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04-10-1998
Avaliação longitudinal de aspectos imunológicos e virológicos durante a gravidez e puerpério em mulheres portadoras do vírus da imunodeficiência humana tipo 1 (HIV-1)
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):170-170
Views98This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
Avaliação longitudinal de aspectos imunológicos e virológicos durante a gravidez e puerpério em mulheres portadoras do vírus da imunodeficiência humana tipo 1 (HIV-1)
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):170-170
DOI 10.1590/S0100-72031998000300011
Views98Avaliação Longitudinal de Aspectos Imunológicos e Virológicos Durante a Gravidez e Puerpério em Mulheres Portadoras do Vírus da Imunodeficiência Humana Tipo 1 (HIV-1) […]See moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
04-10-1998
A dopplervelocimetria com mapeamento em cores dos ramos intramiometriais da artéria uterina de mulheres na pós-menopausa, com e sem carcinoma de endométrio
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):169-170
Views77This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
A dopplervelocimetria com mapeamento em cores dos ramos intramiometriais da artéria uterina de mulheres na pós-menopausa, com e sem carcinoma de endométrio
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):169-170
DOI 10.1590/S0100-72031998000300010
Views77A Dopplervelocimetria com Mapeamento em Cores dos Ramos Intramiometriais da Artéria Uterina de Mulheres na Pós-Menopausa, com e sem Carcinoma de Endométrio[…]See moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
04-10-1998
Avaliação da esteroidogênese das supra-renais em mulheres normais por meio dos testes de ACTH simples de depósito
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):169-169
Views75This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
Avaliação da esteroidogênese das supra-renais em mulheres normais por meio dos testes de ACTH simples de depósito
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):169-169
DOI 10.1590/S0100-72031998000300009
Views75Avaliação da Esteroidogênese das Supra-Renais em Mulheres Normais por Meio dos Testes de ACTH Simples de Depósito[…]See moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Case Report04-10-1998
Recurrent HELLP syndrome: report on two cases
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):165-167
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
Case ReportRecurrent HELLP syndrome: report on two cases
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):165-167
DOI 10.1590/S0100-72031998000300008
Views80See moreHELLP syndrome is a severe complication of preeclampsia that increases maternal and perinatal morbidity and mortality. Two cases of recurrent HELLP syndrome are described, maternal death occurring in one of the cases. This study is a warning about the increased risk of HELLP syndrome in the next pregnancy.
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Case Report04-10-1998
Fetal reanimation: a case report
- José Maria Soares Júnior,
- Wladimir Correa Taborda,
- Anna Maria Bertini,
- Jorge Francisco Kuhn dos Santos
Views85This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
Case ReportFetal reanimation: a case report
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):161-163
DOI 10.1590/S0100-72031998000300007
- José Maria Soares Júnior,
- Wladimir Correa Taborda,
- Anna Maria Bertini,
- Jorge Francisco Kuhn dos Santos
Views85See moreA tocolytic treatment is described with the use of terbutaline in a case of cardiotocographic prolonged deceleration of fetal heart rate with successful outcome.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Equipments and Methods04-10-1998
A new catheter in the treatment of fetal obstructive uropathies
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):155-159
Views74This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
Equipments and MethodsA new catheter in the treatment of fetal obstructive uropathies
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):155-159
DOI 10.1590/S0100-72031998000300006
Views74See moreManagement of prenatally diagnosed uropathies is controversial, mainly because the prognosis for these fetuses is quite different. However pioneering studies have shown that prenatal drainage of obstructed urinary tract can improve the outcome of selected fetuses. The aim of this study is to describe the experience of the Service with the treatment of fetal obstrutive uropathy with the catheter developed by the Centro de Medicina Fetal do Hospital das Clínicas da UFMG. A total of 25 fetuses with obstructive uropathy received the catheter. Three fetuses required more than one insertion. Ten of 25 (40%) shunted fetuses survived with good postnatal renal and pulmonary function. Complications occurred in 12/25 (48%) cases including: 06/25 (24%) inadequate shunt drainage or migration; 01/25 (04%) urinary ascitis; 01/25 (04%) DPP, 01/25 (04%) premature rupture of membranes, 02/25 (08%) premature labor, 01/25 (04%) scarring and fibrosis of the renal parenchyma. Three of 25 (12%) fetuses died intra-utero and 12 (48%) died during the neonatal period. In conclusion, the drainage of the obstructed urinary tract with this catheter proved to be technically feasible and safe for both mother and fetus, with a survival rate of 40%.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Original Article04-10-1998
Prevalence and correlates of hiv infection and syphilis in prostitutes attending a STD/AIDS reference center
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):151-154
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
Original ArticlePrevalence and correlates of hiv infection and syphilis in prostitutes attending a STD/AIDS reference center
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):151-154
DOI 10.1590/S0100-72031998000300005
Views112See moreA retrospective study examining medical records of female prostitutes attending the STD/AIDS Reference Center in Vitória, Brazil from January/93 to December/96 was conducted. During this period, 180 women received medical and psychological care in this clinic. Mean age was 25.9 year (SD=6.8). Out of 180, 140 agreed to be tested for HIV, of whom 12 (8.6%) had a positive result. Among 157 women who agreed to be tested for syphilis, 144 (91.7%) had a negative result, while 13 (8.3%) had a positive one. According to the educational degree, 6 (3.3%) women were illiterate, 114 (63.3%) attended elementary school, 37 (20.6%) attended secondary school, 7 (3.9%) went to college and 16 gave no information. One hundred and forty-one patients (78.3%) were single, 17 (9.4%) married, 10 (5,5%) divorced and 4 (2.2%) widows. The frequency of condom use was: always, 56 (31.3%), sometimes, 93 (52.0%), and 30 (16.8%) never used condoms. Other STDs were reported by 89 (49.4%) women and 9 (5.0%) reported intravenous (IV) drug use. There was a significant difference between the HIV positive and the negative group only regarding IV drug abuse (p=0.031) and syphilis infection (p=0.014). The present study showed prevalence rates of HIV infection among prostitutes in Vitória much higher than those found in the general population. There is a pressing need to improve medical assistance and educational campaigns especially designed to reach this population of women, and focusing the importance of regular condom use and the risks associated with IV drug abuse.
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Original Article04-10-1998
Obstetrical management of fetal death
- Márcia M A de Aquino,
- Ana Cláudia Guedes,
- Maria Rita S Mesquita,
- Mirie Hernandez,
- José Guilherme Cecatti
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
Original ArticleObstetrical management of fetal death
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(3):145-149
DOI 10.1590/S0100-72031998000300004
- Márcia M A de Aquino,
- Ana Cláudia Guedes,
- Maria Rita S Mesquita,
- Mirie Hernandez,
- José Guilherme Cecatti
Views205See moreAlthough 80 to 90% of all dead fetuses may be spontaneously eliminated after two to three weeks from death, labor induction has been the mostly used management. The purpose of the current study was to evaluate the results of labor induction for pregnancies with fetal death and gestation age above 20 weeks. It was a descriptive clinical study which was performed at the Hospital e Maternidade Leonor Mendes de Barros in São Paulo, Brazil. One hundred and twenty-two pregnancies with fetal death were evaluated regarding their social and demographic characteristics, causes of fetal death, previous pregnancies history and delivery (induction, route, complications). The statistical procedures used were estimation of mean and standard deviation and chi². The main causes of fetal death were hypertension and infections. The mostly used drug for labor induction was misoprostol (37.7%) followed by oxytocin (19.7%), while 27% of cases had spontaneous onset of labor. The mean time of induction was 3 hours. The majority of women had vaginal delivery and cesarean section was performed in 9.1% of them. It is concluded that labor induction for fetal death is safe and efficient, irrespective of the method used. Misoprostol when used in the vagina is specially useful for cases with an unripe cervix because of the modifying effect of the drug on the cervix.
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Original Article03-01-2018
The Burden of Indirect Causes of Maternal Morbidity and Mortality in the Processof Obstetric Transition: A Cross-Sectional Multicenter Study
- Jessica Fernandes Cirelli,
- Fernanda Garanhani Surita,
- Maria Laura Costa,
- Mary Angela Parpinelli,
- Samira Maerrawi Haddad, [ … ],
- José Guilherme Cecatti
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
Original ArticleThe Burden of Indirect Causes of Maternal Morbidity and Mortality in the Processof Obstetric Transition: A Cross-Sectional Multicenter Study
Revista Brasileira de Ginecologia e Obstetrícia. 2018;40(3):106-114
- Jessica Fernandes Cirelli,
- Fernanda Garanhani Surita,
- Maria Laura Costa,
- Mary Angela Parpinelli,
- Samira Maerrawi Haddad,
- José Guilherme Cecatti
Views214See moreAbstract
Objective
The aim of this study is to evaluate the burden of indirect causes of maternal morbidity/mortality in Brazil.
Methods
Secondary analysis of a multicenter cross-sectional study conducted in 27 referral obstetric units within the Brazilian Network for Surveillance of Severe Maternal Morbidity.
Results
A total of 82,388 women were surveilled: 9,555 women with severe maternal morbidity were included, and 942 (9.9%) of them had indirect causes of morbidity/ mortality. There was an increased risk of higher severity among the indirect causes group, which presented 7.56 times increased risk of maternal death (prevalence ratio [PR]: 7.56; 95% confidence interval [95%CI]: 4.99-11.45). The main indirect causes of maternal death were H1N1 influenza, sepsis, cancer and cardiovascular disease. Non-public antenatal care (PR: 2.52; 95%CI: 1.70-3.74), diabetes (PR: 1.90; 95%CI: 1.24-2.90), neoplasia (PR: 1.98; 95%CI: 1.25-3.14), kidney diseases (PR: 1.99; 95%CI: 1.14-3.49), sickle cell anemia (PR: 2.50; 95%CI: 1.16-5.41) and drug addiction (PR: 1.98; 95%CI: 1.03-3.80) were independentlyassociatedwithworseresultsintheindirectcausesgroup.Someprocedures for the management of severity were more common for the indirect causes group.
Conclusion
Indirect causes were present in less than 10% of the overall cases, but they represented over 40% of maternal deaths in the current study. Indirect causes of maternal morbidity/mortality were also responsible for an increased risk of higher severity, and they were associated with worse maternal and perinatal outcomes. In middle-income countries there is a mix of indirect causes of maternal morbidity/ mortality that points to some advances in the scale of obstetric transition, but also reveals the fragility of health systems.
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Case Report06-19-2019
Spontaneous Heterotopic Triplet Pregnancy with a Two Viable Intrauterine Embryos and an Ectopic One with Right Tubal Rupture
- Adriano Carvalho Guimarães
,
- Luciano Dias de Oliveira Reis,
- Fabio Chaves Leite,
- Cassiana Franco Dias dos Reis,
- Alex Paula Costa, [ … ],
- Walter Junior Boim de Araujo
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
Case ReportSpontaneous Heterotopic Triplet Pregnancy with a Two Viable Intrauterine Embryos and an Ectopic One with Right Tubal Rupture
Revista Brasileira de Ginecologia e Obstetrícia. 2019;41(4):268-272
- Adriano Carvalho Guimarães
,
- Luciano Dias de Oliveira Reis,
- Fabio Chaves Leite,
- Cassiana Franco Dias dos Reis,
- Alex Paula Costa,
- Walter Junior Boim de Araujo
Views213Abstract
Heterotopic pregnancy (HP) is defined as the simultaneous development of an intra- and an extra uterine gestation. The occurrence of a spontaneous triplet HP is an exceptionally rare medical condition. We report the case of a young woman with spontaneous heterotopic triplets at 8weeks of gestation, with amisdiagnosis of topic twins and acute appendicitis. The ectopic tubal pregnancy was ruptured and a salpingectomy was performed by laparotomy. The intrauterine pregnancy progressed uneventfully. The two healthy babies were delivery by cesarean section at 36 ± 2 weeks of gestation. Heterotopic triplets with ruptured tubal ectopic pregnancy represent a special diagnostic and therapeutic challenge for the obstetrician. A high rate of clinical suspicion and timely treatment by laparotomy or laparoscopy can preserve the intrauterine gestation with a successful outcome of the pregnancy.
Key-words heterotopic pregnancyMultiple pregnancyobstetrical surgeryPregnancy complicationstubal pregnancySee morePlumX Metrics- Citations
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Adriano Carvalho Guimarães
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Original Article08-26-2020
Maternal and Sociodemographic Factors Influence the Consumption of Ultraprocessed and Minimally-Processed Foods in Pregnant Women
- Monique Tavares Pereira
,
- Monica Cattafesta
,
- Edson Theodoro dos Santos Neto
,
- Luciane Bresciani Salaroli
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
Original ArticleMaternal and Sociodemographic Factors Influence the Consumption of Ultraprocessed and Minimally-Processed Foods in Pregnant Women
Revista Brasileira de Ginecologia e Obstetrícia. 2020;42(7):380-389
- Monique Tavares Pereira
,
- Monica Cattafesta
,
- Edson Theodoro dos Santos Neto
,
- Luciane Bresciani Salaroli
Views198See moreAbstract
Objective
To analyze the consumption of minimally-processed and ultraprocessed foods in relation with sociodemographic variables, maternal habits, educational activity received during prenatal care and clinical history.
Methods
A cross-sectional, analytical and descriptive study with 1,035 pregnant women who lives in the municipalities of the metropolitan region of Grande Vitória, Espírito Santo, Brazil (RMGV-ES), and who were hospitalized in establishments of the Unified Health System (SUS) due to childbirth (April-September 2010). The food frequency questionnaire, pregnant woman’s card and information from the medical records of the health facility unit were analyzed. The Chi-square test and the binary logistic regression model were used to investigate the association between the independent variables and the consumption of ultraprocessed foods.
Results
It was identified that pregnant women ≤ 19 years of agewere 2.9 timesmore likely to consume ultraprocessed foods (confidence interval [CI] 95% 1.683-5.168, p< 0.001), while those ≥ 35 years old were less likely to consume them (odds ratio [OR] 0.265, 95% CI 0.105-0.666, p= 0.005). Maternal smoking increased the odds of consumption of ultraprocessed foods by 2.2 times (95% CI 1.202-4.199, p= 0.011) and pregnant womenwho did not obtain information on healthy food during prenatal care presented 54.1% less chances of consuming minimally-processed foods (OR 0.459, 95% CI 0.307-0.687, p< 0.001).
Conclusion
Smoking during the gestational period and being a teenager are factors that influence the consumption of ultraprocessed foods of pregnant women. Race/ color, head of household, age group, receiving of information about feeding in the prenatal period and not having smoked in gestation determined the consumption of minimally-processed foods.
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Monique Tavares Pereira
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Original Article01-12-2021
Association of Overweight and Consistent Anovulation among Infertile Women with Regular Menstrual Cycle: A Case-control Study
- Christiane Ricaldoni Giviziez
,
- Eliane Gouveia de Morais Sanchez
,
- Yanna Andressa Ramos de Lima
,
- Mário Silva Approbato
Views202This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
Original ArticleAssociation of Overweight and Consistent Anovulation among Infertile Women with Regular Menstrual Cycle: A Case-control Study
Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(11):834-839
- Christiane Ricaldoni Giviziez
,
- Eliane Gouveia de Morais Sanchez
,
- Yanna Andressa Ramos de Lima
,
- Mário Silva Approbato
Views202See moreAbstract
Objective
It has been suggested that excess body weight could represent a risk factor for infertility outcomes. The present study aimed to evaluate the association of overweight and anovulation among infertile women with regular menstrual cycles.
Methods
We conducted a retrospective case-control study with consistently anovulatory patients undergoing assisted reproduction treatment. The patients were stratified into normal weight (body mass index [BMI]: 18.5-24.9kg/m2) and overweight (BMI: 25.0- 29.9kg/m2).Those with polycystic ovary syndrome or obesity were excluded. The groups were matched for age, duration of infertility, prolactin, follicle stimulating hormone (FSH), thydroid stimulating hormone (TSH), luteinizing hormone (LH), and estradiol levels.
Results
Overweight was significantly associated with anovulation, when using the World Health Organization (WHO) criteria for anovulation: progesterone levels>5.65 ng/ml and ultrasonography evidence of follicle collapse (odds ratio [OR]: 2.69; 95% confidence interval [CI95%]: 1.04-6.98).
Conclusion
Body mass index above the normal range jeopardizes ovulation among non-obese infertile women with regular menstrual cycles.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Christiane Ricaldoni Giviziez
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Original Article03-11-2022
Cervical Intraepithelial Neoplasia: Analyzing the Disease Present Exclusively in the Endocervical Canal
- Fernanda Villar Fonseca
,
- Maria Victória Gutierrez Cordeiro
,
- Ariadne Cristine Pozza
,
- Carlos Afonso Maestri
Views201This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
Original ArticleCervical Intraepithelial Neoplasia: Analyzing the Disease Present Exclusively in the Endocervical Canal
Revista Brasileira de Ginecologia e Obstetrícia. 2022;44(4):385-390
- Fernanda Villar Fonseca
,
- Maria Victória Gutierrez Cordeiro
,
- Ariadne Cristine Pozza
,
- Carlos Afonso Maestri
Views201See moreAbstract
Objective
To evaluate the role of cervical cytology (Pap smear) in the diagnosis of cervical intraepithelial neoplasia 2 or greater (CIN2+), presented exclusively in the endocervical canal, the clinical-epidemiological characteristics of this lesion, the necessary length of canal to be removed to treat, and the rate of invasive lesion hidden in the endocervical canal.
Methods
Cross-sectional study, by database analysis, of patients with abnormal cytology (high-grade squamous intraepithelial lesion [HSIL]), without visible colposcopy lesion, submitted to loop electrosurgical procedure (LEEP) to evaluate the association of cytology results with the histological product of the conization, to identify the epidemiological characteristics of endocervical lesion and clinical evolution, using a pvalue< 0.05 and 95% CI.
Results
In 444 cases, the Pap smear sensitivity for CIN2+ diagnosis was 75% (95% CI: 69.8-79.7), specificity was 40% (95% CI: 30.2-49.5), and the prevalence rate of histological lesion was 73% (95% CI: 70.1-78.7). There was a higher prevalence of CIN2+ in women over 42 years old and invasive cancer in those over 56 years old (p<0.001), and it was necessary to remove 2.6 cm in length of the canal to reduce the chance of recurrence (p<0.006). The rate of invasive cancer was 2.7%.
Conclusion
Cytology was related to a high prevalence to histological lesion (73%) in the diagnosis of CIN2+ in the endocervical disease; older patients presented a higher relationship with histological lesions in the canal disease, and it was necessary to remove an average of 2.6 cm in length of the endocervical canal to avoid the persistence and progression of CIN. The rate of occult neoplasia in the endocervical canal was 2.7%.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Fernanda Villar Fonseca
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Review Article12-11-2023
Prognostic Impact of AGR3 Protein Expression in Breast Cancer: A Systematic Review and Meta-analysis
- Carolina Leão de Moraes
,
- Carolina Rodrigues Mendonça
,
- Natália Cruz e Melo
,
- Fernanda Sardinha de Abreu Tacon
,
- Jair Pereira de Melo Junior
,
[ … ], - Waldemar Naves do Amaral
Views201This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
Review ArticlePrognostic Impact of AGR3 Protein Expression in Breast Cancer: A Systematic Review and Meta-analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2023;45(10):609-619
- Carolina Leão de Moraes
,
- Carolina Rodrigues Mendonça
,
- Natália Cruz e Melo
,
- Fernanda Sardinha de Abreu Tacon
,
- Jair Pereira de Melo Junior
,
- Waldemar Naves do Amaral
Views201See moreAbstract
Objective
To investigate the clinicopathological significance and prognosis of the expression of the anterior gradient 3 (AGR3) protein in women with breast cancer.
Data Sources
The PubMed, CINAHL, EMBASE, Scopus, and Web of Science databases were searched for studies published in English and without restrictions regarding the year of publication. The search terms were: breast cancer AND anterior gradient 3 OR AGR3 expression.
Study Selection
We included observational or interventional studies, studies on AGR3 protein expression by immunohistochemistry, and studies on invasive breast cancer. Case reports, studies with animals, and reviews were excluded. In total, 4 studies were included, containing 713 cases of breast cancer.
Data Collection
Data were extracted on clinicopathological characteristics and survival. A meta-analysis of the prevalence of AGR3 expression was performed according to the clinicopathological characteristics, hazard ratios (HRs), and overall survival and disease-free survival.
Data Synthesis
The expression of AGR3 was found in 62% of the cases, and it was associated with histological grade II, positivity of estrogen and progesterone receptors, low expression of ki67, recurrence or distant metastasis, and lumen subtypes. In patients with low and intermediate histological grades, AGR3 expression was associated with worse overall survival (HR: 2.39; 95% confidence interval [95%CI]: 0.628–4.159; p = 0.008) and worse disease-free survival (HR: 3.856; 95%CI: 1.026–6.686; p = 0.008).
Conclusion
The AGR3 protein may be a biomarker for the early detection of breast cancer and predict prognosis in luminal subtypes. In addition, in patients with low and intermediate histological grades, AGR3 protein expression may indicate an unfavorable prognosis in relation to survival.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Carolina Leão de Moraes
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Original Article10-01-2017
Clinical Characteristics in a Sample of Transsexual People
- Maria Rita Lerri,
- Adriana Peterson Mariano Salata Romão,
- Manoel Antônio dos Santos,
- Alain Giami,
- Rui Alberto Ferriani, [ … ],
- Lúcia Alves da Silva Lara
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
Original ArticleClinical Characteristics in a Sample of Transsexual People
Revista Brasileira de Ginecologia e Obstetrícia. 2017;39(10):545-551
- Maria Rita Lerri,
- Adriana Peterson Mariano Salata Romão,
- Manoel Antônio dos Santos,
- Alain Giami,
- Rui Alberto Ferriani,
- Lúcia Alves da Silva Lara
Views208See moreAbstract
Purpose
To assess the clinical characteristics of subjects with gender dysphoria (GD).
Method
A cross-sectional study of adults with GD. Symptoms of anxiety and depression were measured using the Hospital Anxiety and Depression Scale (HADS). Sociodemographic data, clinical data and life habits were recorded.
Results
Total of 44 subjects participated in the study: 36 (82%) trans women and 8 (18%) trans men. Forty-three (98%) of the GD patients had anxiety (36 [100%] trans women and 7 [87.5%] trans men), and 36 (82%) had depression (29 [80.5%] trans women and 7 [87.5%] trans men). Suicide had been attempted by 32 (73%) subjects. The rates of depression were lower among the subjects living with partners, parents, or other people than among those living alone (p = 0.03), and it was also lower among the subjects who were married compared to those who were dating or single (p = 0.03).
Conclusion
Improving the relationship status may reduce the prevalence of depressive symptoms in GD patients. There was a high rate of attempted suicide in this sample.
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Review Article09-18-2024
Immunosuppressants in women with repeated implantation failure in assisted reproductive techniques: a systematic review and meta-analysis
- Ana Clara Felix de Farias Santos
,
- Fernanda Valeriano Zamora
,
- Lubna Al-Sharif
,
- Kush Sehgal
,
- Deyvid Vieira Silva Cavalcante
,
[ … ], - Pedro Henrique Costa Matos da Silva
Abstract
Review ArticleImmunosuppressants in women with repeated implantation failure in assisted reproductive techniques: a systematic review and meta-analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo70
- Ana Clara Felix de Farias Santos
,
- Fernanda Valeriano Zamora
,
- Lubna Al-Sharif
,
- Kush Sehgal
,
- Deyvid Vieira Silva Cavalcante
,
- Sarah Hasimyan Ferreira
,
- Pedro Henrique Costa Matos da Silva
Views308Abstract
Objective
To compare outcomes in patients with repeated implantation failure undergoing Intracytoplasmic Sperm Injection/In vitro fertilization (IVF/ICSI) plus immunosuppressants such as prednisolone, prednisone, or cyclosporine A versus the use of IVF/ICSI alone.
Data source
Databases were systematically searched in PubMed, Cochrane, and Embase databases in September 2023.
Study Selection
Randomized clinical trials and observational studies with the outcomes of interest were included.
Data collect
We computed odds ratios (ORs) for binary endpoints, with 95% confidence intervals (CIs). Heterogeneity was assessed using I2 statistics. Data were analyzed using Review Manager 5.4.The main outcomes were live birth, miscarriage, implantation rate, clinical pregnancy, and biochemical pregnancy.
Data synthesis
Seven studies with 2,829 patients were included. Immunosuppressive treatments were used in 1,312 (46.37%). Cyclosporine A improved implantation rate (OR 1.48; 95% CI 1.01-2.18) and clinical pregnancy (1.89, 95% CI 1.14-3.14). Compared to non-immunosuppressive treatment, prednisolone and prednisone did not improve live birth (OR 1.13, 95% CI 0.88-1.46) and miscarriage (OR 1.49, 95% CI 1.07-2.09). Prednisolone showed no significant effect in patients undergoing IVF/ICSI, clinical pregnancy (OR 1.34; 95% CI 0.76-2.36), or implantation rate (OR 1.36; 95% CI 0.76-2.42).
Conclusion
Cyclosporine A may promote implantation and clinical pregnancy rates. However, given the limited sample size, it is important to approach these findings with caution. Our results indicate that prednisolone and prednisone do not have any beneficial effects on clinical outcomes of IVF/ICSI patients with repeated implantation failure.
PROSPERO
CRD42023449655
Key-words Cyclosporine APrednisolone Immunosupressive agentsPrednisoneRepeated implantation failureReproductionReproductive techniques, assistedSee moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Ana Clara Felix de Farias Santos
-
FEBRASGO POSITION STATEMENT06-27-2019
Pre-eclampsia/Eclampsia
- José Carlos Peraçoli
,
- Vera Therezinha Medeiros Borges,
- José Geraldo Lopes Ramos,
- Ricardo de Carvalho Cavalli,
- Sérgio Hofmeister de Almeida Martins Costa, [ … ],
- Edson Viera da Cunha Filho
Views109This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
FEBRASGO POSITION STATEMENTPre-eclampsia/Eclampsia
Revista Brasileira de Ginecologia e Obstetrícia. 2019;41(5):318-332
- José Carlos Peraçoli
,
- Vera Therezinha Medeiros Borges,
- José Geraldo Lopes Ramos,
- Ricardo de Carvalho Cavalli,
- Sérgio Hofmeister de Almeida Martins Costa,
- Leandro Gustavo de Oliveira,
- Francisco Lazaro Pereira de Souza,
- Henri Augusto Korkes,
- Ione Rodrigues Brum,
- Maria Laura Costa,
- Mário Dias Corrêa Junior,
- Nelson Sass,
- Angélica Lemos Debs Diniz,
- Caio Antonio de Campos Prado,
- Edson Viera da Cunha Filho
Views109See moreAbstract
Pre-eclampsia is a multifactorial and multisystemic disease specific to gestation. It is classically diagnosed by the presence of hypertension associated with proteinuria manifested in a previously normotensive pregnant woman after the 20th week of gestation. Pre-eclampsia is also considered in the absence of proteinuria if there is target organ damage. The present review takes a general approach focused on aspects of practical interest in the clinical and obstetric care of these women. Thus, it explores the still unknown etiology, current aspects of pathophysiology and of the diagnosis, the approach to disease prediction, its adverse outcomes and prevention. Management is based on general principles, on nonpharmacological and on pharmacological clinical treatment of severe or nonsevere situations with emphasis on the hypertensive crisis and eclampsia. Obstetric management is based on preeclampsia without or with signs of clinical and/or laboratory deterioration, stratification of gestational age
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - José Carlos Peraçoli
-
Original Article02-01-2019
Syphilis in Pregnancy: The Reality in a Public Hospital
- Rafael Garcia Torres,
- Ana Laura Neves Mendonça,
- Grazielle Cezarine Montes,
- Jacqueline Jácome Manzan,
- João Ulisses Ribeiro, [ … ],
- Marina Carvalho Paschoini
Views295This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
Original ArticleSyphilis in Pregnancy: The Reality in a Public Hospital
Revista Brasileira de Ginecologia e Obstetrícia. 2019;41(2):90-96
- Rafael Garcia Torres,
- Ana Laura Neves Mendonça,
- Grazielle Cezarine Montes,
- Jacqueline Jácome Manzan,
- João Ulisses Ribeiro,
- Marina Carvalho Paschoini
Views295See moreAbstract
Objective:
The present study assessed epidemiological and obstetrical data from pregnant women with syphilis at the Hospital de Clínicas of the Universidade Federal do Triângulo Mineiro (UFTM, in the Portuguese acronym), describing this disease during pregnancy and its vertical transmission for future healthcare actions.
Methods:
Records from pregnant women who had been admitted to the Obstetrics Department of the Hospital de Clínicas of the UFTM and were diagnosed with syphilis between 2007 and 2016 were reviewed. A standardized form was used to collect epidemiological, obstetric data and outcomes of congenital infection. The present research has been authorized by the Ethics Committee of the institution.
Results:
There were 268 women diagnosed with syphilis, with an average age of 23.6 years old. The majority of the patients were from Uberaba. Inadequate prenatal care was observed in 37.9% of the pregnant women. Only 34.2% of the patients completed the treatment according to the guidelines issued by the Ministry of Health of Brazil, and 19.8% of the partners of the patients underwent adequate syphilis treatment; 37 (13.8%) couples (patients and partners) underwent correct treatment. Regarding the obstetric outcomes, 4 (1.5%) patients had a miscarriage and 8 (3.4%) had fetal losses (from the fetal loss group, 7 had no adequate treatment); 61 (25.9%) patients had premature births – this prematurity has been significantly correlated to inadequate or incomplete treatment in 49 (27.9%) patients, compared with 12 (13.0%) patients with premature births and adequate treatment (p = 0.006). The average live newborn weight was 2,840 g; 25.3% had a birth weight < 2,500 g; 74.2% had congenital syphilis, a data with heavy correlation to inadequate or incomplete prenatal care, prematurity, and low birth weight.
Conclusion:
Public awareness policies on adequate prenatal care, intensification of serological screening, and early treatment of syphilis are needed, considering the rise of cases diagnosed during gestation and its potentially preventable deleterious consequences related to congenital transmission.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Systematic Review05-01-2017
Zika Virus Infection in Pregnant Women and Microcephaly
- Geraldo Duarte,
- Antonio Fernandes Moron,
- Artur Timerman,
- César Eduardo Fernandes,
- Corintio Mariani Neto, [ … ],
- Rossana Pulcineli Vieira Francisco
Views388This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
Systematic ReviewZika Virus Infection in Pregnant Women and Microcephaly
Revista Brasileira de Ginecologia e Obstetrícia. 2017;39(5):235-248
- Geraldo Duarte,
- Antonio Fernandes Moron,
- Artur Timerman,
- César Eduardo Fernandes,
- Corintio Mariani Neto,
- Gutemberg Leão de Almeida Filho,
- Heron Werner Junior,
- Hilka Flavia Barra do Espírito Santo,
- João Alfredo Piffero Steibel,
- João Bortoletti Filho,
- Juvenal Barreto Borriello de Andrade,
- Marcelo Burlá,
- Marcos Felipe Silva de Sá,
- Newton Eduardo Busso,
- Paulo César Giraldo,
- Renato Augusto Moreira de Sá,
- Renato Passini Junior,
- Rosiane Mattar,
- Rossana Pulcineli Vieira Francisco
Views388Abstract
From the discovery of the Zika virus (ZIKV) in 1947 in Uganda (Africa), until its arrival in South America, it was not known that it would affect human reproductive life so severely. Today, damagetothe central nervous system is known to be multiple, and microcephaly is considered the tip of the iceberg. Microcephaly actually represents the epilogue of this infection’s devastating process on the central nervous system of embryos and fetuses. As a result of central nervous system aggression by the ZIKV, this infection brings the possibility of arthrogryposis, dysphagia, deafness and visual impairment. All of these changes of varying severity directly or indirectly compromise the future life of these children, and are already considered a congenital syndrome linked to the ZIKV. Diagnosis is one of the main difficulties in the approach of this infection. Considering the clinical part, it has manifestations common to infections by the dengue virus and the chikungunya fever, varying only in subjective intensities. The most frequent clinical variables are rash, febrile state, non-purulent conjunctivitis and arthralgia, among others. In terms of laboratory resources, there are also limitations to the subsidiary diagnosis. Molecular biology tests are based on polymerase chain reaction (PCR)with reverse transcriptase (RT) action, since the ZIKV is a ribonucleic acid (RNA) virus. The RT-PCR shows serum or plasma positivity for a short period of time, no more than five days after the onset of the signs and symptoms. The ZIKVurine test is positive for a longer period, up to 14 days. There are still no reliable techniques for the serological diagnosis of this infection. If there are no complications (meningoencephalitis or Guillain-Barré syndrome), further examination is unnecessary to assess systemic impairment. However, evidence is needed to rule out other infections that also cause rashes, such as dengue, chikungunya, syphilis, toxoplasmosis, cytomegalovirus, rubella, and herpes. There is no specific antiviral therapy against ZIKV, and the therapeutic approach to infected pregnant women is limited to the use of antipyretics and analgesics. Anti-inflammatory drugs should be avoided until the diagnosis of dengue is discarded. There is no need to modify the schedule of prenatal visits for pregnant women infected by ZIKV, but it is necessary to guarantee three ultrasound examinations during pregnancy for low-risk pregnancies, and monthly for pregnant women with confirmed ZIKV infection. Vaginal delivery and natural breastfeeding are advised.
Key-words arbovirus infectionsblindness/ etiologydeafness/ etiologymicrocephaly/ ultrasonographyPregnancy complicationsReal-time polymerase chain reactionZika virusSee moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Editorial09-25-2020
COVID-19 and Maternal Death in Brazil: An Invisible Tragedy
- Marcos Nakamura-Pereira
,
- Melania Maria Ramos Amorim
,
- Rodolfo de Carvalho Pacagnella
,
- Maira Libertad Soligo Takemoto
,
- Fatima Cristina Cunha Penso
,
[ … ], - Maria do Carmo Leal
Views210This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
EditorialCOVID-19 and Maternal Death in Brazil: An Invisible Tragedy
Revista Brasileira de Ginecologia e Obstetrícia. 2020;42(8):445-447
- Marcos Nakamura-Pereira
,
- Melania Maria Ramos Amorim
,
- Rodolfo de Carvalho Pacagnella
,
- Maira Libertad Soligo Takemoto
,
- Fatima Cristina Cunha Penso
,
- Jorge de Rezende-Filho
,
- Maria do Carmo Leal
Views210The infection with the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is responsible for causing the coronavirus disease 2019 (COVID-19), became a devastating threat to the health of the world population and was declared a global pandemic by the World Health Organization (WHO) on March 11, 2020. Beginning in China at the end […]See moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Marcos Nakamura-Pereira
-
Original Article04-01-2017
Influence of Body Image in Women Undergoing Treatment for Breast Cancer
- Ana Carolina Lagos Prates,
- Ruffo Freitas-Junior,
- Mariana Ferreira Oliveira Prates,
- Márcia de Faria Veloso,
- Norami de Moura Barros
Views279This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
Original ArticleInfluence of Body Image in Women Undergoing Treatment for Breast Cancer
Revista Brasileira de Ginecologia e Obstetrícia. 2017;39(4):175-183
- Ana Carolina Lagos Prates,
- Ruffo Freitas-Junior,
- Mariana Ferreira Oliveira Prates,
- Márcia de Faria Veloso,
- Norami de Moura Barros
Views279See moreAbstract
Objective
The objective of this study was to investigate the self-esteem of women with and without breast cancer regarding their body image.
Methods
A quantitative, case-control study in which 90 women with breast cancer were evaluated in the case group, and 77 women without breast cancer in the control group. For data collection, the body satisfaction scale (BSS), a scale adapted and validated in Brazil, and the Rosenberg self-esteem questionnaire were used. For the statistical analysis of the data, the Statistical Package for the Social Sciences software (IBM-SPSS, Chicago, Il, US), version 16.0 was used.
Results
Compared with the women without breast cancer, those with breast cancer were more dissatisfied with body image related to appearance. Women undergoing neoadjuvant chemotherapy were more dissatisfied with their appearance compared with those with cancer who were not undergoing this treatment. Mastectomy also accounted for more dissatisfaction concerning appearance among women who underwent the procedure compared with the women who were submitted to breast-conserving therapy.
Conclusion
Women with breast cancer were more dissatisfied with their body image compared with those without breast cancer, particularly following mastectomy or during chemotherapy. The self-esteem was found to be negatively affected in patients who were dissatisfied with their body image.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Original Article01-01-2018
Premenstrual Syndrome Diagnosis: A Comparative Study between the Daily Record of Severity of Problems (DRSP) and the Premenstrual Symptoms Screening Tool (PSST)
- Aline Henz,
- Charles Francisco Ferreira,
- Carolina Leão Oderich,
- Carin Weirich Gallon,
- Juliana Rintondale Sodré de Castro, [ … ],
- Maria Celeste Osório Wender
Views468This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
Original ArticlePremenstrual Syndrome Diagnosis: A Comparative Study between the Daily Record of Severity of Problems (DRSP) and the Premenstrual Symptoms Screening Tool (PSST)
Revista Brasileira de Ginecologia e Obstetrícia. 2018;40(1):20-25
- Aline Henz,
- Charles Francisco Ferreira,
- Carolina Leão Oderich,
- Carin Weirich Gallon,
- Juliana Rintondale Sodré de Castro,
- Maiara Conzatti,
- Marcelo Pio de Almeida Fleck,
- Maria Celeste Osório Wender
Views468Abstract
Objective
To validate the premenstrual symptoms screening tool (PSST) in relation to the daily record of severity of problems (DRSP) for premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) diagnoses.
Methods
A cross-sectional study with 127 women (20 45 years) with PMS complaints. The women were evaluated in terms of weight, height and body mass index (BMI). After using the primary care evaluation of mental disorders (PRIME-MD) questionnaire to exclude the diagnosis of depression, the PSST was completed and the women were instructed to fill out the DRSP for two consecutive menstrual cycles. The agreement between the two questionnaires was assessed by the Kappa (k) and the prevalence-adjusted, bias-adjusted kappa (PABAK) values.
Results
Two-hundred and eighty-two women met the eligibility criteria and answered the PSST. The DRSP was completed for two cycles by 127 women. The percentages of women with PMS and PMDD diagnoses by the DRSP were 74.8% and 3.9% respectively; by PSST, the percentages were41.7% and 34.6% respectively. The number of patients considered “normal” (with symptoms below the threshold for the diagnosis of PMS) was similar in both questionnaires. There was no agreement (Kappa = 0.12) in the results of PMS/ PMDD diagnosis (the PABAK coefficient confirmed this result = 0.39). The PSST had a high sensitivity (79%) and a low specificity (33.3%) for PMS/PMDD diagnosis.
Conclusion
The PSST should be considered a diagnostic screening tool. Positive PMS/PMDD cases by PSST should be further evaluated by DRSP to confirm the diagnosis.
Key-words Diagnosispremenstrual dysphoric disorderPremenstrual syndromeQuestionnaireSigns and symptomsSee moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Review Article07-01-2017
Abnormal Uterine Bleeding
- Cristina Laguna Benetti-Pinto,
- Ana Carolina Japur de Sá Rosa-e-Silva,
- Daniela Angerame Yela,
- José Maria Soares Júnior
Views315This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
Review ArticleAbnormal Uterine Bleeding
Revista Brasileira de Ginecologia e Obstetrícia. 2017;39(7):358-368
- Cristina Laguna Benetti-Pinto,
- Ana Carolina Japur de Sá Rosa-e-Silva,
- Daniela Angerame Yela,
- José Maria Soares Júnior
Views315Abstract
Abnormal uterine bleeding is a frequent condition in Gynecology. It may impact physical, emotional sexual and professional aspects of the lives of women, impairing their quality of life. In cases of acute and severe bleeding, women may need urgent treatment with volumetric replacement and prescription of hemostatic substances. In some specific cases with more intense and prolonged bleeding, surgical treatment may be necessary. The objective of this chapter is to describe the main evidence on the treatment of women with abnormaluterinebleeding, both acuteand chronic.Didactically,thetreatmentoptions were based on the current International Federation of Gynecology and Obstetrics (FIGO) classification system (PALM-COEIN). The etiologies of PALM-COEIN are: uterine Polyp (P), Adenomyosis (A), Leiomyoma (L), precursor and Malignant lesions of the uterine body (M), Coagulopathies (C), Ovulatory dysfunction (O), Endometrial dysfunction (E), Iatrogenic (I), and Not yet classified (N). The articles were selected according to the recommendation grades of the PubMed, Cochrane and Embase databases, and those in which the main objective was the reduction of uterine menstrual bleeding were included. Only studies written in English were included. All editorial or complete papers that were not consistent with abnormal uterine bleeding, or studies in animal models, were excluded. The main objective of the treatment is the reduction of menstrual flow and morbidity and the improvement of quality of life. It is important to emphasize that the treatment in the acute phase aims to hemodynamically stabilize the patient and stop excessive bleeding, while the treatment in the chronic phase is based on correcting menstrual dysfunction according to its etiology and clinical manifestations. The treatment may be surgical or pharmacological, and thelatterisbasedmainlyonhormonaltherapy,anti-inflammatorydrugsandantifibrinolytics.
Key-words Abnormal uterine bleedingdysfunctional uterine bleedingheavy menstrual bleedingmenorrhagiaPALM-COEINSee moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Original Article03-01-2018
Late-Stage Diagnosis of Breast Cancer in Brazil: Analysis of Data from Hospital-Based Cancer Registries (2000-2012)
Revista Brasileira de Ginecologia e Obstetrícia. 2018;40(3):127-136
Views165This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
Original ArticleLate-Stage Diagnosis of Breast Cancer in Brazil: Analysis of Data from Hospital-Based Cancer Registries (2000-2012)
Revista Brasileira de Ginecologia e Obstetrícia. 2018;40(3):127-136
Views165Abstract
Objective
To analyze the time trend and the factors regarding the diagnosis of latestage breast cancer in Brazil from 2000 to 2012.
Methods
We conducted a retrospective cohort study using data from hospital-based cancer registries. Joinpoint regression was used to analyze the time trends of stage at diagnosis. The risk of late-stage presentation was estimated using multinomial logistic regression.
Results
A total of 170,757 cases were analyzed. The median time from diagnosis to treatment was of 43 days (range: 0-182 days). The percentage of cases with late-stage diagnosis decreased from2000 to 2002, with an annual percent change (APC) of -6.6%(95%confidence interval [95%CI]: -7.6–5.5%); it increased from 2002 until 2009, with an APC of 1.1% (95% CI: 0.9-1.3%), and remained stable up to 2012.Women with college education (compared with illiterate women) had less chance of having a late-stage diagnosis (odds ratio [OR]: 0.32; 95%CI: 0.29-0.35). The odds were greater among brown women (OR: 1.30; 95%CI: 1.21-1.41) and black women (OR: 1.63; 95%CI: 1.47-1.82), compared with white women. The odds were also higher for women treated in facilities located and in the Northern region of Brazil (OR: 1.23; 95%CI: 1.04-1.45) and in the Midwest (OR: 1.61;95%CI: 1.34-1.94), compared with those treated in the southern region of the country. Age, histological type, and marital status were some of the other factors that were positively related to staging at the diagnosis.
Conclusion
Access to diagnosis of breast cancer is uneven in Brazil, and women with lower socioeconomic status present a greater probability of having an advanced stage at diagnosis.
Key-words Breast neoplasmsdisease registriesHealth services accessibilityoncologywomen’s health serviceSee moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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