Vaginal infections Archives - Revista Brasileira de Ginecologia e Obstetrícia
Summary
Rev Bras Ginecol Obstet. 2003;25(2):95-102
DOI 10.1590/S0100-72032003000200004
PURPOSE: to test the efficacy of and tolerance to Schinus terebinthifolius Raddi gel in the treatment of bacterial vaginosis. METHODS: forty-eight women with symptomatic bacterial vaginosis (according to Amsel's criteria) were enrolled in a randomized, double-blind, controlled trial comparing Schinus terebinthifolius Raddi gel (25 cases) with placebo (23 cases). The main outcome parameters were: rate of cure, presence of lactobacilli in Pap smear after treatment and side effects. Statistical analysis was performed using the chi2 and the Fisher exact test at 5% level of significance. RESULTS: using Amsel's clinical parameters of bacterial vaginosis, the cure rate was 84% in the Schinus group and 47.8% in the placebo group (p=0.008). A significant increase in the frequency of lactobacilli was observed in the Pap smear of the group treated with Schinus (43.5%) compared to the patient group (4.3%) (p=0.002). Treatment-related adverse events were not frequent in either group. CONCLUSIOS: the present study indicates that Schinus vaginal gel is effective and safe in the treatment of bacterial vaginosis. In addition, potential beneficial effects on the vaginal flora are suggested.
Summary
Rev Bras Ginecol Obstet. 2003;25(2):95-102
DOI 10.1590/S0100-72032003000200004
PURPOSE: to test the efficacy of and tolerance to Schinus terebinthifolius Raddi gel in the treatment of bacterial vaginosis. METHODS: forty-eight women with symptomatic bacterial vaginosis (according to Amsel's criteria) were enrolled in a randomized, double-blind, controlled trial comparing Schinus terebinthifolius Raddi gel (25 cases) with placebo (23 cases). The main outcome parameters were: rate of cure, presence of lactobacilli in Pap smear after treatment and side effects. Statistical analysis was performed using the chi2 and the Fisher exact test at 5% level of significance. RESULTS: using Amsel's clinical parameters of bacterial vaginosis, the cure rate was 84% in the Schinus group and 47.8% in the placebo group (p=0.008). A significant increase in the frequency of lactobacilli was observed in the Pap smear of the group treated with Schinus (43.5%) compared to the patient group (4.3%) (p=0.002). Treatment-related adverse events were not frequent in either group. CONCLUSIOS: the present study indicates that Schinus vaginal gel is effective and safe in the treatment of bacterial vaginosis. In addition, potential beneficial effects on the vaginal flora are suggested.