Articles - Revista Brasileira de Ginecologia e Obstetrícia

Resumos de Teses06-19-2002

Linfonodo Sentinela no Carcinoma Infiltrativo Inicial de Mama: Estudo de sua Localização e de sua Capacidade Preditiva em Relação ao Estado da Axila
- José Roberto Morales Piato
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):69-69

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Abstract
Resumos de Teses
Linfonodo Sentinela no Carcinoma Infiltrativo Inicial de Mama: Estudo de sua Localização e de sua Capacidade Preditiva em Relação ao Estado da Axila
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):69-69
DOI 10.1590/S0100-72032002000100014
José Roberto Morales Piato
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Linfonodo Sentinela no Carcinoma Infiltrativo Inicial de Mama: Estudo de sua Localização e de sua Capacidade Preditiva em Relação ao Estado da Axila […]
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Resumos de Teses06-19-2002

Avaliação da Função Ovariana Pós-histerectomia Total Abdominal em Mulheres no Menacme
- Eliana Aguiar Petri Nahás
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):69-69

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Resumos de Teses
Avaliação da Função Ovariana Pós-histerectomia Total Abdominal em Mulheres no Menacme
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):69-69
DOI 10.1590/S0100-72032002000100013
Eliana Aguiar Petri Nahás
Views76
Avaliação da Função Ovariana Pós-histerectomia Total Abdominal em Mulheres no Menacme […]
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Resumos de Teses06-19-2002

Efeitos do Tabagismo na Circulação Arterial Materna e Fetal: Estudo Através do Método Doppler
- Renata Alberge Giugliano Meschino
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):68-68

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Resumos de Teses
Efeitos do Tabagismo na Circulação Arterial Materna e Fetal: Estudo Através do Método Doppler
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):68-68
DOI 10.1590/S0100-72032002000100012
Renata Alberge Giugliano Meschino
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Efeitos do Tabagismo na Circulação Arterial Materna e Fetal: Estudo Através do Método Doppler […]
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Resumos de Teses06-19-2002

Terapia com Raloxifeno na Pós-menopausa: Efeitos sobre o Sistema Hemostático
- George Dantas de Azevedo
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):67-67

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Resumos de Teses
Terapia com Raloxifeno na Pós-menopausa: Efeitos sobre o Sistema Hemostático
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):67-67
DOI 10.1590/S0100-72032002000100010
George Dantas de Azevedo
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Terapia com Raloxifeno na Pós-menopausa: Efeitos sobre o Sistema Hemostático […]
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Resumos de Teses06-19-2002

Efeitos da Metiltestosterona sobre a Sexualidade, Metabolismo Lipoproteíco e Hepático e Níveis de Testosterona em Mulheres na Pós-Menopausa em Uso de Reposição Estroprogestativa
- Fernando José Felipe de Paula
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):67-68

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Resumos de Teses
Efeitos da Metiltestosterona sobre a Sexualidade, Metabolismo Lipoproteíco e Hepático e Níveis de Testosterona em Mulheres na Pós-Menopausa em Uso de Reposição Estroprogestativa
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):67-68
DOI 10.1590/S0100-72032002000100011
Fernando José Felipe de Paula
Views53
Efeitos da Metiltestosterona sobre a Sexualidade, Metabolismo Lipoproteíco e Hepático e Níveis de Testosterona em Mulheres na Pós-Menopausa em Uso de Reposição Estroprogestativa […]
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original Article06-19-2002

Knowledge and Opinion of Brazilian Researchers About Informed Consent
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):59-65

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
Knowledge and Opinion of Brazilian Researchers About Informed Consent
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):59-65
DOI 10.1590/S0100-72032002000100009
Hardy Ellen,
Silvana Ferreira Bento,
Maria José Duarte Osis
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Introduction: the Resolution 196/96 of the Conselho Nacional de Saúde (National Council of Health/Ministry of Health) presents the main Brazilian guidelines on research involving human subjects, including the content of written informed consent. Purpose: to present the knowledge and opinion of Brazilian researchers on the contents of Resolution 196/96, specifically related to the informed consent form. Subjects and methods: forty-six doctors responsible for the area of gynecology at Brazilian universities, four directors of research centers and 31 researchers who participated in a study related to fertility regulation during the 12 months preceding September, 2000. Subjects completed a self-reporting questionnaire. Data were analyzed by the chi² test. Results: most subjects declared that they knew the Resolution 196/96 and considered it adequate, although difficult to comply with; they considered that all studies should have an informed consent form, and knew that its content should guarantee confidentiality. More researchers than those responsible for gynecology department/directors knew that the informed consent form should be prepared by the principal investigator. Significantly more responsible for gynecology department/directors than researchers declared that subjects must always sign (or put their thumb print if they do not know how to write) on the informed consent form. Subjects declared that payment of expenses resulting from participation in a study must always be explained in the informed consent form. Conclusion: despite the wide dissemination of the Resolution 196/96, it was not known by all the researchers nor by all those responsible for gynecology departament/directors. The majority agreed with the contents required by the Resolution for the informed consent form.

Key-words Ethics Committee Informed consent
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Original Article06-19-2002

p53 Protein Overexpression as a Prognostic Marker for Vulvar Intraepithelial Neoplasia III Recurrence/Progression
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):51-57

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
p53 Protein Overexpression as a Prognostic Marker for Vulvar Intraepithelial Neoplasia III Recurrence/Progression
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):51-57
DOI 10.1590/S0100-72032002000100008
Isabel Cristina Chulvis do Val Guimarães,
Gutemberg Leão de Almeida Filho,
Maria da Glória de Carvalho,
Christina Maeda Takiya,
Aldo Franklin Ferreira Reis,
Paulo Marcos Valiante,
Maria Consuelo Gondim
Views160
Purpose: to evaluate p53 overexpression value in vulvar intraepithelial neoplasia (VIN) III recurrence/progression. Methods: twenty patients with undifferentiated VIN III were selected and followed up every six months for four years and divided into two groups: fourteen without and six with recurrence/progression lesion. The recurrence/progression cases were distributed as follows: in three patients recurrence occurred only once; in two, twice, and only one progressed to squamous cancer. In both groups the site of vulvar lesion and p53 overexpression and immunostaining pattern were analyzed. A similar study was performed in recurrence/progression cases, besides the analysis of the time interval to occur the arise of recurrence/progression. Results: recurrence was observed in 25% of the cases and, in 5%, progression to carcinoma. The mean time interval for recurrence was 24.5 months. Multifocal location of the initial lesion was the predominant form (50%) in both groups. In the majority of the cases (87.5%) recurrence/progression occurred at the same site of the initial vulvar lesion. p53 overexpression was observed in 50% of the VIN III primary lesions and in 75% of the recurrence/progression cases. Conclusions: p53 overexpression seems to play an important role in VIN III pathogenesis and may predict the clinical course of the lesions. VIN III recurrence/progression has a tendency to occur in the same area of the initial lesion, suggesting the presence of molecular disturbance.

Key-words Oncogenes Vulva: preneoplastic lesions Vulvar intraepithelial neoplasia
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Original Article06-19-2002

Endometrial Adenocarcinoma Frequency in a Hysteroscopy Outpatient Clinic: A Multicenter Study
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):45-50

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
Endometrial Adenocarcinoma Frequency in a Hysteroscopy Outpatient Clinic: A Multicenter Study
Revista Brasileira de Ginecologia e Obstetrícia. 2002;24(1):45-50
DOI 10.1590/S0100-72032002000100007
Francesco Antonio Viscomi,
Sonia Maria Rolim Rosa Lima,
José Mendes Aldrighi,
Mauro Fernando Kürten Ihlenfeld
Views94
Purpose: to perform a census about the frequency of endometrial adenocarcinoma of women submitted to diagnostic hysteroscopy in five Brazilian hysteroscopic centers in São Paulo, Rio de Janeiro, Salvador, Caxias do Sul and Porto Alegre. Methods: information was collected from standard questionnaires about the presence of endometrial adenocarcinoma, hysteroscopic staging and histologic type, in pre- and postmenopausal women. Results: among 6,466 hysteroscopic procedures, endometrial adenocarcinoma was present in 92 patients (1.4%), confirmed by histology in 79 (1.2%) cases. For the hysteroscopic diagnosis of endometrial adenocarcinoma confirmed by histology, a sensitivity of 85.9%, specificity of 100%, positive predictive value of 100% and negative predictive value of 98.6% were obtained. In the premenopausal group, among 3,845 hysteroscopic exams, endometrial cancer was present in 83 (3.2%) and confirmed by histology in 71 cases (2.7%). Conclusions: this study points out the importance of epidemiological methods in the diagnostic and prevention programs of endometrial cancer, specially in postmenopause, revealing the need for further epidemiological studies on endometrial adenocarcinoma diagnostis and prevention programs.

Key-words Cancer screening Endometrial neoplasms Endometrial neoplasms, epidemiology Endometrial neoplasms, histology Hysteroscopy
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Nominata 202412-31-2024

Nominata 2024
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:eRBGO20242024

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Abstract
Nominata 2024
Nominata 2024
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:eRBGO20242024
DOI 10.61622/rbgo/2024nominata02024
Views191
We wish to thank everyone who contributed to the edition of the Revista Brasileira de Ginecologia e Obstetrícia – RBGO volume 46, year 2024, especially the authors and reviewers whose work and opinions were essential to maintain the scientific and methodological rigor of the published articles.A. Seval Ozgu-Erdinc, University of Health Sciences, Ankara Eğitim ve […]
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Review Article12-04-2024

Self-medication among pregnant women in comparison to the general population: a scoping review of the main characteristics
- Gabriela Pereira ,
- Cinthia Madeira de Souza ,
- Amanda Canato Ferracini ,
- Fernanda Garanhani Surita ,
- Sherif Eltonsy ,
- Priscila Gava Mazzola
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo77

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Review Article
Self-medication among pregnant women in comparison to the general population: a scoping review of the main characteristics
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo77
DOI 10.61622/rbgo/2024rbgo77
Gabriela Pereira ,
Cinthia Madeira de Souza ,
Amanda Canato Ferracini ,
Fernanda Garanhani Surita ,
Sherif Eltonsy ,
Priscila Gava Mazzola
Views248
Abstract

Objective:

An in-depth evaluation of the published evidence is needed on self-medication, specifically the evidence focusing on vulnerable groups, such as pregnant women. This scoping review aims to provide an overview of the differences in self-medication prevalence and study characteristics among different groups, while identifying gaps in the literature.

Methods:

A literature search was performed in PubMed and Web of Science, including articles published in the last 10 years for the pregnant women group (PWG) and the general population group (GPG). Data on study design, self-medication prevalence, medications used, and other variables were collected, tabulated, and summarized.

Results:

From 2888 screened articles, 75 were considered including 108,559 individuals. The self-medication (SM) in the PWG ranged from 2.6 to 72.4% and most studies had an SM prevalence between 21 and 50% and in the GPG, 32 from 50 studies had a SM prevalence higher than 50%. The reviewed studies varied considerably in methodology, requiring careful interpretation. While most of the studies assessed self-medication during the entire pregnancy, self-medication definition was often inconsistent between studies. Acetaminophen was the most used medication and headache was the most frequent symptom leading to self-medication initiation in the PWG.

Conclusions:

Self-medication among pregnant women showed a lower prevalence when compared to the general population. The medications used and symptoms reported were similar between groups. However, methodological differences must be carefully considered. Pregnant women should carefully follow their physicians’ advice before initiating self-medication to avoid preventable maternal and fetal adverse effects.

Key-words drug-related side effects and adverse reactions Medication use Pregnant women Self-medication
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Review Article12-04-2024

Metformin versus insulin in gestational diabetes mellitus: a systematic review
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo89

Views318

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Review Article
Metformin versus insulin in gestational diabetes mellitus: a systematic review
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo89
DOI 10.61622/rbgo/2024rbgo89
Giovanna Noronha Berti ,
Igor Gutschov Oviedo Garcia ,
João Pedro Ruas Floriano de Toledo ,
Júlia Rodrigues Tatemoto ,
Lais Watanabe Marino ,
Mariana de Medeiros Legori ,
Sérgio Floriano de Toledo
Views318
Abstract

Objective:

The aim of this study is to assess the use of metformin with or without insulin for the treatment of Gestational Diabetes Mellitus compared to insulin alone.

Data sources:

This article consists of a systematic review of randomized clinical trials. The searches were carried out on MEDLINE including 7 studies, between 2010 to 2021.

Study selection:

Randomized clinical trials comparing metformin and insulin written in English, Spanish or Portuguese, with no time limit, were included.

Data collection:

Data was extracted from all the 7 articles and compared statistically when possible. Whenever data was not available or couldn’t be statistically compared, the main results were described in detail.

Data synthesis:

Insulin alone is not superior than metformin with or without insulin on gestational diabetes mellitus.

Conclusion:

There is a potential viability of using metformin as an alternative compared to insulin alone in the treatment of Gestational Diabetes Mellitus. However, all assessed outcomes have a very low level of certainty of evidence and more studies are necessary to support these findings.

Key-words Gestational diabetes Insulin therapy Metformin Pregnancy complications
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Letter to the Editor12-04-2024

Comment on: Effects of COVID-19 on human placentas in the second and third trimester
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo88

Views141

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Letter to the Editor
Comment on: Effects of COVID-19 on human placentas in the second and third trimester
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo88
DOI 10.61622/rbgo/2024rbgo88
Nayara Ribeiro Máximo de Almeida ,
Mateus Augusto Felix de Melo ,
Pâmela Marillac Rodrigues Feijó de Melo ,
Julio Martinez Santos ,
Johnnatas Mikael Lopes
Views141
Recent evidence demonstrates na increase in negative maternal and neonatal outcomes in cases of SARS-CoV-2 infection, such as greater severity of the disease, need for mechanical ventilation and longer hospitalization in intensive care units.(,) The greater severity of infectious diseases in pregnancy occurs due to anatomical and immunological changes, such as a change in the […]
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Original Article12-04-2024

Analysis of vaginal microbiota before and after treatment of high-grade squamous intraepithelial lesions of the uterine cervix
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo86

Views207

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
Analysis of vaginal microbiota before and after treatment of high-grade squamous intraepithelial lesions of the uterine cervix
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo86
DOI 10.61622/rbgo/2024rbgo86
Patrícia Mendonça Ventura ,
Isabel Cristina Chulvis do Val Guimarães ,
Luis Guillermo Coca Velarde ,
Susana Cristina Aidé Viviani Fialho ,
Douglas Guedes Ferreira ,
Matheus Madureira Fernandes ,
Rafael Augusto Chaves Machado
Views207
Abstract

Objective:

HPV infection is considered the most common sexually transmitted virus today. The persistence of HPV is the main cause for the development of precursor lesions and cervical cancer. There are environmental and non-environmental factors that contribute to the persistence of the virus. Studies indicate a possible relationship between the vaginal microbiota (environmental factor) and the risk of high-grade cervical squamous intraepithelial lesions and cervical cancer. This study evaluates the association between the type of vaginal microbiota and the occurrence of high-grade squamous intraepithelial lesions of the cervix.

Methods:

Observational, longitudinal, prospective, and analytical studies carried out between 2019 and 2021, which evaluated the vaginal microbiota of patients diagnosed with high-grade cervical squamous intraepithelial lesion before and after treatment in two collections with an interval of 6 months, using scrapings and vaginal swabs.

Results:

In Group I (with lesions) 28 women participated and 29 in Group II (without lesions). According to Nugent, in the initial collection of Group I, 16 women (57%) had lactobacillary microbiota, eight (28%) intermediate, and four (14%) coccus. In Group II, twenty-one (75%) were lactobacillary, one (3%) was intermediate, and seven (24%) werecoccus. With p=0.03.

Conclusion:

According to Nugent’s criteria, there was an association between the type of vaginal microbiota and the occurrence of high-grade cervical squamous intraepithelial lesions of the cervix. The same was not observed in the Donders classification. Studies with a larger sample are needed to confirm our results.

Key-words Cervixuteri microbiota Papillomavirus infections squamous intraepithelial lesions of the cervix Uterine cervical neoplasms Vaginosis, bacterial
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Original Article12-04-2024

Systemic inflammatory indices as a non-invasive grading modality for endometriosis: a comparative study versus exploratory laparoscopy
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo84

Views207

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
Systemic inflammatory indices as a non-invasive grading modality for endometriosis: a comparative study versus exploratory laparoscopy
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo84
DOI 10.61622/rbgo/2024rbgo84
Ahmed Sabra Ibrahim Mohammed Sabra ,
Shreen Naguib Aboelezz Moselhy ,
Ahmed Kasem Mohamed Zain Eldin
Views207
Abstract

Objective:

Included evaluation of the possibility of using the systemic inflammatory indices for preoperative screening for the presence and severity of endometriosis (EM) in comparison to the findings of the exploratory laparoscopy

Methods:

88 women with clinical manifestations suggestive of EM were evaluated clinically and by US and gave blood samples for estimation of serum cancer antigen-125 (CA125), platelet and total and differential leucocytic counts for calculation of inflammatory indices; the Systemic Immune-Inflammation index, the Systemic Inflammation Response Index (SIRI), the Neutrophil-Lymphocyte ratio (NLR), the Neutrophil-Monocyte ratio, the Neutrophil-Platelet ratio and the Platelet-Lymphocyte ratio. Then, patients were prepared to undergo laparoscopy for diagnosis and staging.

Results:

Laparoscopy detected EM lesions in 63 patients; 27 of stage I-II and 36 of stage III-IV. Positive laparoscopy showed significant relation with US grading, high serum CA125 levels, platelet and inflammatory cell counts and indices. Statistical analyses defined high SIRI and NLR as the significant predictors for positive laparoscopy and high serum CA125 and NLR as the most significant predictors for severe EM (stage III-IV) on laparoscopy

Conclusion:

The intimate relation between EM and inflammation was reflected systematically as high levels of blood cellular components, but indices related to neutrophil especially NLR and SIRI showed highly significant relation to the presence and severity of EM and might be used as routine, cheap and non-invasive screening test before exploratory laparoscopy to guide the decision-making.

Key-words CA125 antigen Endometriosis Inflammation Laparoscopy Leukocyte count Lymphocytes Neutrophils
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Letter to the Editor12-04-2024

Comment on: Effect of combined training on body image, body composition and functional capacity in patients with breast cancer: controlled clinical trial
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo96

Views193

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Letter to the Editor
Comment on: Effect of combined training on body image, body composition and functional capacity in patients with breast cancer: controlled clinical trial
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo96
DOI 10.61622/rbgo/2024rbgo96
Piyush Bharadwaj ,
Divya Khati ,
Simran Sunil Khutarkar ,
Sweta Verma
Views193
Dear Editor,I am writing to express my appreciation for the recent article titled “Effect of Combined Training on Body Image, Body Composition, and Functional Capacity in Patients with Breast Cancer: Controlled Clinical Trial,” published online on June 20, 2023. The study provides crucial insights into the benefits of combined training for breast cancer patients, highlighting […]
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Review Article12-04-2024

Female genital tract microbiome: the influence of probiotics on assisted reproduction
- Ana Sofia Almeida Santana ,
- Ana Margarida Póvoa
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo82

Views214

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Review Article
Female genital tract microbiome: the influence of probiotics on assisted reproduction
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo82
DOI 10.61622/rbgo/2024rbgo82
Ana Sofia Almeida Santana ,
Ana Margarida Póvoa
Views214
Abstract

Assisted reproductive technology (ART) has been evolving since 1978, with the number of techniques performed increasing over the years. Despite continued advances, some couples continue to have difficulties getting pregnant, and it has recently been considered that the microbiome of the female genital tract (FGT) may influence embryo implantation and the establishment of pregnancy. This review aims to evaluate the role of probiotics on reproductive outcomes in infertile women on ART. A search throughout medical databases was performed, and six articles met the criteria. Five studies showed improvements in pregnancy rates, with only one demonstrating statistical significance. One article showed no improvement but reported a statistically significant reduction in the miscarriage rate in the probiotic group. Further research is needed to evaluate the true potential of probiotics, namely to assess whether they effectively modulate the FGT microbiome and if these changes are maintained over time.

Key-words Abortion, spontaneous Embryo implantation Genitalia, female Infertility, female Pregnancy outcome Pregnancy rate Probiotics Reproductive techniques, assisted, Microbiota
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Review Article03-18-2025

Short cervix and use of cervical pessary for preventing preterm birth in singleton and twin pregnancies: a systematic review and meta-analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo10

Views172

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Review Article
Short cervix and use of cervical pessary for preventing preterm birth in singleton and twin pregnancies: a systematic review and meta-analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo10
DOI 10.61622/rbgo/2025rbgo10
Ana Clara Felix de Farias Santos ,
Nicole dos Santos Pimenta ,
Ana Gabriela Alves Pereira ,
Gabriela Oliveira Gonçalves Molino ,
Maírla Marina Ferreira Dias ,
Pedro Henrique Costa Matos da Silva
Views172
Abstract

Objective:

Preterm birth remains a significant contributor to neonatal morbidity and mortality. The use of cervical pessaries as an intervention for preventing preterm delivery in women with a short cervix has been a subject of interest. We evaluated the effectiveness of cervical pessary compared to standard care in preventing preterm delivery in women with a short cervix.

Data source:

Databases were systematically searched in PubMed, Cochrane, and Embase databases in December 2023.

Study selection:

Randomized clinical trials with the outcomes of interest were included.

Data collect:

We computed risk ratios for binary endpoints, with 95% confidence intervals. Heterogeneity was assessed using I2 statistics. Data were analyzed using R software (version 4.3.0). The primary outcomes of interest were preterm delivery before 37 weeks, and preterm delivery before 34 weeks.

Data synthesis:

Seventeen studies with 5,704 patients were included. The use of cervical pessary was associated with a decreased risk of preterm delivery before 37 (RR 0.88; 95% CI 0.81-0.96) and 34 weeks (RR 0.79; 95% CI 0.63-0.99) of gestation in twin pregnancies as compared to standard care without progesterone. There were no significant differences in preterm delivery in singleton pregnancy, neonatal outcomes, preterm premature rupture of the membranes or chorioamnionitis.

Conclusion:

The use of cervical pessary was associated with a significant reduction in preterm delivery at 34 and 37 weeks of gestation in twin pregnancies among patients with a short cervix compared to no treatment. No significant difference was found in singleton pregnancies or maternal outcomes.

Key-words Cervical length measurement Pessaries Progesterone, Premature birth short cervix
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Short Communication03-18-2025

Contraception in adolescents with mental disorders: adherence and satisfaction in the use of depot medroxyprogesterone acetate
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo9

Views172

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Short Communication
Contraception in adolescents with mental disorders: adherence and satisfaction in the use of depot medroxyprogesterone acetate
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo9
DOI 10.61622/rbgo/2025rbgo9
Giani Silvana Schwengber Cezimbra ,
Edward Araujo Júnior ,
Cristina Aparecida Falbo Guazzelli
Views172
Abstract

Objective:

To evaluate the continuation rate, satisfaction, and reasons for discontinuation of depot medroxyprogesterone acetate (DMPA) in adolescents treated in a mental health service.

Methods:

Prospective cohort study conducted in a reference unit for the care of adolescents with mental disorders (MDs) and intellectual disabilities (IDs). All patients received a gynecological consultation and an educational group on contraceptive methods. Sociodemographic data on age, education and gynecological data (menarche, coitarche, regularity of menstrual cycles and presence of symptoms) were collected. Follow-up was quarterly for 12 months, during which symptoms, desire to continue, and satisfaction with the use of the quarterly injectable were assessed.

Results:

Eight hundred and sixty-two sexually active adolescents were supported, 532 adolescents chose to use the quarterly injectable, and 69 of these agreed to participate in the study. The mean age of users was 15.5 years (SD=0.91). After 12 months of follow-up, 34 (49.3%) of the 69 adolescents continued to use the method and 36 (52.3%) were satisfied. Among the 33 (47.8%) who discontinued use, the most common reasons were irregular bleeding and weight gain.

Conclusions:

Adolescents with intellectual disabilities and/or other mental disorders showed a significant rate of continuation and satisfaction with the use of the depot medroxyprogesterone acetate at 12 months, and the most common reasons for discontinuation were irregular uterine bleeding and weight gain.

Key-words Contraception Medroxyprogesterone acetate Mental disorders Pregnancy Pregnancy in adolescence
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original Article03-18-2025

The experience of pregnancy in the COVID-19 pandemic
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo8

Views187

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
The experience of pregnancy in the COVID-19 pandemic
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo8
DOI 10.61622/rbgo/2025rbgo8
Mariana Corniani Lopes ,
Cheryl Tatano Beck ,
Zelina Hilária de Souza Rosa ,
Erika de Sá Vieira Abuchaim
Views187
Abstract

Objective:

To describe women’s experience of pregnancy during the COVID-19 pandemic.

Methods:

A qualitative study conducted in a private maternity hospital, from May, 2020 to November, 2021, with women aged ≥ 18 years, gestational age ≥ 36 weeks at birth and ≥ 24 hours post-partum. Data collected through semi-structured interviews, recorded, transcribed, and analyzed adopting Krippendorff’s Content Analysis as theoretical-methodological framework.

Results:

Four main themes emerged: Fear, Taking care and celebrating pregnancy: adjusting to the new reality, Harms of Isolation, and Benefits of Isolation. The fear of contamination and its impact on the health of mother and child resulted in the adoption of severe social isolation, including from those considered sources of support by the expecting mother. Overwhelmed, some of the participants reported loneliness and psychic suffering. The opportunity to focus on the pregnancy, the preparations for the arrival of the child, and the family made isolation a beneficial and positive period for other women.

Conclusion:

The experience of pregnancy in the Pandemic was an event outside of the ordinary and common. The expecting mother faced her worst fears on a daily basis and attended prenatal care, in order to ensure her child would be born healthy. The celebration of the baby’s life, amid so many deaths, had to be adjusted to the virtual environment. It was a tense, solitary, and ambiguous period, which demanded a lot from the mental health of some participants, but to others, brought advantages that would not have been possible in different times.

Key-words COVID-19 Mental health pandemics Pregnancy Pregnant women
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original Article03-18-2025

Effect of COVID-19 on Brazilian cesarean and prematurity rates: a cross-sectional study
- Clarissa Suzart ,
- José Paulo de Siqueira Guida
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo6

Views166

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
Effect of COVID-19 on Brazilian cesarean and prematurity rates: a cross-sectional study
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo6
DOI 10.61622/rbgo/2025rbgo6
Clarissa Suzart ,
José Paulo de Siqueira Guida
Views166
Abstract

Objective:

To investigate the relationship between prematurity and cesarean section rate in Brazil during the beginning of COVID-19 pandemic.

Methods:

Utilizing the Robson Classification, this study analyzed data from the Brazilian Ministry of Health’s Live Births Panel, comparing CSR) and group 10 (preterm deliveries) between 2019 (pre-pandemic) and 2021 (pandemic) in each of Brazilian states and the overall country. The prematurity and CSR were compared using prevalence ratio and confidence interval, and p-value was obtained. The variation of prematurity and CSR were compared through the coefficient of determination (R2).

Results:

A total of 5,522,910 deliveries were evaluated during the period. The CSR increased from 56.34% to 57.05% (p<0.01), and the frequency of preterm deliveries rose from 8.99% to 9.13% (p<0.01). The CSR increased in 23 States and decreased in 4 States, while the prematurity rate increased in 16 States and decreased in 10 States. A positive relationship between the increase of CSR and prematurity was observed during COVID-19, with an R2 value of 0.3121, suggesting a moderate association between these two variables.

Conclusion:

Between 2019 (pre-COVID-19 pandemic) and 2021 (the first full year of the COVID-19 pandemic), there was an increase in prematurity and CSR in Brazil. These increases were observed in most Brazilian states and may be correlated. However, it is impossible to establish a cause-effect relationship given the design of this study.

Key-words Cesarean delivery COVID-19 Infant, newborn Live birth Maternal mortality pandemics Prematurity
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original Article03-18-2025

Accurate evaluation of mode of delivery and labor progression with angle of progression: a prospective cross-sectional
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo5

Views156

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
Accurate evaluation of mode of delivery and labor progression with angle of progression: a prospective cross-sectional
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo5
DOI 10.61622/rbgo/2025rbgo5
Huong Lam Le ,
Huy Vu Quoc Nguyen ,
Tam Minh Le ,
Lam Hoang Vo
Views156
Abstract

Objective:

To determine the validity of the angle of progression (AoP) in predicting delivery mode among women in the second stage of labor.

Designs:

This prospective cohort study was conducted at the Obstetrics and Gynecology unit (OBGYN) of two hospitals in Vietnam. Transperineal ultrasound was performed for each woman to measure the progression angle in the second phase of labor.

Participants:

A total of 725 women with singleton pregnancies with cephalic presentation at term

Methods:

Transperineal ultrasound was used to measure the angle of progression in the second labor phase and to identify the delivery method.

Results:

The rate of vaginal birth in women with an AoP ≥ 120° on transperineal ultrasound was 70.2%. The optimal cutoff point of AOP ≥122° with sensitivity and specificity for vaginal birth were 87.8% and 80.7%, respectively the area under the ROC curve of 0.887 (p<0.0001). The study's sample size was restricted owing to deficiencies in resources and time.

Conclusion:

The likelihood of achieving spontaneous vaginal delivery can be predicted by the angle of progression measured with transperineal intrapartum ultrasonography during the second stage of labor in women.

Key-words Cesarean section Delivery, obstetric Labor stage, second Pregnancy Ultrasonography
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Original Article03-18-2025

Gastrin-releasing peptide receptor: a promising new biomarker to identify cervical precursor lesions and cancer
- Martina Lichtenfels ,
- Rafaella Almeida Lima Nunes ,
- Rossana Veronica Mendoza López ,
- Camila Alves da Silva ,
- Luiz Carlos Zeferino ,
- Lara Termini
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo4

Views137

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Original Article
Gastrin-releasing peptide receptor: a promising new biomarker to identify cervical precursor lesions and cancer
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo4
DOI 10.61622/rbgo/2025rbgo4
Martina Lichtenfels ,
Rafaella Almeida Lima Nunes ,
Rossana Veronica Mendoza López ,
Camila Alves da Silva ,
Luiz Carlos Zeferino ,
Vanesca de Souza Lino ,
Adhemar Longatto-Filho ,
Louise De Brot ,
Silvia Helena Rabelo-Santos ,
Daniela Baumann Cornelio ,
Enrique Boccardo ,
Caroline Brunetto de Farias ,
Lara Termini
Views137
Abstract

Objective:

This study aimed to verify the relation between gastrin-releasing peptide receptor (GRPR), oncogenic Human Papillomavirus (HPV) and cervical lesions severity.

Methods:

GRPR mRNA levels were evaluated in cervical cancer-derived cell lines and in primary keratinocytes expressing HPV16 oncogenes by RT-PCR. GRPR protein expression was assessed by immunohistochemistry in organotypic cell cultures derived from keratinocytes transduced with HPV16 oncogenes and in 208 cervical samples, including 59 non-neoplastic tissue, 28 cervical intraepithelial neoplasia grade 3 (CIN3), 44 squamous cell carcinomas (SCC) and 77 adenocarcinomas (ADC). Generic primers (GP5+/GP6+) were used to identify HPV infection in tissue samples. Experiments involving cell lines were analyzed through non-parametric tests (Kruskal Wallis), and Fisher’s Exact Test for human tissues samples. All statistical tests were considered significant at p <0.05. Immunohistochemical evaluation was conducted independently and blindly by two observers (AD- LO). Any discordant findings were resolved through discussion to reach a consensus score.

Results:

GRPR mRNA levels were not increased in cells expressing HPV16 or HPV18 oncogenes. However, at the protein level, GRPR was upregulated in organotypic cell cultures containing HPV oncogenes. Besides, it was identified an association between GRPR expression and cervical lesion severity (p < 0.0001). The detection rate of high-risk HPV DNA was directly correlated with cervical disease. Nonetheless, HPV infection was not directly associated with GRPR in cervical samples.

Conclusion:

GRPR expression is highly predictive of cervical lesion severity, irrespective of HPV infection and might contribute to improving patient’s therapeutic management as well as being used a marker of disease progression.

Key-words Adenocarcinoma Carcinoma, squamous cell Gastrin-releasing peptide receptor Human papillomavirus Oncogenes Papillomavirus infections Uterine cervical dysplasia Uterine cervical neoplasms
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Review Article03-18-2025

Low-level laser therapy for nipple trauma and pain during breastfeeding: systematic review and meta-analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo3

Views147

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Review Article
Low-level laser therapy for nipple trauma and pain during breastfeeding: systematic review and meta-analysis
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo3
DOI 10.61622/rbgo/2025rbgo3
Maria Victória Candida Gaitero ,
Ticiana Aparecida Alves de Mira ,
Edna Jéssica Lima Gondim ,
Simony Lira do Nascimento ,
Fernanda Garanhani Surita
Views147
Abstract

Objective:

This study aimed to investigate the effect of low-level laser therapy (LLLT) on nipple trauma and pain during breastfeeding through a systematic review with a meta-analysis of selected studies.

Source of the data:

A thorough search was conducted on March 22, 2022, using the databases PubMed, SciELO, LILACS, PEDro, CINAHL, EMBASE, ScienceDirect, Scopus, Google Scholar, MEDLINE, the Cochrane Library, Clinical Trials, Web of Science, TRIP, DARE, and ProQuest. The search terms included various combinations of low-level laser therapy, nipple pain, nipple trauma, and breastfeeding.

Studies selection:

Out of 107 articles identified, only three controlled and randomized clinical trials was included. The extracted data encompassed breast and trauma characteristics, treatment types, outcomes (pain and healing process), evaluation tools, LLLT usage, laser brand, and parameters.

Data collection:

Data extraction was performed using RAYYAN for systematic reviews. The risk of bias in the studies was evaluated.

Data synthesis:

Pain was measured using the visual analog scale (VAS). The included studies did not use validated tools for assessing physical conditions. All studies employed LLLT with a 660-nm wavelength, though there were variations in equipment power, energy dose, and application methods. The meta-analysis revealed an average difference of −0.60 points (95% CI: −1.52 to 0.31) in the VAS pain scores between the LLLT and control groups. No heterogeneity was observed among the studies (I2=0%), indicating no significant difference in pain relief between LLLT (red light) and control groups.

Conclusion:

LLLT may offer a promising option for managing breastfeeding-related complications, though further research is required.

Key-words Breast feeding Laser therapy Low level light therapy Low-level laser Nipple pain Nipple trauma Nipples
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Review Article03-18-2025

Clinical repercussions of statin use during pregnancy: a review of the literature
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo2

Views126

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Review Article
Clinical repercussions of statin use during pregnancy: a review of the literature
Revista Brasileira de Ginecologia e Obstetrícia. 2025;47:e-rbgo2
DOI 10.61622/rbgo/2025rbgo2
Joan Lins Serafim ,
Pedro Lucas Santos de Menezes Teles ,
Amanda Katharinne Souza Lima ,
Jéssica dos Santos Coelho ,
Paloma Luna Maranhão Conrado ,
Valda Lúcia Moreira Luna ,
Pauliana Valéria Machado Galvão ,
George Alessandro Maranhão Conrado
Views126
Abstract

Statins are the most widely used pharmacological class for treating hyperlipidemia, although they are contraindicated during pregnancy. This study aims to demonstrate the clinical effects of statins in pregnant women through an interactive review. Fifteen original articles were selected, in English or Portuguese, within of five years. Statins have not been associated with the development of fetal malformations and their use may be useful in preventing unfavorable cardiovascular outcomes, with the potential to reduce oxidative stress and angiogenic dysfunction. However, the use of statins to prevent pre-eclampsia in humans has not been properly clarified and further studies are needed. Pravastatin is considered safer than statins for use during pregnancy.

Key-words Antihypertensive agents Hydroxymethylglutaryl-CoA reductase inhibitors Pravastatin Pre-eclampsia Pregnancy Pregnant woman
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Linfonodo Sentinela no Carcinoma Infiltrativo Inicial de Mama: Estudo de sua Localização e de sua Capacidade Preditiva em Relação ao Estado da Axila

Avaliação da Função Ovariana Pós-histerectomia Total Abdominal em Mulheres no Menacme

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Efeitos da Metiltestosterona sobre a Sexualidade, Metabolismo Lipoproteíco e Hepático e Níveis de Testosterona em Mulheres na Pós-Menopausa em Uso de Reposição Estroprogestativa

Knowledge and Opinion of Brazilian Researchers About Informed Consent

p53 Protein Overexpression as a Prognostic Marker for Vulvar Intraepithelial Neoplasia III Recurrence/Progression

Endometrial Adenocarcinoma Frequency in a Hysteroscopy Outpatient Clinic: A Multicenter Study

Nominata 2024

Self-medication among pregnant women in comparison to the general population: a scoping review of the main characteristics

Abstract

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Conclusions:

Metformin versus insulin in gestational diabetes mellitus: a systematic review

Abstract

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Data sources:

Study selection:

Data collection:

Data synthesis:

Conclusion:

Comment on: Effects of COVID-19 on human placentas in the second and third trimester

Analysis of vaginal microbiota before and after treatment of high-grade squamous intraepithelial lesions of the uterine cervix

Abstract

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Methods:

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Conclusion:

Systemic inflammatory indices as a non-invasive grading modality for endometriosis: a comparative study versus exploratory laparoscopy

Abstract

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Conclusion:

Comment on: Effect of combined training on body image, body composition and functional capacity in patients with breast cancer: controlled clinical trial

Female genital tract microbiome: the influence of probiotics on assisted reproduction

Abstract

Short cervix and use of cervical pessary for preventing preterm birth in singleton and twin pregnancies: a systematic review and meta-analysis

Abstract

Objective:

Data source:

Study selection:

Data collect:

Data synthesis:

Conclusion:

Contraception in adolescents with mental disorders: adherence and satisfaction in the use of depot medroxyprogesterone acetate

Abstract

Objective:

Methods:

Results:

Conclusions:

The experience of pregnancy in the COVID-19 pandemic

Abstract

Objective:

Methods:

Results:

Conclusion:

Effect of COVID-19 on Brazilian cesarean and prematurity rates: a cross-sectional study

Abstract

Objective:

Methods:

Results:

Conclusion:

Accurate evaluation of mode of delivery and labor progression with angle of progression: a prospective cross-sectional

Abstract

Objective:

Designs:

Participants:

Methods:

Results:

Conclusion:

Gastrin-releasing peptide receptor: a promising new biomarker to identify cervical precursor lesions and cancer

Abstract

Objective:

Methods:

Results:

Conclusion:

Low-level laser therapy for nipple trauma and pain during breastfeeding: systematic review and meta-analysis