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Revista Brasileira de Ginecologia e Obstetrícia. 2010;32(5):229-233
DOI 10.1590/S0100-72032010000500005
PURPOSE: to assess a possible association between polymorphism of the progesterone receptor gene (PROGINS) and recurrent spontaneous abortion (RSA). METHODS: in this case-control study, 85 women with at least three previous spontaneous abortions without an identifiable cause (RSA Group) and 157 women with at least two previous term pregnancies without pathologies and no previous miscarriage (Control Group) were selected. An amount of 10 mL of peripheral blood was collected by venipuncture and genomic DNA was extracted by the DTAB/CTAB method, followed by the polymerase chain reaction (PCR) under specific conditions for this polymorphism and by amplification by 2% agarose gel electrophoresis. The bands were visualized with an ultraviolet light transilluminator and the gels were photographed. Differences in the PROGINS genotype and allele frequencies between groups were analyzed by the χ2 test, with the level of significance set at p<0.05. The Odds Ratio (OR) was also used, with 95% confidence intervals 95%CI. RESULTS: PROGINS genotypic frequencies were 72.3% T1T1 and 27.7% T1T2 for the RSA group and 764% T1T1, 22.3% T1T2 and 1.3% T2T2 for the control group. There were no differecnes between groups when the genotype and allele frequencies were analyzed: respectively p=0.48 (OR: 0.8) and p=0.65 (OR: 0.9). CONCLUSIONS: our results suggest that PROGINS polymorphism is not associated with RSA.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2010;32(5):229-233
DOI 10.1590/S0100-72032010000500005
PURPOSE: to assess a possible association between polymorphism of the progesterone receptor gene (PROGINS) and recurrent spontaneous abortion (RSA). METHODS: in this case-control study, 85 women with at least three previous spontaneous abortions without an identifiable cause (RSA Group) and 157 women with at least two previous term pregnancies without pathologies and no previous miscarriage (Control Group) were selected. An amount of 10 mL of peripheral blood was collected by venipuncture and genomic DNA was extracted by the DTAB/CTAB method, followed by the polymerase chain reaction (PCR) under specific conditions for this polymorphism and by amplification by 2% agarose gel electrophoresis. The bands were visualized with an ultraviolet light transilluminator and the gels were photographed. Differences in the PROGINS genotype and allele frequencies between groups were analyzed by the χ2 test, with the level of significance set at p<0.05. The Odds Ratio (OR) was also used, with 95% confidence intervals 95%CI. RESULTS: PROGINS genotypic frequencies were 72.3% T1T1 and 27.7% T1T2 for the RSA group and 764% T1T1, 22.3% T1T2 and 1.3% T2T2 for the control group. There were no differecnes between groups when the genotype and allele frequencies were analyzed: respectively p=0.48 (OR: 0.8) and p=0.65 (OR: 0.9). CONCLUSIONS: our results suggest that PROGINS polymorphism is not associated with RSA.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(9):697-701
DOI 10.1590/S0100-72032004000900004
PURPOSE: to evaluate perinatal results in pregnant women over 35 years old and to check differences between two groups: 35 to 39-year-old women and women older than 40. METHODS: a retrospective survey was made during the period between January/2000 and July/2003, through the analysis of obstetric charts of 3,093 pregnant women who delivered in the "Hospital do Servidor Público Estadual - Francisco Morato de Oliveira", excluding 933 patients. The patients were divided into 3 groups: 18 to 29 years old (control group), 35 to 39 years old, and over 40 years old. Data collection was done with standardized forms, and the data were transferred to an electronic spreadsheet (Excel - Microsoft Office 2000). Statistical analysis was performed using the chi2 test and the Fisher test. The alpha risk was less or equal to 5% and the confidence interval 95%. RESULTS: cesarean section was the most used method not only in the 35 to 39-year-old group (438/792; 55.3%) but also in the group of women over 40 (153/236; 64.8%). The rates of prematurity (39/236; 16.5%), low weight (37/236; 15.7%), and restriction of fetal growth (38/236; 16.1%) were significantly higher in the group of women over 40, when compared to the other groups. Concerning fetal death, a five times higher incidence was observed in the group over 40 years old, as compared to the other groups, a statistically significant difference. CONCLUSION: the only difference between the 35 to 39-year-old group and the control group was the cesarean section rate. This allows us to suggest a differentiated prenatal attendance for pregnant women over 40.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(9):697-701
DOI 10.1590/S0100-72032004000900004
PURPOSE: to evaluate perinatal results in pregnant women over 35 years old and to check differences between two groups: 35 to 39-year-old women and women older than 40. METHODS: a retrospective survey was made during the period between January/2000 and July/2003, through the analysis of obstetric charts of 3,093 pregnant women who delivered in the "Hospital do Servidor Público Estadual - Francisco Morato de Oliveira", excluding 933 patients. The patients were divided into 3 groups: 18 to 29 years old (control group), 35 to 39 years old, and over 40 years old. Data collection was done with standardized forms, and the data were transferred to an electronic spreadsheet (Excel - Microsoft Office 2000). Statistical analysis was performed using the chi2 test and the Fisher test. The alpha risk was less or equal to 5% and the confidence interval 95%. RESULTS: cesarean section was the most used method not only in the 35 to 39-year-old group (438/792; 55.3%) but also in the group of women over 40 (153/236; 64.8%). The rates of prematurity (39/236; 16.5%), low weight (37/236; 15.7%), and restriction of fetal growth (38/236; 16.1%) were significantly higher in the group of women over 40, when compared to the other groups. Concerning fetal death, a five times higher incidence was observed in the group over 40 years old, as compared to the other groups, a statistically significant difference. CONCLUSION: the only difference between the 35 to 39-year-old group and the control group was the cesarean section rate. This allows us to suggest a differentiated prenatal attendance for pregnant women over 40.