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  • Review Article

    Commercial Surrogacy: An Overview

    Revista Brasileira de Ginecologia e Obstetrícia. 2022;44(12):1141-1158

    Summary

    Review Article

    Commercial Surrogacy: An Overview

    Revista Brasileira de Ginecologia e Obstetrícia. 2022;44(12):1141-1158

    DOI 10.1055/s-0042-1759774

    Views203

    Abstract

    Objective

    Surrogacy is the process in which a woman carries and delivers a baby to other person or couple, known as intended parents. When carriers are paid for surrogacy, this is known as commercial surrogacy. The objective of the present work is to review the legal, ethical, social, and cultural aspects of commercial surrogacy, as well as the current panorama worldwide.

    Methods

    This is a review of the literature published in the 21st century on commercial surrogacy.

    Results

    A total of 248 articles were included as the core of the present review. The demand for surrogate treatments by women without uterus or with important uterine disorders, single men and same-sex male couples is constantly increasing worldwide. This reproductive treatment has important ethical dilemmas. In addition, legislation defers widely worldwide and is in constant change. Therefore, patients look more and more for treatments abroad, which can lead to important legal problems between countries with different laws. Commercial surrogacy is practiced in several countries, in most of which there is no specific legislation. Some countries have taken restrictive measures against this technique because of reports of exploitation of carriers.

    Conclusion

    Commercial surrogacy is a common practice, despite important ethical and legal dilemmas. As a consequence of diverse national legislations, patients frequently resort to international commercial surrogacy programs. As of today, there is no standard international legal context, and this practice remains largely unregulated.

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    Commercial Surrogacy: An Overview
  • Original Article

    The Pathway of Female Couples in a Fertility Clinic

    Revista Brasileira de Ginecologia e Obstetrícia. 2022;44(7):660-666

    Summary

    Original Article

    The Pathway of Female Couples in a Fertility Clinic

    Revista Brasileira de Ginecologia e Obstetrícia. 2022;44(7):660-666

    DOI 10.1055/s-0042-1744444

    Views21

    Abstract

    Objective

    The present study aims to describe the main characteristics of female couples resorting to a fertility clinic, to understand whether these patients have clear previous plans concerning procreation and how they end up completing their family planning, and to briefly describe the main outcomes of the recepción de ovocitos de pareja (ROPA, in the Spanish acronym: in English, reception of partner's oocytes) method.

    Methods

    This is a descriptive retrospective study of the pathway and outcomes of female couples in a fertility clinic during a 2-year period.

    Results

    A total of 129 couples were treated. Only one third of the couples had no condition potentially affecting fertility or advanced age. Most couples were decided to undergo artificial insemination or in vitro fertilization and the majority kept their plans, as opposed to 38% of the couples who decided to the ROPA method (lesbian shared in vitro fertilization) who changed plans. Live birth rates per treatment (including frozen embryo transfers) for artificial insemination, 58% for in vitro fertilization, 80% for treatments with donated oocytes or embryos, and 79% for ROPA. Four in five couples achieved live births.

    Conclusion

    The present study highlights the importance of a thorough medical workup in same-sex couples resorting to assisted reproduction. Despite the higher-than-expected rates of fertility disorders, the outcomes were good. Most couples end up in a single parented method. Furthermore, the results of the ROPA method are reassuring.

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    The Pathway of Female Couples in a Fertility Clinic
  • Case Report

    Complete Androgen Insensitivity Syndrome: A Rare Case of Prenatal Diagnosis

    Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(9):710-712

    Summary

    Case Report

    Complete Androgen Insensitivity Syndrome: A Rare Case of Prenatal Diagnosis

    Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(9):710-712

    DOI 10.1055/s-0041-1735986

    Views5

    Abstract

    With the widespread uptake of noninvasive prenatal testing (NIPT), a larger cohort of women has access to fetal chromosomal sex, which increases the potential to identify prenatal sex discordance. The prenatal diagnosis of androgen insensitivity syndrome (AIS) is an incidental and rare finding. We wish to present the diagnosis of a prenatal index case after NIPT of cell-free fetal DNA and mismatch between fetal sex and ultrasound phenotype. In this particular case, the molecular analysis of the androgen receptor (AR) gene showed the presence of a pathogenic mutation, not previously reported, consistent with complete androgen insensitivity syndrome. Carrier testing for the mother revealed the presence of the same variant, confirming maternal hemizygous inheritance. Identification of the molecular basis of these genetic conditions enables the preimplantation or prenatal diagnosis in future pregnancies.

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    Complete Androgen Insensitivity Syndrome: A Rare Case of Prenatal Diagnosis
  • Case Report

    Febrile Neutropenia following Parvovirus B19 Infection and Cross Anti-Kell Reaction to E. Coli in Pregnancy

    Revista Brasileira de Ginecologia e Obstetrícia. 2018;40(6):372-376

    Summary

    Case Report

    Febrile Neutropenia following Parvovirus B19 Infection and Cross Anti-Kell Reaction to E. Coli in Pregnancy

    Revista Brasileira de Ginecologia e Obstetrícia. 2018;40(6):372-376

    DOI 10.1055/s-0038-1657787

    Views5

    Abstract

    Parvovirus B19 has tropism for red line blood cells, causing immune hydrops during pregnancy. A positive anti-Kell Coombs reaction usually happens during pregnancy when there is production of antibodies that target Kell antigens, but cross reactions to other antigens may occur. A 24-year-old Gypsy primigravida, 0 Rhesus positive, presented with persistent isolated hyperthermia for 2 weeks and a positive indirect Coombs test result with anti-Kell antibodies at routine tests. She had a 19-week live fetus. The blood tests revealed bicytopenia with iron deficiency anemia, leucopoenia with neutropenia, and elevated C-reactive protein. She was medicated with imipenem, and had a slow clinical recovery. Blood, urine and sputum samples were taken to perform cultures and to exclude other systemic infections. Escherichia coli was isolated in the urine, which most probably caused a transient cross anti-Kell reaction. Haemophilus influenza in the sputum and seroconversion to parvovirus B19 was confirmed, causing unusual deficits in the white cells, culminating in febrile neutropenia. Despite the patient’s lack of compliance to the medical care, both maternal and fetal/neonatal outcomes were good. This a rare case report of 2 rare phenomena, a cross anti-Kell reaction to E. coli and parvovirus B19 infection with tropism for white cells causing febrile neutropenia, both events occurring simultaneously during pregnancy.

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