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Original Article01-19-2004
Can polycystic ovary syndrome interfere with the outcome of in vitro fertilization?
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(9):727-733
Abstract
Original ArticleCan polycystic ovary syndrome interfere with the outcome of in vitro fertilization?
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(9):727-733
DOI 10.1590/S0100-72032004000900009
Views154PURPOSE: to evaluate the results of ovulation hyperinduction followed by in vitro fertilization (IVF) in women with polycystic ovary syndrome (POS), as compared to normal cycle women. METHODS: a controlled retrospective study conducted on 36 women with POS (POS group) and on 44 women with infertility due to mild male factor (control group), submitted to IVF from 1997 to 2003. Subject ages ranged from 18 to 36 years. Ovulation hyperinduction was obtained with recombinant follicle-stimulating hormone and a gonadotrophin-releasing hormone agonist. The analyzed variables were the follicles with a mean diameter of 14 to 17 mm and the follicles with diameters of 18 mm or above on the day of human chorionic gonadotrophin administration, percentage of follicles >18 mm, the number of retrieved oocytes, fertilization rate, cleavage rate, incidence of ovarian hyperstimulation syndrome (OHS), clinical pregnancy rate, and abortion rate. The variables were analyzed by the unpaired t test, Fisher exact test and Mann-Whitney test, with level of significance set at p<0.05. RESULTS: the POS group presented a larger number of retrieved follicles, most of them measuring 14 to 17 mm in diameter, compared to the control group (64.8 vs 53.9%), a lower fertilization rate (59.43 vs 79.57%) and a higher incidence of OHS (38.9 vs 9.1%). The number of retrieved oocytes, cleavage rates, pregnancy rates per embryo transfer, abortion rates and live born rates did not differ between groups. CONCLUSION: the success of IVF is impaired in women with POS due to their larger number of retrieved follicles of reduced diameter, reduced fertilization rate and high OHS rates.
Key-words Fertilization rateIn vitro fertilizationOvarian hyperstimulation syndromeOvulation InductionPolycystic ovary syndromeSee moreViews154
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
Original ArticleCan polycystic ovary syndrome interfere with the outcome of in vitro fertilization?
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(9):727-733
DOI 10.1590/S0100-72032004000900009
Views154PURPOSE: to evaluate the results of ovulation hyperinduction followed by in vitro fertilization (IVF) in women with polycystic ovary syndrome (POS), as compared to normal cycle women. METHODS: a controlled retrospective study conducted on 36 women with POS (POS group) and on 44 women with infertility due to mild male factor (control group), submitted to IVF from 1997 to 2003. Subject ages ranged from 18 to 36 years. Ovulation hyperinduction was obtained with recombinant follicle-stimulating hormone and a gonadotrophin-releasing hormone agonist. The analyzed variables were the follicles with a mean diameter of 14 to 17 mm and the follicles with diameters of 18 mm or above on the day of human chorionic gonadotrophin administration, percentage of follicles >18 mm, the number of retrieved oocytes, fertilization rate, cleavage rate, incidence of ovarian hyperstimulation syndrome (OHS), clinical pregnancy rate, and abortion rate. The variables were analyzed by the unpaired t test, Fisher exact test and Mann-Whitney test, with level of significance set at p<0.05. RESULTS: the POS group presented a larger number of retrieved follicles, most of them measuring 14 to 17 mm in diameter, compared to the control group (64.8 vs 53.9%), a lower fertilization rate (59.43 vs 79.57%) and a higher incidence of OHS (38.9 vs 9.1%). The number of retrieved oocytes, cleavage rates, pregnancy rates per embryo transfer, abortion rates and live born rates did not differ between groups. CONCLUSION: the success of IVF is impaired in women with POS due to their larger number of retrieved follicles of reduced diameter, reduced fertilization rate and high OHS rates.
Key-words Fertilization rateIn vitro fertilizationOvarian hyperstimulation syndromeOvulation InductionPolycystic ovary syndromeSee moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Original Article06-26-2001
Polycystic Ovary Syndrome: Doppler Flow Measurement Evaluation
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(5):307-312
Abstract
Original ArticlePolycystic Ovary Syndrome: Doppler Flow Measurement Evaluation
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(5):307-312
DOI 10.1590/S0100-72032001000500006
Views127See morePurpose: to evaluate the effectiveness of color Doppler as a diagnosis method for polycystic ovary syndrome (PCOS) through blood flow variations in the ovarian stroma, in the uterine arteries and in the subendometrial tissue. Methods: thirty patients divided into two groups were selected: fifteen patients with amenorrhea or oligomenorrhea, hirsutism (Ferriman and Gallwey score >8), body mass index >25 kg/m² and echographic examination identifying increased hyperechogenic stromal and ovarian polycystosis (study group), and an identical number of patients presenting normal menstrual cycles, with no signs of hirsutism and with normal ultrasonography (control group). Transvaginal Doppler flowmetry measured systolic peak velocity or maximal velocity (Vmax) pulsatility index (PI) and resistance of ovarian stromal vessels, uterine arteries and subendometrial layer. Results: Doppler velocimetry showed significantly higher Vmax layer (p<=0,0004) in the ovarian stromal of patients with PCOS (12.2 cm/s) when compared to the control group (8.05 cm/s); the uterine artery PI was also higher in the PCOS group (3.3 cm/s) versus the control group (2.7 cm/s); other Doppler velocimetry parameters did not show significant differences. As we established a cutoff = 9 cm/s for the sample for Vmax, we obtained the percentages of 95.2 for sensitivity, 80.0 for specificity, 83.3 for positive predictive value and 94.1 for negative predictive value. Conclusion: Doppler velocimetry might constitute an additional tool to be incorporated in clinical and ultrasonographic investigation concerning the PCOS diagnosis.
Views127This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
Original ArticlePolycystic Ovary Syndrome: Doppler Flow Measurement Evaluation
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(5):307-312
DOI 10.1590/S0100-72032001000500006
Views127See morePurpose: to evaluate the effectiveness of color Doppler as a diagnosis method for polycystic ovary syndrome (PCOS) through blood flow variations in the ovarian stroma, in the uterine arteries and in the subendometrial tissue. Methods: thirty patients divided into two groups were selected: fifteen patients with amenorrhea or oligomenorrhea, hirsutism (Ferriman and Gallwey score >8), body mass index >25 kg/m² and echographic examination identifying increased hyperechogenic stromal and ovarian polycystosis (study group), and an identical number of patients presenting normal menstrual cycles, with no signs of hirsutism and with normal ultrasonography (control group). Transvaginal Doppler flowmetry measured systolic peak velocity or maximal velocity (Vmax) pulsatility index (PI) and resistance of ovarian stromal vessels, uterine arteries and subendometrial layer. Results: Doppler velocimetry showed significantly higher Vmax layer (p<=0,0004) in the ovarian stromal of patients with PCOS (12.2 cm/s) when compared to the control group (8.05 cm/s); the uterine artery PI was also higher in the PCOS group (3.3 cm/s) versus the control group (2.7 cm/s); other Doppler velocimetry parameters did not show significant differences. As we established a cutoff = 9 cm/s for the sample for Vmax, we obtained the percentages of 95.2 for sensitivity, 80.0 for specificity, 83.3 for positive predictive value and 94.1 for negative predictive value. Conclusion: Doppler velocimetry might constitute an additional tool to be incorporated in clinical and ultrasonographic investigation concerning the PCOS diagnosis.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Original Article06-24-2001
Leptin Levels in Women with Polycystic Ovary Syndrome
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(8):481-488
Abstract
Original ArticleLeptin Levels in Women with Polycystic Ovary Syndrome
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(8):481-488
DOI 10.1590/S0100-72032001000800002
Views74See morePurpose: to investigate leptin levels in patients with polycystic ovary syndrome (PCOS), and relationships with testosterone, estradiol, follicle-stimulating hormone (FSH) and insulin levels. Methods: transversal study on 40 patients with PCOS divided into two groups: Group I (n = 20)- obese women (body mass index - BMI > or = 28 kg/m²), and Group II (n = 20) - non obese women (BMI <28 kg/m²). Results: BMI was different between the two groups (p=0.04). We observed that leptin concentrations were significantly correlated with BMI (p<0.001). After adjusting for BMI, no correlation between leptin, insulin (p=0.194), FSH (p=0.793), and total (p=0.441) and free (p=0.422) testosterone was found. However, we only observed positive correlations between leptin and estradiol (p=0.043). Conclusions: there is a strong correlation between leptin levels, BMI and estradiol levels in women with PCOS.
Views74This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
Original ArticleLeptin Levels in Women with Polycystic Ovary Syndrome
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(8):481-488
DOI 10.1590/S0100-72032001000800002
Views74See morePurpose: to investigate leptin levels in patients with polycystic ovary syndrome (PCOS), and relationships with testosterone, estradiol, follicle-stimulating hormone (FSH) and insulin levels. Methods: transversal study on 40 patients with PCOS divided into two groups: Group I (n = 20)- obese women (body mass index - BMI > or = 28 kg/m²), and Group II (n = 20) - non obese women (BMI <28 kg/m²). Results: BMI was different between the two groups (p=0.04). We observed that leptin concentrations were significantly correlated with BMI (p<0.001). After adjusting for BMI, no correlation between leptin, insulin (p=0.194), FSH (p=0.793), and total (p=0.441) and free (p=0.422) testosterone was found. However, we only observed positive correlations between leptin and estradiol (p=0.043). Conclusions: there is a strong correlation between leptin levels, BMI and estradiol levels in women with PCOS.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Polycystic ovary syndrome Archives - Revista Brasileira de Ginecologia e Obstetrícia
