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Artigos Originais
Characterization of yeasts isolated from the vagina and their association with vulvovaginal candidíasis in two cities of the South of Brazil
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(2):58-63
07-06-2005
Summary
Artigos OriginaisCharacterization of yeasts isolated from the vagina and their association with vulvovaginal candidíasis in two cities of the South of Brazil
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(2):58-63
07-06-2005DOI 10.1590/S0100-72032005000200003
Views56See morePURPOSE: to evaluate the distribution of yeast species isolated from the vagina in two cities of the South of Brazil and compare the in vitro susceptibility profile of these yeasts against some antifungals, which are used in clinical routine. METHODS: all women attended from January to June 2004 for vaginal routine examinations, independent of being symptomatic or not were included in the study. Only those who presented immunodeficiency like AIDS or any other genital infection were excluded. Samples of vaginal discharge from the women (Jaraguá do Sul - SC (n=130) and Maringá - PR (n=97)) were cultivated. The yeasts were identified and submitted to the susceptibility test against the antifungals fluconazole, nystatin and amphotericin B. RESULTS: the frequency of positive cultures for yeasts was the same in both cities; C. albicans was the most prevalent species (about 24%), but its frequency was different: in SC it corresponded to 77.4% of the yeasts both in symptomatic and asymptomatic women and in PR it was 50.0% with predominance in symptomatic women. We observed high rates of susceptibility to fluconazole and amphotericin B, but 51.1% of the yeasts presented dose-dependent susceptibility (DDS) to nystatin. C. albicans showed a higher tendency to be nystatin resistant (52.8% DDS) than non-albicans species (44.4%). CONCLUSIONS: our data showed geographic differences among the species of yeasts isolated from the vagina and suggest that this fact has clinical relevance considering the differences in susceptibility, especially regarding nystatin, which could be important for the management of vulvovaginal candidiasis.
Views56
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Artigos OriginaisCharacterization of yeasts isolated from the vagina and their association with vulvovaginal candidíasis in two cities of the South of Brazil
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(2):58-63
07-06-2005DOI 10.1590/S0100-72032005000200003
Views56See morePURPOSE: to evaluate the distribution of yeast species isolated from the vagina in two cities of the South of Brazil and compare the in vitro susceptibility profile of these yeasts against some antifungals, which are used in clinical routine. METHODS: all women attended from January to June 2004 for vaginal routine examinations, independent of being symptomatic or not were included in the study. Only those who presented immunodeficiency like AIDS or any other genital infection were excluded. Samples of vaginal discharge from the women (Jaraguá do Sul - SC (n=130) and Maringá - PR (n=97)) were cultivated. The yeasts were identified and submitted to the susceptibility test against the antifungals fluconazole, nystatin and amphotericin B. RESULTS: the frequency of positive cultures for yeasts was the same in both cities; C. albicans was the most prevalent species (about 24%), but its frequency was different: in SC it corresponded to 77.4% of the yeasts both in symptomatic and asymptomatic women and in PR it was 50.0% with predominance in symptomatic women. We observed high rates of susceptibility to fluconazole and amphotericin B, but 51.1% of the yeasts presented dose-dependent susceptibility (DDS) to nystatin. C. albicans showed a higher tendency to be nystatin resistant (52.8% DDS) than non-albicans species (44.4%). CONCLUSIONS: our data showed geographic differences among the species of yeasts isolated from the vagina and suggest that this fact has clinical relevance considering the differences in susceptibility, especially regarding nystatin, which could be important for the management of vulvovaginal candidiasis.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Artigos Originais
Frequency of infection with Mycoplasma hominis and Ureaplasma urealyticum in infertile women and clinical repercussions
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(2):64-68
07-06-2005
Summary
Artigos OriginaisFrequency of infection with Mycoplasma hominis and Ureaplasma urealyticum in infertile women and clinical repercussions
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(2):64-68
07-06-2005DOI 10.1590/S0100-72032005000200004
Views104PURPOSE: to determine the frequency of Mycoplasma hominis and Ureaplasma urealyticum infection, and relate it to the associated clinical variables of infertile women. METHODS: transversal study involving 322 infertile women, submitted to collection of endocervix swab for research of Mycoplasma hominis and Ureaplasma urealyticum infecction, from October 2002 to May 2004. All patients were submitted to a basic infertility investigation protocol. As control, a historical series of 51 non-pregnant women previously investigated as for the studied infectious agents, was used. RESULTS: the frequency of Mycoplasma hominis and Ureaplasma urealyticum infection was 4.9% in the infertile women and 13.8% in the control group. Among the infertile patients, a relationship between the presence of the two agents and changes in the histerosalpingography result (OR: 3.20; IC 95%: 1.05-9.73), presence of dyspareunia (OR: 10.72; IC 95%: 3.21-35.77) and vaginal discharge (OR: 8.5; IC 95%: 2.83-26.02), besides endocervical culture positive for Escherichia coli (OR: 6.09; IC 95%: 4.95-52.25) was observed. CONCLUSION: Mycoplasma hominis and Ureaplasma urealyticum infection rate is low in infertile patients and is associated with reproductive sequels.
Key-words HysterosalpingographyInfertility and Escherichia coliMycoplasma hominisUreaplasma urealyticumSee moreViews104This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Artigos OriginaisFrequency of infection with Mycoplasma hominis and Ureaplasma urealyticum in infertile women and clinical repercussions
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(2):64-68
07-06-2005DOI 10.1590/S0100-72032005000200004
Views104PURPOSE: to determine the frequency of Mycoplasma hominis and Ureaplasma urealyticum infection, and relate it to the associated clinical variables of infertile women. METHODS: transversal study involving 322 infertile women, submitted to collection of endocervix swab for research of Mycoplasma hominis and Ureaplasma urealyticum infecction, from October 2002 to May 2004. All patients were submitted to a basic infertility investigation protocol. As control, a historical series of 51 non-pregnant women previously investigated as for the studied infectious agents, was used. RESULTS: the frequency of Mycoplasma hominis and Ureaplasma urealyticum infection was 4.9% in the infertile women and 13.8% in the control group. Among the infertile patients, a relationship between the presence of the two agents and changes in the histerosalpingography result (OR: 3.20; IC 95%: 1.05-9.73), presence of dyspareunia (OR: 10.72; IC 95%: 3.21-35.77) and vaginal discharge (OR: 8.5; IC 95%: 2.83-26.02), besides endocervical culture positive for Escherichia coli (OR: 6.09; IC 95%: 4.95-52.25) was observed. CONCLUSION: Mycoplasma hominis and Ureaplasma urealyticum infection rate is low in infertile patients and is associated with reproductive sequels.
Key-words HysterosalpingographyInfertility and Escherichia coliMycoplasma hominisUreaplasma urealyticumSee moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Artigos Originais
Evaluation of body mass index of women from an outpatient gynecological general clinic
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(2):69-74
07-06-2005
Summary
Artigos OriginaisEvaluation of body mass index of women from an outpatient gynecological general clinic
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(2):69-74
07-06-2005DOI 10.1590/S0100-72032005000200005
Views83See morePURPOSE: to determine the prevalence of overweight, obesity, and associated factors among women who visited a general gynecologic clinic in a secondary hospital of reference. METHODS: the following variables were studied: age, race, educational level, family income, job (paid work done by the women), type of the women's job, current partner, menstrual cycle characteristics at the time of interview, and body mass index (BMI). The patients were divided into three groups, according to their BMI values: <25 kg/m² (normal), between 25-29 kg/m² (overweight) and >30 kg/m² (obesity). The odds ratio (OR) and respective 95% confidence interval (95% CI) were calculated in the overweight and obese groups. Subsequently, the OR was calculated and adjusted for other variables. RESULTS: among the 676 studied women, 89.8% had received up to 8 years of formal education, 83.0% had a partner, 77.6% were Caucasian, 61.4% earned less than 5 minimum wages, and 36.0% of these women were menopausal. The prevalence of overweight was 35.6% and of obesity 24.6%. Overweight was related to age ranging from 50 to 59 years (OR: 3.22; 95% CI: 1.67-6.20) and menopause (OR: 1.52; 95% CI: 1.03-2.26), and obesity was related to menopause (OR: 2.57; 95% CI: 1.66-4.00) and to age range above 40 years (OR: 2.95; 95% CI: 1.37-6.37). According to the multiple regression analysis, only obesity was associated with age range above 40 years (OR: 2,51; 95% CI: 1.05-6.00). CONCLUSION: the prevalence rates of overweight and obesity were high in our sample of low-income women and those with less education. Obesity was associated with women aged over 40. Attempts should be made to reduce the prevalence of overweight and obesity in women.
Views83This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Artigos OriginaisEvaluation of body mass index of women from an outpatient gynecological general clinic
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(2):69-74
07-06-2005DOI 10.1590/S0100-72032005000200005
Views83See morePURPOSE: to determine the prevalence of overweight, obesity, and associated factors among women who visited a general gynecologic clinic in a secondary hospital of reference. METHODS: the following variables were studied: age, race, educational level, family income, job (paid work done by the women), type of the women's job, current partner, menstrual cycle characteristics at the time of interview, and body mass index (BMI). The patients were divided into three groups, according to their BMI values: <25 kg/m² (normal), between 25-29 kg/m² (overweight) and >30 kg/m² (obesity). The odds ratio (OR) and respective 95% confidence interval (95% CI) were calculated in the overweight and obese groups. Subsequently, the OR was calculated and adjusted for other variables. RESULTS: among the 676 studied women, 89.8% had received up to 8 years of formal education, 83.0% had a partner, 77.6% were Caucasian, 61.4% earned less than 5 minimum wages, and 36.0% of these women were menopausal. The prevalence of overweight was 35.6% and of obesity 24.6%. Overweight was related to age ranging from 50 to 59 years (OR: 3.22; 95% CI: 1.67-6.20) and menopause (OR: 1.52; 95% CI: 1.03-2.26), and obesity was related to menopause (OR: 2.57; 95% CI: 1.66-4.00) and to age range above 40 years (OR: 2.95; 95% CI: 1.37-6.37). According to the multiple regression analysis, only obesity was associated with age range above 40 years (OR: 2,51; 95% CI: 1.05-6.00). CONCLUSION: the prevalence rates of overweight and obesity were high in our sample of low-income women and those with less education. Obesity was associated with women aged over 40. Attempts should be made to reduce the prevalence of overweight and obesity in women.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Artigos Originais
Oligohydramnios without premature rupture of membranes: perinatal outcomes
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(2):75-79
07-06-2005
Summary
Artigos OriginaisOligohydramnios without premature rupture of membranes: perinatal outcomes
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(2):75-79
07-06-2005DOI 10.1590/S0100-72032005000200006
Views121See morePURPOSE: to evaluate perinatal outcomes in cases of oligohydramnios without premature rupture of membranes. METHODS: a total of 51 consecutive cases of oligohydramnios (amniotic fluid index, AFI < 5 cm) born between March 1998 and September 2001 were studied retrospectively. Data were compared to 61 cases with intermediate and normal volume of amniotic fluid AFI >5). Maternal and neonatal variables, as well as fetal mortality, early neonatal, and perinatal mortality rates were analyzed. For statistical analysis the c² test with Yates correction and Student's t test were used with level of signicance set at 5%. RESULTS: there were no significant differences between groups when the presence of gestational hypertensive syndromes, meconium-stained amniotic fluid, 1- and 5-minute Apgar score, need of neonatal intensive center unit, and preterm birth were analyzed. Oligohydramnios was associated with the way of delivery (p<0.0002; RR=0.3), fetal distress (p<0.0004; RR=2.2) and fetal malformations (p<0.01; RR=5.4). Fetal malformation rates were 17.6 and 3.3% in oligohydramnios and normal groups, respectively. Fetal mortality (2.0 vs 1.6%), early neonatal (5.9 vs 1.6%) and perinatal mortality (7.8 vs 3.3%) rates in both groups did not show statistical significance. CONCLUSION: Oligohydramnios was related to increased risk factor for cesarean section, fetal distress and fetal malformations.
Views121This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Artigos OriginaisOligohydramnios without premature rupture of membranes: perinatal outcomes
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(2):75-79
07-06-2005DOI 10.1590/S0100-72032005000200006
Views121See morePURPOSE: to evaluate perinatal outcomes in cases of oligohydramnios without premature rupture of membranes. METHODS: a total of 51 consecutive cases of oligohydramnios (amniotic fluid index, AFI < 5 cm) born between March 1998 and September 2001 were studied retrospectively. Data were compared to 61 cases with intermediate and normal volume of amniotic fluid AFI >5). Maternal and neonatal variables, as well as fetal mortality, early neonatal, and perinatal mortality rates were analyzed. For statistical analysis the c² test with Yates correction and Student's t test were used with level of signicance set at 5%. RESULTS: there were no significant differences between groups when the presence of gestational hypertensive syndromes, meconium-stained amniotic fluid, 1- and 5-minute Apgar score, need of neonatal intensive center unit, and preterm birth were analyzed. Oligohydramnios was associated with the way of delivery (p<0.0002; RR=0.3), fetal distress (p<0.0004; RR=2.2) and fetal malformations (p<0.01; RR=5.4). Fetal malformation rates were 17.6 and 3.3% in oligohydramnios and normal groups, respectively. Fetal mortality (2.0 vs 1.6%), early neonatal (5.9 vs 1.6%) and perinatal mortality (7.8 vs 3.3%) rates in both groups did not show statistical significance. CONCLUSION: Oligohydramnios was related to increased risk factor for cesarean section, fetal distress and fetal malformations.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Artigos Originais
Uterine leiomyomas and pregnancy
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(2):80-85
07-06-2005
Summary
Artigos OriginaisUterine leiomyomas and pregnancy
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(2):80-85
07-06-2005DOI 10.1590/S0100-72032005000200007
Views159See morePURPOSE: to evaluate the evolution of pregnancy and the maternofetal prognosis in women with uterine leiomyomas. METHODS: a descriptive retrospective analysis of the medical records of 75 pregnant women with leiomyomas attended at the University Hospital, Faculty of Medicine of Ribeirão Preto, University of São Paulo, from January 1992 to January 2002. RESULTS: seventy-five pregnant women with leiomyomas were identified in a population of 34,467 pregnant women attended during this period (incidence of 0.2%). The diagnosis was made before pregnancy in 18 patients (24%), during the current pregnancy in 41 (54.6%), and during cesarean section in 16 (21.3%), of whom only six were not submitted to ultrasound scan during the prenatal period. Ten deliveries with preterm fetuses and five cases of premature rupture of the amniotic membranes were observed. Forty-seven patients (75.8%) were submitted to cesarean section, with the indication being directly related to the leiomyomas in 38.3% of them (anomalous presentation, obstruction of the birth canal, or uterine scar due to a previous myomectomy). Four cases of central necrosis, two cases of hyaline degeneration and one case of malignant potential of the leiomyoma were identified in patients submitted to postpartum myomectomy or hysterectomy. Sixty-one newborns (98.4%) had an Apgar score above 7 at the fifth minute of life, and surgery did not lead to a worse maternofetal prognosis when performed during pregnancy. CONCLUSIONS: the incidence of leiomyomas during pregnancy was 0.2% during the study period, with ultrasonography failing to diagnose 10 patients. Cesarean section was frequently indicated for this group of patients, but the presence of leiomyomas during pregnancy did not compromise the Apgar score of the newborns.
Views159This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Artigos OriginaisUterine leiomyomas and pregnancy
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(2):80-85
07-06-2005DOI 10.1590/S0100-72032005000200007
Views159See morePURPOSE: to evaluate the evolution of pregnancy and the maternofetal prognosis in women with uterine leiomyomas. METHODS: a descriptive retrospective analysis of the medical records of 75 pregnant women with leiomyomas attended at the University Hospital, Faculty of Medicine of Ribeirão Preto, University of São Paulo, from January 1992 to January 2002. RESULTS: seventy-five pregnant women with leiomyomas were identified in a population of 34,467 pregnant women attended during this period (incidence of 0.2%). The diagnosis was made before pregnancy in 18 patients (24%), during the current pregnancy in 41 (54.6%), and during cesarean section in 16 (21.3%), of whom only six were not submitted to ultrasound scan during the prenatal period. Ten deliveries with preterm fetuses and five cases of premature rupture of the amniotic membranes were observed. Forty-seven patients (75.8%) were submitted to cesarean section, with the indication being directly related to the leiomyomas in 38.3% of them (anomalous presentation, obstruction of the birth canal, or uterine scar due to a previous myomectomy). Four cases of central necrosis, two cases of hyaline degeneration and one case of malignant potential of the leiomyoma were identified in patients submitted to postpartum myomectomy or hysterectomy. Sixty-one newborns (98.4%) had an Apgar score above 7 at the fifth minute of life, and surgery did not lead to a worse maternofetal prognosis when performed during pregnancy. CONCLUSIONS: the incidence of leiomyomas during pregnancy was 0.2% during the study period, with ultrasonography failing to diagnose 10 patients. Cesarean section was frequently indicated for this group of patients, but the presence of leiomyomas during pregnancy did not compromise the Apgar score of the newborns.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Artigos Originais
Comparison between three protocols for ovulation Induction in cycles of intrauterine insemination and related endometrial thickness and pregnancy rate achieved in each protocol
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(1):7-11
07-06-2005
Summary
Artigos OriginaisComparison between three protocols for ovulation Induction in cycles of intrauterine insemination and related endometrial thickness and pregnancy rate achieved in each protocol
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(1):7-11
07-06-2005DOI 10.1590/S0100-72032005000100003
Views117See morePURPOSE: to compare pregnancy rates and mean endometrial thickness obtained with three protocols for induction of ovulation in cycles of intrauterine insemination (IUI). METHODS: one hundred and ten IUI cycles were retrospectively evaluated in the study, divided into three groups, according to the used ovulation induction protocols: 100 mg clomiphene citrate (CC) on days 3 to 7 of the cycle (CC group, n=24), 100 mg/day CC on days 3 to 7 of the cycle + 75 IU/day of human menopausal gonadotrophin (hMG) on days 3, 5 and 7 of the cycle (CC+hMG group, n=29), and 75 IU/day of hMG on days 3 to 8 of the cycle (hMG group, n=57). Statistical analysis was performed using Student's t test to compare the means and the c² test to compare the rates. Results were considered statistically significant at p<0.05. RESULTS: the patients' average age at the onset of the first cycle was 2340 years (mean age, 33.3 years). There were no statistically significant differences between groups. The mean endometrial thickness on the day of the human chorionic gonadotrophin (hCG) administration was significantly higher in the hMG group (10.2±0.2 mm), as compared with the CC and CC+hMG group (7.9±0.4 and 8.7±0.2 mm, respectively, p<0.001). The overall clinical pregnancy rate was 18.2%, and there were no statistically significant differences between the groups (CC group=12.5%; CC+hMG group=24.1% and hMG group=19.3%). CONCLUSION: the results indicate higher mean endometrial thickness in the hMG group as compared with the CC group and the CC+hMG group. There were no significant differences between clinical pregnancy rates obtained with each protocol (CC, CC+hMG and hMG).
Views117This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Artigos OriginaisComparison between three protocols for ovulation Induction in cycles of intrauterine insemination and related endometrial thickness and pregnancy rate achieved in each protocol
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(1):7-11
07-06-2005DOI 10.1590/S0100-72032005000100003
Views117See morePURPOSE: to compare pregnancy rates and mean endometrial thickness obtained with three protocols for induction of ovulation in cycles of intrauterine insemination (IUI). METHODS: one hundred and ten IUI cycles were retrospectively evaluated in the study, divided into three groups, according to the used ovulation induction protocols: 100 mg clomiphene citrate (CC) on days 3 to 7 of the cycle (CC group, n=24), 100 mg/day CC on days 3 to 7 of the cycle + 75 IU/day of human menopausal gonadotrophin (hMG) on days 3, 5 and 7 of the cycle (CC+hMG group, n=29), and 75 IU/day of hMG on days 3 to 8 of the cycle (hMG group, n=57). Statistical analysis was performed using Student's t test to compare the means and the c² test to compare the rates. Results were considered statistically significant at p<0.05. RESULTS: the patients' average age at the onset of the first cycle was 2340 years (mean age, 33.3 years). There were no statistically significant differences between groups. The mean endometrial thickness on the day of the human chorionic gonadotrophin (hCG) administration was significantly higher in the hMG group (10.2±0.2 mm), as compared with the CC and CC+hMG group (7.9±0.4 and 8.7±0.2 mm, respectively, p<0.001). The overall clinical pregnancy rate was 18.2%, and there were no statistically significant differences between the groups (CC group=12.5%; CC+hMG group=24.1% and hMG group=19.3%). CONCLUSION: the results indicate higher mean endometrial thickness in the hMG group as compared with the CC group and the CC+hMG group. There were no significant differences between clinical pregnancy rates obtained with each protocol (CC, CC+hMG and hMG).
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Artigos Originais
Interobserver variation of the histopathologic diagnosis of ductal carcinoma in situ of the breast
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(1):1-6
07-05-2005
Summary
Artigos OriginaisInterobserver variation of the histopathologic diagnosis of ductal carcinoma in situ of the breast
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(1):1-6
07-05-2005DOI 10.1590/S0100-72032005000100002
Views51See morePURPOSE: to perform a critical evaluation of the histopathological diagnosis of ductal carcinoma in situ (DCIS) of the breast, through the analysis of interobserver variation related to diagnosis, architectural pattern, nuclear grade, and histological grade. METHODS: eighty-five cases with an initial diagnosis of DCIS were reviewed by the same pathologist, specialist in breast pathology, who selected 15 cases for interobserver analysis. The analysis was carried out by five pathologists and an international expert in breast pathology, who received the same slides and a protocol for classifying the lesions as atypical ductal hyperplasia (ADH), DCIS, or ductal carcinoma in situ with microinvasion (DCIS-MIC). If the diagnosis was DCIS, the pathologists should classify it according to the dominant architectural pattern, nuclear grade, and histological grade. The results were analyzed using percent concordance and the kappa test. RESULTS: there was a great interobserver diagnostic variation. In one case we had all diagnoses, from ADH, DCIS to DCIS-MIC. The kappa test for the comparison among the five observers' and the expert's diagnoses showed minimum interobservers' concordance (<0.40). Regarding DCIS classification related to the dominant architectural pattern and the histological grade, the kappa test values were considered poor among the pathologists. The best results were obtained for the nuclear grading, with a kappa index up to 0.80, considered as good concordance. CONCLUSION: the low index of interobserver concordance in diagnosis and classification of DCIS of the breast indicates the difficulty in using the most common diagnostic criteria of the literature and the need for specific training of non-specialist pathologists in breast pathology for the diagnosis of these lesions.
Views51This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Artigos OriginaisInterobserver variation of the histopathologic diagnosis of ductal carcinoma in situ of the breast
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(1):1-6
07-05-2005DOI 10.1590/S0100-72032005000100002
Views51See morePURPOSE: to perform a critical evaluation of the histopathological diagnosis of ductal carcinoma in situ (DCIS) of the breast, through the analysis of interobserver variation related to diagnosis, architectural pattern, nuclear grade, and histological grade. METHODS: eighty-five cases with an initial diagnosis of DCIS were reviewed by the same pathologist, specialist in breast pathology, who selected 15 cases for interobserver analysis. The analysis was carried out by five pathologists and an international expert in breast pathology, who received the same slides and a protocol for classifying the lesions as atypical ductal hyperplasia (ADH), DCIS, or ductal carcinoma in situ with microinvasion (DCIS-MIC). If the diagnosis was DCIS, the pathologists should classify it according to the dominant architectural pattern, nuclear grade, and histological grade. The results were analyzed using percent concordance and the kappa test. RESULTS: there was a great interobserver diagnostic variation. In one case we had all diagnoses, from ADH, DCIS to DCIS-MIC. The kappa test for the comparison among the five observers' and the expert's diagnoses showed minimum interobservers' concordance (<0.40). Regarding DCIS classification related to the dominant architectural pattern and the histological grade, the kappa test values were considered poor among the pathologists. The best results were obtained for the nuclear grading, with a kappa index up to 0.80, considered as good concordance. CONCLUSION: the low index of interobserver concordance in diagnosis and classification of DCIS of the breast indicates the difficulty in using the most common diagnostic criteria of the literature and the need for specific training of non-specialist pathologists in breast pathology for the diagnosis of these lesions.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Artigos Originais
Is there any difference between female pelvic floor muscle contractility in different positions?
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(1):12-19
07-05-2005
Summary
Artigos OriginaisIs there any difference between female pelvic floor muscle contractility in different positions?
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(1):12-19
07-05-2005DOI 10.1590/S0100-72032005000100005
Views98See morePURPOSE: to evaluate and compare results of female pelvic floor surface electromyography in different positions: lying, sitting and standing. METHODS: twenty-six women with the diagnosis of stress urinary incontinence treated with a protocol of exercises to strengthen the pelvic floor muscle were evaluated. Pelvic floor surface electromyography was performed with an intravaginal sensor connected to Myotrac 3G TM equipment, as follows: initial rest of 60 s, five phasic contractions, one 10-s tonic contraction and one 20-s tonic contraction. The amplitudes were obtained from the difference between the final contraction amplitude and the amplitude at rest (in µV). Wilcoxon test was applied for nonparametric data (p value <0.05). RESULTS: the amplitudes of contractions were higher in the lying position, decreasing in the sitting and standing positions. In the lying position, the median values of phasic and tonic contractions were 23.5 (5-73), 18.0 (3-58) and 17.0 (2-48), respectively. In the sitting position, they were 20.0 (2-69), 16.0 (0-58) and 15.5 (1-48). In the standing position they were 16.5 (3-67), 12.5 (2-54) and 13.5 (2-41). All amplitude values were significantly lower in the standing position compared to the lying position (p<0.001, p<0.001 and p=0.003). Similar results were also found in comparison to the sitting position. However, there was no significant difference between the lying and the sitting positions. CONCLUSION: all female pelvic floor contraction amplitudes were lower in the standing position, suggesting that the muscle strength should be intensified in that position.
Views98This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Artigos OriginaisIs there any difference between female pelvic floor muscle contractility in different positions?
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(1):12-19
07-05-2005DOI 10.1590/S0100-72032005000100005
Views98See morePURPOSE: to evaluate and compare results of female pelvic floor surface electromyography in different positions: lying, sitting and standing. METHODS: twenty-six women with the diagnosis of stress urinary incontinence treated with a protocol of exercises to strengthen the pelvic floor muscle were evaluated. Pelvic floor surface electromyography was performed with an intravaginal sensor connected to Myotrac 3G TM equipment, as follows: initial rest of 60 s, five phasic contractions, one 10-s tonic contraction and one 20-s tonic contraction. The amplitudes were obtained from the difference between the final contraction amplitude and the amplitude at rest (in µV). Wilcoxon test was applied for nonparametric data (p value <0.05). RESULTS: the amplitudes of contractions were higher in the lying position, decreasing in the sitting and standing positions. In the lying position, the median values of phasic and tonic contractions were 23.5 (5-73), 18.0 (3-58) and 17.0 (2-48), respectively. In the sitting position, they were 20.0 (2-69), 16.0 (0-58) and 15.5 (1-48). In the standing position they were 16.5 (3-67), 12.5 (2-54) and 13.5 (2-41). All amplitude values were significantly lower in the standing position compared to the lying position (p<0.001, p<0.001 and p=0.003). Similar results were also found in comparison to the sitting position. However, there was no significant difference between the lying and the sitting positions. CONCLUSION: all female pelvic floor contraction amplitudes were lower in the standing position, suggesting that the muscle strength should be intensified in that position.
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