Artigos Originais Archives - Revista Brasileira de Ginecologia e Obstetrícia

  • Artigos Originais

    Factors associated with false-negative cervical cytopathological results

    Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(8):479-485

    Summary

    Artigos Originais

    Factors associated with false-negative cervical cytopathological results

    Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(8):479-485

    DOI 10.1590/S0100-72032006000800007

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    PURPOSE: to evaluate whether factors related to the adequacy of the sample, cell pattern and cytomorphological criteria are associated with false-negative (FN) results of cervical cytopathology during routine examinations. METHODS: this is a case-control study in which the study group included 100 cytopathologic smears with FN results detected during systematic internal quality control consisting of 100% rapid review. For each FN result detected, two smears with a true-positive diagnosis were identified by the same cytotechnician and these constituted the control group, making a total sample size of 300 smears. The variables were established in accordance with the criteria defined for the analysis of sample adequacy, cell pattern and cytomorphological analyzed criteria. The results were evaluated using bivariate analysis and logistic regression with stepwise variable selection criteria expressed in OR (95%). RESULTS: the number of atypical cells, the appearance of nuclear chromatin, and the distribution and presentation of atypical cells in the smear were the variables that showed the greatest risk for FN results with OR of 9.6, 4.2, 4.4, and 3.6, respectively. Inflammatory processes and the presence of blood in the smear were also identified as variables that influence the risk of FN results. CONCLUSIONS: the majority of the factors associated with FN results are dependent on the conditions and techniques of sample collection, since in the majority of cases, the lesion may not be adequately represented in the smear. Confounding factors such as blood and inflammatory processes may also impair analysis. With respect to cytomorphological alterations, thin chromatin strand was the variable that indicated the greatest risk of FN results.

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    Factors associated with false-negative cervical cytopathological results
  • Artigos Originais

    Application of a levonorgestrel-releasing intrauterine device prior to in vitro fertilization cycles in women with adenomyosis

    Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(8):473-478

    Summary

    Artigos Originais

    Application of a levonorgestrel-releasing intrauterine device prior to in vitro fertilization cycles in women with adenomyosis

    Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(8):473-478

    DOI 10.1590/S0100-72032006000800006

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    PURPOSE: to verify the effects of intrauterine levonorgestrel device (IUD) in women with adenomyosis, with implantation failure in previous in vitro fertilization (IVF) cycles. METHODS: eighty infertile women with ages up to 38 years, who had adenomyosis diagnosed by ultrasonography and MRI were selected. All the women presented antecedents of one or more tormer IVF attempts without success due to implantation failure. The women were subdivided into IUD Group, composed of 40 women with an IUD that released 20 µg of levonorgestrel/day during six months, preceding a new IVF cycle, and IVF Group, also composed of 40 women, who were directly submitted to a new IVF cycle without previous adenomyosis treatment. In the IUD Group the uterine volume, thickness and hypersignal foci of the junctional zone were assessed before and after treatment, as well as the pregnancy rates in the new IVF cycle, compared to the data obtained with the IVF Group. Statistical analyses were performed adopting the significance level of 5% (p<0,05), using the Mann-Whitney and Sudent's t tests. RESULTS: after treatment, there was a reduction of 77.7% in the cases of focal adenomyosis, in addition to a significant reduction of the uterine volume and of the mean thickness of the junctional zone from 128.8 to 93.6 ml and from 12.3 to 11.3 mm, respectively. In the IUD Group, pregnancy rate reached 30%, which was higher than, but not significantly different from that of the IVF group, which was 17.5%. CONCLUSION: the use of an IUD with levonorgestrel may be administered prior to IVF cycles in patients with adenomyosis who suffered previous implantation failure.

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  • Artigos Originais

    Human T-cell lymphotropic virus type I seroprevalence among pregnant women in Goiânia, GO, Brazil

    Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(8):467-472

    Summary

    Artigos Originais

    Human T-cell lymphotropic virus type I seroprevalence among pregnant women in Goiânia, GO, Brazil

    Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(8):467-472

    DOI 10.1590/S0100-72032006000800005

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    PURPOSE: to assess human T-cell lymphotropic virus type I (HTLV-I) seroprevalence among pregnant women attended at Public Health Units in Goiânia-Goiás and some epidemiologic characteristics of the studied group. METHODS: from September/2003 to December/2004, 15,485 pregnant women were submitted to enzyme-linked immunoabsorbent assays (ELISA), to screen HTLV-I, using filter paper - dried blood in, and to confirm the infection, polymerase chain reaction (PCR) of whole blood was performed. The epidemiologic factors evaluated were: average age, age of 30 years and above, schooling less than nine years, marital status and number of pregnancies. The factors average age, age of 30 years and above, and schooling less than nine years were compared between the infected and non-infected pregnant group. Statistical analysis used Fisher's exact test and Student's t test. RESULTS: the found prevalence was 0.1%. The average age among the infected pregnant group was 26.4 years, 43.7% of them being 30 years old and above, and 62.5% with schooling less than nine years. The non-infected group showed an average age of 24.4 years, 15.4% of them being ³ 30 years old and above, and only 41.5% with schooling less than nine years. Significant statistical difference was noticed only regarding age of 30 years and above and schooling less than nine years. CONCLUSION: the study shows that HTLV-I seroprevalence among pregnant women in Goiânia during the studied period was 0.1%. It occurred more among pregnant women who were 30 years old and above and those with schooling of less than nine years.

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  • Artigos Originais

    Lamellar body count versus the shake test in the assessment of fetal lung maturity in diabetics

    Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(8):460-466

    Summary

    Artigos Originais

    Lamellar body count versus the shake test in the assessment of fetal lung maturity in diabetics

    Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(8):460-466

    DOI 10.1590/S0100-72032006000800004

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    PURPOSE: to assess the performance of lamellar body count compared to the shake (Clements) test in the prediction of fetal lung maturity in diabetics. METHODS: prospective study of 62 patients who underwent amniocentesis between the 26th and 39th week of pregnancy. Immediately after collection, the amniotic fluid sample was submitted to the shake test and lamellar body count. Deliveries occurred within three days of amniocentesis. Immature test results (absence of a complete bubble ring in the third tube for the shake test and less than 50,000 lamellar bodies) were confronted with the occurrence of pulmonary immaturity in the neonate (respiratory distress syndrome). The performance of both tests was compared using the chi2 test and p<0.05 was considered to be significant. RESULTS: seven infants had respiratory distress syndrome (11.3%). The lamellar body count and shake test were similar regarding sensitivity (100 vs 71.4%, respectively) and negative predictive value (100 vs 93.5%). Lamellar body count was superior as regards specificity (87.3 vs 52.7%, p=0.0001), positive predictive value (50 vs 16.1%, p=0.017), and accuracy (88.7 vs 54.8%, p<0.001). CONCLUSIONS: lamellar body count is a simple and accurate method of assessing fetal lung maturity. It performs slightly better than the shake test in terms of specificity, positive predictive value and accuracy, with the advantage of not requiring manipulation or reagents. Similar to the shake test, lamellar body count has a high-negative predictive value: mature results (50,000 or more) indicate thar the infant will not have hyaline membrane.

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  • Artigos Originais

    Fetal heart rate and umbilical artery Dopplervelocimetry between the 18th and 20th weeks of gestation in pregnancies complicated by pregestational diabetes mellitus

    Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(8):453-459

    Summary

    Artigos Originais

    Fetal heart rate and umbilical artery Dopplervelocimetry between the 18th and 20th weeks of gestation in pregnancies complicated by pregestational diabetes mellitus

    Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(8):453-459

    DOI 10.1590/S0100-72032006000800003

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    PURPOSE: to analyze the fetal heart rate (FHR) and umbilical artery Dopplervelocimetry between 18th and 20th weeks of gestation in pregnant women complicated by pregestational diabetes mellitus. METHODS: twenty-eight pregnancies with pregestational diabetes and 27 normal pregnant women were analyzed prospectively, in a cross-sectional and case-control study. The inclusion criteria were the following: singleton pregnancy between 18 and 29 weeks, no other associated maternal diseases and no fetal abnormality. Ultrasonography was performed and FHR was calculated by the interval between the beginnings of two consecutive cardiac cycles, in the three umbilical artery Doppler sonograms, obtained in the umbilical cord near to the placental insertion, using color Doppler. Five consecutive FHR cycles from each sonogram were measured, to analyze mean FHR and its variation. The following Doppler indices were studied: systolic/diastolic ratio, pulsatility index (PI) and resistance index (RI). Student's t test and Mann-Whitney Utest were applied to comparative study. p values were considered significant when p<0.05. Results: no significant difference was observed in mean FHR between the studied groups (diabetic group: 149.2 bpm, control group: 147.2 bpm; p = 0.12). FHR variation revealed similar results between the groups (diabetic group: 5.3 bpm; control group: 5.3 bpm; p=0.50). No significant difference was found in the Doppler indices S/D (p=0.79), PI (p=0.25) and RI (p=0.71) between the groups. CONCLUSIONS: the absence of differences in FHR characteristics between the 18th and 20th gestational weeks indicates similar neurological maturation of FHR regulatory systems in this period, between fetuses of diabetic mothers and controls. Abnormalities in the uteroplacental resistance were not identified in the studied period, in pregnancies complicated by pregestational diabetes.

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  • Artigos Originais

    Precocious and late pregnancy in adolescents: is there a difference comparing the obstetric risks?

    Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(8):446-452

    Summary

    Artigos Originais

    Precocious and late pregnancy in adolescents: is there a difference comparing the obstetric risks?

    Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(8):446-452

    DOI 10.1590/S0100-72032006000800002

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    PURPOSE: to describe the obstetric outcomes in pregnant adolescents at a tertiary hospital and to compare the maternal and labor outcomes between precocious and late adolescents. METHODS: in a transversal analytical study, 2058 cases were evaluated, considering 322 (15.65%) from the precocious group and 1736 (84.35%) from the late group that delivered at the "Maternidade Escola Assis Chateaubriand/UFC" from January 1, 2000 to December 31, 2000. The clinical complications in the prenatal period, kind of delivery, indications for cesarean section, birth gestational age at birth, birth weight, comparison of birth weight and gestational age, Apgar score at the first and fifth minute, presence of malformations, and neonatal death were analyzed. The exact Fisher and the chi2 tests were used to compare both groups. The prevalence ratio was calculated. RESULTS: from of total of deliveries, 25.95% belonged to adolescents. The average age was 17.19 years. Prenatal visits were made by 88% of the patients, but 60% had an insufficient number of visits. The most frequent clinical situations were preeclampsia (14.72%), anemia (12.97%) and urinary tract infections (6.37%), with no statistical difference between the groups. Thirty-one and three percent of the births were by cesarean section, preeclampsia being the main indication in the two age groups (25 and 23%, respectively). The frequency of an Apgar score less than 7 at the first minute was 19,9% in the precocious adolescent group and 14,2% in the late adolescent group (x²=6,96, p=0.008). There was no statistical difference regarding prematurity rate (20.2 vs 16.1%), low-birth weight infants (12.4 vs 10.4%), low Apgar score at the fifth minute (5.3 vs 3.3%), congenital malformations (3.1 vs 2.7%), and neonatal death (5.3 vs 3.3%). CONCLUSIONS: the precocious and late pregnant adolescents presented similar pregnancy evolution and obstetric outcomes, except for the differences of the first minute Apgar scores.

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  • Artigos Originais

    Stress and anxiety in infertile women

    Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(6):358-364

    Summary

    Artigos Originais

    Stress and anxiety in infertile women

    Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(6):358-364

    DOI 10.1590/S0100-72032006000600007

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    PURPOSE: to assess the frequency of stress and anxiety levels in infertile women, in order to obtain data for specific psychological intervention. METHODS: a cross-sectional study involving 152 infertile (mean age 30.3±5.4 years), and 150 healthy control women (25.7±7.9 years). All patients were evaluated with the Lipp's Inventory of Stress Symptoms and the State-Trait Anxiety Inventory. Considered dependent variables were: stress frequency and anxiety scores (state and trait). Statistical analysis was performed by the chi2 and Mann-Whitney tests, and logistical regression to test associations between response variables and considered risk factors. Statistical significance was defined as p<0.05. RESULTS: the stress was more frequent in the infertile group than in the control group (61.8 and 36.0%, respectively); however, no significant differences were observed between groups in relation to stress phases and predominant symptoms. With respect to anxiety, there were no significant differences between infertile and control groups as to median state scores (39.5 and 41.0, respectively) and anxiety trait scores (44.0 and 42.0, respectively). Factors significantly associated with greater risk for high anxiety scores in the infertile group were: unawareness of the causal factor, diagnostic phase investigation, and lack of children from other marriages. CONCLUSIONS: it can be concluded that infertile women are more vulnerable to stress; however, they are capable of adapting themselves to stressful events without serious physical or psychological compromise.

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    Stress and anxiety in infertile women
  • Artigos Originais

    Comparisons of quality life index between women with urinary incontinence submitted or not to surgical treatment

    Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(6):352-357

    Summary

    Artigos Originais

    Comparisons of quality life index between women with urinary incontinence submitted or not to surgical treatment

    Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(6):352-357

    DOI 10.1590/S0100-72032006000600006

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    PURPOSE: to analyze the impact of urinary incontinence on women's quality of life, submitted or not to surgical treatment. METHODS: sixty women with urinary incontinence during stress were interviewed and divided into two groups classified as: S-CIR group, including 30 women not yet submitted to specific surgical treatment for urinary incontinence, and C-CIR group, including 30 women who had already undergone surgery. The scores obtained after the addition of values attributed to each question of the questionnaires were compared between the two groups. The number of patients who showed any impairment on quality of life due to specific symptoms of incontinence was also compared between groups. Data were analyzed by the variance test and the chi-square test, when applicable. RESULTS: symptoms, limitations and concerns related to urinary incontinence exhibited a strong negative impact on quality of life in patients from the S-CIR group. Impairment during physical exercises, domestic activities and daily working activities was the most important affected aspect in patients of the S-CIR group. Furtherimore, patients of the S-CIR group reported more fatigue, embarrassment, and excessive nervousness. Urine loss during stress followed by urgency were also significantly relevant aspects when groups were compared. CONCLUSIONS: the study allowed the identification and quantification of the derangements of quality of life due to urinary incontinence and demonstrated that these derangements either become less important or even disappear in women submitted to surgery.

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    Comparisons of quality life index between women with urinary incontinence submitted or not to surgical treatment

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