Vulvar cancer Archives - Revista Brasileira de Ginecologia e Obstetrícia

  • Original Article

    Study of 138 vulvar lichen sclerosus patients and the malignant risk transformation

    Revista Brasileira de Ginecologia e Obstetrícia. 07-26-2024;46:e-rbgo62

    Summary

    Original Article

    Study of 138 vulvar lichen sclerosus patients and the malignant risk transformation

    Revista Brasileira de Ginecologia e Obstetrícia. 07-26-2024;46:e-rbgo62

    DOI 10.61622/rbgo/2024rbgo62

    Views56

    Abstract

    Objective

    To report the prevalence of malignant transformation of vulvar lichen sclerosus (VLS) and possible risk factors.

    Methods

    This is a cohort study with data analysis from medical records of 138 patients with histological diagnosis of VLS registered at the Vulvar Pathology Outpatient Clinic of the University Hospital, between 2007 and 2017. Predominance of risk factors was performed using logistic regression analysis. The variables studied were the length of follow-up, age, regular or irregular follow up; presence of symptoms (dyspareunia, pruritus and/or vulvar burning); histology characteristics, the presence of epithelial hyperplasia; and the presence of autoimmune diseases.

    Results

    There were 138 patients included in the study, and among them five progressed to malignant transformation. The patients had a median age of 59 years and 83% were symptomatic. The most frequent symptom was itching with 72%. Autoimmune diseases were present in 11.6%, the most prevalent being thyroid disease. All five case of malignant transformation (0.6%) had an irregular follow up. The logistic regression analysis was used among the studied variables, and no statistical significance was found among them (p ≥ 0.05). The relationship between hyperplasia and the clinical outcome of malignant transformation, in which non-significant but acceptable p value close to 0.05 was observed.

    Conclusion

    The prevalence of malignant transformation in patients with VLS was 0.6%, and common factors were the lack of adherence to medical treatments and the loss of follow-up.

    See more
    This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Search

Search in:

Article type
Article type
abstract
book-review
brief-report
case-report
correction
editorial
letter
other
rapid-communication
research-article
review-article
Section
Section
Arigos Originais
Article
Artigo de Revisão
Original Articles
Carta ao Editor
Carta ao Editor
Carta ao Editor
Cartas
Cartas
Case Report
Case Reports
Caso e Tratamento
Clinical Consensus Recommendation
Corrigendum
Editoriais
Editorial
Editorial
Equipamentos e Métodos
Errata
Erratas
Erratas
Erratum
FEBRASGO POSITION STATEMENT
Febrasgo Statement
Febrasgo Statement Position
FIGO Statement
GUIDELINES
Integrative Review
Letter to Editor
Letter to the Editor
Métodos e Técnicas
Nota do Editor
Nota Prévia
Original Article
Original Article/Contraception
Original Article/Infertility
Original Article/Obstetrics
Original Article/Oncology
Original Article/Sexual Violence/Pediatric and Adolescent Gynecology
Original Article/Teaching and Training
Original Articles
Relato de Caso
Relato de Casos
Relatos de Casos
Reply to the Letter to the Editor
Resposta dos Autores
Resumo De Tese
Resumo De Tese
Resumos de Tese
Resumos de Tese
Resumos de Teses
Resumos de Teses
Resumos dos Trabalhos Premiados no 50º Congresso Brasileiro de Ginecologia e Obstetrícia
Review
Review Article
Review Articles
Revisão
Revisão
Short Communication
Special Article
Systematic Review
Técnica e Equipamentos
Técnicas e Equipamentos
Técnicas e Métodos
Trabalhos Originais
Trabalhos Originais
Year / Volume
Year / Volume
2025; v.47
2025; v.46
2024; v.46
2023; v.45
2022; v.44
2021; v.43
2020; v.42
2019; v.41
2018; v.40
2017; v.39
2016; v.38
2015; v.37
2014; v.36
2013; v.35
2012; v.34
2011; v.33
2010; v.32
2009; v.31
2008; v.30
2007; v.29
2006; v.28
2005; v.27
2004; v.26
2003; v.25
2002; v.24
2001; v.23
2000; v.22
1999; v.21
1998; v.20
ISSUE
ISSUE