Unified Health System Archives - Revista Brasileira de Ginecologia e Obstetrícia
, , , , , Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo93
, , , , , , , To analyze the prognosis of patients with breast cancer who developed trastuzumab-induced cardiotoxicity and to analyze factors associated with and resulting from cardiotoxicity.
This was a retrospective cohort study that included 255 HER2-positive breast cancer patients who received adjuvant trastuzumab therapy. The inclusion criteria were a diagnosis of HER2-positive breast cancer and adjuvant trastuzumab therapy; disease stage I-III; <70 years; and a baseline echocardiogram showing a left ventricular ejection fraction (LVEF) ≥ 55%. The Kaplan-Meier method, the log-rank test, and the Cox proportional hazards model were used.
In all, 15.3% (39/255) of patients presented with cardiotoxicity. Treatment was suspended in 92.3% (36/39) of patients who presented with cardiotoxicity during trastuzumab treatment. The treatment was suspended in 46 of 255 patients and it was permanently interrupted in 84.8% (33/46) of these patients, with 84.8% (28/33) due to cardiotoxicity. Cardiotoxicity was not associated with disease-free survival (DFS) (hazard ratio (HR) = 1.48; 95% confidence interval (CI = 0.79-2.78) or overall survival (OS) (HR = 1.68; 95%CI= 0.83-3.41). Patients with clinical stage III and whom trastuzumab therapy was suspended (all causes) had worse DFS; (HR = 3.19; 95% CI=1.77-5.74) and (HR = 1.83; 95% CI=1.01-3.32) respectively. Those with clinical stage III and whom trastuzumab therapy was permanently interrupted had worse OS; (HR = 3.80; 95% CI =1.82-7.94), and (HR = 2,26; 95% CI =1.09-4.68 respectively.
Cardiotoxicity was not associated with DFS or OS. Clinical stage III, Suspension and permanent interruption of treatment regardless of the cause were associated with worse DFS and OS in breast cancer patients.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo93
, , , , , , , To analyze the prognosis of patients with breast cancer who developed trastuzumab-induced cardiotoxicity and to analyze factors associated with and resulting from cardiotoxicity.
This was a retrospective cohort study that included 255 HER2-positive breast cancer patients who received adjuvant trastuzumab therapy. The inclusion criteria were a diagnosis of HER2-positive breast cancer and adjuvant trastuzumab therapy; disease stage I-III; <70 years; and a baseline echocardiogram showing a left ventricular ejection fraction (LVEF) ≥ 55%. The Kaplan-Meier method, the log-rank test, and the Cox proportional hazards model were used.
In all, 15.3% (39/255) of patients presented with cardiotoxicity. Treatment was suspended in 92.3% (36/39) of patients who presented with cardiotoxicity during trastuzumab treatment. The treatment was suspended in 46 of 255 patients and it was permanently interrupted in 84.8% (33/46) of these patients, with 84.8% (28/33) due to cardiotoxicity. Cardiotoxicity was not associated with disease-free survival (DFS) (hazard ratio (HR) = 1.48; 95% confidence interval (CI = 0.79-2.78) or overall survival (OS) (HR = 1.68; 95%CI= 0.83-3.41). Patients with clinical stage III and whom trastuzumab therapy was suspended (all causes) had worse DFS; (HR = 3.19; 95% CI=1.77-5.74) and (HR = 1.83; 95% CI=1.01-3.32) respectively. Those with clinical stage III and whom trastuzumab therapy was permanently interrupted had worse OS; (HR = 3.80; 95% CI =1.82-7.94), and (HR = 2,26; 95% CI =1.09-4.68 respectively.
Cardiotoxicity was not associated with DFS or OS. Clinical stage III, Suspension and permanent interruption of treatment regardless of the cause were associated with worse DFS and OS in breast cancer patients.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2018;40(2):86-91
To compare the quality of cervicovaginal samples obtained from basic health units (BHUs) of the Unified Health System (SUS) and those obtained fromprivate clinics to screen precursor lesions of cervical cancer.
It was an intervention study whose investigated variables were: adequacy of the samples; presence of epithelia in the samples, and cytopathological results. A total of 940 forms containing the analysis of the biological samples were examined: 470 forms of women attended at BHUs of the SUS and 470 forms of women examined in private clinics in January and February of 2016.
All the unsatisfactory samples were collected at BHUs and corresponded to 4% of the total in this sector (p < 0.0001). There was a higher percentage of samples containing only squamous cells in the SUS (43.9%). There was squamocolumnar junction (SJC) representativeness in 82.1% of the samples from the private clinics (p < 0.0001). Regarding negative results for intraepithelial lesions and/or malignancies, the percentages obtained were 95.9% and 99.1% (p < 0.0049) in the exams collected in the private system and SUS, respectively. Less serious lesions corresponded to 0.89% of the samples from the SUS and 2.56% of the tests from the private sector; more serious lesions were not represented in the samples obtained from BHUs, whereas the percentage was 1.49% in private institutions.
Unsatisfactory cervical samples were observed only in exams performed at the SUS. There is a need for guidance and training of professionals who perform this procedure to achieve higher reliability in the results and more safety for women who undergo this preventive test.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2018;40(2):86-91
To compare the quality of cervicovaginal samples obtained from basic health units (BHUs) of the Unified Health System (SUS) and those obtained fromprivate clinics to screen precursor lesions of cervical cancer.
It was an intervention study whose investigated variables were: adequacy of the samples; presence of epithelia in the samples, and cytopathological results. A total of 940 forms containing the analysis of the biological samples were examined: 470 forms of women attended at BHUs of the SUS and 470 forms of women examined in private clinics in January and February of 2016.
All the unsatisfactory samples were collected at BHUs and corresponded to 4% of the total in this sector (p < 0.0001). There was a higher percentage of samples containing only squamous cells in the SUS (43.9%). There was squamocolumnar junction (SJC) representativeness in 82.1% of the samples from the private clinics (p < 0.0001). Regarding negative results for intraepithelial lesions and/or malignancies, the percentages obtained were 95.9% and 99.1% (p < 0.0049) in the exams collected in the private system and SUS, respectively. Less serious lesions corresponded to 0.89% of the samples from the SUS and 2.56% of the tests from the private sector; more serious lesions were not represented in the samples obtained from BHUs, whereas the percentage was 1.49% in private institutions.
Unsatisfactory cervical samples were observed only in exams performed at the SUS. There is a need for guidance and training of professionals who perform this procedure to achieve higher reliability in the results and more safety for women who undergo this preventive test.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2015;37(8):374-380
DOI 10.1590/SO100-720320150005394
To identify the impact of urinary incontinence (UI) on quality of life (QoL), to compare the scores of QoL domains in women with stress urinary incontinence (SUI), overactive bladder (OAB) and mixed incontinence (MUI) and to establish the association between the clinical type of UI and the impact on QoL.
Data of 181 incontinent women attended at a public hospital were collected regarding age, body mass index (BMI) and co-morbidities. King's Health Questionnaire (KHQ) was applied and patients were classified into two groups according to the self-assessment of incontinence impact. KHQ scores were compared by the Mann-Whitney test. Depending on their urinary symptoms, women were divided into SUI, OAB and MUI groups and their scores in the KHQ domains were compared by the Kruskal-Wallis and Dunn tests. The odds ratio (OR) of a woman reporting a worse effect of UI on QoL was estimated using the binary logistic model. The control variables were: age, BMI and number of co-morbidities.
A significant difference was found between the two groups of self-assessment of UI impact for all KHQ domains. The MUI group showed worse scores than the SUI group for all domains, and OAB group, for limitation of physical and daily activities. There was a significant difference between the odds of the women in the SUI and MUI groups reporting worse effects of UI on QoL (OR=2.9; p=0.02).
As reported at other reference services, MUI was the most commom type, and urinary loss had a moderate/major impact on QoL, affecting mainly role limitations domain. The adjusted analysis showed that women with MUI had almost three times greater odds of reporting worse impact on QoL than women with SUI.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2015;37(8):374-380
DOI 10.1590/SO100-720320150005394
To identify the impact of urinary incontinence (UI) on quality of life (QoL), to compare the scores of QoL domains in women with stress urinary incontinence (SUI), overactive bladder (OAB) and mixed incontinence (MUI) and to establish the association between the clinical type of UI and the impact on QoL.
Data of 181 incontinent women attended at a public hospital were collected regarding age, body mass index (BMI) and co-morbidities. King's Health Questionnaire (KHQ) was applied and patients were classified into two groups according to the self-assessment of incontinence impact. KHQ scores were compared by the Mann-Whitney test. Depending on their urinary symptoms, women were divided into SUI, OAB and MUI groups and their scores in the KHQ domains were compared by the Kruskal-Wallis and Dunn tests. The odds ratio (OR) of a woman reporting a worse effect of UI on QoL was estimated using the binary logistic model. The control variables were: age, BMI and number of co-morbidities.
A significant difference was found between the two groups of self-assessment of UI impact for all KHQ domains. The MUI group showed worse scores than the SUI group for all domains, and OAB group, for limitation of physical and daily activities. There was a significant difference between the odds of the women in the SUI and MUI groups reporting worse effects of UI on QoL (OR=2.9; p=0.02).
As reported at other reference services, MUI was the most commom type, and urinary loss had a moderate/major impact on QoL, affecting mainly role limitations domain. The adjusted analysis showed that women with MUI had almost three times greater odds of reporting worse impact on QoL than women with SUI.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(2):56-64
DOI 10.1590/S0100-72032014000200003
To evaluate the adequacy of the process of prenatal care according to the
parameters of the Program for the Humanization of Prenatal Care (PHPN) and of the
procedures provided by the Stork Network of Unified Health System (SUS) in the
microregion of Espirito Santo state, Brazil.
A cross-sectional study was conducted in 2012-2013 by interviewing and analyzing
the records of 742 women during the postpartum period and of their newborns in 7
hospitals in the region chosen for the research. The information was collected,
processed and analyzed by the χ2 and Fisher's exact test to determine
the difference in proportion between the criteria adopted by the PHPN and the
Stork Network and the place of residence, family income and type of coverage of
prenatal service. The level of significance was set at 5%.
The parameters showing the lowest adequacy rate were quick tests and repeated
exams, with frequencies around 10 and 30%, respectively, in addition to
educational activities (57.9%) and tetanus immunization (58.7%). In contrast, risk
management (92.6%) and the fasting plasma glucose test (91.3%) showed the best
results. Adequacy was 7.4% for the PHPN, 0.4% for the Stork Network, with respect
to the parameters of normal risk pregnancies, and 0 for high risk pregnancies.
There was a significant difference between puerperae according to housing location
regarding the execution of serology for syphilis (VDRL), anti-HIV and repeated
fasting glucose tests, and monthly income influenced the execution of blood
type/Rh factor tests, VDRL, hematocrit and anti-HIV test.
Prenatal care in the SUS proved to be inadequate regarding the procedures
required by the PHPN and Stork Network in the micro-region of a state in
southeastern Brazil, especially for women of lower income, PACS users and
residents of rural areas.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(2):56-64
DOI 10.1590/S0100-72032014000200003
To evaluate the adequacy of the process of prenatal care according to the
parameters of the Program for the Humanization of Prenatal Care (PHPN) and of the
procedures provided by the Stork Network of Unified Health System (SUS) in the
microregion of Espirito Santo state, Brazil.
A cross-sectional study was conducted in 2012-2013 by interviewing and analyzing
the records of 742 women during the postpartum period and of their newborns in 7
hospitals in the region chosen for the research. The information was collected,
processed and analyzed by the χ2 and Fisher's exact test to determine
the difference in proportion between the criteria adopted by the PHPN and the
Stork Network and the place of residence, family income and type of coverage of
prenatal service. The level of significance was set at 5%.
The parameters showing the lowest adequacy rate were quick tests and repeated
exams, with frequencies around 10 and 30%, respectively, in addition to
educational activities (57.9%) and tetanus immunization (58.7%). In contrast, risk
management (92.6%) and the fasting plasma glucose test (91.3%) showed the best
results. Adequacy was 7.4% for the PHPN, 0.4% for the Stork Network, with respect
to the parameters of normal risk pregnancies, and 0 for high risk pregnancies.
There was a significant difference between puerperae according to housing location
regarding the execution of serology for syphilis (VDRL), anti-HIV and repeated
fasting glucose tests, and monthly income influenced the execution of blood
type/Rh factor tests, VDRL, hematocrit and anti-HIV test.
Prenatal care in the SUS proved to be inadequate regarding the procedures
required by the PHPN and Stork Network in the micro-region of a state in
southeastern Brazil, especially for women of lower income, PACS users and
residents of rural areas.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2013;35(10):447-452
DOI 10.1590/S0100-72032013001000004
PURPOSE: To analyze prenatal care in public and private services. METHODS: A cross-sectional, retrospective and analytic study was conducted based on the audit of files of pregnant women who had given birth at a reference hospital for low risk cases in the area of Campos Gerais - Paraná State, in the first semester of 2011. The Yates chi-squared test or exact Fisher test were used to determine the association between the lack of registration files for pregnant women regarding prenatal assistance in the public and private services, with the level of significance set at p≤0.05. The quality of prenatal care was determined based on the percentile of non-registrations. RESULTS: A total of 500 prenatal files were analyzed. There was a significant attendance of six or more prenatal visits, with a larger proportion in the private service (91.9%). The laboratory and obstetric exams most frequently not registered in the public and in the private services were, respectively: hepatitis B (79.3 and 48.4%), hemoglobin and hematocrit values (35.6 and 21.8%), anti-HIV serology (29.3 and 12.9%), fetal movement (84.3 and 58.9%) and length (60.4 and 88.7%), edema verification (60.9 and 54.8%), and fetal presentation (52.4 and 61.3%). The audit of the files of pregnant women allowed to determine the quality of the prenatal care provided and confirmed differences in assistance according to the place, showing excellent and good quality of private care, and regular public care for ultrasonography and blood type/Rh factor; regular quality of private care and poor quality of public care for urine tests and weight. For the other types of laboratory and obstetric exams and vaccines, the quality was poor or very poor in both types of services. CONCLUSION: The differences between the services showed that there is a need for actions aiming at the improvement of the prenatal care provided by public services.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2013;35(10):447-452
DOI 10.1590/S0100-72032013001000004
PURPOSE: To analyze prenatal care in public and private services. METHODS: A cross-sectional, retrospective and analytic study was conducted based on the audit of files of pregnant women who had given birth at a reference hospital for low risk cases in the area of Campos Gerais - Paraná State, in the first semester of 2011. The Yates chi-squared test or exact Fisher test were used to determine the association between the lack of registration files for pregnant women regarding prenatal assistance in the public and private services, with the level of significance set at p≤0.05. The quality of prenatal care was determined based on the percentile of non-registrations. RESULTS: A total of 500 prenatal files were analyzed. There was a significant attendance of six or more prenatal visits, with a larger proportion in the private service (91.9%). The laboratory and obstetric exams most frequently not registered in the public and in the private services were, respectively: hepatitis B (79.3 and 48.4%), hemoglobin and hematocrit values (35.6 and 21.8%), anti-HIV serology (29.3 and 12.9%), fetal movement (84.3 and 58.9%) and length (60.4 and 88.7%), edema verification (60.9 and 54.8%), and fetal presentation (52.4 and 61.3%). The audit of the files of pregnant women allowed to determine the quality of the prenatal care provided and confirmed differences in assistance according to the place, showing excellent and good quality of private care, and regular public care for ultrasonography and blood type/Rh factor; regular quality of private care and poor quality of public care for urine tests and weight. For the other types of laboratory and obstetric exams and vaccines, the quality was poor or very poor in both types of services. CONCLUSION: The differences between the services showed that there is a need for actions aiming at the improvement of the prenatal care provided by public services.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2011;33(3):144-149
DOI 10.1590/S0100-72032011000300008
PURPOSE: to identify the nomenclature for reporting cervical cytological diagnoses used by laboratories which render services to the Brazilian Unified Health System (SUS) and which participate in External Quality Monitoring (MEQ). To evaluate the information acquired from gynecologists of the SUS regarding the various diagnostic classifications that they receive in the cervical cytology diagnostic reports. METHODS: we evaluated 94 cytology reports issued by laboratories which participate in the MEQ in the State of São Paulo, Brazil, and 126 questionnaires applied to gynecologists who work for the SUS. RESULTS: out of the 94 laboratories, 81 (86.2%) use one diagnostic classification: 79 (97.6%) use the Brazilian Nomenclature for Cytological Reports (NBLC), 1 (1.2%) uses the Papanicolaou classification and 1 (1.2%) uses the Richart diagnostic classification. Of the 13 (13.8%) laboratories that use more than one classification, 5 use 2 types and 8 use 3 to 4 types, with 9 including the Papanicolau diagnostic classification. The study showed that 52 (55.3%) laboratories presented more than one descriptive diagnosis in the same report. Out of the 126 gynecologists who filled out a questionnaire evaluating the cytopathology reports, 78 (61.9 %) stated that they received laboratory reports with only one diagnostic classification, 48 (38.1%) received reports with more than one classification and 2 received reports with all 4 classifications. Among the 93 (73.8%) gynecologists who prefer only one classification, 56 (60.2%) claimed that the NBLC contributes to clinical practice, 13 (14.0%) opted for the Richart classification, 8 (8.6%) for the Reagan classification and 16 (17.2%) for the Papanicolaou classification. Out of 33 (26.2%) gynecologists who prefer more than one classification, 5 opted for the 4 classifications. CONCLUSIONS: these data suggest that there is still resistance on the part of pathologists about using the official nomenclature in cytology reports for SUS. There is discrepancy between the information that gynecologists would like to see in the reports and the information provided by the pathologists. Greater efforts should be made to stimulate the use of the official nomenclature.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2011;33(3):144-149
DOI 10.1590/S0100-72032011000300008
PURPOSE: to identify the nomenclature for reporting cervical cytological diagnoses used by laboratories which render services to the Brazilian Unified Health System (SUS) and which participate in External Quality Monitoring (MEQ). To evaluate the information acquired from gynecologists of the SUS regarding the various diagnostic classifications that they receive in the cervical cytology diagnostic reports. METHODS: we evaluated 94 cytology reports issued by laboratories which participate in the MEQ in the State of São Paulo, Brazil, and 126 questionnaires applied to gynecologists who work for the SUS. RESULTS: out of the 94 laboratories, 81 (86.2%) use one diagnostic classification: 79 (97.6%) use the Brazilian Nomenclature for Cytological Reports (NBLC), 1 (1.2%) uses the Papanicolaou classification and 1 (1.2%) uses the Richart diagnostic classification. Of the 13 (13.8%) laboratories that use more than one classification, 5 use 2 types and 8 use 3 to 4 types, with 9 including the Papanicolau diagnostic classification. The study showed that 52 (55.3%) laboratories presented more than one descriptive diagnosis in the same report. Out of the 126 gynecologists who filled out a questionnaire evaluating the cytopathology reports, 78 (61.9 %) stated that they received laboratory reports with only one diagnostic classification, 48 (38.1%) received reports with more than one classification and 2 received reports with all 4 classifications. Among the 93 (73.8%) gynecologists who prefer only one classification, 56 (60.2%) claimed that the NBLC contributes to clinical practice, 13 (14.0%) opted for the Richart classification, 8 (8.6%) for the Reagan classification and 16 (17.2%) for the Papanicolaou classification. Out of 33 (26.2%) gynecologists who prefer more than one classification, 5 opted for the 4 classifications. CONCLUSIONS: these data suggest that there is still resistance on the part of pathologists about using the official nomenclature in cytology reports for SUS. There is discrepancy between the information that gynecologists would like to see in the reports and the information provided by the pathologists. Greater efforts should be made to stimulate the use of the official nomenclature.