Articles - Revista Brasileira de Ginecologia e Obstetrícia

Resumos de Teses06-19-2002

Linfonodo Sentinela no Carcinoma Infiltrativo Inicial de Mama: Estudo de sua Localização e de sua Capacidade Preditiva em Relação ao Estado da Axila
- José Roberto Morales Piato
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):69-69

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Abstract
Resumos de Teses
Linfonodo Sentinela no Carcinoma Infiltrativo Inicial de Mama: Estudo de sua Localização e de sua Capacidade Preditiva em Relação ao Estado da Axila
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):69-69
DOI 10.1590/S0100-72032002000100014
José Roberto Morales Piato
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Linfonodo Sentinela no Carcinoma Infiltrativo Inicial de Mama: Estudo de sua Localização e de sua Capacidade Preditiva em Relação ao Estado da Axila […]
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Resumos de Teses06-19-2002

Avaliação da Função Ovariana Pós-histerectomia Total Abdominal em Mulheres no Menacme
- Eliana Aguiar Petri Nahás
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):69-69

Views76

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Resumos de Teses
Avaliação da Função Ovariana Pós-histerectomia Total Abdominal em Mulheres no Menacme
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):69-69
DOI 10.1590/S0100-72032002000100013
Eliana Aguiar Petri Nahás
Views76
Avaliação da Função Ovariana Pós-histerectomia Total Abdominal em Mulheres no Menacme […]
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Resumos de Teses06-19-2002

Efeitos do Tabagismo na Circulação Arterial Materna e Fetal: Estudo Através do Método Doppler
- Renata Alberge Giugliano Meschino
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):68-68

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Resumos de Teses
Efeitos do Tabagismo na Circulação Arterial Materna e Fetal: Estudo Através do Método Doppler
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):68-68
DOI 10.1590/S0100-72032002000100012
Renata Alberge Giugliano Meschino
Views52
Efeitos do Tabagismo na Circulação Arterial Materna e Fetal: Estudo Através do Método Doppler […]
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Resumos de Teses06-19-2002

Terapia com Raloxifeno na Pós-menopausa: Efeitos sobre o Sistema Hemostático
- George Dantas de Azevedo
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):67-67

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Resumos de Teses
Terapia com Raloxifeno na Pós-menopausa: Efeitos sobre o Sistema Hemostático
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):67-67
DOI 10.1590/S0100-72032002000100010
George Dantas de Azevedo
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Terapia com Raloxifeno na Pós-menopausa: Efeitos sobre o Sistema Hemostático […]
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Resumos de Teses06-19-2002

Efeitos da Metiltestosterona sobre a Sexualidade, Metabolismo Lipoproteíco e Hepático e Níveis de Testosterona em Mulheres na Pós-Menopausa em Uso de Reposição Estroprogestativa
- Fernando José Felipe de Paula
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):67-68

Views53

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Resumos de Teses
Efeitos da Metiltestosterona sobre a Sexualidade, Metabolismo Lipoproteíco e Hepático e Níveis de Testosterona em Mulheres na Pós-Menopausa em Uso de Reposição Estroprogestativa
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):67-68
DOI 10.1590/S0100-72032002000100011
Fernando José Felipe de Paula
Views53
Efeitos da Metiltestosterona sobre a Sexualidade, Metabolismo Lipoproteíco e Hepático e Níveis de Testosterona em Mulheres na Pós-Menopausa em Uso de Reposição Estroprogestativa […]
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original Article06-19-2002

Knowledge and Opinion of Brazilian Researchers About Informed Consent
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):59-65

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
Knowledge and Opinion of Brazilian Researchers About Informed Consent
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):59-65
DOI 10.1590/S0100-72032002000100009
Hardy Ellen,
Silvana Ferreira Bento,
Maria José Duarte Osis
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Introduction: the Resolution 196/96 of the Conselho Nacional de Saúde (National Council of Health/Ministry of Health) presents the main Brazilian guidelines on research involving human subjects, including the content of written informed consent. Purpose: to present the knowledge and opinion of Brazilian researchers on the contents of Resolution 196/96, specifically related to the informed consent form. Subjects and methods: forty-six doctors responsible for the area of gynecology at Brazilian universities, four directors of research centers and 31 researchers who participated in a study related to fertility regulation during the 12 months preceding September, 2000. Subjects completed a self-reporting questionnaire. Data were analyzed by the chi² test. Results: most subjects declared that they knew the Resolution 196/96 and considered it adequate, although difficult to comply with; they considered that all studies should have an informed consent form, and knew that its content should guarantee confidentiality. More researchers than those responsible for gynecology department/directors knew that the informed consent form should be prepared by the principal investigator. Significantly more responsible for gynecology department/directors than researchers declared that subjects must always sign (or put their thumb print if they do not know how to write) on the informed consent form. Subjects declared that payment of expenses resulting from participation in a study must always be explained in the informed consent form. Conclusion: despite the wide dissemination of the Resolution 196/96, it was not known by all the researchers nor by all those responsible for gynecology departament/directors. The majority agreed with the contents required by the Resolution for the informed consent form.

Key-words Ethics Committee Informed consent
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Original Article06-19-2002

p53 Protein Overexpression as a Prognostic Marker for Vulvar Intraepithelial Neoplasia III Recurrence/Progression
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):51-57

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
p53 Protein Overexpression as a Prognostic Marker for Vulvar Intraepithelial Neoplasia III Recurrence/Progression
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):51-57
DOI 10.1590/S0100-72032002000100008
Isabel Cristina Chulvis do Val Guimarães,
Gutemberg Leão de Almeida Filho,
Maria da Glória de Carvalho,
Christina Maeda Takiya,
Aldo Franklin Ferreira Reis,
Paulo Marcos Valiante,
Maria Consuelo Gondim
Views160
Purpose: to evaluate p53 overexpression value in vulvar intraepithelial neoplasia (VIN) III recurrence/progression. Methods: twenty patients with undifferentiated VIN III were selected and followed up every six months for four years and divided into two groups: fourteen without and six with recurrence/progression lesion. The recurrence/progression cases were distributed as follows: in three patients recurrence occurred only once; in two, twice, and only one progressed to squamous cancer. In both groups the site of vulvar lesion and p53 overexpression and immunostaining pattern were analyzed. A similar study was performed in recurrence/progression cases, besides the analysis of the time interval to occur the arise of recurrence/progression. Results: recurrence was observed in 25% of the cases and, in 5%, progression to carcinoma. The mean time interval for recurrence was 24.5 months. Multifocal location of the initial lesion was the predominant form (50%) in both groups. In the majority of the cases (87.5%) recurrence/progression occurred at the same site of the initial vulvar lesion. p53 overexpression was observed in 50% of the VIN III primary lesions and in 75% of the recurrence/progression cases. Conclusions: p53 overexpression seems to play an important role in VIN III pathogenesis and may predict the clinical course of the lesions. VIN III recurrence/progression has a tendency to occur in the same area of the initial lesion, suggesting the presence of molecular disturbance.

Key-words Oncogenes Vulva: preneoplastic lesions Vulvar intraepithelial neoplasia
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Original Article06-19-2002

Endometrial Adenocarcinoma Frequency in a Hysteroscopy Outpatient Clinic: A Multicenter Study
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):45-50

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
Endometrial Adenocarcinoma Frequency in a Hysteroscopy Outpatient Clinic: A Multicenter Study
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):45-50
DOI 10.1590/S0100-72032002000100007
Francesco Antonio Viscomi,
Sonia Maria Rolim Rosa Lima,
José Mendes Aldrighi,
Mauro Fernando Kürten Ihlenfeld
Views94
Purpose: to perform a census about the frequency of endometrial adenocarcinoma of women submitted to diagnostic hysteroscopy in five Brazilian hysteroscopic centers in São Paulo, Rio de Janeiro, Salvador, Caxias do Sul and Porto Alegre. Methods: information was collected from standard questionnaires about the presence of endometrial adenocarcinoma, hysteroscopic staging and histologic type, in pre- and postmenopausal women. Results: among 6,466 hysteroscopic procedures, endometrial adenocarcinoma was present in 92 patients (1.4%), confirmed by histology in 79 (1.2%) cases. For the hysteroscopic diagnosis of endometrial adenocarcinoma confirmed by histology, a sensitivity of 85.9%, specificity of 100%, positive predictive value of 100% and negative predictive value of 98.6% were obtained. In the premenopausal group, among 3,845 hysteroscopic exams, endometrial cancer was present in 83 (3.2%) and confirmed by histology in 71 cases (2.7%). Conclusions: this study points out the importance of epidemiological methods in the diagnostic and prevention programs of endometrial cancer, specially in postmenopause, revealing the need for further epidemiological studies on endometrial adenocarcinoma diagnostis and prevention programs.

Key-words Cancer screening Endometrial neoplasms Endometrial neoplasms, epidemiology Endometrial neoplasms, histology Hysteroscopy
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Nominata 202412-31-2024

Nominata 2024
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:eRBGO20242024

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Abstract
Nominata 2024
Nominata 2024
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:eRBGO20242024
DOI 10.61622/rbgo/2024nominata02024
Views191
We wish to thank everyone who contributed to the edition of the Revista Brasileira de Ginecologia e Obstetrícia – RBGO volume 46, year 2024, especially the authors and reviewers whose work and opinions were essential to maintain the scientific and methodological rigor of the published articles.A. Seval Ozgu-Erdinc, University of Health Sciences, Ankara Eğitim ve […]
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Review Article12-04-2024

Self-medication among pregnant women in comparison to the general population: a scoping review of the main characteristics
- Gabriela Pereira ,
- Cinthia Madeira de Souza ,
- Amanda Canato Ferracini ,
- Fernanda Garanhani Surita ,
- Sherif Eltonsy ,
- Priscila Gava Mazzola
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo77

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Review Article
Self-medication among pregnant women in comparison to the general population: a scoping review of the main characteristics
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo77
DOI 10.61622/rbgo/2024rbgo77
Gabriela Pereira ,
Cinthia Madeira de Souza ,
Amanda Canato Ferracini ,
Fernanda Garanhani Surita ,
Sherif Eltonsy ,
Priscila Gava Mazzola
Views249
Abstract

Objective:

An in-depth evaluation of the published evidence is needed on self-medication, specifically the evidence focusing on vulnerable groups, such as pregnant women. This scoping review aims to provide an overview of the differences in self-medication prevalence and study characteristics among different groups, while identifying gaps in the literature.

Methods:

A literature search was performed in PubMed and Web of Science, including articles published in the last 10 years for the pregnant women group (PWG) and the general population group (GPG). Data on study design, self-medication prevalence, medications used, and other variables were collected, tabulated, and summarized.

Results:

From 2888 screened articles, 75 were considered including 108,559 individuals. The self-medication (SM) in the PWG ranged from 2.6 to 72.4% and most studies had an SM prevalence between 21 and 50% and in the GPG, 32 from 50 studies had a SM prevalence higher than 50%. The reviewed studies varied considerably in methodology, requiring careful interpretation. While most of the studies assessed self-medication during the entire pregnancy, self-medication definition was often inconsistent between studies. Acetaminophen was the most used medication and headache was the most frequent symptom leading to self-medication initiation in the PWG.

Conclusions:

Self-medication among pregnant women showed a lower prevalence when compared to the general population. The medications used and symptoms reported were similar between groups. However, methodological differences must be carefully considered. Pregnant women should carefully follow their physicians’ advice before initiating self-medication to avoid preventable maternal and fetal adverse effects.

Key-words drug-related side effects and adverse reactions Medication use Pregnant women Self-medication
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Review Article12-04-2024

Metformin versus insulin in gestational diabetes mellitus: a systematic review
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo89

Views318

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Review Article
Metformin versus insulin in gestational diabetes mellitus: a systematic review
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo89
DOI 10.61622/rbgo/2024rbgo89
Giovanna Noronha Berti ,
Igor Gutschov Oviedo Garcia ,
João Pedro Ruas Floriano de Toledo ,
Júlia Rodrigues Tatemoto ,
Lais Watanabe Marino ,
Mariana de Medeiros Legori ,
Sérgio Floriano de Toledo
Views318
Abstract

Objective:

The aim of this study is to assess the use of metformin with or without insulin for the treatment of Gestational Diabetes Mellitus compared to insulin alone.

Data sources:

This article consists of a systematic review of randomized clinical trials. The searches were carried out on MEDLINE including 7 studies, between 2010 to 2021.

Study selection:

Randomized clinical trials comparing metformin and insulin written in English, Spanish or Portuguese, with no time limit, were included.

Data collection:

Data was extracted from all the 7 articles and compared statistically when possible. Whenever data was not available or couldn’t be statistically compared, the main results were described in detail.

Data synthesis:

Insulin alone is not superior than metformin with or without insulin on gestational diabetes mellitus.

Conclusion:

There is a potential viability of using metformin as an alternative compared to insulin alone in the treatment of Gestational Diabetes Mellitus. However, all assessed outcomes have a very low level of certainty of evidence and more studies are necessary to support these findings.

Key-words Gestational diabetes Insulin therapy Metformin Pregnancy complications
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Letter to the Editor12-04-2024

Comment on: Effects of COVID-19 on human placentas in the second and third trimester
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo88

Views141

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Letter to the Editor
Comment on: Effects of COVID-19 on human placentas in the second and third trimester
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo88
DOI 10.61622/rbgo/2024rbgo88
Nayara Ribeiro Máximo de Almeida ,
Mateus Augusto Felix de Melo ,
Pâmela Marillac Rodrigues Feijó de Melo ,
Julio Martinez Santos ,
Johnnatas Mikael Lopes
Views141
Recent evidence demonstrates na increase in negative maternal and neonatal outcomes in cases of SARS-CoV-2 infection, such as greater severity of the disease, need for mechanical ventilation and longer hospitalization in intensive care units.(,) The greater severity of infectious diseases in pregnancy occurs due to anatomical and immunological changes, such as a change in the […]
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Original Article12-04-2024

Analysis of vaginal microbiota before and after treatment of high-grade squamous intraepithelial lesions of the uterine cervix
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo86

Views207

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
Analysis of vaginal microbiota before and after treatment of high-grade squamous intraepithelial lesions of the uterine cervix
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo86
DOI 10.61622/rbgo/2024rbgo86
Patrícia Mendonça Ventura ,
Isabel Cristina Chulvis do Val Guimarães ,
Luis Guillermo Coca Velarde ,
Susana Cristina Aidé Viviani Fialho ,
Douglas Guedes Ferreira ,
Matheus Madureira Fernandes ,
Rafael Augusto Chaves Machado
Views207
Abstract

Objective:

HPV infection is considered the most common sexually transmitted virus today. The persistence of HPV is the main cause for the development of precursor lesions and cervical cancer. There are environmental and non-environmental factors that contribute to the persistence of the virus. Studies indicate a possible relationship between the vaginal microbiota (environmental factor) and the risk of high-grade cervical squamous intraepithelial lesions and cervical cancer. This study evaluates the association between the type of vaginal microbiota and the occurrence of high-grade squamous intraepithelial lesions of the cervix.

Methods:

Observational, longitudinal, prospective, and analytical studies carried out between 2019 and 2021, which evaluated the vaginal microbiota of patients diagnosed with high-grade cervical squamous intraepithelial lesion before and after treatment in two collections with an interval of 6 months, using scrapings and vaginal swabs.

Results:

In Group I (with lesions) 28 women participated and 29 in Group II (without lesions). According to Nugent, in the initial collection of Group I, 16 women (57%) had lactobacillary microbiota, eight (28%) intermediate, and four (14%) coccus. In Group II, twenty-one (75%) were lactobacillary, one (3%) was intermediate, and seven (24%) werecoccus. With p=0.03.

Conclusion:

According to Nugent’s criteria, there was an association between the type of vaginal microbiota and the occurrence of high-grade cervical squamous intraepithelial lesions of the cervix. The same was not observed in the Donders classification. Studies with a larger sample are needed to confirm our results.

Key-words Cervixuteri microbiota Papillomavirus infections squamous intraepithelial lesions of the cervix Uterine cervical neoplasms Vaginosis, bacterial
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Original Article12-04-2024

Systemic inflammatory indices as a non-invasive grading modality for endometriosis: a comparative study versus exploratory laparoscopy
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo84

Views207

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
Systemic inflammatory indices as a non-invasive grading modality for endometriosis: a comparative study versus exploratory laparoscopy
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo84
DOI 10.61622/rbgo/2024rbgo84
Ahmed Sabra Ibrahim Mohammed Sabra ,
Shreen Naguib Aboelezz Moselhy ,
Ahmed Kasem Mohamed Zain Eldin
Views207
Abstract

Objective:

Included evaluation of the possibility of using the systemic inflammatory indices for preoperative screening for the presence and severity of endometriosis (EM) in comparison to the findings of the exploratory laparoscopy

Methods:

88 women with clinical manifestations suggestive of EM were evaluated clinically and by US and gave blood samples for estimation of serum cancer antigen-125 (CA125), platelet and total and differential leucocytic counts for calculation of inflammatory indices; the Systemic Immune-Inflammation index, the Systemic Inflammation Response Index (SIRI), the Neutrophil-Lymphocyte ratio (NLR), the Neutrophil-Monocyte ratio, the Neutrophil-Platelet ratio and the Platelet-Lymphocyte ratio. Then, patients were prepared to undergo laparoscopy for diagnosis and staging.

Results:

Laparoscopy detected EM lesions in 63 patients; 27 of stage I-II and 36 of stage III-IV. Positive laparoscopy showed significant relation with US grading, high serum CA125 levels, platelet and inflammatory cell counts and indices. Statistical analyses defined high SIRI and NLR as the significant predictors for positive laparoscopy and high serum CA125 and NLR as the most significant predictors for severe EM (stage III-IV) on laparoscopy

Conclusion:

The intimate relation between EM and inflammation was reflected systematically as high levels of blood cellular components, but indices related to neutrophil especially NLR and SIRI showed highly significant relation to the presence and severity of EM and might be used as routine, cheap and non-invasive screening test before exploratory laparoscopy to guide the decision-making.

Key-words CA125 antigen Endometriosis Inflammation Laparoscopy Leukocyte count Lymphocytes Neutrophils
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Letter to the Editor12-04-2024

Comment on: Effect of combined training on body image, body composition and functional capacity in patients with breast cancer: controlled clinical trial
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo96

Views193

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Letter to the Editor
Comment on: Effect of combined training on body image, body composition and functional capacity in patients with breast cancer: controlled clinical trial
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo96
DOI 10.61622/rbgo/2024rbgo96
Piyush Bharadwaj ,
Divya Khati ,
Simran Sunil Khutarkar ,
Sweta Verma
Views193
Dear Editor,I am writing to express my appreciation for the recent article titled “Effect of Combined Training on Body Image, Body Composition, and Functional Capacity in Patients with Breast Cancer: Controlled Clinical Trial,” published online on June 20, 2023. The study provides crucial insights into the benefits of combined training for breast cancer patients, highlighting […]
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Review Article12-04-2024

Female genital tract microbiome: the influence of probiotics on assisted reproduction
- Ana Sofia Almeida Santana ,
- Ana Margarida Póvoa
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo82

Views214

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Review Article
Female genital tract microbiome: the influence of probiotics on assisted reproduction
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo82
DOI 10.61622/rbgo/2024rbgo82
Ana Sofia Almeida Santana ,
Ana Margarida Póvoa
Views214
Abstract

Assisted reproductive technology (ART) has been evolving since 1978, with the number of techniques performed increasing over the years. Despite continued advances, some couples continue to have difficulties getting pregnant, and it has recently been considered that the microbiome of the female genital tract (FGT) may influence embryo implantation and the establishment of pregnancy. This review aims to evaluate the role of probiotics on reproductive outcomes in infertile women on ART. A search throughout medical databases was performed, and six articles met the criteria. Five studies showed improvements in pregnancy rates, with only one demonstrating statistical significance. One article showed no improvement but reported a statistically significant reduction in the miscarriage rate in the probiotic group. Further research is needed to evaluate the true potential of probiotics, namely to assess whether they effectively modulate the FGT microbiome and if these changes are maintained over time.

Key-words Abortion, spontaneous Embryo implantation Genitalia, female Infertility, female Pregnancy outcome Pregnancy rate Probiotics Reproductive techniques, assisted, Microbiota
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Original Article04-30-2025

Assessıng the predıctıve accuracy of blood-based bıomarkers ın neonatal outcomes for pregestatıonal dıabetes mellıtus
- Ayse Cigdem Bayrak ,
- Erdem Fadiloglu ,
- Haticegul Tuncer ,
- Edip Alptug Kir ,
- Umutcan Kayikci ,
- Ozgur Deren
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo17

Views68

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
Assessıng the predıctıve accuracy of blood-based bıomarkers ın neonatal outcomes for pregestatıonal dıabetes mellıtus
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo17
DOI 10.61622/rbgo/2025rbgo17
Ayse Cigdem Bayrak ,
Erdem Fadiloglu ,
Haticegul Tuncer ,
Edip Alptug Kir ,
Umutcan Kayikci ,
Ozgur Deren
Views68
Abstract

Objective:

This retrospective study aimed to investigate blood-based immune-inflammatory biomarkers (IIBs) in predicting neonatal outcomes in pregnancies with pregestational diabetes mellitus (PGDM).PIV[(neutrophil×platelet×monocyte)/lymphocyte)], SII (neutrophil×platelet/lymphocyte), and NLR neutrophil/lymphocyte) values were evaluated in all three trimesters, and their correlation with neonatal outcomes was examined.

Methods:

We included 82 cases of PGDM pregnancies delivered after 32 weeks. Maternal age, gravidity, parity, types of diabetes, and route of delivery were noted. For neonatal outcomes, we recorded gestational age at birth, birth weight percentile, existence of fetal growth restriction, LGA, neonatal intensive care unit (NICU) requirement, Apgar Score <7 at 1, 5, or 10 minutes, need for positive pressure ventilation (PPV), need for mechanical ventilation, hypoglycaemia, hyperbilirubinemia and the need for phototherapy. PIV, SII and NLR values were calculated in each trimester and their association with adverse neonatal outcomes was analyzed.

Results:

We could not detect any consistent and significant correlation between SII and PIV values and adverse neonatal outcomes for each trimester. There was a correlation between 3rd trimester NLR and adverse neonatal outcomes, including APGAR <7, the requirement for PPV and mechanical ventilation (p=0.056, 0.013 and 0.060, respectively).

Conclusion:

While SII and PIV values did not consistently correlate with adverse neonatal outcomes throughout each trimester in PGDM pregnancies, 3rd-trimester NLR showed a notable association with the requirement for PPV with statistical significance and with Apgar Score <7 and the requirement for mechanical ventilation without statistical significance. NLR in the third trimester may hold potential as a predictive marker for specific adverse neonatal outcomes in PGDM pregnancies, warranting further investigation.

Key-words biomarkers Diabetes mellitus Gestational age Hypoglycemia Infant, newborn Intensive care units, neonatal Lymphocytes Maternal age Monocytes Neuthrophils Pregancy Pregnancy in diabetes Respiration, artificial
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Original Article04-30-2025

Effects of domestic violence on menopausal symptoms, sexual function, and quality of life: a cross-sectional study
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo16

Views76

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
Effects of domestic violence on menopausal symptoms, sexual function, and quality of life: a cross-sectional study
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo16
DOI 10.61622/rbgo/2025rbgo16
Laís Lima Ferreira ,
Charles Francisco Ferreira ,
Maria Celeste Osório Wender
Views76
Abstract

Objective:

To investigate the association between lifetime experience of domestic violence and climacteric symptoms, sexual function, and quality of life in climacteric women in Rio Grande do Sul, Brazil.

Methods:

A cross-sectional study was conducted with 700 pre-, peri-, and postmenopausal women, recruited online via an anonymous questionnaire (REDCap platform). Women aged 40 to 65 years, residing in Rio Grande do Sul, and classified by the STRAW+10 criteria were included. Climacteric symptoms and sexual function were assessed using the 10-item Cervantes Scale (CS-10) and the 6-item Female Sexual Function Index (FSFI-6). Data were analyzed using SPSS version 18.0; quantitative data as median [IQR], qualitative as frequencies. Group comparisons used Kruskal-Wallis, Chi-Square, and Spearman’s correlation between violence against women (VAW) and/or climacteric groups on CS-10 or FSFI-6. Significance was set at 5%.

Results:

The median [IQR] age of pre- (46 [43 – 50] years), peri- (50 [47 – 52] years), and postmenopausal (55 [51 – 58] years) were different among groups. Prevalence rates of psychological (38.8%), sexual (34.9%), and physical (21.3%) violence were observed. Postmenopausal women showed the poorest outcomes. Premenopausal women experiencing violence had severe anxiety, while postmenopausal women reported feeling worthless. Various sexual dysfunctions were associated with violence, including low desire, lubrication issues, and sexual pain.

Conclusions:

Domestic violence was linked to worse climacteric symptoms, sexual function, and quality of life, particularly in postmenopausal women. These findings underscore the need for improved care and public policies to enhance safety and well-being among women of all ages.

Key-words Anxiety Climacteric Domestic violence Menopause Postmenopause Quality of life Sexuality surveys and questionnaires Violence against women
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Original Article04-30-2025

The ımpact of demographic and obstetric factors on perception of traumatic birth and breastfeeding attitudes
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo15

Views49

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
The ımpact of demographic and obstetric factors on perception of traumatic birth and breastfeeding attitudes
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo15
DOI 10.61622/rbgo/2025rbgo15
Ayşe Çuvadar ,
Elnaz Karamelikli ,
Yeter Çuvadar Baş
Views49
Abstract

Objective:

This study aims to examine the effects of sociodemographic and obstetric factors on traumatic birth perception and breastfeeding attitudes in primiparous mothers who have had a vaginal birth in the early postpartum period.

Methods:

The sample of the research, developed with a cross-sectional and correlational design, consisted of 252 women residing in a province in the Western Black Sea region of Türkiye. The data were obtained by employing a Personal Information Form, Traumatic Childbirth Perception Scale, and Breastfeeding Attitudes of The Evaluation Scale. Data analysis was conducted using the statistical programming language R (R version 4.3.3).

Results:

Women who were not employed, had a planned pregnancy, and did not experience health problems during pregnancy had higher mean breastfeeding attitude scores, and this difference was statistically significant. It was determined that a one-unit increase in gestational week led to an average increase of 1.926 units in breastfeeding attitude score, and a one-unit increase in Traumatic Childbirth Perception Scale score led to an average decrease of 0.110 units in breastfeeding attitude score. The mean traumatic childbirth perception scores of women living in urban areas were found to be lower than those living in villages or towns, and the difference was statistically significant.

Conclusion:

The research findings indicate that gestational age, perception of traumatic childbirth, and certain sociodemographic factors significantly affect breastfeeding attitudes. Additionally, mothers living in urban areas have a lower perception of traumatic childbirth. Therefore, individualized approaches to childbirth and breastfeeding support are crucial.

Key-words Breast feeding Delivery, obstetric Parturition perception Postpartum period Sociodemographic factors Stress disorders, post-traumatic
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Original Article04-30-2025

Clinical and epidemiological profile of pregnant and postpartum women affected by COVID-19 who required respiratory support
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo14

Views50

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
Clinical and epidemiological profile of pregnant and postpartum women affected by COVID-19 who required respiratory support
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo14
DOI 10.61622/rbgo/2025rbgo14
Carolina Maria Pires Cunha ,
Melania Maria Ramos Amorim ,
Julianna de Azevedo Guendler ,
Alex Sandro Rolland Souza ,
Leila Katz
Views50
Abstract

Objective:

This study described the clinical and epidemiological profile and the management provided to pregnant and postpartum women with COVID-19 who required respiratory support.

Methods:

A descriptive study was conducted with pregnant and postpartum women with confirmed COVID-19 who received care between April 2020 and December 2021 in eight referral centers in northeastern Brazil. Statistical analysis was conducted using Epi-Info 7.2.5 and Medcalc, version 20.112.

Results:

Of the 720 patients admitted, 208 (32.7%) required respiratory support. Mean age of the participants was 28.9±7.1 years. Most (52.8%) were brown-skinned; 31.3% had little formal schooling; 41.1% had a personal income and 23.1% were married. Around half were referred from another hospital. Overall, 36.8% were obese and 36.9% were hypertensive. Criteria for severe acute respiratory syndrome (SARS) were present in 80.7% of cases. Overall, 151 patients (74.7%) required corticoids, and 150 (76.1%) were admitted to an intensive care unit. Non-invasive ventilation was needed in 89.4% of cases, with nasal catheters being the most common type (55.3% of cases). Invasive mechanical ventilation was necessary in 35.5% of cases and 91.6% had a cesarean section. Maternal near miss and death occurred in 24% and 12.9% of cases, respectively.

Conclusion:

Pregnant and postpartum women with COVID-19 who required respiratory support were predominantly brown-skinned, in the third trimester of pregnancy and had been referred from another hospital. The cesarean section rate was high; the presence of criteria for SARS was common and the rates of COVID-19-related maternal near miss and death were high.

Clinical Trials registry:

NCT04462367

Key-words Cesarian section COVID-19 Intensive care units Near miss, healthcare Noninvasive ventilation Obesity Postpartum period Pregnancy Pregnancy trimester, third Respiration, artificial SARS-CoV-2 severe acute respiratory syndrome
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Original Article04-30-2025

Evaluation of pathological complete response rates in breast cancer patients undergoing neoadjuvant therapy
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo13

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
Evaluation of pathological complete response rates in breast cancer patients undergoing neoadjuvant therapy
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo13
DOI 10.61622/rbgo/2025rbgo13
Gabriella Ferezini Oliveira de Sá ,
Pedro Vilar de Oliveira Villarim ,
Pedro Hortêncio Saboia da Escossia Melo ,
Ayane Cristine Alves Sarmento ,
Ana Katherine Gonçalves ,
Kleyton Santos de Medeiros ,
Cristina Rocha de Medeiros Miranda
Views60
Abstract

Objective:

This study aims to assess the rate of pathological complete response (pCR) in breast cancer patients undergoing neoadjuvant therapy and to explore its correlation with clinical, molecular, and prognostic factors.

Methods:

We conducted this retrospective observational study at Liga Contra o Câncer, a major public oncology reference center in Northeast Brazil. We included patients diagnosed with breast cancer who initiated neoadjuvant therapy between June 2018 and June 2019. Patients with a history of recurrent breast cancer or those who did not undergo surgery were excluded. The primary outcome was the pCR rate, with secondary outcomes including Overall Survival (OS), Disease-Free Survival (DFS), mortality, and disease recurrence. Follow-up extended until August 2022. We performed multivariate Cox regression analysis to correlate outcomes with predetermined variables.

Results:

Of the 292 included patients, 63 (21.6%) achieved pCR. The mean follow-up duration was 42.8 months. Multivariate logistic regression analysis revealed an association between pCR and the AC-TH regimen [OR = 2.4; 95%CI = 1.13 – 5.24; p=0.023], as well as between pCR and HER2-positive tumors [OR 2.49; 95% CI = 1.14 – 5.86; p=0.028]. Complete pathological response was associated with higher DFS [HR 0.33; 95%CI 0.13-0.86; p=0.024].

Conclusion:

Neoadjuvant therapy demonstrated significant efficacy in achieving pathological response in breast cancer patients. We observed a strong association between the AC-TH regimen, HER2-positive status, and pCR.

Key-words Breast neoplasm Neoadjuvant therapy Surgical oncology
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FEBRASGO POSITION STATEMENT03-28-2025

Follow-up of women after gynecological cancer treatment
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-FPS3

Views176

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
FEBRASGO POSITION STATEMENT
Follow-up of women after gynecological cancer treatment
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-FPS3
DOI 10.61622/rbgo/2025FPS3
Agnaldo Lopes da Silva Filho ,
Mariana Seabra Leite Praça ,
Matheus Eduardo Soares Pinhati ,
Laura Guimarães Castro ,
Renato Moretti-Marques ,
Angélica Nogueira-Rodrigues ,
Eduardo Batista Cândido
Views176
Key points

•The population of female cancer survivors has increased over the last few years, highlighting the importance of appropriate follow-up of these patients.

•The main objective of long-term follow-up for patients treated for cancer is the early detection of recurrences, whether local, lymph node or distant metastases.

•Symptom assessment and physical examination play an important role in the follow-up of patients treated for gynecological neoplasms.

•The use of laboratory or imaging tests to detect recurrence in asymptomatic patients should be based on evidence that it improves survival or provides less morbid treatments, also considering cost and availability.

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Letter to the Editor03-18-2025

Comment on: Access and adequacy of antenatal care in during two phases of the COVID-19 pandemic
- Amnuay Kleebayoon ,
- Viroj Wiwanitkit
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo12

Views176

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Letter to the Editor
Comment on: Access and adequacy of antenatal care in during two phases of the COVID-19 pandemic
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo12
DOI 10.61622/rbgo/2025rbgo12
Amnuay Kleebayoon ,
Viroj Wiwanitkit
Views176
The publication on “Access and adequacy of antenatal care in a city in Brazil during two phases of the COVID-19 pandemic.”() Is an interesting issue. This study investigated antenatal care consumption and appropriateness among postpartum caregivers at Florianópolis Hospital from 2020 to 2022, with an emphasis on socio-demographic characteristics and antenatal care. Although this study […]
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Letter to the Editor03-18-2025

Use of calcium during pregnancy: far beyond pre-eclampsia
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo11

Views191

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Letter to the Editor
Use of calcium during pregnancy: far beyond pre-eclampsia
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo11
DOI 10.61622/rbgo/2025rbgo11
Melania Maria Ramos Amorim ,
Marina Amorim Albuquerque ,
Lucas Félix ,
Anna Catharina Carneiro da Cunha ,
Leila Katz
Views191
Dear Editor,We read with interest the Editorial of the Revista Brasileira de Ginecologia e Obstetrícia (RBGO) in which Braga et al. present the initiative of the state of Rio de Janeiro (Brazil) for prediction and secondary prevention of pre-eclampsia.() The authors highlight universal calcium supplementation during pregnancy as a significant innovation, implemented for the first […]
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Linfonodo Sentinela no Carcinoma Infiltrativo Inicial de Mama: Estudo de sua Localização e de sua Capacidade Preditiva em Relação ao Estado da Axila

Avaliação da Função Ovariana Pós-histerectomia Total Abdominal em Mulheres no Menacme

Efeitos do Tabagismo na Circulação Arterial Materna e Fetal: Estudo Através do Método Doppler

Terapia com Raloxifeno na Pós-menopausa: Efeitos sobre o Sistema Hemostático

Efeitos da Metiltestosterona sobre a Sexualidade, Metabolismo Lipoproteíco e Hepático e Níveis de Testosterona em Mulheres na Pós-Menopausa em Uso de Reposição Estroprogestativa

Knowledge and Opinion of Brazilian Researchers About Informed Consent

p53 Protein Overexpression as a Prognostic Marker for Vulvar Intraepithelial Neoplasia III Recurrence/Progression

Endometrial Adenocarcinoma Frequency in a Hysteroscopy Outpatient Clinic: A Multicenter Study

Nominata 2024

Self-medication among pregnant women in comparison to the general population: a scoping review of the main characteristics

Abstract

Objective:

Methods:

Results:

Conclusions:

Metformin versus insulin in gestational diabetes mellitus: a systematic review

Abstract

Objective:

Data sources:

Study selection:

Data collection:

Data synthesis:

Conclusion:

Comment on: Effects of COVID-19 on human placentas in the second and third trimester

Analysis of vaginal microbiota before and after treatment of high-grade squamous intraepithelial lesions of the uterine cervix

Abstract

Objective:

Methods:

Results:

Conclusion:

Systemic inflammatory indices as a non-invasive grading modality for endometriosis: a comparative study versus exploratory laparoscopy

Abstract

Objective:

Methods:

Results:

Conclusion:

Comment on: Effect of combined training on body image, body composition and functional capacity in patients with breast cancer: controlled clinical trial

Female genital tract microbiome: the influence of probiotics on assisted reproduction

Abstract

Assessıng the predıctıve accuracy of blood-based bıomarkers ın neonatal outcomes for pregestatıonal dıabetes mellıtus

Abstract

Objective:

Methods:

Results:

Conclusion:

Effects of domestic violence on menopausal symptoms, sexual function, and quality of life: a cross-sectional study

Abstract

Objective:

Methods:

Results:

Conclusions:

The ımpact of demographic and obstetric factors on perception of traumatic birth and breastfeeding attitudes

Abstract

Objective:

Methods:

Results:

Conclusion:

Clinical and epidemiological profile of pregnant and postpartum women affected by COVID-19 who required respiratory support

Abstract

Objective:

Methods:

Results:

Conclusion:

Clinical Trials registry:

Evaluation of pathological complete response rates in breast cancer patients undergoing neoadjuvant therapy

Abstract

Objective:

Methods:

Results:

Conclusion:

Follow-up of women after gynecological cancer treatment

Key points

Comment on: Access and adequacy of antenatal care in during two phases of the COVID-19 pandemic

Use of calcium during pregnancy: far beyond pre-eclampsia

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