Articles - Revista Brasileira de Ginecologia e Obstetrícia

Resumos de Teses07-01-2001

Avaliação Prospectiva dos Índices de Resistência e Pulsatilidade nas Artérias Renais de Gestantes Normais
- Flávio Ribeiro Dib
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(10):676-677

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Abstract
Resumos de Teses
Avaliação Prospectiva dos Índices de Resistência e Pulsatilidade nas Artérias Renais de Gestantes Normais
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(10):676-677
DOI 10.1590/S0100-72032001001000015
Flávio Ribeiro Dib
Views47
Avaliação Prospectiva dos Índices de Resistência e Pulsatilidade nas Artérias Renais de Gestantes Normais […]
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Resumos de Teses07-01-2001

Acurácia dos Métodos Clínico e Ecográfico no Diagnóstico de Adenomiose
- Sérgio Fernandes Cabral Júnior
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(10):676-676

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Resumos de Teses
Acurácia dos Métodos Clínico e Ecográfico no Diagnóstico de Adenomiose
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(10):676-676
DOI 10.1590/S0100-72032001001000014
Sérgio Fernandes Cabral Júnior
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Acurácia dos Métodos Clínico e Ecográfico no Diagnóstico de Adenomiose[…]
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Resumos de Teses07-01-2001

Cirurgia de Alta Freqüência em Lesões Intra-epiteliais de Alto Grau do Colo Uterino
- Cleuza Maria Staudt Pascotini
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(10):675-675

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Resumos de Teses
Cirurgia de Alta Freqüência em Lesões Intra-epiteliais de Alto Grau do Colo Uterino
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(10):675-675
DOI 10.1590/S0100-72032001001000013
Cleuza Maria Staudt Pascotini
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Cirurgia de Alta Freqüência em Lesões Intra-epiteliais de Alto Grau do Colo Uterino […]
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Resumos de Teses07-01-2001

Curva de Normalidade da Área de Secção Transversa do Cordão Umbilical Aferida pela Ultra-Sonografia e sua Correlação com Parâmetros Antropométricos em Gestações Normais
- Flávio Augusto Prado Vasques
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(10):675-675

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Resumos de Teses
Curva de Normalidade da Área de Secção Transversa do Cordão Umbilical Aferida pela Ultra-Sonografia e sua Correlação com Parâmetros Antropométricos em Gestações Normais
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(10):675-675
DOI 10.1590/S0100-72032001001000012
Flávio Augusto Prado Vasques
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Curva de Normalidade da Área de Secção Transversa do Cordão Umbilical Aferida pela Ultra-Sonografia e sua Correlação com Parâmetros Antropométricos em Gestações Normais […]
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Resumos de Teses07-01-2001

Diferencial dos Tumores Sólidos Palpáveis da Mama
- Alexandre Vicente de Andrade
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(10):674-674

Views42

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Resumos de Teses
Diferencial dos Tumores Sólidos Palpáveis da Mama
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(10):674-674
DOI 10.1590/S0100-72032001001000011
Alexandre Vicente de Andrade
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Diferencial dos Tumores Sólidos Palpáveis da Mama […]
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Resumos de Teses07-01-2001

Aspectos Clínicos e Epidemiológicos das Mulheres Climatéricas de um Programa de Saúde da Família em Cuiabá: MT, 1999.
- Vivaldo Naves de Oliveira
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(10):674-674

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Resumos de Teses
Aspectos Clínicos e Epidemiológicos das Mulheres Climatéricas de um Programa de Saúde da Família em Cuiabá: MT, 1999.
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(10):674-674
DOI 10.1590/S0100-72032001001000010
Vivaldo Naves de Oliveira
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Aspectos Clínicos e Epidemiológicos das Mulheres Climatéricas de um Programa de Saúde da Família em Cuiabá ¾ MT, 1999. […]
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Original Article07-01-2001

Effect of Betamethasone on Pregnant Rats: Impact on Corticosterone Level and Maternal and Fetal Adrenal Glands
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(10):667-673

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
Effect of Betamethasone on Pregnant Rats: Impact on Corticosterone Level and Maternal and Fetal Adrenal Glands
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(10):667-673
DOI 10.1590/S0100-72032001001000009
Eduardo de Souza,
Sérgio Kobayashi,
Manuel de Jesus Simões,
Luiz Camano,
Luiz Kulay Júnior
Views116
Purpose: the repetitive use of antenatal corticosteroid therapy for acceleration of fetal lung maturation has been common in cases at risk of preterm delivery. We studied the corticosterone levels at term and the morphologic aspects in the maternal and fetal adrenal glands submitted to the effect of betamethasone in the second half of rat pregnancy in order to verify its consequences. Methods: thirty female pregnant rats were divided into three groups of ten animals each. Group I received betamethasone on the 11th, 12th, 18th and 19th day of pregnancy. Group II received distilled water on the same days (control group). Group III did not receive any drug (stress control group). All rats were sacrificed on the 20th day of pregnancy when plasma corticosterone levels of dams were assessed and the maternal and fetal adrenal glands were studied by light microscopy. Results: plasma corticosterone level of dams was lower in the group treated with betamethasone (4.8 mg/dL) when compared with the control groups (17.7 and 26.8 mg/dL). The light microscopy study revealed cytoplasmatic vacuolation in the fasciculate zone in the maternal and fetal adrenal glands, which indicates adrenal suppression. Conclusions: the antenatal repetitive and prolonged use of corticosteroids in pregnant rats for acceleration of lung fetal maturation causes maternal and fetal adrenal suppression.

Key-words Adrenal suppression Betamethasone Corticosterone
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Original Article07-01-2001

Brain-sparing Effect Detected by Color Doppler: Perinatal Outcome
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(10):659-665

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
Brain-sparing Effect Detected by Color Doppler: Perinatal Outcome
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(10):659-665
DOI 10.1590/S0100-72032001001000008
Cleide Mara Mazzotti Oliveira Franzin,
João Luiz Pinto e Silva,
Emílio Francisco Marussi,
Silvana Varella Parmigiani
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Purpose: evaluation of perinatal outcome of brain-sparing effect detected by color Doppler. Methods: brain-sparing effect was detected in 32 fetuses at the Ultrasound Service of the Center for Integral Attention to Women’s Health at Campinas State University (UNICAMP). The diagnosis of brain-sparing effect was made when the ratio between middle cerebral artery and umbilical artery pulsatility indexes was below one (IPACM/IPAU <1). The measurement was obtained with color Doppler equipment Toshiba SSH-140A. Results: admission to neonatal intensive care unit (ICU) was necessary in 26 fetuses (89.6%). The number of days in ICU varied from 1 to 83 days, with a mean of 22 days. Fetal mortality rate was 3 in 32 (9.4%) and perinatal mortality was 9 in 29 (31%). Considering the gestational age by the Capurro method, the incidence of birth below 36 weeks was 21 in 32 (65.6%). Intrauterine growth restriction occurred in 71.8% of the cases and hypoglycemia in 44.8%. Conclusions: brain-sparing effect is a condition in which the fetus is at serious risk of adverse perinatal outcome and Doppler studies might be helpful in the obstetric management.

Key-words Brain-sparing effect Doppler velocimetry Fetal outcome
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Review Article09-18-2024

Neonatal and maternal outcomes of mRNA versus Non-mRNA COVID-19 vaccines in pregnant patients: a systematic review and meta-analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo69

Views252

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Review Article
Neonatal and maternal outcomes of mRNA versus Non-mRNA COVID-19 vaccines in pregnant patients: a systematic review and meta-analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo69
DOI 10.61622/rbgo/2024rbgo69
Juliana Almeida Oliveira ,
Eloisa Gonçalves da Silva ,
Ayse Filiz Gokmen Karasu ,
Anelise Maria Nicolau Silva ,
Chris Elizabeth Philip
Views252
Abstract

Objective

To compare the effectiveness and safety of non-mRNA versus mRNA COVID-19 vaccines on pregnant women and their newborns in a systematic review with meta-analysis.

Data sources

We searched PubMed, Embase, and Cochrane Central in May 2023.

Study selection

The search strategy yielded 4451 results, 16 studies were fully reviewed. We selected case-control studies analysing non-mRNA versus mRNA vaccines. Data collection and analysis: we assessed the risk of bias using the Cochrane Risk of Bias in Non-randomized Studies of Interventions (ROBINS-I) tool. Standardised mean differences were pooled using random-effect models.

Data synthesis

We identified 8 prospective and retrospective studies with a total of 32,153 patients. Non-mRNA vaccines were associated with a higher incidence of fever (OR 2.67; 95% CI 2.08-3.43; p<0.001), and a lower incidence of fetal or neonatal death (OR 0.16; 95% CI 0.08-0.33; p<0.001). In subgroup analyses, the Jansen vaccine (Ad26.COV2.S) was found to have a higher rate of premature labor/delivery (OR 4.48; 95% CI 1.45-13.83; p=0.009) and missed/spontaneous abortion (OR 1.90; 95% CI 1.09-3.30; p=0.02), as compared with the Pfizer (BNT162b2) vaccine.

Conclusion

non-mRNA vaccines are associated with a lower incidence of fetal or neonatal death among pregnant women who receive a Covid19 vaccine, although at an increased rate of pyrexia compared with mRNA vaccines. Other studies are required for better assessment.

PROSPERO

CRD42023421814

Key-words coronavirus infections COVID-19 COVID-19 vaccines Infant, newborn mRNA vaccines Pregnancy complications Pregnant women SARS-CoV-2
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Original Article09-18-2024

Multidisciplinary team training in postpartum hemorrhage: impact on the use of blood products
- Carina Bauer Luiz ,
- Ana Lúcia Letti Müller ,
- Cristiano Caetano Salazar ,
- Teresinha Zanella ,
- Gabriel Cardozo Müller ,
- Janete Vettorazzi
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo67

Views268

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
Multidisciplinary team training in postpartum hemorrhage: impact on the use of blood products
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo67
DOI 10.61622/rbgo/2024rbgo67
Carina Bauer Luiz ,
Ana Lúcia Letti Müller ,
Cristiano Caetano Salazar ,
Teresinha Zanella ,
Gabriel Cardozo Müller ,
Amanda Vilaverde Perez ,
Mariana Sbaraini ,
Maria Lucia Oppermann ,
Janete Vettorazzi
Views268
Abstract

Objective

Compare the number of puerperal women submitted to blood transfusion before and after the implementation of a care protocol for postpartum hemorrhage (PPH) with multidisciplinary team training.

Methods

Cross-sectional study in a university hospital, analyzing births from 2015 to 2019, compared the use of blood products before and after the adoption of a PPH protocol with multidisciplinary training.

Results

Between 2015 and 2019, there were 17,731 births, with 299 (1.7%) postpartum women receiving blood products and 278 postpartum women were considered for this analysis, 128 (0.7%) at Time 1 and 150 (0.8%) at Time 2. After the multiprofessional team training (T2), there was a difference in the complete use of the PPH protocol (use of oxytocin, misoprostol and tranexamic acid) (T1 = 5.1% x T2 = 49.5%, p≤0.0001). An individual categorized analysis revealed that, in the T2 period, there was lower use of blood component units per patient compared to T1 (Mann-Whitney, p=0.006). It should be noted that at T1 and T2, 54% and 24% respectively received two units of blood products. It is important to highlight that after the multidisciplinary team training for the PPH protocol, the goal of zero maternal death due to hemorrhage was reached.

Conclusion

The adoption of a specific protocol for PPH, combined with the training of a multidisciplinary team, had an impact on the ability to identify women at high risk of hemorrhage, resulting in a decrease in the use of blood components.

Key-words Blood transfusion Maternal death Mentoring Patient care team Postpartum hemorrhage
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Original Article09-06-2024

Immediate prepectoral versus submuscular breast reconstruction in nipple-sparing mastectomy: a retrospective cohort analysis
- Francisco Pimentel Cavalcante ,
- Ticiane Oliveira Lima ,
- Ryane Alcantara ,
- Amanda Cardoso ,
- Guilherme Novita ,
- Eduardo Millen
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo76

Views261

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
Immediate prepectoral versus submuscular breast reconstruction in nipple-sparing mastectomy: a retrospective cohort analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo76
DOI 10.61622/rbgo/2024rbgo76
Francisco Pimentel Cavalcante ,
Ticiane Oliveira Lima ,
Ryane Alcantara ,
Amanda Cardoso ,
Guilherme Novita ,
Felipe Zerwes ,
Eduardo Millen
Views261
Abstract

Objective

To evaluate early complications in prepectoral breast reconstruction.

Methods

A retrospective cohort study including 180 consecutive cases of nipple-sparing mastectomy, comparing immediate breast reconstruction with subpectoral to prepectoral mammary implants in 2012-2022. Clinical and demographic characteristics and complications in the first three months following surgery were compared between the two techniques.

Results

The prepectoral technique was used in 22 cases (12.2%) and the subpectoral in 158 (87.8%). Median age was higher in the prepectoral group (47 versus 43.8 years; p=0.038), as was body mass index (25.1 versus 23.8; p=0.002) and implant volume (447.5 versus 409 cc; p=0.001). The prepectoral technique was more associated with an inframammary fold (IMF) incision (19 cases, 86.4% versus 85, 53.8%) than with periareolar incisions (3 cases, 13.6% versus 73, 46.2%); (p=0.004). All cases in the prepectoral group underwent direct-to-implant reconstruction compared to 54 cases (34.2%) in the subpectoral group. Thirty-eight complications were recorded: 36 (22.8%) in the subpectoral group and 2 (9.1%) in the prepectoral group (p=0.24). Necrosis of the nipple-areola complex/skin flap occurred in 27 patients (17.1%) in the subpectoral group (prepectoral group: no cases; p=0.04). The groups were comparable regarding dehiscence, seroma, infection, and hematoma. Reconstruction failed in one case per group (p=0.230). In the multivariate analysis, IMF incision was associated with the prepectoral group (aOR: 34.72; 95%CI: 2.84-424.63).

Conclusion

The incidence of early complications was comparable between the two techniques and compatible with previous reports. The clinical and demographic characteristics differed between the techniques. Randomized clinical trials are required.

Key-words Breast implantation Breast implants Breast neoplasms Mammaplasty Mastectomy Nipples Pectoralis muscles Surgical procedures, operative
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Editorial09-06-2024

The importance of the quadrivalent HPV vaccine in the elimination of cervical cancer in Brazil
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgoedt4

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Editorial
The importance of the quadrivalent HPV vaccine in the elimination of cervical cancer in Brazil
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgoedt4
DOI 10.61622/rbgo/2024EDT04
Cecília Martins Roteli-Martins ,
Ana Goretti Kalume Maranhão ,
Susana Cristina Aidé Viviani Fialho ,
Agnaldo Lopes da Silva-Filho
Views202
HPV vaccination program in BrazilThe introduction of the quadrivalent HPV vaccine Gardasil 4V into the Brazilian National Immunization Schedule was approved by the National Committee for Technology Incorporation into the Unified Health System (Conitec) and incorporated into the National Immunization Schedule in 2014. This decision was based on a previous cost-effectiveness study that analyzed different […]
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Original Article09-06-2024

Thinking on the purposes, roles and activities of networks for research on maternal and perinatal health: opinions of coordinators and members
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo75

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
Thinking on the purposes, roles and activities of networks for research on maternal and perinatal health: opinions of coordinators and members
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo75
DOI 10.61622/rbgo/2024rbgo75
Vilma Zotareli ,
Silvana Bento ,
Renato Souza ,
José Guilherme Cecatti
Views124
Abstract

Objective

To identify the opinion of coordinators and members about the essential characteristics and to understand the research networks characteristics, to facilitate their implementation, sustainability and effectiveness so it can be replicated in low and middle-income countries.

Methods

A qualitative study using a semi-structured interview technique was conducted. We selected potential members, managers and participants of networks from publications identified in PubMed. After checking the FIGO congress program, we identified authors who were assigned as speakers at the event. An invitation was sent and interviews were scheduled.

Results

In total, eleven interviews were performed. Coordinators and members of networks have the same goal when they decide to participate in a network. In general, they cited that these individuals had to be committed, responsible and enthusiastic people. The network should be composed also of postgraduate students. A network should allow multi-leadership, co-responsibility, autonomy and empowerment of its members. Effective communication was mentioned as an important pillar for network maintenance. Another motivation is being an author or coauthor in publications. One way to maintain a network running is social or governmental commitment, after resources expire, studies continue.

Conclusion

Networks are different due to the social context where they are inserted, however, some characteristics are common to all of them, such as having engaged leaders. For an effective and sustainable network, commitment and motivation in a leader and members are more in need than financial resources. Ideally, to ensure the operation of the network, the institution where the leader is linked should support this network.

Key-words Goals Interview Leadership Motivation Networking Perinatal care Reproductive health
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Original Article09-06-2024

Morbidity associated with emergency surgery versus scheduled surgery in patients with placenta accreta spectrum
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo74

Views148

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
Morbidity associated with emergency surgery versus scheduled surgery in patients with placenta accreta spectrum
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo74
DOI 10.61622/rbgo/2024rbgo74
Juan José Saldarriaga-Hoyos ,
Daniela Sarria-Ortiz ,
Valentina Galindo-Velasco ,
Luisa Fernanda Rivera-Torres ,
Albaro José Nieto-Calvache
Views148
Abstract

Objective

This study aims to evaluate the clinical outcomes of surgical management for placenta accreta spectrum in a Latin American reference hospital specializing in this condition. The evaluation involves a comparison between surgeries performed on an emergent and scheduled basis.

Methods

A retrospective cohort study was conducted on patients with placenta accreta spectrum who underwent surgery between January 2011 and November 2021 at a hospital in Colombia, using data from the institutional PAS registry. The study included patients with intraoperative and/or histological confirmation of PAS, regardless of prenatal suspicion. Clinical outcomes were compared between patients who had emergent surgeries and those who had scheduled surgeries. Descriptive analysis involved summary measures and the Shapiro-Wilk test for quantitative variables, with comparisons made using Pearson’s Chi-squared test and the Wilcoxon rank sum test, applying a significance level of 5%.

Results

A total of 113 patients were included, 84 (74.3%) of them underwent scheduled surgery, and 29 (25.6%) underwent emergency surgery. The emergency surgery group required more transfusions (72.4% vs 48.8%, p=0.047). Patients with intraoperative diagnosis of placenta accreta spectrum (21 women, 19.5%) had a greater volume of blood loss than patients taken into surgery with known presence of placenta accreta spectrum (3500 ml, IQR 1700 – 4000 vs 1700 ml, IQR 1195-2135. p <0.001).

Conclusion

Patients with placenta accreta spectrum undergoing emergency surgery require transfusions more frequently than those undergoing scheduled surgery

Key-words Emergencies Morbidity Obstetric surgical procedures Placenta accreta
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Review Article09-06-2024

Biochemical markers for prediction of the first half pregnancy losses: a review
- Meruyet Kuspanova ,
- Andrey Gaiday ,
- Nurzhamal Dzhardemaliyeva ,
- Maxat Tuganbayev ,
- Maksym Gorobeiko ,
- Akylbek Tussupkaliyev
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo72

Views222

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Review Article
Biochemical markers for prediction of the first half pregnancy losses: a review
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo72
DOI 10.61622/rbgo/2024rbgo72
Meruyet Kuspanova ,
Andrey Gaiday ,
Nurzhamal Dzhardemaliyeva ,
Maxat Tuganbayev ,
Maksym Gorobeiko ,
Andrii Dinets ,
Saule Bermagambetova ,
Zhanna Amirbekova ,
Gulshat Oraltayeva ,
Dinara Omertayeva ,
Akylbek Tussupkaliyev
Views222
Abstract

Objective

26% of all pregnancies end in miscarriage, and up to 10% of clinically diagnosed pregnancies, and recurrent pregnancy loss is 5% among couples of childbearing ages. Although there are several known causes of pregnancy loss in the first half, including recurrent pregnancy loss, including parental chromosomal abnormalities, uterine malformations, endocrinological disorders, and immunological abnormalities, about half of the cases of pregnancy loss in its first half remain unexplained.

Methods

The review includes observational controlled studies (case-control or cohort, longitudinal studies, reviews, meta-analyses), which include the study of biochemical factors for predicting pregnancy losses in the first half, in singlet pregnancy. The Newcastle-Ottawa Scale (NOS) was used to assess the research quality.

Results

Finally, 27 studies were included in the review, which has 134904 examined patients. The results of the review include estimates of β-human chorionic gonadotropin, progesterone, pregnancy-associated protein – A, angiogenic vascular factors, estradiol, α-fetoprotein, homocysteine and CA-125 as a predictors or markers of the first half pregnancy losses.

Conclusion

It may be concluded that to date, research data indicate the unavailability of any reliable biochemical marker for predicting pregnancy losses in its first half and require either a combination of them or comparison with clinical evidence. A fairly new model shall be considered for the assessment of α-fetoprotein in vaginal blood, which may have great prospects in predicting spontaneous miscarriages.

Key-words Biochemical marker Laboratory marker Miscarriage missed abortion prediction Pregnancy Spontaneous abortion
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Original Article09-06-2024

Association between dietary patterns and infant birth weight in brazilian pregnancy women with gestational diabetes: a cross-sectional study
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo68

Views183

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
Association between dietary patterns and infant birth weight in brazilian pregnancy women with gestational diabetes: a cross-sectional study
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo68
DOI 10.61622/rbgo/2024rbgo68
Luciana da Cunha Bernardes Argenta ,
Nadya Helena Alves dos Santos ,
Cláudia Saunders ,
Joana Dias da Costa ,
Letícia Victoria Souza da Cunha ,
Pamela Melo Krok Fedeszen ,
Patricia de Carvalho Padilha
Views183
Abstract

Objective

To evaluate the association between the dietary patterns (DPs) of pregnant women with GDM (gestational diabetes mellitus) and the birth weight (BW) of the infants.

Methods

Cross-sectional study with 187 adult pregnant women with GDM attended at a maternity in Rio de Janeiro from 2011 to 2014. Dietary intake was assessed in the third trimester using a semiquantitative food frequency questionnaire (FFQ). The outcomes were BW and weight adequacy for gestational age (GA). Reduced Rank Regression (RRR) was used to explain the following response variables: density of carbohydrates, fibres, and saturated fatty acids. Statistical analyzes included multinomial logistic regression models.

Results

The mean BW was 3261.9 (± 424.5) g. Three DPs were identified, with DP 3 (high consumption of refined carbohydrates, fast foods/snacks, whole milk, sugars/sweets, and soft drinks and low consumption of beans, vegetables, and low-fat milk and derivatives) being the main pattern, explaining 48.37% of the response variables. In the multinomial logistic regression analysis no statistically significant association was found between the tertiles of DPs and BW or the adequacy of weight for GA, even after adjustments of confounding covariates.

Conclusion

No significant associations were found between maternal DPs in the third trimester of pregnancy and infant BW or adequacy of weight for GA.

Key-words Birth weight Diabetes, gestational Dietary patterns Infant, newborn Pregnant women
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Original Article04-30-2025

Assessıng the predıctıve accuracy of blood-based bıomarkers ın neonatal outcomes for pregestatıonal dıabetes mellıtus
- Ayse Cigdem Bayrak ,
- Erdem Fadiloglu ,
- Haticegul Tuncer ,
- Edip Alptug Kir ,
- Umutcan Kayikci ,
- Ozgur Deren
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo17

Views69

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
Assessıng the predıctıve accuracy of blood-based bıomarkers ın neonatal outcomes for pregestatıonal dıabetes mellıtus
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo17
DOI 10.61622/rbgo/2025rbgo17
Ayse Cigdem Bayrak ,
Erdem Fadiloglu ,
Haticegul Tuncer ,
Edip Alptug Kir ,
Umutcan Kayikci ,
Ozgur Deren
Views69
Abstract

Objective:

This retrospective study aimed to investigate blood-based immune-inflammatory biomarkers (IIBs) in predicting neonatal outcomes in pregnancies with pregestational diabetes mellitus (PGDM).PIV[(neutrophil×platelet×monocyte)/lymphocyte)], SII (neutrophil×platelet/lymphocyte), and NLR neutrophil/lymphocyte) values were evaluated in all three trimesters, and their correlation with neonatal outcomes was examined.

Methods:

We included 82 cases of PGDM pregnancies delivered after 32 weeks. Maternal age, gravidity, parity, types of diabetes, and route of delivery were noted. For neonatal outcomes, we recorded gestational age at birth, birth weight percentile, existence of fetal growth restriction, LGA, neonatal intensive care unit (NICU) requirement, Apgar Score <7 at 1, 5, or 10 minutes, need for positive pressure ventilation (PPV), need for mechanical ventilation, hypoglycaemia, hyperbilirubinemia and the need for phototherapy. PIV, SII and NLR values were calculated in each trimester and their association with adverse neonatal outcomes was analyzed.

Results:

We could not detect any consistent and significant correlation between SII and PIV values and adverse neonatal outcomes for each trimester. There was a correlation between 3rd trimester NLR and adverse neonatal outcomes, including APGAR <7, the requirement for PPV and mechanical ventilation (p=0.056, 0.013 and 0.060, respectively).

Conclusion:

While SII and PIV values did not consistently correlate with adverse neonatal outcomes throughout each trimester in PGDM pregnancies, 3rd-trimester NLR showed a notable association with the requirement for PPV with statistical significance and with Apgar Score <7 and the requirement for mechanical ventilation without statistical significance. NLR in the third trimester may hold potential as a predictive marker for specific adverse neonatal outcomes in PGDM pregnancies, warranting further investigation.

Key-words biomarkers Diabetes mellitus Gestational age Hypoglycemia Infant, newborn Intensive care units, neonatal Lymphocytes Maternal age Monocytes Neuthrophils Pregancy Pregnancy in diabetes Respiration, artificial
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Original Article04-30-2025

Effects of domestic violence on menopausal symptoms, sexual function, and quality of life: a cross-sectional study
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo16

Views78

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
Effects of domestic violence on menopausal symptoms, sexual function, and quality of life: a cross-sectional study
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo16
DOI 10.61622/rbgo/2025rbgo16
Laís Lima Ferreira ,
Charles Francisco Ferreira ,
Maria Celeste Osório Wender
Views78
Abstract

Objective:

To investigate the association between lifetime experience of domestic violence and climacteric symptoms, sexual function, and quality of life in climacteric women in Rio Grande do Sul, Brazil.

Methods:

A cross-sectional study was conducted with 700 pre-, peri-, and postmenopausal women, recruited online via an anonymous questionnaire (REDCap platform). Women aged 40 to 65 years, residing in Rio Grande do Sul, and classified by the STRAW+10 criteria were included. Climacteric symptoms and sexual function were assessed using the 10-item Cervantes Scale (CS-10) and the 6-item Female Sexual Function Index (FSFI-6). Data were analyzed using SPSS version 18.0; quantitative data as median [IQR], qualitative as frequencies. Group comparisons used Kruskal-Wallis, Chi-Square, and Spearman’s correlation between violence against women (VAW) and/or climacteric groups on CS-10 or FSFI-6. Significance was set at 5%.

Results:

The median [IQR] age of pre- (46 [43 – 50] years), peri- (50 [47 – 52] years), and postmenopausal (55 [51 – 58] years) were different among groups. Prevalence rates of psychological (38.8%), sexual (34.9%), and physical (21.3%) violence were observed. Postmenopausal women showed the poorest outcomes. Premenopausal women experiencing violence had severe anxiety, while postmenopausal women reported feeling worthless. Various sexual dysfunctions were associated with violence, including low desire, lubrication issues, and sexual pain.

Conclusions:

Domestic violence was linked to worse climacteric symptoms, sexual function, and quality of life, particularly in postmenopausal women. These findings underscore the need for improved care and public policies to enhance safety and well-being among women of all ages.

Key-words Anxiety Climacteric Domestic violence Menopause Postmenopause Quality of life Sexuality surveys and questionnaires Violence against women
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Original Article04-30-2025

The ımpact of demographic and obstetric factors on perception of traumatic birth and breastfeeding attitudes
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo15

Views51

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
The ımpact of demographic and obstetric factors on perception of traumatic birth and breastfeeding attitudes
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo15
DOI 10.61622/rbgo/2025rbgo15
Ayşe Çuvadar ,
Elnaz Karamelikli ,
Yeter Çuvadar Baş
Views51
Abstract

Objective:

This study aims to examine the effects of sociodemographic and obstetric factors on traumatic birth perception and breastfeeding attitudes in primiparous mothers who have had a vaginal birth in the early postpartum period.

Methods:

The sample of the research, developed with a cross-sectional and correlational design, consisted of 252 women residing in a province in the Western Black Sea region of Türkiye. The data were obtained by employing a Personal Information Form, Traumatic Childbirth Perception Scale, and Breastfeeding Attitudes of The Evaluation Scale. Data analysis was conducted using the statistical programming language R (R version 4.3.3).

Results:

Women who were not employed, had a planned pregnancy, and did not experience health problems during pregnancy had higher mean breastfeeding attitude scores, and this difference was statistically significant. It was determined that a one-unit increase in gestational week led to an average increase of 1.926 units in breastfeeding attitude score, and a one-unit increase in Traumatic Childbirth Perception Scale score led to an average decrease of 0.110 units in breastfeeding attitude score. The mean traumatic childbirth perception scores of women living in urban areas were found to be lower than those living in villages or towns, and the difference was statistically significant.

Conclusion:

The research findings indicate that gestational age, perception of traumatic childbirth, and certain sociodemographic factors significantly affect breastfeeding attitudes. Additionally, mothers living in urban areas have a lower perception of traumatic childbirth. Therefore, individualized approaches to childbirth and breastfeeding support are crucial.

Key-words Breast feeding Delivery, obstetric Parturition perception Postpartum period Sociodemographic factors Stress disorders, post-traumatic
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Original Article04-30-2025

Clinical and epidemiological profile of pregnant and postpartum women affected by COVID-19 who required respiratory support
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo14

Views52

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
Clinical and epidemiological profile of pregnant and postpartum women affected by COVID-19 who required respiratory support
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo14
DOI 10.61622/rbgo/2025rbgo14
Carolina Maria Pires Cunha ,
Melania Maria Ramos Amorim ,
Julianna de Azevedo Guendler ,
Alex Sandro Rolland Souza ,
Leila Katz
Views52
Abstract

Objective:

This study described the clinical and epidemiological profile and the management provided to pregnant and postpartum women with COVID-19 who required respiratory support.

Methods:

A descriptive study was conducted with pregnant and postpartum women with confirmed COVID-19 who received care between April 2020 and December 2021 in eight referral centers in northeastern Brazil. Statistical analysis was conducted using Epi-Info 7.2.5 and Medcalc, version 20.112.

Results:

Of the 720 patients admitted, 208 (32.7%) required respiratory support. Mean age of the participants was 28.9±7.1 years. Most (52.8%) were brown-skinned; 31.3% had little formal schooling; 41.1% had a personal income and 23.1% were married. Around half were referred from another hospital. Overall, 36.8% were obese and 36.9% were hypertensive. Criteria for severe acute respiratory syndrome (SARS) were present in 80.7% of cases. Overall, 151 patients (74.7%) required corticoids, and 150 (76.1%) were admitted to an intensive care unit. Non-invasive ventilation was needed in 89.4% of cases, with nasal catheters being the most common type (55.3% of cases). Invasive mechanical ventilation was necessary in 35.5% of cases and 91.6% had a cesarean section. Maternal near miss and death occurred in 24% and 12.9% of cases, respectively.

Conclusion:

Pregnant and postpartum women with COVID-19 who required respiratory support were predominantly brown-skinned, in the third trimester of pregnancy and had been referred from another hospital. The cesarean section rate was high; the presence of criteria for SARS was common and the rates of COVID-19-related maternal near miss and death were high.

Clinical Trials registry:

NCT04462367

Key-words Cesarian section COVID-19 Intensive care units Near miss, healthcare Noninvasive ventilation Obesity Postpartum period Pregnancy Pregnancy trimester, third Respiration, artificial SARS-CoV-2 severe acute respiratory syndrome
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Original Article04-30-2025

Evaluation of pathological complete response rates in breast cancer patients undergoing neoadjuvant therapy
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo13

Views61

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
Evaluation of pathological complete response rates in breast cancer patients undergoing neoadjuvant therapy
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo13
DOI 10.61622/rbgo/2025rbgo13
Gabriella Ferezini Oliveira de Sá ,
Pedro Vilar de Oliveira Villarim ,
Pedro Hortêncio Saboia da Escossia Melo ,
Ayane Cristine Alves Sarmento ,
Ana Katherine Gonçalves ,
Kleyton Santos de Medeiros ,
Cristina Rocha de Medeiros Miranda
Views61
Abstract

Objective:

This study aims to assess the rate of pathological complete response (pCR) in breast cancer patients undergoing neoadjuvant therapy and to explore its correlation with clinical, molecular, and prognostic factors.

Methods:

We conducted this retrospective observational study at Liga Contra o Câncer, a major public oncology reference center in Northeast Brazil. We included patients diagnosed with breast cancer who initiated neoadjuvant therapy between June 2018 and June 2019. Patients with a history of recurrent breast cancer or those who did not undergo surgery were excluded. The primary outcome was the pCR rate, with secondary outcomes including Overall Survival (OS), Disease-Free Survival (DFS), mortality, and disease recurrence. Follow-up extended until August 2022. We performed multivariate Cox regression analysis to correlate outcomes with predetermined variables.

Results:

Of the 292 included patients, 63 (21.6%) achieved pCR. The mean follow-up duration was 42.8 months. Multivariate logistic regression analysis revealed an association between pCR and the AC-TH regimen [OR = 2.4; 95%CI = 1.13 – 5.24; p=0.023], as well as between pCR and HER2-positive tumors [OR 2.49; 95% CI = 1.14 – 5.86; p=0.028]. Complete pathological response was associated with higher DFS [HR 0.33; 95%CI 0.13-0.86; p=0.024].

Conclusion:

Neoadjuvant therapy demonstrated significant efficacy in achieving pathological response in breast cancer patients. We observed a strong association between the AC-TH regimen, HER2-positive status, and pCR.

Key-words Breast neoplasm Neoadjuvant therapy Surgical oncology
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FEBRASGO POSITION STATEMENT03-28-2025

Follow-up of women after gynecological cancer treatment
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-FPS3

Views177

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
FEBRASGO POSITION STATEMENT
Follow-up of women after gynecological cancer treatment
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-FPS3
DOI 10.61622/rbgo/2025FPS3
Agnaldo Lopes da Silva Filho ,
Mariana Seabra Leite Praça ,
Matheus Eduardo Soares Pinhati ,
Laura Guimarães Castro ,
Renato Moretti-Marques ,
Angélica Nogueira-Rodrigues ,
Eduardo Batista Cândido
Views177
Key points

•The population of female cancer survivors has increased over the last few years, highlighting the importance of appropriate follow-up of these patients.

•The main objective of long-term follow-up for patients treated for cancer is the early detection of recurrences, whether local, lymph node or distant metastases.

•Symptom assessment and physical examination play an important role in the follow-up of patients treated for gynecological neoplasms.

•The use of laboratory or imaging tests to detect recurrence in asymptomatic patients should be based on evidence that it improves survival or provides less morbid treatments, also considering cost and availability.

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Letter to the Editor03-18-2025

Comment on: Access and adequacy of antenatal care in during two phases of the COVID-19 pandemic
- Amnuay Kleebayoon ,
- Viroj Wiwanitkit
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo12

Views176

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Letter to the Editor
Comment on: Access and adequacy of antenatal care in during two phases of the COVID-19 pandemic
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo12
DOI 10.61622/rbgo/2025rbgo12
Amnuay Kleebayoon ,
Viroj Wiwanitkit
Views176
The publication on “Access and adequacy of antenatal care in a city in Brazil during two phases of the COVID-19 pandemic.”() Is an interesting issue. This study investigated antenatal care consumption and appropriateness among postpartum caregivers at Florianópolis Hospital from 2020 to 2022, with an emphasis on socio-demographic characteristics and antenatal care. Although this study […]
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Letter to the Editor03-18-2025

Use of calcium during pregnancy: far beyond pre-eclampsia
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo11

Views193

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Letter to the Editor
Use of calcium during pregnancy: far beyond pre-eclampsia
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo11
DOI 10.61622/rbgo/2025rbgo11
Melania Maria Ramos Amorim ,
Marina Amorim Albuquerque ,
Lucas Félix ,
Anna Catharina Carneiro da Cunha ,
Leila Katz
Views193
Dear Editor,We read with interest the Editorial of the Revista Brasileira de Ginecologia e Obstetrícia (RBGO) in which Braga et al. present the initiative of the state of Rio de Janeiro (Brazil) for prediction and secondary prevention of pre-eclampsia.() The authors highlight universal calcium supplementation during pregnancy as a significant innovation, implemented for the first […]
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Articles - Revista Brasileira de Ginecologia e Obstetrícia

Avaliação Prospectiva dos Índices de Resistência e Pulsatilidade nas Artérias Renais de Gestantes Normais

Acurácia dos Métodos Clínico e Ecográfico no Diagnóstico de Adenomiose

Cirurgia de Alta Freqüência em Lesões Intra-epiteliais de Alto Grau do Colo Uterino

Curva de Normalidade da Área de Secção Transversa do Cordão Umbilical Aferida pela Ultra-Sonografia e sua Correlação com Parâmetros Antropométricos em Gestações Normais

Diferencial dos Tumores Sólidos Palpáveis da Mama

Aspectos Clínicos e Epidemiológicos das Mulheres Climatéricas de um Programa de Saúde da Família em Cuiabá: MT, 1999.

Effect of Betamethasone on Pregnant Rats: Impact on Corticosterone Level and Maternal and Fetal Adrenal Glands

Brain-sparing Effect Detected by Color Doppler: Perinatal Outcome

Neonatal and maternal outcomes of mRNA versus Non-mRNA COVID-19 vaccines in pregnant patients: a systematic review and meta-analysis

Multidisciplinary team training in postpartum hemorrhage: impact on the use of blood products

Immediate prepectoral versus submuscular breast reconstruction in nipple-sparing mastectomy: a retrospective cohort analysis

The importance of the quadrivalent HPV vaccine in the elimination of cervical cancer in Brazil

Thinking on the purposes, roles and activities of networks for research on maternal and perinatal health: opinions of coordinators and members

Morbidity associated with emergency surgery versus scheduled surgery in patients with placenta accreta spectrum

Biochemical markers for prediction of the first half pregnancy losses: a review

Association between dietary patterns and infant birth weight in brazilian pregnancy women with gestational diabetes: a cross-sectional study

Assessıng the predıctıve accuracy of blood-based bıomarkers ın neonatal outcomes for pregestatıonal dıabetes mellıtus

Effects of domestic violence on menopausal symptoms, sexual function, and quality of life: a cross-sectional study

The ımpact of demographic and obstetric factors on perception of traumatic birth and breastfeeding attitudes

Clinical and epidemiological profile of pregnant and postpartum women affected by COVID-19 who required respiratory support

Evaluation of pathological complete response rates in breast cancer patients undergoing neoadjuvant therapy

Follow-up of women after gynecological cancer treatment

Comment on: Access and adequacy of antenatal care in during two phases of the COVID-19 pandemic

Use of calcium during pregnancy: far beyond pre-eclampsia

Tag Cloud

Avaliação Prospectiva dos Índices de Resistência e Pulsatilidade nas Artérias Renais de Gestantes Normais

Acurácia dos Métodos Clínico e Ecográfico no Diagnóstico de Adenomiose

Cirurgia de Alta Freqüência em Lesões Intra-epiteliais de Alto Grau do Colo Uterino

Curva de Normalidade da Área de Secção Transversa do Cordão Umbilical Aferida pela Ultra-Sonografia e sua Correlação com Parâmetros Antropométricos em Gestações Normais

Diferencial dos Tumores Sólidos Palpáveis da Mama

Aspectos Clínicos e Epidemiológicos das Mulheres Climatéricas de um Programa de Saúde da Família em Cuiabá: MT, 1999.

Effect of Betamethasone on Pregnant Rats: Impact on Corticosterone Level and Maternal and Fetal Adrenal Glands

Brain-sparing Effect Detected by Color Doppler: Perinatal Outcome

Neonatal and maternal outcomes of mRNA versus Non-mRNA COVID-19 vaccines in pregnant patients: a systematic review and meta-analysis

Abstract

Objective

Data sources

Study selection

Data synthesis

Conclusion

PROSPERO

Multidisciplinary team training in postpartum hemorrhage: impact on the use of blood products

Abstract

Objective

Methods

Results

Conclusion

Immediate prepectoral versus submuscular breast reconstruction in nipple-sparing mastectomy: a retrospective cohort analysis

Abstract

Objective

Methods

Results

Conclusion

The importance of the quadrivalent HPV vaccine in the elimination of cervical cancer in Brazil

Thinking on the purposes, roles and activities of networks for research on maternal and perinatal health: opinions of coordinators and members

Abstract

Objective

Methods

Results

Conclusion

Morbidity associated with emergency surgery versus scheduled surgery in patients with placenta accreta spectrum

Abstract

Objective

Methods

Results

Conclusion

Biochemical markers for prediction of the first half pregnancy losses: a review

Abstract

Objective

Methods

Results

Conclusion

Association between dietary patterns and infant birth weight in brazilian pregnancy women with gestational diabetes: a cross-sectional study

Abstract

Objective

Methods

Results

Conclusion

Assessıng the predıctıve accuracy of blood-based bıomarkers ın neonatal outcomes for pregestatıonal dıabetes mellıtus

Abstract

Objective:

Methods:

Results:

Conclusion:

Effects of domestic violence on menopausal symptoms, sexual function, and quality of life: a cross-sectional study

Abstract

Objective:

Methods:

Results:

Conclusions:

The ımpact of demographic and obstetric factors on perception of traumatic birth and breastfeeding attitudes

Abstract

Objective:

Methods:

Results:

Conclusion:

Clinical and epidemiological profile of pregnant and postpartum women affected by COVID-19 who required respiratory support

Abstract

Objective:

Methods:

Results:

Conclusion:

Clinical Trials registry:

Evaluation of pathological complete response rates in breast cancer patients undergoing neoadjuvant therapy

Abstract