-
Original Article
Oncological Outcomes of Nipple-Sparing Mastectomy in an Unselected Population Evaluated in a Single Center
- Francisco Pimentel Cavalcante
, - Mirella Macedo Parente Araújo ,
- Igor Moreira Veras ,
- Ruffo Freitas Junior
01-23-2022
Summary
Original ArticleOncological Outcomes of Nipple-Sparing Mastectomy in an Unselected Population Evaluated in a Single Center
Revista Brasileira de Ginecologia e Obstetrícia. 2022;44(11):1052-1058
01-23-2022- Francisco Pimentel Cavalcante ,
- Mirella Macedo Parente Araújo ,
- Igor Moreira Veras ,
- Ruffo Freitas Junior
Views105Abstract
Objective
Nipple-sparing mastectomy (NSM) has been traditionally used in selected cases with tumor-to-nipple distance > 2 cm and negative frozen section of the base of the nipple. Recommending NSM in unselected populations remains controversial. The present study evaluated the oncological outcomes of patients submitted to NSM in an unselected population seen at a single center.
Methods
This retrospective cohort study included unselected patients with invasive carcinoma or ductal carcinoma in situ (DCIS) who underwent NSM in 2010 to 2020. The endpoints were locoregional recurrence, disease-free survival (DFS), and overall survival (OS), irrespective of tumor size or tumor-to-nipple distance.
Results
Seventy-six patients (mean age 46.1 years) (58 invasive carcinomas/18 DCIS) were included. The most invasive carcinomas were hormone-positive (60%) (HER2 overexpression: 24%; triple-negative: 16%), while 39% of DCIS were high-grade. Invasive carcinomas were T2 in 66% of cases, with axillary metastases in 38%. Surgical margins were all negative. All patients with invasive carcinoma received systemic treatment and 38% underwent radiotherapy. After a mean of 34.8 months, 3 patients with invasive carcinoma (5.1%) and 1 with DCIS (5.5%) had local recurrence. Two patients had distant metastasis and died during follow-up. The 5-year OS and DFS rates for invasive carcinoma were 98% and 83%, respectively.
Conclusion
In unselected cases, the 5-year oncological outcomes following NSM were found to be acceptable and comparable to previous reports. Further studies are required.
Key-words Breast neoplasmsMastectomynipple-sparing mastectomysegmental mastectomysubcutaneous mastectomySee moreViews105
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Original ArticleOncological Outcomes of Nipple-Sparing Mastectomy in an Unselected Population Evaluated in a Single Center
Revista Brasileira de Ginecologia e Obstetrícia. 2022;44(11):1052-1058
01-23-2022- Francisco Pimentel Cavalcante ,
- Mirella Macedo Parente Araújo ,
- Igor Moreira Veras ,
- Ruffo Freitas Junior
Views105Abstract
Objective
Nipple-sparing mastectomy (NSM) has been traditionally used in selected cases with tumor-to-nipple distance > 2 cm and negative frozen section of the base of the nipple. Recommending NSM in unselected populations remains controversial. The present study evaluated the oncological outcomes of patients submitted to NSM in an unselected population seen at a single center.
Methods
This retrospective cohort study included unselected patients with invasive carcinoma or ductal carcinoma in situ (DCIS) who underwent NSM in 2010 to 2020. The endpoints were locoregional recurrence, disease-free survival (DFS), and overall survival (OS), irrespective of tumor size or tumor-to-nipple distance.
Results
Seventy-six patients (mean age 46.1 years) (58 invasive carcinomas/18 DCIS) were included. The most invasive carcinomas were hormone-positive (60%) (HER2 overexpression: 24%; triple-negative: 16%), while 39% of DCIS were high-grade. Invasive carcinomas were T2 in 66% of cases, with axillary metastases in 38%. Surgical margins were all negative. All patients with invasive carcinoma received systemic treatment and 38% underwent radiotherapy. After a mean of 34.8 months, 3 patients with invasive carcinoma (5.1%) and 1 with DCIS (5.5%) had local recurrence. Two patients had distant metastasis and died during follow-up. The 5-year OS and DFS rates for invasive carcinoma were 98% and 83%, respectively.
Conclusion
In unselected cases, the 5-year oncological outcomes following NSM were found to be acceptable and comparable to previous reports. Further studies are required.
Key-words Breast neoplasmsMastectomynipple-sparing mastectomysegmental mastectomysubcutaneous mastectomySee moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Francisco Pimentel Cavalcante
-
Original Article
Nipple-sparing Mastectomy with Immediate Implant-based Reconstruction for Patients with Pure Ductal Carcinoma in Situ
- Antônio Luiz Frasson ,
- Ana Beatriz Falcone ,
- Isabela Miranda ,
- Alessandra Borba Anton de Souza ,
- Betina Vollbrecht , [ ... ],
- Martina Lichtenfels
06-27-2022
Summary
Original ArticleNipple-sparing Mastectomy with Immediate Implant-based Reconstruction for Patients with Pure Ductal Carcinoma in Situ
Revista Brasileira de Ginecologia e Obstetrícia. 2022;44(4):376-384
06-27-2022- Antônio Luiz Frasson ,
- Ana Beatriz Falcone ,
- Isabela Miranda ,
- Alessandra Borba Anton de Souza ,
- Betina Vollbrecht ,
- Fernanda Barbosa ,
- Mônica Adriana Rodriguez Martinez Frasson ,
- Martina Lichtenfels
Views96See moreAbstract
Objective
The presence of an extensive intraductal component is associated to an increasing risk of relapse in the nipple-areola complex. The aim of the present study was to evaluate the outcomes of patients diagnosed with ductal carcinoma in situ (DCIS) who underwent nipple-sparing mastectomy (NSM) with immediate breast reconstruction using silicone implants.
Methods
We retrospectively analyzed the postoperative complications and oncological safety of 67 breast cancer patients diagnosed with pure DCIS who underwent NSM with immediate breast reconstruction using silicone implants between 2004 and 2018.
Results
Among the 127 NSM procedures performed, 2 hematomas (1.5%) and 1 partial nipple necrosis (0.7%) were observed. After a mean follow-up of 60months, the local recurrence rate was of 8.9%, the disease-free survival rate was of 90%, and 1 of the patients died.
Conclusion
Despite the local recurrence rate, we showed that NSM with immediate breast reconstruction using silicone implants is a feasible surgical approach, with a low rate of complications and high survival rates for patients with a diagnosis of pure DCIS when breast-conserving surgery is not an option.
Views96This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Original ArticleNipple-sparing Mastectomy with Immediate Implant-based Reconstruction for Patients with Pure Ductal Carcinoma in Situ
Revista Brasileira de Ginecologia e Obstetrícia. 2022;44(4):376-384
06-27-2022- Antônio Luiz Frasson ,
- Ana Beatriz Falcone ,
- Isabela Miranda ,
- Alessandra Borba Anton de Souza ,
- Betina Vollbrecht ,
- Fernanda Barbosa ,
- Mônica Adriana Rodriguez Martinez Frasson ,
- Martina Lichtenfels
Views96See moreAbstract
Objective
The presence of an extensive intraductal component is associated to an increasing risk of relapse in the nipple-areola complex. The aim of the present study was to evaluate the outcomes of patients diagnosed with ductal carcinoma in situ (DCIS) who underwent nipple-sparing mastectomy (NSM) with immediate breast reconstruction using silicone implants.
Methods
We retrospectively analyzed the postoperative complications and oncological safety of 67 breast cancer patients diagnosed with pure DCIS who underwent NSM with immediate breast reconstruction using silicone implants between 2004 and 2018.
Results
Among the 127 NSM procedures performed, 2 hematomas (1.5%) and 1 partial nipple necrosis (0.7%) were observed. After a mean follow-up of 60months, the local recurrence rate was of 8.9%, the disease-free survival rate was of 90%, and 1 of the patients died.
Conclusion
Despite the local recurrence rate, we showed that NSM with immediate breast reconstruction using silicone implants is a feasible surgical approach, with a low rate of complications and high survival rates for patients with a diagnosis of pure DCIS when breast-conserving surgery is not an option.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Antônio Luiz Frasson
-
Original Article
Salvage Nipple-sparing Mastectomy for Patients with Breast Cancer Recurrence: A Case Series of Brazilian Patients
- Antônio Luiz Frasson ,
- Martina Lichtenfels ,
- Fernanda Barbosa ,
- Alessandra Borba Anton de Souza ,
- Ana Beatriz Falcone , [ ... ],
- José Yoshikazu Tariki
02-24-2022
Summary
Original ArticleSalvage Nipple-sparing Mastectomy for Patients with Breast Cancer Recurrence: A Case Series of Brazilian Patients
Revista Brasileira de Ginecologia e Obstetrícia. 2022;44(5):489-496
02-24-2022- Antônio Luiz Frasson ,
- Martina Lichtenfels ,
- Fernanda Barbosa ,
- Alessandra Borba Anton de Souza ,
- Ana Beatriz Falcone ,
- Isabela Miranda ,
- Betina Vollbrecht ,
- Carolina Malhone ,
- José Yoshikazu Tariki
Views84See moreAbstract
Objective
Few studies analyzed the safety of salvage nipple-sparing mastectomy (NSM) for local relapse treatment. We evaluated the outcomes of patients with indications for mastectomy who chose to undergo NSM for ipsilateral breast tumor recurrence (IBTR).
Methods
Between January 2001 and December 2018, we evaluated 24 women who underwent NSM for local relapse after conservative surgery.
Results
Thepatientswere followedupfor amean time of132months since thefirst surgery. After the NSM, 5 (20.8%) patients were diagnosed with local recurrence and only 1 (4.2%) patient died. The patients presented 4.8% (2) of partial and 2.4% (1) of total nipple necrosis.
Conclusion
In this long-term follow-up since the first surgery, we observed low rates of complication and good survival, although associated with high local recurrence in patients diagnosed with IBTR undergoing NSM as salvage surgery.We demonstrated that NSMmay be considered after IBTR for patients who did not want to undergo total mastectomy.
Views84This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Original ArticleSalvage Nipple-sparing Mastectomy for Patients with Breast Cancer Recurrence: A Case Series of Brazilian Patients
Revista Brasileira de Ginecologia e Obstetrícia. 2022;44(5):489-496
02-24-2022- Antônio Luiz Frasson ,
- Martina Lichtenfels ,
- Fernanda Barbosa ,
- Alessandra Borba Anton de Souza ,
- Ana Beatriz Falcone ,
- Isabela Miranda ,
- Betina Vollbrecht ,
- Carolina Malhone ,
- José Yoshikazu Tariki
Views84See moreAbstract
Objective
Few studies analyzed the safety of salvage nipple-sparing mastectomy (NSM) for local relapse treatment. We evaluated the outcomes of patients with indications for mastectomy who chose to undergo NSM for ipsilateral breast tumor recurrence (IBTR).
Methods
Between January 2001 and December 2018, we evaluated 24 women who underwent NSM for local relapse after conservative surgery.
Results
Thepatientswere followedupfor amean time of132months since thefirst surgery. After the NSM, 5 (20.8%) patients were diagnosed with local recurrence and only 1 (4.2%) patient died. The patients presented 4.8% (2) of partial and 2.4% (1) of total nipple necrosis.
Conclusion
In this long-term follow-up since the first surgery, we observed low rates of complication and good survival, although associated with high local recurrence in patients diagnosed with IBTR undergoing NSM as salvage surgery.We demonstrated that NSMmay be considered after IBTR for patients who did not want to undergo total mastectomy.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Antônio Luiz Frasson
subcutaneous mastectomy Archives - Revista Brasileira de Ginecologia e Obstetrícia
