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Original Article
The Effect of Small Size Uterine Fibroids on Pregnancy Outcomes in High-risk Pregnancies
Revista Brasileira de Ginecologia e Obstetrícia. 2020;42(9):535-539
10-23-2020
Summary
Original ArticleThe Effect of Small Size Uterine Fibroids on Pregnancy Outcomes in High-risk Pregnancies
Revista Brasileira de Ginecologia e Obstetrícia. 2020;42(9):535-539
10-23-2020Views99See moreAbstract
Objective
To evaluate the obstetric outcomes of singleton high-risk pregnancies with a small size uterine fibroid.
Methods
This retrospective cohort study was conducted among 172 high-risk pregnant women who were followed-up by a single surgeon between 2016 and 2019. Pregnant women with preconceptionally diagnosed small size (< 5 cm) single uterine fibroids (n = 25) were compared with pregnant women without uterine fibroids (n = 147) in terms of obstetric outcomes.
Results
There was no statistically significant difference between the groups in terms of adverse pregnancy outcomes. The size of the fibroids was increased in 60% of the cases, and the growth percentage of the fibroids was 25% during pregnancy. Intrapartum and short-term complication was not observed in women who underwent cesarean myomectomy.
Conclusion
Small size uterine fibroids seem to have no adverse effect on pregnancy outcomes even in high-risk pregnancies, and cesarean myomectomy may be safelyperformed in properly selected cases.
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Original Article
Women’s Obstetric History and Midtrimester Cervical Length Measurements by 2D/3D and Doppler Ultrasound
Revista Brasileira de Ginecologia e Obstetrícia. 2020;42(9):540-546
10-23-2020
Summary
Original ArticleWomen’s Obstetric History and Midtrimester Cervical Length Measurements by 2D/3D and Doppler Ultrasound
Revista Brasileira de Ginecologia e Obstetrícia. 2020;42(9):540-546
10-23-2020Views144Abstract
Objective
The aim of the present study was to compare the obstetric history and both two- and tri-dimensional ultrasound parameters according to different cervical lengths.
Methods
The present cross-sectional study analyzed 248 midtrimester pregnant women according to cervical length and compared the data with the obstetric history and 2D/3D ultrasound parameters. Patients were divided into 3 groups according to cervical length: The Short Cervix group for cervical lengths ≥ 15mm and< 25mm(n= 68), the Very Short Cervix group for cervical lengths< 15mm (n = 18) and the Control group, composed of 162 pregnant women with uterine cervical lengths ≥ 25mm.
Results
When analyzing the obstetric history of only non-nulliparous patients, a significant association between the presence of a short cervix in the current pregnancy and at least one previous preterm birth was reported (p = 0.021). Cervical length and volume were positively correlated (Pearson coefficient = 0.587, p < 0.0001). The flow index (FI) parameter of cervical vascularization was significantly different between the Control and Very Short Cervix groups. However, after linear regression, in the presence of volume information, we found no association between the groups and FI. Uterine artery Doppler was also not related to cervical shortening.
Conclusion
The present study showed a significant association between the presence of a short cervix in the current pregnancy and at least one previous preterm birth. None of the vascularization indexes correlate with cervical length as an independent parameter. Uterine artery Doppler findings do not correlate with cervical length.
Key-words Cervical length measurementCervix uteriPregnancy trimester, secondPregnancy, high riskreproductive historySee more -
Original Article
Epidemiological Profile of the Victims of Sexual Violence Treated at a Referral Center in Southern Brazil
Revista Brasileira de Ginecologia e Obstetrícia. 2020;42(9):547-554
10-23-2020
Summary
Original ArticleEpidemiological Profile of the Victims of Sexual Violence Treated at a Referral Center in Southern Brazil
Revista Brasileira de Ginecologia e Obstetrícia. 2020;42(9):547-554
10-23-2020Views167See moreAbstract
Objective
To characterize the sociodemographic profile of women victims of sexual violence treated at a university hospital in southern Brazil.
Method
The present cross-sectional study included all female victims of sexual violence who attended the sexual violence unit at the Hospital de Clínicas de Porto Alegre (HCPA, in the Portuguese acronym) from April 18, 2000 to December 31, 2017.Data were extracted from the electronic record of the patients and stored in a standardized questionnaire database with epidemiological aspects of the victim, the perpetrators and the type of aggression. Statistical analysis was performed using the chi-squared test for trend and descriptive statistics with 95% confidence interval (CI).
Results
During the length of the study, 711 women victims of sexual violence were treated. The mean age of the patients was 24.4 (±10) years old (range from 11 to 69 years old) and most of the victims were white (77.4%), single (75.9%) and sought care at the unit within 72 hours after the occurrence (80.7%). In most cases, violence was exerted by a single perpetrator (87.1%), who was unknown in 67.2% of cases. Victims < 19 years old showed a higher risk of not using contraception (relative risk [RR] = 2.7; 95% CI = 1.9-3.6).
Conclusion
Most victims of sexual violence were treated within 72 hours of the occurrence. The majority of these victims were white and young, and those < 19 years old had a higher risk of not using contraception and to know the sexual perpetrator.
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Original Article
Preoperative Differentiation of Benign and Malignant Non-epithelial Ovarian Tumors: Clinical Features and Tumor Markers
Revista Brasileira de Ginecologia e Obstetrícia. 2020;42(9):555-561
10-23-2020
Summary
Original ArticlePreoperative Differentiation of Benign and Malignant Non-epithelial Ovarian Tumors: Clinical Features and Tumor Markers
Revista Brasileira de Ginecologia e Obstetrícia. 2020;42(9):555-561
10-23-2020Views70Abstract
Objective
To evaluate the role of clinical features and preoperativemeasurement of cancer antigen 125 (CA125), human epididymis protein(HE4), and carcinoembryonic antigen (CEA) serum levels in women with benign and malignant non-epithelial ovarian tumors.
Methods
One hundred and nineteen consecutive women with germ cell, sex cordstromal, and ovarian leiomyomas were included in this study. The preoperative levels of biomarkers were measured, and then surgery and histopathological analysis were performed. Information about the treatment and disease recurrence were obtained from the medical files of patients.
Results
Our sample included 71 women with germ cell tumors (64 benign and 7 malignant), 46 with sex cord-stromal tumors (32 benign and 14 malignant), and 2 with ovarian leiomyomas. Among benign germ cell tumors, 63 were mature teratomas, and, amongmalignant, fourwere immatureteratomas. Themost common tumors in the sex cordstromal group were fibromas (benign) and granulosa cell tumor (malignant). The biomarker serum levels were not different among benign andmalignant non-epithelial ovarian tumors. Fertility-sparing surgeries were performed in 5 (71.4%) women with malignant germ cell tumor. Eleven (78.6%) patients with malignant sex cord-stromal tumors were treated with fertility-sparing surgeries. Five women (71.4%) with germ cell tumors and only 1 (7.1%) with sex cord-stromal tumor were treated with chemotherapy. One woman with germ cell tumor recurred and died of the disease and one woman with sex cord-stromal tumor recurred.
Conclusion
Non-epithelial ovarian tumors were benign in the majority of cases, and the malignant caseswere diagnosed at initial stages with good prognosis. Themeasurements of CA125, HE4, and CEA serum levels were not useful in the preoperative diagnosis of these tumors.
Key-words biomarkersgerm cell tumorsnon-epithelial ovarian tumorsOvarian cancersex cord-stromal tumorsSee more -
Original Article
Interaction Between NOS3 and HMOX1 on Antihypertensive Drug Responsiveness in Preeclampsia
Revista Brasileira de Ginecologia e Obstetrícia. 2020;42(8):460-467
09-25-2020
Summary
Original ArticleInteraction Between NOS3 and HMOX1 on Antihypertensive Drug Responsiveness in Preeclampsia
Revista Brasileira de Ginecologia e Obstetrícia. 2020;42(8):460-467
09-25-2020Views189See moreAbstract
Objective
We examined the interaction of polymorphisms in the genes heme oxygenase- 1 (HMOX1) and nitric oxide synthase (NOS3) in patients with preeclampsia (PE) as well as the responsiveness to methyldopa and to total antihypertensive therapy.
Methods
The genes HMOX1 (rs2071746, A/T) and NOS3 (rs1799983, G/T) were genotyped using TaqMan allele discrimination assays (Applied Biosystems, Foster City, CA, USA ), and the levels of enzyme heme oxygenase-1 (HO-1) were measured using enzyme-linked immunosorbent assay (ELISA).
Results
We found interactions between genotypes of the HMOX-1 and NOS3 genes and responsiveness tomethyldopa and that PE genotyped as AT presents lower levels of protein HO-1 compared with AA.
Conclusion
We found interactions between the HMOX-1 and NOS3 genes and responsiveness to methyldopa and that the HMOX1 polymorphism affects the levels of enzyme HO-1 in responsiveness to methyldopa and to total antihypertensive therapy. These data suggest impact of the combination of these two polymorphisms on antihypertensive responsiveness in PE.
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Original Article
Preoperative Fasting Abbreviation and its Effects on Postoperative Nausea and Vomiting Incidence in Gynecological Surgery Patients
Revista Brasileira de Ginecologia e Obstetrícia. 2020;42(8):468-475
09-25-2020
Summary
Original ArticlePreoperative Fasting Abbreviation and its Effects on Postoperative Nausea and Vomiting Incidence in Gynecological Surgery Patients
Revista Brasileira de Ginecologia e Obstetrícia. 2020;42(8):468-475
09-25-2020Views161Abstract
Objective
To investigate the effects of preoperative fasting abbreviation with a carbohydrate and protein-enriched solution, on postoperative nausea and vomiting (PONV) incidence in gynecological surgery patients, a population naturally at risk for such unpleasant episodes.
Methods
The present prospective double-blind randomized study was performed at The Hospital Municipal e Maternidade Dr. Odelmo Leão Carneiro (HMMOLC, in the Portuguese acronym), in Uberlândia, state of Minas Gerais, Brazil, in partnership with the Gynecology Department of the Universidade Federal de São Paulo (UNIFESP), approved by the Human Research EthicsCommittee ofUNIFESP and theboard ofHMMOLC, and included in the Brazil Platform and in the Brazilian Clinical Trial Registry. After signing the consent form, 80 women, who were submitted to gynecological surgery in the period from January to June 2016,were randomized into 2 groups: control group (n= 42) and juice group (n= 38). They received, respectively, 200mL of inert solution or liquid enriched with carbohydrate and protein 4 hours presurgery. The incidence, frequency and intensity of PONV were studied using the Visual Analogue Scale (VAS), with statistical analysis performed by the software IBM SPSS Statistics for Windows, Version 20.0 (IBM Corp, Armonk, NY, USA).
Results
The incidence of nausea and vomiting was lower than in the literature, to this population, with 18.9% (14/74) for the control group and 10.8% (8/74) for the juice group, respectively, with no statistically significant difference between the groups.
Conclusion
The incidence of nausea and vomiting was lower than in the literature, but it cannot be said that this is due to the abbreviation of fasting. It can provide greater comfort, with the possibility of PONV prevention in patients at risk for these episodes.
Key-words carbohydratescontrolled random clinical trialpostoperative nausea and vomitingpreoperative careproteinssurgical procedures in gynecologySee more -
Original Article
Factors Associated with the Complications of Hysteroscopic Myomectomy
Revista Brasileira de Ginecologia e Obstetrícia. 2020;42(8):476-485
09-25-2020
Summary
Original ArticleFactors Associated with the Complications of Hysteroscopic Myomectomy
Revista Brasileira de Ginecologia e Obstetrícia. 2020;42(8):476-485
09-25-2020Views144See moreAbstract
Objective
To evaluate the factors associated with complete myomectomy in a single surgical procedure and the aspects related to the early complications.
Methods
A cross-sectional study with women with submucous myomas. The dependent variables were the complete myomectomy performed in a single hysteroscopic procedure, and the presence of early complications related to the procedure.
Results
We identified 338 women who underwent hysteroscopic myomectomy. In 89.05% of the cases, there was a single fibroid to be treated. According to the classification of the International Federation of Gynecology and Obstetrics (Fédération Internationale de Gynécologie et d’Obstétrique, FIGO, in French),most fibroids were of grade 0 (66.96%), followed by grade 1 (20.54%), and grade 2 (12.50%). The myomectomies were complete in 63.31% of the cases, and the factors independently associated with complete myomectomy were the diameter of the largest fibroid (prevalence ratio [PR]: 0.97; 95% confidence interval [95%CI]: 0.96-0.98) and the classification 0 of the fibroid according to the FIGO (PR: 2.04; 95%CI: 1.18-3.52). We observed early complications in 13.01% of the hysteroscopic procedures (4.44% presented excessive bleeding during the procedure, 4.14%, uterine perforation, 2.66%, false route, 1.78%, fluid overload, 0.59%, exploratory laparotomy, and 0.3%, postoperative infection). The only independent factor associated with the occurrence of early complications was incomplete myomectomy (PR: 2.77; 95%CI: 1.43-5.38).
Conclusions
Our results show that hysteroscopic myomectomy may result in up to 13% of complications, and the chance of complete resection is greater in small and completely intracavitary fibroids; women with larger fibroids and with a high degree of myometrial penetration have a greater chance of developing complications from hysteroscopic myomectomy.
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Original Article
Analysis of Body Composition and Pain Intensity inWomen with Chronic Pelvic Pain Secondary to Endometriosis
Revista Brasileira de Ginecologia e Obstetrícia. 2020;42(8):486-492
09-25-2020
Summary
Original ArticleAnalysis of Body Composition and Pain Intensity inWomen with Chronic Pelvic Pain Secondary to Endometriosis
Revista Brasileira de Ginecologia e Obstetrícia. 2020;42(8):486-492
09-25-2020Views210See moreAbstract
Objective
To determine the average body composition (percentage of body fat), the anthropometric markers, and the intensity of clinical pain in women with a clinical diagnosis of chronic pelvic pain (CPP) secondary to endometriosis.
Methods
A case-control study performed with 91 women, 46 of whom with CPP secondary to endometriosis and 45 of whom with CPP secondary to other causes. They underwent an evaluation of the anthropometric parameters by means of the body mass index (BMI), the perimeters (waist, abdomen, hip), and the percentage of body fat (%BF), which were assessed on a body composition monitor by bioimpedance; the intensity of the clinical pain was evaluated using the visual analog scale (VAS), and the symptoms of anxiety and depression, using the hospital’s anxiety and depression scale (HAD).
Results
The groups did not differ in terms of mean age, BMI, %BF or regarding the available waist-to-hip ratio (WHR). The mean intensity of the clinical pain by the VAS was of 7.2 ± 2.06 in the group with CPP secondary to endometriosis, and of 5.93 ± 2.64 in the group with CPP secondary to other causes (p = 0.03), revealing significant differences between the groups.
Conclusion
We concluded that, despite the difference in the pain score assessed between the two groups, there was no difference regarding body composition and anthropometry.