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Original Articles
Telomerase activity associated with progression of cervical lesions in a group of Colombian patients
Revista Brasileira de Ginecologia e Obstetrícia. 2015;37(12):559-564
12-01-2015
Summary
Original ArticlesTelomerase activity associated with progression of cervical lesions in a group of Colombian patients
Revista Brasileira de Ginecologia e Obstetrícia. 2015;37(12):559-564
12-01-2015DOI 10.1590/SO100-720320150005462
Views51See moreAbstract
PURPOSE
To analyze the relation between the cytological findings and telomerase activity (TA).
METHODS
Cervical samples were evaluated and classified according to the Bethesda System. Telomerase activity was measured total product generated values (TPG) using the TRAP assay (telomeric repeat amplification protocol); data were analyzed statistically using the χ2 test, with the level of significance set at p<0.05.
RESULTS
The study was conducted on 102 patients. Of these, 3.9% showed normal cytological findings, 8.8% showed cervicitis; 2% showed Atypical Squamous Cells of Undetermined Significance (ASCUS); 67.6% showed Low Grade Squamous Intraepithelial Lesion (LSIL); 11.8% showed High Grade Squamous Intraepithelial Lesion (H-SIL) and 5.9% showed Squamous Carcinoma. Among telomerase-positive samples, the TPG values were cervicitis
CONCLUSION
Results show increased telomerase activity with increasing severity of lesion, supporting the association between TA and type of lesion.