ,
- Mona Najaf Najafi , [ ... ],
- Fatemeh Abdi
01-12-2021
Summary
Review ArticleCan Prenatal and Postnatal Cell Phone Exposure Increase Adverse Maternal, Infant and Child Outcomes?
Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(11):870-877
01-12-2021- Farzaneh Ashrafinia ,
- Somayeh Moeindarbari ,
- Parisa Razmjouei ,
- Masumeh Ghazanfarpour ,
- Mona Najaf Najafi ,
- Amir Ali Moodi Ghalibaf ,
- Fatemeh Abdi
Views171See moreAbstract
Objective
To determine the association between maternal mobile phone use and adverse outcomes in infants, children, and mothers.
Method
In March 202, we conducted a search on the MEDLINE, Embase, and Scopus databases. Data extraction and an assessment of the quality of the studies were performed by two authors. The quality of the studies was assessed using the checklist of the Newcastle-Ottawa scale.
Results
Studies assessing behavioral problems in infants aged 6 to 18 months reported null findings. However, an increased risk of emotional and behavioral disorders was observed in children aged between 7 and 11 years whose mothers had been exposed to cell phones. The findings regarding the association between maternal cell phone exposure and adverse outcomes in children aged 3 to 5 are controversial. A study found a significant association between the call time (p=0.002) or the history of mobile phone use (in months) and speech disorders in the children (p=0.003). However, another study found that maternal cell phone use during pregnancy was not significantly associated with child psychomotor and mental developments. Inconclusive results were observed about the adverse outcomes in fetuses, such as fetal growth restriction or t scores for birth weight in cell phone users as opposed to non-users. On the contrary, the children ofmothers who were cell phone users had a lower risk of scoring low on motor skills. Similar results were observed regarding the adverse outcomes of cell phone use in infants, such as fetal growth restriction or low birth weight, and the risk of preeclampsia was lower among subjects with medium and high cell phone exposure, as opposed to those with low exposure.
Conclusion
Studies on behavioral problems have reported different postnatal results, such as null findings among infants and a positive association in children.
Views171This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Review ArticleCan Prenatal and Postnatal Cell Phone Exposure Increase Adverse Maternal, Infant and Child Outcomes?
Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(11):870-877
01-12-2021- Farzaneh Ashrafinia ,
- Somayeh Moeindarbari ,
- Parisa Razmjouei ,
- Masumeh Ghazanfarpour ,
- Mona Najaf Najafi ,
- Amir Ali Moodi Ghalibaf ,
- Fatemeh Abdi
Views171See moreAbstract
Objective
To determine the association between maternal mobile phone use and adverse outcomes in infants, children, and mothers.
Method
In March 202, we conducted a search on the MEDLINE, Embase, and Scopus databases. Data extraction and an assessment of the quality of the studies were performed by two authors. The quality of the studies was assessed using the checklist of the Newcastle-Ottawa scale.
Results
Studies assessing behavioral problems in infants aged 6 to 18 months reported null findings. However, an increased risk of emotional and behavioral disorders was observed in children aged between 7 and 11 years whose mothers had been exposed to cell phones. The findings regarding the association between maternal cell phone exposure and adverse outcomes in children aged 3 to 5 are controversial. A study found a significant association between the call time (p=0.002) or the history of mobile phone use (in months) and speech disorders in the children (p=0.003). However, another study found that maternal cell phone use during pregnancy was not significantly associated with child psychomotor and mental developments. Inconclusive results were observed about the adverse outcomes in fetuses, such as fetal growth restriction or t scores for birth weight in cell phone users as opposed to non-users. On the contrary, the children ofmothers who were cell phone users had a lower risk of scoring low on motor skills. Similar results were observed regarding the adverse outcomes of cell phone use in infants, such as fetal growth restriction or low birth weight, and the risk of preeclampsia was lower among subjects with medium and high cell phone exposure, as opposed to those with low exposure.
Conclusion
Studies on behavioral problems have reported different postnatal results, such as null findings among infants and a positive association in children.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Farzaneh Ashrafinia
-
Review Article
Association of the Maternal Folic Acid Supplementation with the Autism Spectrum Disorder: A Systematic Review
- Adalberto Cruz Sampaio ,
- Francisco Facundo de Matos Neto ,
- Lucas de Lucena Lopes ,
- Ítalo Marcelo Maia Marques ,
- Ravel Moreira Tavares , [ ... ],
- Magaly Lima Mota
12-17-2021
Summary
Review ArticleAssociation of the Maternal Folic Acid Supplementation with the Autism Spectrum Disorder: A Systematic Review
Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(10):775-781
12-17-2021- Adalberto Cruz Sampaio ,
- Francisco Facundo de Matos Neto ,
- Lucas de Lucena Lopes ,
- Ítalo Marcelo Maia Marques ,
- Ravel Moreira Tavares ,
- Marcus Vinicius de Macedo Fernandes ,
- Maria Raquel Vieira da Silva Teixeira ,
- Alessandra Bezerra de Brito ,
- Andrea Couto Feitosa ,
- Tarciana Oliveira Guedes ,
- Magaly Lima Mota
Views269See moreAbstract
Objective
To analyze the scientific production regarding maternal folic acid (FA) supplementation and its relationship with autistic spectrum disorder (ASD).
Data Sources
We performed unrestricted electronic searches in the BIREME virtual bank, Virtual Health Library (VHL) and Medical Literature Analysis and Retrieval System Online (MEDLINE/PubMed) databases.
Selection of Studies
For sample selection, articles that met the proposed objectives were included, published in English, Spanish and Portuguese, the use of Health Sciences Descriptors (DeCS): autistic OR autism AND autism spectrum disorder AND folic acid, AND, with the use of the Medical Subject Headings (MeSH): autistic OR autism AND autistic spectrum disorder AND folic acid.
Data Collection
Data extraction was performed by the reviewers with a preestablished data collection formulary.
Data Synthesis
The Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) was used based on a checklist with 27 items and a 4-step flowchart.
Results
A total of 384 articles was found by the search strategies, of which 17 were eligible following the pre-established criteria. The main findings of the present review point to maternal FA supplementation in the pre-conception period and beginning of pregnancy as a protective effect in relation to ASD, which should be indicated in this period as prevention to the problem.
Conclusion
According to the research analyzed, more studies are necessary to know its effects on pregnancy, since the consumption of excessive FA may not be innocuous.
Views269This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Review ArticleAssociation of the Maternal Folic Acid Supplementation with the Autism Spectrum Disorder: A Systematic Review
Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(10):775-781
12-17-2021- Adalberto Cruz Sampaio ,
- Francisco Facundo de Matos Neto ,
- Lucas de Lucena Lopes ,
- Ítalo Marcelo Maia Marques ,
- Ravel Moreira Tavares ,
- Marcus Vinicius de Macedo Fernandes ,
- Maria Raquel Vieira da Silva Teixeira ,
- Alessandra Bezerra de Brito ,
- Andrea Couto Feitosa ,
- Tarciana Oliveira Guedes ,
- Magaly Lima Mota
Views269See moreAbstract
Objective
To analyze the scientific production regarding maternal folic acid (FA) supplementation and its relationship with autistic spectrum disorder (ASD).
Data Sources
We performed unrestricted electronic searches in the BIREME virtual bank, Virtual Health Library (VHL) and Medical Literature Analysis and Retrieval System Online (MEDLINE/PubMed) databases.
Selection of Studies
For sample selection, articles that met the proposed objectives were included, published in English, Spanish and Portuguese, the use of Health Sciences Descriptors (DeCS): autistic OR autism AND autism spectrum disorder AND folic acid, AND, with the use of the Medical Subject Headings (MeSH): autistic OR autism AND autistic spectrum disorder AND folic acid.
Data Collection
Data extraction was performed by the reviewers with a preestablished data collection formulary.
Data Synthesis
The Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) was used based on a checklist with 27 items and a 4-step flowchart.
Results
A total of 384 articles was found by the search strategies, of which 17 were eligible following the pre-established criteria. The main findings of the present review point to maternal FA supplementation in the pre-conception period and beginning of pregnancy as a protective effect in relation to ASD, which should be indicated in this period as prevention to the problem.
Conclusion
According to the research analyzed, more studies are necessary to know its effects on pregnancy, since the consumption of excessive FA may not be innocuous.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Adalberto Cruz Sampaio
-
Review Article
Oral Iron Supplementation in Pregnancy: Current Recommendations and Evidence-Based Medicine Suplementação oral de ferro na gravidez: recomendações atuais e medicina baseada na evidência
- Ana Filipa Moreira Duarte ,
- Ana Catarina Simões Viana Carneiro ,
- Ana Teresa Barbosa Maciel Meira Peixoto ,
- Daniela Filipa Pereira Montenegro ,
- Débora Sofia Carvalho Campos , [ ... ],
- Andreia Patrícia Machado Fino
12-17-2021
Summary
Review ArticleOral Iron Supplementation in Pregnancy: Current Recommendations and Evidence-Based Medicine Suplementação oral de ferro na gravidez: recomendações atuais e medicina baseada na evidência
Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(10):782-788
12-17-2021- Ana Filipa Moreira Duarte ,
- Ana Catarina Simões Viana Carneiro ,
- Ana Teresa Barbosa Maciel Meira Peixoto ,
- Daniela Filipa Pereira Montenegro ,
- Débora Sofia Carvalho Campos ,
- Ana Patrícia Ribeiro Alves ,
- Ana Rita Mota Magalhães Costa ,
- Andreia Patrícia Machado Fino
Views338See moreAbstract
Objective
To review the evidence about universal iron supplementation in pregnancy to prevent maternal anemia.
Methods
Bibliographic research of randomized and controlled clinical trials, meta-analyses, systematic reviews, and clinical guidelines, published between August 2009 and August 2019, using the MeSH terms: iron; therapeutic use; pregnancy; anemia, prevention and control.
Results
We included six clinical guidelines, three meta-analyses and one randomized controlled clinical trial.
Discussion
Most articles point to the improvement of hematological parameters and reduction of maternal anemia risk, with supplementary iron. However, they do not correlate this improvement in pregnant women without previous anemia with the eventual improvement of clinical parameters.
Conclusion
Universal iron supplementation in pregnancy is controversial, so we attribute a SORT C recommendation strength.
Views338This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Review ArticleOral Iron Supplementation in Pregnancy: Current Recommendations and Evidence-Based Medicine Suplementação oral de ferro na gravidez: recomendações atuais e medicina baseada na evidência
Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(10):782-788
12-17-2021- Ana Filipa Moreira Duarte ,
- Ana Catarina Simões Viana Carneiro ,
- Ana Teresa Barbosa Maciel Meira Peixoto ,
- Daniela Filipa Pereira Montenegro ,
- Débora Sofia Carvalho Campos ,
- Ana Patrícia Ribeiro Alves ,
- Ana Rita Mota Magalhães Costa ,
- Andreia Patrícia Machado Fino
Views338See moreAbstract
Objective
To review the evidence about universal iron supplementation in pregnancy to prevent maternal anemia.
Methods
Bibliographic research of randomized and controlled clinical trials, meta-analyses, systematic reviews, and clinical guidelines, published between August 2009 and August 2019, using the MeSH terms: iron; therapeutic use; pregnancy; anemia, prevention and control.
Results
We included six clinical guidelines, three meta-analyses and one randomized controlled clinical trial.
Discussion
Most articles point to the improvement of hematological parameters and reduction of maternal anemia risk, with supplementary iron. However, they do not correlate this improvement in pregnant women without previous anemia with the eventual improvement of clinical parameters.
Conclusion
Universal iron supplementation in pregnancy is controversial, so we attribute a SORT C recommendation strength.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Ana Filipa Moreira Duarte
Review Article Archives - Page 4 of 16 - Revista Brasileira de Ginecologia e Obstetrícia
