Sarcoma Archives - Revista Brasileira de Ginecologia e Obstetrícia
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(7):455-458
DOI 10.1590/S0100-72032000000700009
Primary angiosarcoma of the breast is a rare tumor, which appears between 14 and 82 years, with an average of 35 years of age. Its predominant clinical aspect is a painful mass with diffuse increase in the breast and violet or blackened color. Equally to other cases of sarcoma, the medium size of the lesion is approximately 5 cm at the diagnosis. Histologically, it is characterized by the proliferation of endothelial cells that form vascular channels linked to each other infiltrating glandular structures and fatty tissue. Its histological diagnosis is difficult and not always the right diagnosis is immediately established, mainly in the cases of a low malignancy degree, due to limited biopsy material. Because of the difficult diagnosis and aggressivity, it is a neoplasia with ominous prognosis, due to frequent metastasis. In our service, a 18-year-old patient presented with a painful lump which grew quickly. It was biopsied and a hemangioma was diagnosed, a wide excision being indicated. Three months later, she suffered a tumoral relapse, that was biopsied again and mastectomy was indicated, because it was an angiosarcoma with low degree of malignancy. After other relapses, chemotherapy was indicated and later, radiotherapy. During radiotherapy she developed new metastases, and died of pulmonary metastasis.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(7):455-458
DOI 10.1590/S0100-72032000000700009
Primary angiosarcoma of the breast is a rare tumor, which appears between 14 and 82 years, with an average of 35 years of age. Its predominant clinical aspect is a painful mass with diffuse increase in the breast and violet or blackened color. Equally to other cases of sarcoma, the medium size of the lesion is approximately 5 cm at the diagnosis. Histologically, it is characterized by the proliferation of endothelial cells that form vascular channels linked to each other infiltrating glandular structures and fatty tissue. Its histological diagnosis is difficult and not always the right diagnosis is immediately established, mainly in the cases of a low malignancy degree, due to limited biopsy material. Because of the difficult diagnosis and aggressivity, it is a neoplasia with ominous prognosis, due to frequent metastasis. In our service, a 18-year-old patient presented with a painful lump which grew quickly. It was biopsied and a hemangioma was diagnosed, a wide excision being indicated. Three months later, she suffered a tumoral relapse, that was biopsied again and mastectomy was indicated, because it was an angiosarcoma with low degree of malignancy. After other relapses, chemotherapy was indicated and later, radiotherapy. During radiotherapy she developed new metastases, and died of pulmonary metastasis.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(3):211-214
DOI 10.1590/S0100-72032003000300011
The authors present a case of lymphangiosarcoma in the upper left limb of a 52-year-old patient previously submitted to a left-sided modified radical mastectomy followed by radiotherapy due to breast cancer six years earlier. This rare syndrome is associated with chronic lymphedema as a consequence of radical mastectomy followed by radiotherapy. Approximately 400 cases have been reported in the literature. The infrequent occurrence of this disease and the rather innocuous appearance of the tumor often lead to late diagnosis and treatment. In the present case, the diagnosis was based on an incision biopsy of the lesion and confirmed immunohistochemically using endothelial markers, antibodies (anti-CD31), vimentin and muscle actin. The patient's limb was amputated and no local or distant recurrence has so far been observed during 18 months of follow-up.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(3):211-214
DOI 10.1590/S0100-72032003000300011
The authors present a case of lymphangiosarcoma in the upper left limb of a 52-year-old patient previously submitted to a left-sided modified radical mastectomy followed by radiotherapy due to breast cancer six years earlier. This rare syndrome is associated with chronic lymphedema as a consequence of radical mastectomy followed by radiotherapy. Approximately 400 cases have been reported in the literature. The infrequent occurrence of this disease and the rather innocuous appearance of the tumor often lead to late diagnosis and treatment. In the present case, the diagnosis was based on an incision biopsy of the lesion and confirmed immunohistochemically using endothelial markers, antibodies (anti-CD31), vimentin and muscle actin. The patient's limb was amputated and no local or distant recurrence has so far been observed during 18 months of follow-up.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(2):131-135
DOI 10.1590/S0100-72032003000200009
Liposarcoma is a rare neoplasia that originates from primitive mesenchymal cells and is the most common histological type of sarcoma. It mainly affects the limbs but can reach other regions. Genital localization is, however, rare. The authors report a case of vulvar liposarcoma in a 27-year-old patient, who presented a progressively growing mass that limited her movements. Physical examination showed a large ulcerated vulvar tumor. The patient underwent local resection and histopathological examination diagnosed a well-differentiated liposarcoma with uncompromised margins. At the present time, 24 months after surgery, the patient is well and without recurrence of the disease.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(2):131-135
DOI 10.1590/S0100-72032003000200009
Liposarcoma is a rare neoplasia that originates from primitive mesenchymal cells and is the most common histological type of sarcoma. It mainly affects the limbs but can reach other regions. Genital localization is, however, rare. The authors report a case of vulvar liposarcoma in a 27-year-old patient, who presented a progressively growing mass that limited her movements. Physical examination showed a large ulcerated vulvar tumor. The patient underwent local resection and histopathological examination diagnosed a well-differentiated liposarcoma with uncompromised margins. At the present time, 24 months after surgery, the patient is well and without recurrence of the disease.
