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Original Article03-18-2025
Effect of COVID-19 on Brazilian cesarean and prematurity rates: a cross-sectional study
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo6
Abstract
Original ArticleEffect of COVID-19 on Brazilian cesarean and prematurity rates: a cross-sectional study
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo6
Views253See moreAbstract
Objective:
To investigate the relationship between prematurity and cesarean section rate in Brazil during the beginning of COVID-19 pandemic.
Methods:
Utilizing the Robson Classification, this study analyzed data from the Brazilian Ministry of Health’s Live Births Panel, comparing CSR) and group 10 (preterm deliveries) between 2019 (pre-pandemic) and 2021 (pandemic) in each of Brazilian states and the overall country. The prematurity and CSR were compared using prevalence ratio and confidence interval, and p-value was obtained. The variation of prematurity and CSR were compared through the coefficient of determination (R2).
Results:
A total of 5,522,910 deliveries were evaluated during the period. The CSR increased from 56.34% to 57.05% (p<0.01), and the frequency of preterm deliveries rose from 8.99% to 9.13% (p<0.01). The CSR increased in 23 States and decreased in 4 States, while the prematurity rate increased in 16 States and decreased in 10 States. A positive relationship between the increase of CSR and prematurity was observed during COVID-19, with an R2 value of 0.3121, suggesting a moderate association between these two variables.
Conclusion:
Between 2019 (pre-COVID-19 pandemic) and 2021 (the first full year of the COVID-19 pandemic), there was an increase in prematurity and CSR in Brazil. These increases were observed in most Brazilian states and may be correlated. However, it is impossible to establish a cause-effect relationship given the design of this study.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 
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Original Article03-18-2025
Accurate evaluation of mode of delivery and labor progression with angle of progression: a prospective cross-sectional
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo5
Abstract
Original ArticleAccurate evaluation of mode of delivery and labor progression with angle of progression: a prospective cross-sectional
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo5
Views250See moreAbstract
Objective:
To determine the validity of the angle of progression (AoP) in predicting delivery mode among women in the second stage of labor.
Designs:
This prospective cohort study was conducted at the Obstetrics and Gynecology unit (OBGYN) of two hospitals in Vietnam. Transperineal ultrasound was performed for each woman to measure the progression angle in the second phase of labor.
Participants:
A total of 725 women with singleton pregnancies with cephalic presentation at term
Methods:
Transperineal ultrasound was used to measure the angle of progression in the second labor phase and to identify the delivery method.
Results:
The rate of vaginal birth in women with an AoP ≥ 120° on transperineal ultrasound was 70.2%. The optimal cutoff point of AOP ≥122° with sensitivity and specificity for vaginal birth were 87.8% and 80.7%, respectively the area under the ROC curve of 0.887 (p<0.0001). The study's sample size was restricted owing to deficiencies in resources and time.
Conclusion:
The likelihood of achieving spontaneous vaginal delivery can be predicted by the angle of progression measured with transperineal intrapartum ultrasonography during the second stage of labor in women.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 
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Original Article03-18-2025
Gastrin-releasing peptide receptor: a promising new biomarker to identify cervical precursor lesions and cancer
- Martina Lichtenfels
, - Rafaella Almeida Lima Nunes ,
- Rossana Veronica Mendoza López ,
- Camila Alves da Silva ,
- Luiz Carlos Zeferino , [ … ],
- Lara Termini
Abstract
Original ArticleGastrin-releasing peptide receptor: a promising new biomarker to identify cervical precursor lesions and cancer
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo4
- Martina Lichtenfels ,
- Rafaella Almeida Lima Nunes ,
- Rossana Veronica Mendoza López ,
- Camila Alves da Silva ,
- Luiz Carlos Zeferino ,
- Vanesca de Souza Lino ,
- Adhemar Longatto-Filho ,
- Louise De Brot ,
- Silvia Helena Rabelo-Santos ,
- Daniela Baumann Cornelio ,
- Enrique Boccardo ,
- Caroline Brunetto de Farias ,
- Lara Termini
Views225Abstract
Objective:
This study aimed to verify the relation between gastrin-releasing peptide receptor (GRPR), oncogenic Human Papillomavirus (HPV) and cervical lesions severity.
Methods:
GRPR mRNA levels were evaluated in cervical cancer-derived cell lines and in primary keratinocytes expressing HPV16 oncogenes by RT-PCR. GRPR protein expression was assessed by immunohistochemistry in organotypic cell cultures derived from keratinocytes transduced with HPV16 oncogenes and in 208 cervical samples, including 59 non-neoplastic tissue, 28 cervical intraepithelial neoplasia grade 3 (CIN3), 44 squamous cell carcinomas (SCC) and 77 adenocarcinomas (ADC). Generic primers (GP5+/GP6+) were used to identify HPV infection in tissue samples. Experiments involving cell lines were analyzed through non-parametric tests (Kruskal Wallis), and Fisher’s Exact Test for human tissues samples. All statistical tests were considered significant at p <0.05. Immunohistochemical evaluation was conducted independently and blindly by two observers (AD- LO). Any discordant findings were resolved through discussion to reach a consensus score.
Results:
GRPR mRNA levels were not increased in cells expressing HPV16 or HPV18 oncogenes. However, at the protein level, GRPR was upregulated in organotypic cell cultures containing HPV oncogenes. Besides, it was identified an association between GRPR expression and cervical lesion severity (p < 0.0001). The detection rate of high-risk HPV DNA was directly correlated with cervical disease. Nonetheless, HPV infection was not directly associated with GRPR in cervical samples.
Conclusion:
GRPR expression is highly predictive of cervical lesion severity, irrespective of HPV infection and might contribute to improving patient’s therapeutic management as well as being used a marker of disease progression.
Key-words AdenocarcinomaCarcinoma, squamous cellGastrin-releasing peptide receptorHuman papillomavirusOncogenesPapillomavirus infectionsUterine cervical dysplasiaUterine cervical neoplasmsSee moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 
- Martina Lichtenfels
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Review Article03-18-2025
Low-level laser therapy for nipple trauma and pain during breastfeeding: systematic review and meta-analysis
- Maria Victória Candida Gaitero ,
- Ticiana Aparecida Alves de Mira ,
- Edna Jéssica Lima Gondim ,
- Simony Lira do Nascimento ,
- Fernanda Garanhani Surita
Abstract
Review ArticleLow-level laser therapy for nipple trauma and pain during breastfeeding: systematic review and meta-analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo3
- Maria Victória Candida Gaitero ,
- Ticiana Aparecida Alves de Mira ,
- Edna Jéssica Lima Gondim ,
- Simony Lira do Nascimento ,
- Fernanda Garanhani Surita
Views274Abstract
Objective:
This study aimed to investigate the effect of low-level laser therapy (LLLT) on nipple trauma and pain during breastfeeding through a systematic review with a meta-analysis of selected studies.
Source of the data:
A thorough search was conducted on March 22, 2022, using the databases PubMed, SciELO, LILACS, PEDro, CINAHL, EMBASE, ScienceDirect, Scopus, Google Scholar, MEDLINE, the Cochrane Library, Clinical Trials, Web of Science, TRIP, DARE, and ProQuest. The search terms included various combinations of low-level laser therapy, nipple pain, nipple trauma, and breastfeeding.
Studies selection:
Out of 107 articles identified, only three controlled and randomized clinical trials was included. The extracted data encompassed breast and trauma characteristics, treatment types, outcomes (pain and healing process), evaluation tools, LLLT usage, laser brand, and parameters.
Data collection:
Data extraction was performed using RAYYAN for systematic reviews. The risk of bias in the studies was evaluated.
Data synthesis:
Pain was measured using the visual analog scale (VAS). The included studies did not use validated tools for assessing physical conditions. All studies employed LLLT with a 660-nm wavelength, though there were variations in equipment power, energy dose, and application methods. The meta-analysis revealed an average difference of −0.60 points (95% CI: −1.52 to 0.31) in the VAS pain scores between the LLLT and control groups. No heterogeneity was observed among the studies (I2=0%), indicating no significant difference in pain relief between LLLT (red light) and control groups.
Conclusion:
LLLT may offer a promising option for managing breastfeeding-related complications, though further research is required.
Key-words Breast feedingLaser therapyLow level light therapyLow-level laserNipple painNipple traumaNipplesSee moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 
- Maria Victória Candida Gaitero
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Review Article03-18-2025
Clinical repercussions of statin use during pregnancy: a review of the literature
- Joan Lins Serafim ,
- Pedro Lucas Santos de Menezes Teles ,
- Amanda Katharinne Souza Lima ,
- Jéssica dos Santos Coelho ,
- Paloma Luna Maranhão Conrado , [ … ],
- George Alessandro Maranhão Conrado
Abstract
Review ArticleClinical repercussions of statin use during pregnancy: a review of the literature
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo2
- Joan Lins Serafim ,
- Pedro Lucas Santos de Menezes Teles ,
- Amanda Katharinne Souza Lima ,
- Jéssica dos Santos Coelho ,
- Paloma Luna Maranhão Conrado ,
- Valda Lúcia Moreira Luna ,
- Pauliana Valéria Machado Galvão ,
- George Alessandro Maranhão Conrado
Views221Abstract
Statins are the most widely used pharmacological class for treating hyperlipidemia, although they are contraindicated during pregnancy. This study aims to demonstrate the clinical effects of statins in pregnant women through an interactive review. Fifteen original articles were selected, in English or Portuguese, within of five years. Statins have not been associated with the development of fetal malformations and their use may be useful in preventing unfavorable cardiovascular outcomes, with the potential to reduce oxidative stress and angiogenic dysfunction. However, the use of statins to prevent pre-eclampsia in humans has not been properly clarified and further studies are needed. Pravastatin is considered safer than statins for use during pregnancy.
Key-words Antihypertensive agentsHydroxymethylglutaryl-CoA reductase inhibitorsPravastatinPre-eclampsiaPregnancyPregnant womanSee moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 
- Joan Lins Serafim
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Review Article03-18-2025
Efficacy of vitamin C supplementation during pregnancy in the prevention of preterm birth: a systematic review and meta-analysis
- Ana Gabriela Alves Pereira ,
- Gabriela Oliveira Gonçalves Molino ,
- Ana Clara Felix de Farias Santos ,
- Maírla Marina Ferreira Dias ,
- Nicole dos Santos Pimenta , [ … ],
- Pedro Henrique Costa Matos da Silva
Abstract
Review ArticleEfficacy of vitamin C supplementation during pregnancy in the prevention of preterm birth: a systematic review and meta-analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo1
- Ana Gabriela Alves Pereira ,
- Gabriela Oliveira Gonçalves Molino ,
- Ana Clara Felix de Farias Santos ,
- Maírla Marina Ferreira Dias ,
- Nicole dos Santos Pimenta ,
- Pedro Henrique Costa Matos da Silva
Views224Abstract
Objective:
Preterm birth is a leading global cause of neonatal mortality and morbidity, with oxidative stress playing a role in its pathogenesis. Vitamin C, a powerful antioxidant, may help reduce this risk. This study assessed the effectiveness of vitamin C supplementation, both alone and with vitamin E, in preventing preterm birth compared to a placebo.
Data source:
Databases were systematically searched in PubMed, Cochrane and Embase in December 2023 and updated in May 2024.
Study Selection:
Included RCTs evaluated vitamin C’s effect on preterm birth and related neonatal outcomes.
Data collect:
Statistical analyses used a random-effects model for pooled risk ratios (RR) and 95% confidence intervals (CI). Heterogeneity was assessed with the I² statistic.
Data synthesis:
Seventeen RCTs (21,567 patients) were analyzed. Vitamin C supplementation showed no significant difference compared to placebo for preterm birth (RR 1.04; 95% CI 0.96, 1.14). No significant differences were observed for neonatal death (RR 0.77; 95% CI 0.55, 1.08), NICU admission (RR 1.03; 95% CI 0.95, 1.13), preterm PROM (RR 1.04; 95% CI 0.63, 1.71), or birth weight (MD 52.41; 95% CI −19.65, 124.47). A slight decrease in gestational age was observed (MD 0.26; 95% CI −0.02, 0.55).
Conclusion:
Vitamin C supplementation alone or in combination with vitamin E does not significantly prevent preterm birth or improve related neonatal outcomes.
Key-words Ascorbic acidFetal membranes, premature ruptureGestational ageIntensive care units, neonatalPregnancyPremature birthVitamin C supplementationVitamin ESee moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 
- Ana Gabriela Alves Pereira
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FEBRASGO POSITION STATEMENT03-18-2025
Use of synthetic slings in the treatment of female stress urinary incontinence: Number 2 – 2025
- Marair Gracio Ferreira Sartori ,
- Marilene Vale de Castro Monteiro ,
- Cássia Raquel Teatin Juliato ,
- Luiz Gustavo Oliveira Brito ,
- Sergio Brasileiro Martins , [ … ],
- Emerson de Oliveira
Abstract
FEBRASGO POSITION STATEMENTUse of synthetic slings in the treatment of female stress urinary incontinence: Number 2 – 2025
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-FPS2
- Marair Gracio Ferreira Sartori ,
- Marilene Vale de Castro Monteiro ,
- Cássia Raquel Teatin Juliato ,
- Luiz Gustavo Oliveira Brito ,
- Sergio Brasileiro Martins ,
- José Miguel de Deus ,
- Ana Selma Bertelli Picoloto ,
- Jorge Milhem Haddad ,
- Andreisa Paiva Monteiro Bilhar ,
- Leticia Maria de Oliveira ,
- Rafael Mendes Moroni ,
- Lucas Schreiner ,
- Aljerry Dias do Rego ,
- Daniela Siqueira Prado ,
- Emerson de Oliveira
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Marair Gracio Ferreira Sartori
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Original Article02-13-2025
Anemia levels in the preconception period and the first trimester of pregnancy: a national, multicentric and cross-sectional study
- Aytaj Jafarzade ,
- Veli Mi̇hmanli ,
- And Yavuz ,
- Murat Akbaş ,
- Gürcan Türkyilmaz , [ … ],
- Muhittin Tamer Mungan
Abstract
Original ArticleAnemia levels in the preconception period and the first trimester of pregnancy: a national, multicentric and cross-sectional study
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:-e-rbgo1001
DOI 10.61622/rbgo/2025rbgo10001
- Aytaj Jafarzade ,
- Veli Mi̇hmanli ,
- And Yavuz ,
- Murat Akbaş ,
- Gürcan Türkyilmaz ,
- Esra Nur Özkan ,
- Murat İbrahim Toplu ,
- Yücel Kaya ,
- Damla Yasemin Yenli̇k Kaya ,
- Mustafa Yildiz ,
- Ali Emre Ati̇k ,
- Elif İlgazi̇ Kiliç ,
- Burcu Özata ,
- Sehtap Nazlı Kiliç Çeti̇n ,
- Berk Bulut ,
- Halide Gül Okuducu Aydin ,
- Lale Aslanova ,
- Çağdaş Nurettin Emekli̇oğlu ,
- Melike Eren ,
- Elif Uçar ,
- Kaan Eray Uzun ,
- Osman Ufuk Eki̇z ,
- Muhittin Tamer Mungan
Views420Abstract
Objective
The study aimed to determine the level of anemia in pregnant women in the first trimester and in the preconception period by conducting nationwide research.
Methods
The study was designed as retrospective, cross-sectional, and multicenter research. A total of 17 centers from 13 provinces were included in the study. The study was conducted with the participation of two groups of patients who applied to the obstetrics polyclinic between 1 January 2023 and 1 July 2023, who were in the first trimester of pregnancy and who were in the preconception period planning pregnancy.
Results
In total 4,265 women were included in the study. Of these women, 3,884 (91%) were in the first trimester of their pregnancy and 381 (9%) were in the preconception period. Anemia was detected in 24.1% (n=1030) of the patients. Of these patients, 20.6% (n=877) were pregnant women in the first trimester and 3.6% (n=153) were in the preconception period. A statistically significant and positive relationship was found between anemia and meat consumption frequency, educational status, and socioeconomic status of the patients (p=0.000, p=0.000, p=0.000). In addition, a statistically significant and negative correlation was determined between anemia and the number of pregnancies and the parity number (p=0.001, p=0.000) in both groups.
Conclusion
Anemia is a public health problem. Anemia has been determined to be an important problem both in the preconception period and early periods of pregnancy. It is necessary to revise the programs and interventions to reduce the prevalence of anemia and redesign them in line with current conditions.
Key-words Anemia, iron-deficiencypreconception carePregnancy complications, hematologicPregnancy trimester, firstSee moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 
- Aytaj Jafarzade
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Original Article10-01-2016
Uterine Fibroid Symptom – Quality of Life questionnaire translation and validation into Brazilian Portuguese
Revista Brasileira de Ginecologia e Obstetrícia. 2016;38(10):518-523
Abstract
Original ArticleUterine Fibroid Symptom – Quality of Life questionnaire translation and validation into Brazilian Portuguese
Revista Brasileira de Ginecologia e Obstetrícia. 2016;38(10):518-523
Views240See moreAbstract
Purpose
To translate into Portuguese, culturally adapt and validate the Uterine Fibroid Symptom – Quality of Life (UFS-QoL) questionnaire for Brazilian women with uterine leiomyoma.
Methods
Initially, the UFS-QoL questionnaire was translated into Brazilian Portuguese in accordance with international standards, with subsequent cultural, structural, conceptual and semantic adaptations, so that patients were able to properly answer the questionnaire. Fifty patients with uterine leiomyoma and 19 patients without the disease, confirmed by abdominal pelvic examination and/or transvaginal ultrasound, were selected at the outpatient clinics of the Department of Gynecology of the Universidade Federal de São Paulo (Unifesp). The UFS-QoL questionnaire was administered to all women twice on the same day, with two different interviewers, with an interval of 15 minutes between interviews. After 15 days, the questionnaire was readministered by the first interviewer. Reliability (internal consistency and test-retest), construct and discriminative validity were tested to ratify the questionnaire.
Results
The reliability of the instrument was assessed by Cronbach’s α coefficient with an overall result of 0.97, indicating high reliability. The survey results showed a high correlation (p= 0.94; p 0.001).
Conclusion
The UFS-QoL questionnaire was successfully adapted to the Brazilian Portuguese language and Brazilian culture, showing reliability and validity.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Case Report03-01-2017
Limb Body Wall Complex Associated with Placenta Accreta: A Mere Coincidence or a Sign of an Etiopathogenic Link?
Revista Brasileira de Ginecologia e Obstetrícia. 2017;39(3):142-146
Abstract
Case ReportLimb Body Wall Complex Associated with Placenta Accreta: A Mere Coincidence or a Sign of an Etiopathogenic Link?
Revista Brasileira de Ginecologia e Obstetrícia. 2017;39(3):142-146
Views242See moreAbstract
A case was reported of a fetus with the anomaly of limb body wall complex associated with placenta accreta. To date, only one account of this condition has been published in the world literature. Due to the low frequency of both complications, the hypothesis has been raised that this association may have happened not by mere coincidence, but rather by a possible common etiopathogenic mechanism. For the first time, a study proposes the existence of a possible etiopathogenic connection between the anomaly of limb body wall complex and hypoxic disorders caused by inadequate placentation in previous uterine scarring.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 
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Original Article01-01-2018
Body Mass Index Changes during Pregnancy and Perinatal Outcomes – A Cross-Sectional Study
Revista Brasileira de Ginecologia e Obstetrícia. 2018;40(1):11-19
Abstract
Original ArticleBody Mass Index Changes during Pregnancy and Perinatal Outcomes – A Cross-Sectional Study
Revista Brasileira de Ginecologia e Obstetrícia. 2018;40(1):11-19
Views219See moreAbstract
Objective
To evaluate the relation between changes the body mass index (BMI) percentile, reflected in the Atalah curve, and perinatal outcomes.
Methods
A cross-sectional study with 1,279 women was performed. Data regarding gestational weight, sociodemographic characteristics and perinatal outcomes were collected through medical charts, prenatal card and interviews in the postpartum period. Women could be classified according to the Atalah curve in the following categories: low weight, adequateweight, overweight, and obese. The BMIwas calculated at the first and at the last prenatal care visits, and these values were compared.
Results
An increase in the BMI category according to the Atalah classification occurred in 19.9% of pregnant women, and an increase of 3.4, 5.8 and 6.4 points of BMI were found for women respectively classified in the adequate weight, overweight and obese categories at the first prenatal visit. Women with high school education presented a lower chance of increasing their BMI (odds ratio [OR] 0:47 [0.24- 0.95]). Women who evolved with an increase in the the Atalah classification were associated with cesarean section (OR 1.97-2.28), fetalmacrosomia (OR 4.13-12.54) and large for gestational age newborn (OR 2.88-9.83).
Conclusion
Pregnant women who gained enough weight to move up in their BMI classification according to the Atalah curve had a higher chance of cesarean section and macrosomia. Women classified as obese, according to the Atalah curve, at the first prenatal visit had a high chance of cesarean section and delivering a large for gestational age newborn.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Original Article03-01-2018
Improving Perinatology Residents’ Skills in Breaking Bad News: A Randomized Intervention Study
Revista Brasileira de Ginecologia e Obstetrícia. 2018;40(3):137-146
Abstract
Original ArticleImproving Perinatology Residents’ Skills in Breaking Bad News: A Randomized Intervention Study
Revista Brasileira de Ginecologia e Obstetrícia. 2018;40(3):137-146
Views233Abstract
Objective
Breaking bad news (BBN) is particularly difficult in perinatology. Previous research has shown that BBN skills can be learned and improved when taught and practiced. This project evaluated whether a structured training session would enhance perinatology residents’ skills in BBN.
Methods
This was a randomized controlled intervention study with year 1 to 4 Perinatology residents from a medical school in Brazil, during the 2014/15 school year. A total of 61 out of 100 (61%) eligible residents volunteered to a structured training program involving communicating a perinatal loss to a simulated patient (SP) portraying the mother followed by the SP’s immediatefeedback,bothvideo recorded. Later, residents were randomly assigned to BBN training based on a setting, perception, invitation, knowledge, emotion and summary (SPIKES) strategy with video reviews (intervention) or no training (control group). All residents returned for a second simulation with the same SP blinded to the intervention and portraying a similar case. Residents’ performances were then evaluated by the SP with a checklist. The statistical analysis included a repeated measures analysis of covariance (RM-ANCOVA). Complementarily, the residents provided their perceptions about the simulation with feedback activities.
Results
Fifty-eight residents completed the program. The simulations lasted on average 12 minutes, feedback 5 minutes and SPIKES training between 1h and 2h30m. There was no significant difference in the residents’ performances according to the SPs’ evaluations (p = 0.55). The participants rated the simulation with feedback exercises highly. These educational activities might have offset SPIKES training impact. Conclusion The SPIKES training did not significantly impact the residents’ performance. The residents endorsed the simulation with feedback as a useful training modality. Further research is needed to determine which modality is more effective.
Key-words educationHealth communicationinternship and residencymedicalpatient simulationperinatologySee moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Case Report09-01-2018
Diagnosis of Atelosteogenesis Type I suggested by Fetal Ultrasonography and Atypical Paternal Phenotype with Mosaicism
Revista Brasileira de Ginecologia e Obstetrícia. 2018;40(9):570-575
Abstract
Case ReportDiagnosis of Atelosteogenesis Type I suggested by Fetal Ultrasonography and Atypical Paternal Phenotype with Mosaicism
Revista Brasileira de Ginecologia e Obstetrícia. 2018;40(9):570-575
Views245Abstract
Atelosteogenesis type I (AOI) is an autosomal dominant skeletal dysplasia caused by mutations in the filamin B (FLNB) gene with classic and well-recognizable clinical findings. However, parents affected with a mild phenotype, probably with somatic mosaicism, can generate offspring with a much more severe phenotype of AOI. In the present report, we describe a female newborn with classic AOI leading to early neonatal death, whose diagnostic was based on prenatal radiological findings and on the physical examination of the father. Since her father had limb deformities and corporal asymmetry, suggesting somatic mosaicism, his biological samples were analyzed through a gene panel for skeletal dysplasias. A missense mutation not previously described in the literature was detected in the FLNB gene, affecting ~ 20% of the evaluated cells and, therefore, confirming the diagnosis ofmosaic AOI in the father. The molecular analysis of the father was crucial to suggest the diagnosis of AOI in the newborn, since she died early and there were no biological samples available.
Key-words atelosteogenesisexome-target sequencingFetal ultrasonographyFLNBskeletal dysplasiasomatic mosaicismSee moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 
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Case Report01-24-2021
Antenatal Diagnosis of Parapagus Conjoined Twins: 3D Virtual and 3D Physical Models
- Pedro Castro ,
- Heron Werner ,
- Ana Paula Matos ,
- Gerson Ribeiro ,
- Jorge Lopes , [ … ],
- Edward Araujo Júnior
Abstract
Case ReportAntenatal Diagnosis of Parapagus Conjoined Twins: 3D Virtual and 3D Physical Models
Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(12):985-987
Views233See moreAbstract
Conjoined twins (CTs) are a rare complication from monochorionic and monoamniotic twin pregnancies. We describe the use of 3D technologies, including 3D virtual and 3D physical models on prenatal evaluation of one parapagus CT. A 16-year-old G1P0 woman was referred for fetal magnetic resonance imaging (MRI) anatomical evaluation of a CT at 28 weeks of gestation. 3D images of the fetal surface were generated by the software during the examination for spatial comprehension of the relationship between the fetal parts. The pair of CTs died at the 32nd week of gestation, a few hours after cesarean section. 3D technologies are an important tool for parental counseling and preparation of the multidisciplinary care team for delivery and neonatal assistance and possible surgical planning for postnatal separation in CTs cases.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 
- Pedro Castro
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Original Article05-24-2021
Disease Progression and Obstetric Outcomes of Women with Multiple Sclerosis at a Reference Center in Northeastern Brazil
- Gabrielle Maria Carvalho de Barros ,
- Bianca Etelvina Santos de Oliveira ,
- Gabriela Januário Oliveira ,
- Rômulo Kunrath Pinto Silva ,
- Thiago Nóbrega Cardoso , [ … ],
- Sabina Bastos Maia
Abstract
Original ArticleDisease Progression and Obstetric Outcomes of Women with Multiple Sclerosis at a Reference Center in Northeastern Brazil
Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(3):165-171
- Gabrielle Maria Carvalho de Barros ,
- Bianca Etelvina Santos de Oliveira ,
- Gabriela Januário Oliveira ,
- Rômulo Kunrath Pinto Silva ,
- Thiago Nóbrega Cardoso ,
- Sabina Bastos Maia
Views250See moreAbstract
Objective
To describe the obstetric outcomes of patients withmultiple sclerosis (MS) and the impact of pregnancy and the postpartum period on the progression of the disease.
Methods
A case series study performed between December 2019 and February 2020, reporting pregnancies occurred between 1996 and 2019. The subjects included were women with MS undergoing follow-up at an MS referral center in Northeastern Brazil, and who had at least one pregnancy after the onset of MS symptoms, or who had their first relapse in the first year after delivery.
Results
In total, 26 women and 38 pregnancies were analyzed – 32 of them resulted in delivery, and the remaining 6, in miscarriages. There was a significant increase in the prevalence of relapse during the postpartum period when compared with the gestational period. In 16 (42.1%) of the pregnancies, there was exposure to diseasemodifying therapies (DMTs) – 14 (36.8%), to interferon β, and 2 (5.3%), to fingolimod. Higher rates of abortion, prematurity and low birth weight were reported in the group was exposed to DMT when compared with the one who was not.
Conclusion
In the sample of the present study, there was a significant increase in the rate of MS relapse during the postpartum period when compared with the gestational period. Additionally, it seems that exposure to DMTs during pregnancy may affect the obstetric outcomes of the patients.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 
- Gabrielle Maria Carvalho de Barros
-
FEBRASGO POSITION STATEMENT01-23-2022
Screening, diagnosis and management of hypothyroidism in pregnancy: Number 10 – October 2022
- Sara Toassa Gomes Solha ,
- Rosiane Mattar ,
- Patrícia de Fátima dos Santos Teixeira ,
- Maria Izabel Chiamolera ,
- Carlos Alberto Maganha , [ … ],
- Renato Teixeira Souza
Abstract
FEBRASGO POSITION STATEMENTScreening, diagnosis and management of hypothyroidism in pregnancy: Number 10 – October 2022
Revista Brasileira de Ginecologia e Obstetrícia. 2022;44(10):999-1009
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Sara Toassa Gomes Solha
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