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Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(3):153-157
DOI 10.1590/S0100-72032001000300004
Purpose: to evaluate the clinical and therapeutic aspects of septic abortion, and to identify a group at high risk for complications. Methods: a retrospective study of 224 cases of patients with septic abortion was conducted. Age, parity, clinical and ultrasonographic diagnosis, and therapeutic data were collected from medical charts. The information about induced abortion was provided by the patients and/or their relatives and accompanying persons. Septic abortion was diagnosed based on clinical data, leukocyte count, adnexal and uterine pain, and purulent cervical discharge. Results: the average age of patients was 21.4 ± 6.2 years. Forty-five (20.1%) patients were 19 years old or less. Sixty-six (29.5%) were primiparous and 55 (24.5%) were secundiparous. In 143 (63.8%) women it was the first abortion. The most common clinical signs were hemorrhage (83.9%) and fever (61.1%). Of the total of patients, 37.9% declared that they had an induced abortion, 33.9% declared spontaneous abortion and 28.2% did not inform. Hysterectomies were performed in five cases. No hysterectomy was performed in the group with spontaneous abortion (2.2%), which had a reduced number of complications: (3.9% versus 11.8% in the group with induced abortion), p<0.05. Conclusion: septic abortion is a more serious problem in patients who declared induced abortion.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(3):153-157
DOI 10.1590/S0100-72032001000300004
Purpose: to evaluate the clinical and therapeutic aspects of septic abortion, and to identify a group at high risk for complications. Methods: a retrospective study of 224 cases of patients with septic abortion was conducted. Age, parity, clinical and ultrasonographic diagnosis, and therapeutic data were collected from medical charts. The information about induced abortion was provided by the patients and/or their relatives and accompanying persons. Septic abortion was diagnosed based on clinical data, leukocyte count, adnexal and uterine pain, and purulent cervical discharge. Results: the average age of patients was 21.4 ± 6.2 years. Forty-five (20.1%) patients were 19 years old or less. Sixty-six (29.5%) were primiparous and 55 (24.5%) were secundiparous. In 143 (63.8%) women it was the first abortion. The most common clinical signs were hemorrhage (83.9%) and fever (61.1%). Of the total of patients, 37.9% declared that they had an induced abortion, 33.9% declared spontaneous abortion and 28.2% did not inform. Hysterectomies were performed in five cases. No hysterectomy was performed in the group with spontaneous abortion (2.2%), which had a reduced number of complications: (3.9% versus 11.8% in the group with induced abortion), p<0.05. Conclusion: septic abortion is a more serious problem in patients who declared induced abortion.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(4):217-221
DOI 10.1590/S0100-72032001000400004
Purpose: to evaluate the influence of pregnancy, habit of smoking, and the contraceptive method in HPV infection and the frequency of cytologic findings in adolescent women with HPV infection. Methods: a total of 54,985 cytologic examinations of patients seen between July, 1993 and December, 1998 were retrospectively analyzed. Of this total, 6,498 (11.8%) examinations were from patients under 20 years old. Of the total of 6,498 cytologic examinations, 326 (5.9%) presented signs of HPV infection, with or without grade I cervical intraepithelial neoplasia (CIN). Patients with diagnosis of grade II and III CIN were excluded. The control group consisted of 333 patients paired by age, without cytological signs of HPV infection. Results: in adolescents, HPV infection was more frequent in oral contraceptive users (16.9% versus 13.8%, p<0.01) and in those who presented with clue cells in cytologic smears (22.4% versus 14.7%, p<0.001). The frequency of HPV infection in couples who used condom was 0% versus 2.1% in the control group (p<0.01). The difference in the number of pregnant women (41.1% versus 44.1%) and smokers (21.8% versus 16.5%) was not statistically significant. Conclusions: HPV infection is more frequent in adolescent women in use of oral contraceptive and with clue cells as cytologic finding. HPV infection did not occur in couples who used condom. Gestation and the habit of smoking did not influence the incidence of HPV infection.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(4):217-221
DOI 10.1590/S0100-72032001000400004
Purpose: to evaluate the influence of pregnancy, habit of smoking, and the contraceptive method in HPV infection and the frequency of cytologic findings in adolescent women with HPV infection. Methods: a total of 54,985 cytologic examinations of patients seen between July, 1993 and December, 1998 were retrospectively analyzed. Of this total, 6,498 (11.8%) examinations were from patients under 20 years old. Of the total of 6,498 cytologic examinations, 326 (5.9%) presented signs of HPV infection, with or without grade I cervical intraepithelial neoplasia (CIN). Patients with diagnosis of grade II and III CIN were excluded. The control group consisted of 333 patients paired by age, without cytological signs of HPV infection. Results: in adolescents, HPV infection was more frequent in oral contraceptive users (16.9% versus 13.8%, p<0.01) and in those who presented with clue cells in cytologic smears (22.4% versus 14.7%, p<0.001). The frequency of HPV infection in couples who used condom was 0% versus 2.1% in the control group (p<0.01). The difference in the number of pregnant women (41.1% versus 44.1%) and smokers (21.8% versus 16.5%) was not statistically significant. Conclusions: HPV infection is more frequent in adolescent women in use of oral contraceptive and with clue cells as cytologic finding. HPV infection did not occur in couples who used condom. Gestation and the habit of smoking did not influence the incidence of HPV infection.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(4):225-228
DOI 10.1590/S0100-72032000000400006
Purpose: to analyze the frequency of glove perforation during gynecologic surgeries. Methods: a prospective study of 454 gloves used in 65 surgeries by the water pressure method. Results: of a total of 454 gloves, 54 (11.9%) had perforations. Comparison with the control group showed p<0.05 (chi² test), 1 (1.7%) perforation in 60 gloves tested. Of the total of gloves used in 65 surgeries, 29 (44.6%) had perforations, 44 (81%) had one perforation and 10 (19%) had more than one perforation. The two most common sites of perforations were the index finger, 20 (29.5%) and the thumb, 14 (25.9%). Perforation was predominant in the left hand (72.1%). The surgeons were the members of the team with the greatest number of glove perforations. Total hysterectomy was the most frequent surgery in which glove perforations occurred (50% of the cases). Conclusion: the glove perforations occurred with relatively high frequency during gynecologic surgeries. The index finger of the left hand proved to be the most affected region. Among the members of the team, the highest percentage of glove perforations occurred in those of the surgeons. Total hysterectomy had the highest perforation rate.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(4):225-228
DOI 10.1590/S0100-72032000000400006
Purpose: to analyze the frequency of glove perforation during gynecologic surgeries. Methods: a prospective study of 454 gloves used in 65 surgeries by the water pressure method. Results: of a total of 454 gloves, 54 (11.9%) had perforations. Comparison with the control group showed p<0.05 (chi² test), 1 (1.7%) perforation in 60 gloves tested. Of the total of gloves used in 65 surgeries, 29 (44.6%) had perforations, 44 (81%) had one perforation and 10 (19%) had more than one perforation. The two most common sites of perforations were the index finger, 20 (29.5%) and the thumb, 14 (25.9%). Perforation was predominant in the left hand (72.1%). The surgeons were the members of the team with the greatest number of glove perforations. Total hysterectomy was the most frequent surgery in which glove perforations occurred (50% of the cases). Conclusion: the glove perforations occurred with relatively high frequency during gynecologic surgeries. The index finger of the left hand proved to be the most affected region. Among the members of the team, the highest percentage of glove perforations occurred in those of the surgeons. Total hysterectomy had the highest perforation rate.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(1):33-35
DOI 10.1590/S0100-72031998000100006
We have analyzed 93 pregnant women with Papanicolaou smears suggesting human papillomavirus (HPV) infection (Schneider et al's criteria) with the purpose of studying the effect of maternal age, stage of pregnancy and number of pregnancies on the incidence of this infection. The control group consisted of 93pregnant women with Papanicolaou smears not suggestive of HPV infection. The results demonstrated that HPV infection is associated with pregnant women under 20 years of age, but no differences were found regarding stage and number of pregnancies.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(1):33-35
DOI 10.1590/S0100-72031998000100006
We have analyzed 93 pregnant women with Papanicolaou smears suggesting human papillomavirus (HPV) infection (Schneider et al's criteria) with the purpose of studying the effect of maternal age, stage of pregnancy and number of pregnancies on the incidence of this infection. The control group consisted of 93pregnant women with Papanicolaou smears not suggestive of HPV infection. The results demonstrated that HPV infection is associated with pregnant women under 20 years of age, but no differences were found regarding stage and number of pregnancies.
, , , Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(5):368-373
, , , To evaluate the antitumoral role of γδ TDC cells and αβ TDC cells in an experimental model of breast cancer.
Thirty female Balb/c mice were divided into 2 groups: control group (n=15) and induced-4T1 group (n=15), in which the mice received 2 x 105 4T1 mammary tumor cell line. Following the 28-day experimental period, immune cells were collected from the spleen and analyzed by flow cytometry for comparison of αβ TDC (TCRαβ+ CD11c+MHCII+) and γδ TDC (TCRγδ+CD11c+MHCII+) cells regarding surface markers (CD4+ and C8+) and cytokines (IFN-γ, TNF-α, IL-12 and IL-17).
A total of 26.53% of γδ TDC- control group (p<0.0001) - the proportion of αβ TDC was lower in splenic cells than γδ TDC; however, these 2 cell types were reduced in tumor conditions (p<0.0001), and the proportion of IFN-γ, TNF-α, IL-12 and IL-17 cytokines produced by γδ TDC was higher than those produced by αβ TDC, but it decreased under conditions of tumor-related immune system response (p<0.0001).
Healthy mice engrafted with malignant cells 4T1 breast tumor presented TDC with γδ TCR repertoire. These cells express cytotoxic molecules of lymphocytes T, producing anti-tumor proinflammatory cytokines.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(5):368-373
, , , To evaluate the antitumoral role of γδ TDC cells and αβ TDC cells in an experimental model of breast cancer.
Thirty female Balb/c mice were divided into 2 groups: control group (n=15) and induced-4T1 group (n=15), in which the mice received 2 x 105 4T1 mammary tumor cell line. Following the 28-day experimental period, immune cells were collected from the spleen and analyzed by flow cytometry for comparison of αβ TDC (TCRαβ+ CD11c+MHCII+) and γδ TDC (TCRγδ+CD11c+MHCII+) cells regarding surface markers (CD4+ and C8+) and cytokines (IFN-γ, TNF-α, IL-12 and IL-17).
A total of 26.53% of γδ TDC- control group (p<0.0001) - the proportion of αβ TDC was lower in splenic cells than γδ TDC; however, these 2 cell types were reduced in tumor conditions (p<0.0001), and the proportion of IFN-γ, TNF-α, IL-12 and IL-17 cytokines produced by γδ TDC was higher than those produced by αβ TDC, but it decreased under conditions of tumor-related immune system response (p<0.0001).
Healthy mice engrafted with malignant cells 4T1 breast tumor presented TDC with γδ TCR repertoire. These cells express cytotoxic molecules of lymphocytes T, producing anti-tumor proinflammatory cytokines.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(6):377-382
DOI 10.1590/S0100-72032001000600006
Purpose: to evaluate a group of pregnant women with human papillomavirus (HPV) infection, analyzing age, gestational age, number of gestations and cytological findings. Methods: in the period from July 1993 to December 1998, 245 pregnant patients seen in our service presented cytological alterations compatible with HPV infection, associated or not with cervical intraepithelial neoplasia (CIN) grade 1. Clinical data were related to age, gestational period (first or second half), number of gestations and cytological finding of Trichomonas vaginalis, Candida sp and clue cells. The control group consisted of 386 pregnant patients seen during the same period and without cytological signs of HPV infection. In the statistical analysis, chi² (chi-square) test was used with Yates correction and a significance level lower than 0.05. Results: HPV infection was more frequent among pregnant women younger than 20 years old (45.3% versus 28.2%, p<0.001). The most frequent cytological finding, among the pregnant women with HPV infection, was the presence of clue cells, compared to the controls (21.6% versus 12.4%, p<0.02). Clue cells were more frequent in pregnant women with HPV infection in the second half of gestation and older than 20 years (27% versus 12.2%, p<0,01). The difference regarding number of gestations was not significant. Conclusion: HPV infection was more frequent among pregnant women younger than 20 years old. Clue cells and HPV were the most frequent cytological findings in pregnant women older than 20 years and in the second half of gestation.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(6):377-382
DOI 10.1590/S0100-72032001000600006
Purpose: to evaluate a group of pregnant women with human papillomavirus (HPV) infection, analyzing age, gestational age, number of gestations and cytological findings. Methods: in the period from July 1993 to December 1998, 245 pregnant patients seen in our service presented cytological alterations compatible with HPV infection, associated or not with cervical intraepithelial neoplasia (CIN) grade 1. Clinical data were related to age, gestational period (first or second half), number of gestations and cytological finding of Trichomonas vaginalis, Candida sp and clue cells. The control group consisted of 386 pregnant patients seen during the same period and without cytological signs of HPV infection. In the statistical analysis, chi² (chi-square) test was used with Yates correction and a significance level lower than 0.05. Results: HPV infection was more frequent among pregnant women younger than 20 years old (45.3% versus 28.2%, p<0.001). The most frequent cytological finding, among the pregnant women with HPV infection, was the presence of clue cells, compared to the controls (21.6% versus 12.4%, p<0.02). Clue cells were more frequent in pregnant women with HPV infection in the second half of gestation and older than 20 years (27% versus 12.2%, p<0,01). The difference regarding number of gestations was not significant. Conclusion: HPV infection was more frequent among pregnant women younger than 20 years old. Clue cells and HPV were the most frequent cytological findings in pregnant women older than 20 years and in the second half of gestation.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2009;31(8):377-379
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2009;31(8):377-379
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2016;38(1):41-46
To compare the diagnostic accuracy of the classic Meisels cytologic criteria and the Schneider secondary criteria relative to the hybrid capture method for diagnosing HPV infection.
This was a retrospective study performed at a public university hospital. A total of 41 patients with a cytologic diagnosis of HPV infection and 40 HPV-negative patients were selected for review of the cervical-vaginal smears seeking to classical and secondary criteria. A single pathologist reviewed the slides in search of the criteria. The classical and secondary cytologic criteria were compared with the hybrid capture for diagnosing HPV infection. Bartleti test was applied for the age analysis, and Fisher's exact test was used to compare proportions. The tests were considered significant when the probability of rejecting the null hypothesis was less than 5% (p < 0.05).
The Meisels criteria were less sensitive (34.0%) than the secondary Schneider criteria (57.5%) when compared with the hybrid capture (p < 0.0001), although the specificity of the former criteria was non-significantly higher (91.2% and 67.7%, respectively). In cases of moderate or intense inflammation, the sensitivity and specificity of the Schneider criteria were decreased, 33.3% and 50.0% respectively (p = 0.0115).
Compared with hybrid capture for diagnosis of HPV infection, the sensitivity of the secondary Schneider criteria was higher than the classical Meisels criteria.Moderate or intense inflammation reduces the sensitivity and specificity of the secondary Schneider criteria for diagnosing HPV infection using the hybrid capture as the gold standard.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2016;38(1):41-46
To compare the diagnostic accuracy of the classic Meisels cytologic criteria and the Schneider secondary criteria relative to the hybrid capture method for diagnosing HPV infection.
This was a retrospective study performed at a public university hospital. A total of 41 patients with a cytologic diagnosis of HPV infection and 40 HPV-negative patients were selected for review of the cervical-vaginal smears seeking to classical and secondary criteria. A single pathologist reviewed the slides in search of the criteria. The classical and secondary cytologic criteria were compared with the hybrid capture for diagnosing HPV infection. Bartleti test was applied for the age analysis, and Fisher's exact test was used to compare proportions. The tests were considered significant when the probability of rejecting the null hypothesis was less than 5% (p < 0.05).
The Meisels criteria were less sensitive (34.0%) than the secondary Schneider criteria (57.5%) when compared with the hybrid capture (p < 0.0001), although the specificity of the former criteria was non-significantly higher (91.2% and 67.7%, respectively). In cases of moderate or intense inflammation, the sensitivity and specificity of the Schneider criteria were decreased, 33.3% and 50.0% respectively (p = 0.0115).
Compared with hybrid capture for diagnosis of HPV infection, the sensitivity of the secondary Schneider criteria was higher than the classical Meisels criteria.Moderate or intense inflammation reduces the sensitivity and specificity of the secondary Schneider criteria for diagnosing HPV infection using the hybrid capture as the gold standard.