Vaginal smears Archives - Page 2 of 2 - Revista Brasileira de Ginecologia e Obstetrícia

  • Original Articles

    Comparison of Classical and Secondary Cytologic Criteria Relative to Hybrid Capture for Diagnosing Cervical-vaginal Infection by Human Papillomavirus

    Revista Brasileira de Ginecologia e Obstetrícia. 2016;38(1):41-46

    Summary

    Original Articles

    Comparison of Classical and Secondary Cytologic Criteria Relative to Hybrid Capture for Diagnosing Cervical-vaginal Infection by Human Papillomavirus

    Revista Brasileira de Ginecologia e Obstetrícia. 2016;38(1):41-46

    DOI 10.1055/s-0035-1570105

    Views12

    Objective

    To compare the diagnostic accuracy of the classic Meisels cytologic criteria and the Schneider secondary criteria relative to the hybrid capture method for diagnosing HPV infection.

    Methods

    This was a retrospective study performed at a public university hospital. A total of 41 patients with a cytologic diagnosis of HPV infection and 40 HPV-negative patients were selected for review of the cervical-vaginal smears seeking to classical and secondary criteria. A single pathologist reviewed the slides in search of the criteria. The classical and secondary cytologic criteria were compared with the hybrid capture for diagnosing HPV infection. Bartleti test was applied for the age analysis, and Fisher's exact test was used to compare proportions. The tests were considered significant when the probability of rejecting the null hypothesis was less than 5% (p < 0.05).

    Results

    The Meisels criteria were less sensitive (34.0%) than the secondary Schneider criteria (57.5%) when compared with the hybrid capture (p < 0.0001), although the specificity of the former criteria was non-significantly higher (91.2% and 67.7%, respectively). In cases of moderate or intense inflammation, the sensitivity and specificity of the Schneider criteria were decreased, 33.3% and 50.0% respectively (p = 0.0115).

    Conclusions

    Compared with hybrid capture for diagnosis of HPV infection, the sensitivity of the secondary Schneider criteria was higher than the classical Meisels criteria.Moderate or intense inflammation reduces the sensitivity and specificity of the secondary Schneider criteria for diagnosing HPV infection using the hybrid capture as the gold standard.

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  • Artigos Originais

    Abnormal vaginal secretion: sensitivity, specificity and concordance between clinical and cytological diagnosis

    Revista Brasileira de Ginecologia e Obstetrícia. 2015;37(5):222-228

    Summary

    Artigos Originais

    Abnormal vaginal secretion: sensitivity, specificity and concordance between clinical and cytological diagnosis

    Revista Brasileira de Ginecologia e Obstetrícia. 2015;37(5):222-228

    DOI 10.1590/SO100-720320150005183

    Views10

    PURPOSE:

    To estimate the prevalence of bacterial vaginosis (BV), candidiasis and
    trichomoniasis and compare the findings of physical examination of the vaginal
    secretion with the microbiological diagnosis obtained by cytology study of a
    vaginal smear using the Papanicolaou method.

    METHODS:

    A cross-sectional study of 302 women aged 20 to 87 years, interviewed and
    submitted to a gynecology test for the evaluation of vaginal secretion and
    collection of a cytology smear, from June 2012 to May 2013. Sensitivity analyses
    were carried out and specificity, positive predictive value (PPV) and negative
    predictive value (NPV) with their respective 95%CI were determined to assess the
    accuracy of the characteristics of vaginal secretion in relation to the
    microbiological diagnosis of the cytology smear . The kappa index (k) was used to
    assess the degree of agreement between the clinical features of vaginal secretion
    and the microbiological findings obtained by cytology.

    RESULTS

    The prevalence of BV, candidiasis and trichomoniasis was 25.5, 9.3 and 2.0%,
    respectively. The sensitivity, specificity, PPV and NPV of the clinical
    characteristics of vaginal secretion for the cytological diagnosis of BV were 74,
    78.6, 54.3 and 89.9%, respectively. The sensitivity, specificity, PPV and the NPV
    of the clinical characteristics of vaginal secretion for the cytological diagnosis
    of candidiasis were 46.4, 86.2, 25.5 and 94%, respectively. The correlation
    between the clinical evaluation of vaginal secretion and the microbiological
    diagnosis of BV, candidiasis and trichomoniasis, assessed by the kappa index, was
    0.47, 0.23 and 0.28, respectively.

    CONCLUSION

    The most common cause of abnormal vaginal secretion was BV. The clinical
    evaluation of vaginal secretion presented amoderate to weak agreement with the
    microbiological diagnosis, indicating the need for complementary investigation of
    the clinical findings of abnormal vaginal secretion.

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  • Artigos Originais

    Cytological smears of women diagnosed with adenocarcinoma of the uterine cervix

    Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(1):40-45

    Summary

    Artigos Originais

    Cytological smears of women diagnosed with adenocarcinoma of the uterine cervix

    Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(1):40-45

    DOI 10.1590/S0100-72032014000100009

    Views5

    PURPOSE:

    To analyze the cytological findings of women with cervical adenocarcinoma, taking
    into account the patient's history in the year prior to diagnosis and the
    histopathological aspects of the lesions.

    METHODS:

    A retrospective comparative study was conducted using data from women with
    cervical adenocarcinoma or squamous carcinoma detected between 2002 and 2008. The
    cytological reports were synthesized according to the Bethesda System revised in
    2001 and were compared to the histopathological findings of cervical
    adenocarcinoma and squamous carcinoma. The distributions of cytological findings
    were calculated, as well as the global agreement and chance-corrected agreement
    using the Cohen's Kappa Coefficient. For this purpose, the cytological findings
    were grouped according to the epithelial origin, forming the glandular cell and
    squamous cell groups, with the histopathologically confirmed tumor types
    (adenocarcinoma versus squamous carcinoma) being used as the gold
    standard.

    RESULTS:

    A total of 284 cases of cervical cancer were diagnosed during the study period.
    The effectively studied cases were 27 and 54 patients with adenocarcinoma and
    squamous carcinoma, respectively. The adenocarcinoma group represented 9.5% of the
    total cases diagnosed, and 56.0% of the women in this group were younger than 50
    years. Cervical cytology was collected on average 92 days before the cancer
    diagnosis (range: 19 days to 310 days). In 41.6% of cases the cytological results
    were consistent with glandular alterations such as adenocarcinoma cells or
    atypical glandular cells. The global agreement and Cohen's Kappa Coefficient were
    73.7 and 48.7%, suggesting substantial and moderate agreement, respectively.

    CONCLUSIONS:

    In this population, the cytological smears had an important role in screening
    women with adenocarcinoma, although some of them were referred to clarify the
    clinical symptoms. The agreement between cytological and histopathological
    findings was moderate.

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  • Artigos Originais

    Non adherence to cancer screening guidelines for cervical cancer among women who attended prenatal care

    Revista Brasileira de Ginecologia e Obstetrícia. 2013;35(7):323-330

    Summary

    Artigos Originais

    Non adherence to cancer screening guidelines for cervical cancer among women who attended prenatal care

    Revista Brasileira de Ginecologia e Obstetrícia. 2013;35(7):323-330

    DOI 10.1590/S0100-72032013000700007

    Views9

    PURPOSE: To estimate the prevalence and identify the factors associated with delayed pap smear test of the cervix (carried out more than three years ago) among mothers with sons under two years of age, who attended the prenatal care. METHODS: Cross-sectional, population-based household survey. Women with sons under two years old, living in the northern area of the city of Juiz de Fora (MG), Brazil, were interviewed. Stratification and clustering were used in a complex sampling procedure. We applied a survey questionnaire to capture women's demographic and socioeconomic characteristics of women and information about prenatal and practices for preventing cancer of the cervix. For statistical analysis of the possible bivariate association of factors, we used χ² test and a logistic regression model with the explanatory variables that had a significance less than or equal to 0.05 in the bivariate analysis. RESULTS: We found a delayed test prevalence of 26.6% (95%CI 21.3 - 32.6), including women who were never submitted to the exam. The variables associated with the non-adherence to the examination within the stipulated time were: to be married (OR 0.5; 95%CI 0.2 - 0.9), and divorced/widowed (OR 0.1; 95%CI 0.02 - 0,8), having performed gynecological examination in prenatal care (OR 0.3; 95%CI 0.1 - 0.6) and number of prenatal visits (OR 0.09; 95%CI 0.03 - 0.25 for more than 11 visits), being all protection factors. CONCLUSIONS: The prevalence of adherence to Pap smear guidelines is slightly lower than the percentage recommended by the World Health Organization. Apart from that, the fact that the woman was submitted to the prenatal care did not guarantee the adherence to Pap smear frequency guidelines.

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  • Artigos Originais

    Pap smears among pregnant women in Southern Brazil: a representative cross-sectional survey

    Revista Brasileira de Ginecologia e Obstetrícia. 2012;34(11):518-523

    Summary

    Artigos Originais

    Pap smears among pregnant women in Southern Brazil: a representative cross-sectional survey

    Revista Brasileira de Ginecologia e Obstetrícia. 2012;34(11):518-523

    DOI 10.1590/S0100-72032012001100007

    Views10

    PURPOSE: To determine the prevalence and risk factors associated with failure of voluntary screening for cervical cancer during the gestational period in Rio Grande, Rio Grande do Sul State, Southern Brazil. METHODS: Previously trained interviewers applied a standardized questionnaire in the maternity to all mothers from this municipality who had delivered from January 1st to December 31st 2010 to obtain information about the demographic characteristics of the pregnant women, family socioeconomic status, and prenatal care received. The χ² test was used to compare proportions and Poisson regression with robust adjustment of variance was used in the multivariate analysis. RESULTS: Among the 2,288 respondents, 33% were not submitted to the Pap smear during pregnancy. Two thirds of these women stated that they were not aware of the need to perform it, 18% were not screened out of fear or shame, and the rest for other reasons. After adjustment, the highest prevalence ratios (PR) for noncompliance with the Pap smear occurred among young women (PR=1.5; 95%CI 1.25 - 1.80), with lower educational level (PR=1.5; 95%CI 1.12 - 2.12), who were living without a partner (PR=1.4; 95%CI 1.24 - 1.62), smokers (PR=1.2; 95%CI 1.07 - 1.39), who did not plan the current pregnancy (PR=1.3; 95%CI 1,21 - 1.61), who had attended less than six medical visits during the prenatal period (PR=1.4; 95%CI 1.32 - 1.69) and among users of oral contraceptives (PR=1.2; 95%CI 1.04 - 1.38). CONCLUSIONS: The higher the risk for uterine cervical cancer, the less likely a pregnant woman is to undergo a Pap smear. This definitely contributed to the increased morbidity and mortality from this disease in this setting.

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  • Artigos Originais

    Factors associated with the use of the Papanicolaou smear screening among older women in the interior of Brazil

    Revista Brasileira de Ginecologia e Obstetrícia. 2012;34(9):432-437

    Summary

    Artigos Originais

    Factors associated with the use of the Papanicolaou smear screening among older women in the interior of Brazil

    Revista Brasileira de Ginecologia e Obstetrícia. 2012;34(9):432-437

    DOI 10.1590/S0100-72032012000900008

    Views12

    PURPOSE: To verify the coverage, by Pap testing, of older women and the associated factors. METHODS: A population-based study was conducted by home interviews. The inclusion criteria were women aged 60 and over, living on the north side of the city of Juiz de Fora, Minas Gerais, Brazil, self-sufficient to answer the questionnaire or having someone to answer on their behalf. The interview consisted of sociodemographic questions, regarding the general health of the older women, and preventive practices in women's health. The selection was made by random sampling, stratified and clustered in multiple stages. To analyze associated factors, a theoretical model was formulated with three hierarchical blocks of variables, adjusted to each other in each block. The variables that had a level of significance of 0.2 or less were included in the Poisson regression model and adjusted to their next highest level (p<0.1). RESULTS: Pap testing occurred in 84.1% of cases (95%CI 79.0-88.4). Based on multivariate regression analysis, three variables remained significantly associated with access to Pap testing: the marital status "without partner" (older women who were single, widowed, separated or divorced), self-sufficiency to perform Instrumental Activities of Daily Living (IADLs) and adherence to mammography. In the interblock analysis these variables remained significantly associated with the outcome variable, and self-sufficiency for IADLs had the highest association. CONCLUSIONS: Among the older women comprising the study sample, was observed variation in the use of Pap testing. An adjustment of public health policies towards the formulation of policies giving priority to universal preventive care may be an alternative to solve the disparities observed.

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  • Artigos Originais

    External quality control for cervical cytology exams performed in the Brazilian Public Health System of Mato Grosso do Sul State

    Revista Brasileira de Ginecologia e Obstetrícia. 2012;34(8):351-356

    Summary

    Artigos Originais

    External quality control for cervical cytology exams performed in the Brazilian Public Health System of Mato Grosso do Sul State

    Revista Brasileira de Ginecologia e Obstetrícia. 2012;34(8):351-356

    DOI 10.1590/S0100-72032012000800002

    Views8

    PURPOSE: To evaluate the diagnostic agreement between the cytopathology reports issued by accredited laboratories and those obtained by quality control. METHODS: We calculated the overall agreement and Cohen's kappa coefficients of a convenience sample of smears selected monthly by the Information System of Cervical Cancer (SISCOLO) for External Quality Control of the 15 laboratories that performed cytopathological PAP tests for the Brazilian Public Health System (SUS) between 2002 and 2011 in Mato Grosso do Sul, a State of the Midwest Region of the country. A comparison of the reliability values (coefficient of concordance and Kappa coefficient) between the initial and final years was computed by the absolute change (delta) and relative percent difference (RPD). RESULTS: There were 15.989 smears sent for rereading, 48.1% of which had a report of normal/benign changes, followed by atypical/low-grade squamous intraepithelial lesions (36.3%), high grade squamous intraepithelial lesion/carcinoma/adenocarcinoma (4.2%), and unsatisfactory (11.4%). The overall correlation coefficient ranged between 0.2 and 1.0, and the median value increased from 0.7 in 2002 to 1 in 2011 (RPD=+36.6%). During the same period, the median values of the Kappa coefficient increased from 0.5 to 0.9 (RPD=+80.8%). CONCLUSIONS: These results emphasize the feasibility of the External Quality Control of cytopathology at the state level and its implementation results in improvement in the diagnoses performed in the SUS network.

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    External quality control for cervical cytology exams performed in the Brazilian Public Health System of Mato Grosso do Sul State
  • Artigos Originais

    Cytopathological coverage of the cervix in Basic Health Units of the Family

    Revista Brasileira de Ginecologia e Obstetrícia. 2011;33(9):258-263

    Summary

    Artigos Originais

    Cytopathological coverage of the cervix in Basic Health Units of the Family

    Revista Brasileira de Ginecologia e Obstetrícia. 2011;33(9):258-263

    DOI 10.1590/S0100-72032011000900007

    Views9

    PURPOSE: To evaluate the coverage of Pap smear cytology at Basic Family Health Units (BFHU) and to describe the characteristics of non-performance of this test in the last three years. METHODS: A cross-sectional study was conducted in Rio Grande (RS), Brazil, in areas covered by the Family Health Teams Family (FHT). The interviews were conducted by students participating in the Health-PET, at women’s home. Crude analysis was performed using SPSS software to calculate prevalence ratio, 95% confidence intervals and p value. Multivariate analysis was performed by Poisson regression using Stata 9.0 software, which were included the variables with p value of up to 0.20 in the crude analysis. At the first level, the variables were age, having a partner, and literacy. At the second level, the variables were number of visits and offer of a Pap smear. RESULTS: The prevalence of Pap cytology performed 36 months ago or less was 66.3%. In adjusted analysis, women aged 19 years or less (p<0.001), without a partner (p<0.001), illiterate (p= 0.01), who had never consulted at the basic unit (p=0.02) and who had not been offered the examination during the visit (p=0.006), were more likely not to have had a cytopathology exam in the last 36 months. CONCLUSION: The local health proved to be ineffective and inequitable. Ineffective because it covers fewer women than indicated by the World Health Organization and uneven because access to this test varied according to some characteristics of the users.

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