-
Artigos Originais
Genetic polymorphisms of vascular endothelial growth factor in pre-eclampsia
Revista Brasileira de Ginecologia e Obstetrícia. 2011;33(7):158-163
10-11-2011
Summary
Artigos OriginaisGenetic polymorphisms of vascular endothelial growth factor in pre-eclampsia
Revista Brasileira de Ginecologia e Obstetrícia. 2011;33(7):158-163
10-11-2011DOI 10.1590/S0100-72032011000700007
Views52See morePURPOSE: To identify genetic polymorphisms of endothelial growth factor (VEGF), positions +936C/T and -2578C/A, in women with pre-eclampsia. METHODS: This was a cross-sectional study conducted on 80 women divided into two groups: pre-eclampsia and control. The sample was characterized using a pre-structured interview and data transcribed from the medical records. DNA extraction, amplification of sequences by the Polymerase Chain Reaction (PCR) with specific primers and polymorphism analysis of Restriction Fragment Length Polymorphism (RFLP) were performed to identify polymorphisms. The statistical analysis was performedin a descriptive manner and using the
test. The multiple logistic regression model was used to determine the effect of polymorphisms on pre-eclampsia. RESULTS:Ahigher frequency of the T allele of theVEGF +936C/T polymorphism was observedin patients with pre-eclampsia, but with no significant difference. The presence of allele A of the VEGF -2578C/A was significantly higher in the control group. CONCLUSIONS:No significant association was observed between VEGF +936C/Tpolymorphism andpre-eclampsia. For the VEGF -2578C/A polymorphism a significant differencewas observed between thecontrol and pre-eclampsia group, with allele A being the most frequent in the control, suggesting the possibility that carriers of allele A have lower susceptibility to the development of pre-eclampsia.
PlumX Metrics- Citations
- Citation Indexes: 14
- Usage
- Full Text Views: 14390
- Abstract Views: 894
- Captures
- Readers: 15
-
Artigos Originais
Gait force propulsion modifications during pregnancy: effects of changes in feet’s dimensions
Revista Brasileira de Ginecologia e Obstetrícia. 2011;33(7):164-169
10-11-2011
Summary
Artigos OriginaisGait force propulsion modifications during pregnancy: effects of changes in feet’s dimensions
Revista Brasileira de Ginecologia e Obstetrícia. 2011;33(7):164-169
10-11-2011DOI 10.1590/S0100-72032011000700008
Views87See morePURPOSE: to analyze the gait propulsion force and relate it to changes in the dimensions of the feet and to the influence on the quality of life of pregnant women. METHODS: two groups were studied, a control (C) one consisting of 20 non-pregnant women and a group of 13 pregnant women investigated during the three gestational trimesters (Gfirst, Gsecond, Gthird). The groups were subjected to an initial assessment; evaluation of gait propulsion force using the force platform (Bertec); measurement of foot length and width; assessment of perimetry by the figure eight method; and assessment of quality of life using the World Health Organization Quality of Life Instrument Bref (Whoqol-bref). The Mann-Whitney test was used to evaluate differences between group C and Gfirst, the Friedman test was used to determine differences between Gfirst, Gsecond and Gthird, and the Wilcoxon test was applied to significant cases. The level of significance was set at 5%. RESULTS: There was an increase in body mass (10.5 kg) and ankle edema (2.4 cm) during pregnancy. There was a decrease of gait propulsion force (10% of body mass) and an increase of mediolateral sway (10% of body mass) compared to Control Group. There was a reduced quality of life among pregnnat women, especially in the physical domain. CONCLUSIONS: Gait disorders occur during pregnancy, which can increase the risk of falls and musculoskeletal discomfort, which may affect the quality of life of pregnant wome
PlumX Metrics- Citations
- Citation Indexes: 17
- Usage
- Full Text Views: 30955
- Abstract Views: 1446
- Captures
- Readers: 64
-
Relato de Caso
Inflammatory bowel disease – Crohn’s disease and pregnancy: case report
Revista Brasileira de Ginecologia e Obstetrícia. 2011;33(4):196-204
08-05-2011
Summary
Relato de CasoInflammatory bowel disease – Crohn’s disease and pregnancy: case report
Revista Brasileira de Ginecologia e Obstetrícia. 2011;33(4):196-204
08-05-2011DOI 10.1590/S0100-72032011000400008
Views102See moreThe Crohn's disease, a form of inflammatory bowel disease, is frequent in women of childbearing age. Its management requires greater attention during pregnancy. We report a case of refractory Crohn's disease in a pregnant patient that evolued to ileocolectomy at puerperium. The literature regarding pregnant patients with Crohn's disease was reviewed, including counseling of patients and investigation of active disease, and the existing data was summarized on the safety of medications used to treat Crohn's disease in pregnancy and breastfeeding.
PlumX Metrics- Citations
- Citation Indexes: 1
- Usage
- Full Text Views: 64501
- Abstract Views: 770
- Captures
- Readers: 25
-
Artigos Originais
Gestational and neonatal outcomes in women with positive screening for diabetes mellitus and 100g oral glucose challenge test normal
Revista Brasileira de Ginecologia e Obstetrícia. 2011;33(2):81-86
07-08-2011
Summary
Artigos OriginaisGestational and neonatal outcomes in women with positive screening for diabetes mellitus and 100g oral glucose challenge test normal
Revista Brasileira de Ginecologia e Obstetrícia. 2011;33(2):81-86
07-08-2011DOI 10.1590/S0100-72032011000200005
Views56See morePURPOSE: to determine the prevalence of adverse gestational and neonatal outcomes in women with a positive screening and negative diagnosis for gestational diabetes mellitus (GDM). METHODS: a retrospective descriptive cross-sectional study was conducted from 2000 to 2009 on 409 women with positive screening for GDM. The maternal variables studied were: age, body mass index, history of cesarean section, macrosomia or diabetes mellitus in a previous pregnancy and a personal or family history of diabetes mellitus and chronic arterial hypertension. The neonatal variables studied were: polyhydramnios, gestational age at birth, prematurity, cesarean delivery, large for gestational age (LGA) newborn, macrosomia, Apgar score, neonatal respiratory distress syndrome, hypoglycemia and hyperbilirubinemia. Uni- and multivariate descriptive analyses were first performed regarding risk factors and neonatal outcome and the prevalences and respective 95% confidence intervals were determined. RESULTS: the route of delivery was cesarian section in 255 cases (62.3%), preterm birth occurred in 14.2% of cases and 19.3% of the newborns were LGA. The risk factors correlated with LGA newborns were overweight or obesity, maternal age and a history of macrosomia in a previous pregnancy. CONCLUSIONS: a high rate of LGA newborns was observed in the population with positive risk factors or altered fasting glycemia on the occasion of the first prenatal visit, even when the glycemia curve was normal, with cesarean rates above those habitually observed in populations considered to be of low risk. Pregnant women with these characteristics represent a differential group.
PlumX Metrics- Citations
- Citation Indexes: 10
- Usage
- Full Text Views: 32092
- Abstract Views: 1720
- Captures
- Readers: 41
-
Artigos Originais
Dietary intake of pregnant women and maternal weight gain after nutritional counseling
Revista Brasileira de Ginecologia e Obstetrícia. 2011;33(2):87-92
07-08-2011
Summary
Artigos OriginaisDietary intake of pregnant women and maternal weight gain after nutritional counseling
Revista Brasileira de Ginecologia e Obstetrícia. 2011;33(2):87-92
07-08-2011DOI 10.1590/S0100-72032011000200006
Views95See morePURPOSE: to determine the dietary consumption of pregnant women, by assessing the intake of macronutrients and micronutrients, and to verify the maternal weight gain during pregnancy. METHODS: a retrospective study conducted from June 2002 to June 2008 with pregnant women who received nutritional counseling during prenatal care at a university hospital, grouped according to anthropometric nutritional status classified by pregestational body mass index (BMI). The dietary intake was analyzed according to the information obtained in food frequency interviews, performed at the first evaluation of pregnant women in the service of nutrition to obtain data about eating habits, and the intake of macronutrients and micronutrients was calculated. The pregnant women received nutritional counseling, and the maternal weight gain was investigated. RESULTS: a total of 187 pregnant women who received nutritional counseling were analyzed. Twenty-three (12.2%) were underweight, 84 (45.0%) normal weight, 37 (19.8%) overweight, and 43 (23.0%) obese. The underweight pregnant women had lower consumption of lipids when compared to the normal weight group (101.4 versus 137.3 g; p=0.043). The average iron intake was higher in normal weight pregnant women (14.6 mg/d) compared to the overweight (12.2 mg/d) or obese (10.9 mg/d; p<0.001) groups. The average intake of folate was higher in normal weight pregnant women compared to obese ones (336.5 µg/d versus 234.5 µg/d; p=0.002). Excessive maternal weight gain was significantly (p=0.009) more frequent in overweight (56.7%) and obese (39.5%) pregnant women compared to underweight (17.4%) and normal weight (31.0%) women. CONCLUSIONS: The maternal weight gain above recommended levels was associated with overweight and obesity. The dietary intake of pregnant women differs according to maternal anthropometric nutritional status, with a lower daily intake of iron in overweight and obese women and a lower intake of folate in obese ones, a fact that reinforces the importance of prenatal vitamin supplementation.
PlumX Metrics- Citations
- Citation Indexes: 22
- Usage
- Full Text Views: 62285
- Abstract Views: 1539
- Captures
- Readers: 105
-
Artigos Originais
Prenatal screening for toxoplasmosis and factors associated with seropositivity of pregnant women in Goiânia, Goiás
Revista Brasileira de Ginecologia e Obstetrícia. 2011;33(2):93-98
07-08-2011
Summary
Artigos OriginaisPrenatal screening for toxoplasmosis and factors associated with seropositivity of pregnant women in Goiânia, Goiás
Revista Brasileira de Ginecologia e Obstetrícia. 2011;33(2):93-98
07-08-2011DOI 10.1590/S0100-72032011000200007
Views67PURPOSE: to estimate the prevalence and risk factors associated with seropositivity for Toxoplasma gondii in pregnant women. METHODS: a cross-sectional retrospective study based on the records of women screened for toxoplasmosis by the Pregnancy Protection Program in 2008, living in Goiânia (GO). These records were connected to records from the database of the National Information System on Live Births from the State of Goiás. The process occurred in three phases, with 10,316 records being paired for analysis, among the 12,846 initial records. The following variables were evaluated in this process: woman's name, age, date of birth, estimated date of delivery, date of infant birth and household information. Anti-Toxoplasma gondii antibodies were detected with the Q-Preven Toxo IgG and IgMin tests in dried blood samples collected on filter paper. The χ2 test and χ2 test for trend were used for data analysis, and the odds ratio (OR) was used to estimate the chance of association between exposure and outcome. RESULTS: the prevalence of infection was 67.7%, with 0.7% of the samples presenting anti-Toxoplasma gondii IgM and IgG reagents. Out of these, only three did not undergo confirmatory testing in venous blood. The median interval between the screening and the new collection of venous blood was of 12.5 days, and from screening to confirmatory test and avidity it was of 20 days. The variables associated with exposure were: age 20-30 years, OR=1.6 and >31 years, OR=1.8; brown skin color, OR=1.4, and black skin color, OR=1.6; and education of 8-11 years, OR=0.7, and >12 years of education, OR=0.6. CONCLUSION: a high prevalence of infection was estimated among the studied pregnant women. The associated factors that were found found should be considered during prenatal care, along with educational activities for the prevention of infection and assessment of serological status of seronegative pregnant women.
Key-words Cross-sectional studiesInfectious disease transmission, verticalPregnancyPrenatal careToxoplasmosisSee morePlumX Metrics- Citations
- Citation Indexes: 20
- Usage
- Full Text Views: 29437
- Abstract Views: 1788
- Captures
- Readers: 136
-
Artigos Originais
Impact of a dietary counseling program on the gain weight speed of pregnant women attended in a primary care service
Revista Brasileira de Ginecologia e Obstetrícia. 2011;33(1):13-19
05-17-2011
Summary
Artigos OriginaisImpact of a dietary counseling program on the gain weight speed of pregnant women attended in a primary care service
Revista Brasileira de Ginecologia e Obstetrícia. 2011;33(1):13-19
05-17-2011DOI 10.1590/S0100-72032011000100002
Views22See morePURPOSE: to evaluate the impact of dietary counseling on controlling weight gain in pregnant women, who were served in a public health service facility. METHODS: the study was conducted at a known health unit located in the metropolitan region of the city of Porto Alegre, in Rio Grande do Sul, Brazil. Three hundred and fifteen pregnant women between the 10th and 29th week of gestation were randomized to Control and Intervention Groups. The Intervention Group received dietary counseling according to nutritional status, and pregnant women in the Control Group were instructed to follow the routine of the health service facility. Weight and height were measured, and the body mass index (BMI) was calculated. The pre-gestational nutritional status was determined according to the following BMI criteria: low weight (<18.5 kg/m²), eutrophy (18.5 to 24.9 kg/m²), overweight (25.0 to 29.9 kg/m²), and obesity (>30 kg/m²). The nutritional status during pregnancy was determined according to the BMI curve for gestational age adopted by the Health Ministry of Brazil. Data were analyzed by the relative risk and respective 95% confidence interval, and by the Student's t-test and χ2 test. Statistical significance was set at p<0.05. RESULTS: the assessment of nutritional status before pregnancy showed that 28.0% of the women were overweight and 4.1% were underweight. In the first and last interview during pregnancy, the rates of prevalence of excessive weight were 36.2 and 46.0%, respectively. The intervention proved to be effective in reducing the rate of weekly weight gain of pregnant women with excess weight (342.2 versus 420.2; p=0.015) and the prevalence of clinical complications (9.2 versus 24.85; p<0.001). CONCLUSIONS: dietary counseling was effective in decreasing the weight gain of pregnant women who were overweight and reducing clinical complications, such as gestational diabetes, preeclampsia, infant low weight, and prematurity in the Intervention Group.
PlumX Metrics- Citations
- Policy Citations: 1
- Citation Indexes: 11
- Usage
- Full Text Views: 63303
- Abstract Views: 1960