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Resumo De Tese
HOXA10 as well as estrogen and progesterone receptor protein expression in the epithelium, stroma, and adjacent smooth muscle of rectosigmoid endometriosis
Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(8):381-381
08-01-2014
Summary
Resumo De TeseHOXA10 as well as estrogen and progesterone receptor protein expression in the epithelium, stroma, and adjacent smooth muscle of rectosigmoid endometriosis
Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(8):381-381
08-01-2014DOI 10.1590/SO100-72032014T0002
Views50A postagem não tem conteúdoKey-words Endometriosis of the sigmoid colon-rectumEstrogen receptor αEstrogen receptor βHOXA10 geneProfound endometriosisProgesterone receptorProgesterone receptor BSee moreViews50
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Resumo De TeseHOXA10 as well as estrogen and progesterone receptor protein expression in the epithelium, stroma, and adjacent smooth muscle of rectosigmoid endometriosis
Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(8):381-381
08-01-2014DOI 10.1590/SO100-72032014T0002
Views50A postagem não tem conteúdoKey-words Endometriosis of the sigmoid colon-rectumEstrogen receptor αEstrogen receptor βHOXA10 geneProfound endometriosisProgesterone receptorProgesterone receptor BSee moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Artigos Originais
Relation between progesterone receptor gene polymorphism, race, parity, and uterine leiomyoma occurrence
Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(5):278-284
08-28-2006
Summary
Artigos OriginaisRelation between progesterone receptor gene polymorphism, race, parity, and uterine leiomyoma occurrence
Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(5):278-284
08-28-2006DOI 10.1590/S0100-72032006000500003
Views98PURPOSE: to analyze race, parity and presence of the progesterone receptor polymorphism, named PROGINS, as factors related to uterine leiomyoma occurrence in Brazilian women. METHODS: we carried out a case-control study, composed of 122 patients with the diagnosis of uterine fibroid and 125 women without the disease. After recording the clinical data, we collected biological material for DNA extraction, polymerase chain reaction and agarose gel electrophoresis in order to identify the presence of PROGINS polymorphism. Statistical analysis was performed using the non-parametric Mann-Whitney test or the chi2 test, depending on the studied variable. The risk for the occurrence of the disease was calculated by the logistic regression model, providing the odds ratio (OR). The adopted significance level was 5% (p<0.05) and the confidence interval was 95% (95% CI). RESULTS: we observed a higher prevalence of "non-white"women - mulatto and black - (50 vs 22.4%) and nulliparas (23.8 vs 11.2%) in the cases, while the progesterone receptor genotype was more often PROGINS positive - heterozygous or mutant homozygous - among the controls (21.6 vs 10.7%). The OR indicated an elevated risk for leiomyoma related to the "non-white"race (OR=3.46; 95% CI: 2.0-6.0) and the nulliparity (OR=3.30; 95% CI: 1.9-5.6), with reduction in the presence of PROGINS-positive genotypes (OR=0.43; 95% CI: 0.2-0.9). CONCLUSIONS: the "non-white"race and nulliparity were considered risk factors for the occurrence of uterine fibroid in the studied population, while PROGINS polymorphism showed to be a protective factor.
Key-words Ethnical groupsLeyomiomaParityPolymorphismProgesterone receptorRisk factorsUterine neoplasmsSee moreViews98This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Artigos OriginaisRelation between progesterone receptor gene polymorphism, race, parity, and uterine leiomyoma occurrence
Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(5):278-284
08-28-2006DOI 10.1590/S0100-72032006000500003
Views98PURPOSE: to analyze race, parity and presence of the progesterone receptor polymorphism, named PROGINS, as factors related to uterine leiomyoma occurrence in Brazilian women. METHODS: we carried out a case-control study, composed of 122 patients with the diagnosis of uterine fibroid and 125 women without the disease. After recording the clinical data, we collected biological material for DNA extraction, polymerase chain reaction and agarose gel electrophoresis in order to identify the presence of PROGINS polymorphism. Statistical analysis was performed using the non-parametric Mann-Whitney test or the chi2 test, depending on the studied variable. The risk for the occurrence of the disease was calculated by the logistic regression model, providing the odds ratio (OR). The adopted significance level was 5% (p<0.05) and the confidence interval was 95% (95% CI). RESULTS: we observed a higher prevalence of "non-white"women - mulatto and black - (50 vs 22.4%) and nulliparas (23.8 vs 11.2%) in the cases, while the progesterone receptor genotype was more often PROGINS positive - heterozygous or mutant homozygous - among the controls (21.6 vs 10.7%). The OR indicated an elevated risk for leiomyoma related to the "non-white"race (OR=3.46; 95% CI: 2.0-6.0) and the nulliparity (OR=3.30; 95% CI: 1.9-5.6), with reduction in the presence of PROGINS-positive genotypes (OR=0.43; 95% CI: 0.2-0.9). CONCLUSIONS: the "non-white"race and nulliparity were considered risk factors for the occurrence of uterine fibroid in the studied population, while PROGINS polymorphism showed to be a protective factor.
Key-words Ethnical groupsLeyomiomaParityPolymorphismProgesterone receptorRisk factorsUterine neoplasmsSee moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. -
Trabalhos Originais
Progesterone receptor gene polymorphism (PROGINS) in women with pelvic endometriosis
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(8):613-617
11-23-2004
Summary
Trabalhos OriginaisProgesterone receptor gene polymorphism (PROGINS) in women with pelvic endometriosis
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(8):613-617
11-23-2004DOI 10.1590/S0100-72032004000800004
Views115See moreOBJECTIVE: the aim of the present study was to verify whether there is a correlation between the prevalence of the polymorphism in the progesterone receptor gene named PROGINS and pelvic endometriosis at different stages. METHODS: a case-control study carried out from November 2003 to May 2004. The genotypes of 104 women were analyzed 66 women had had surgically confirmed endometriosis (26 women at stages I-II and 40 at stages III-IV), and 38 were healthy women. The 306-base pair Alu insertion polymorphism in the intron G of the progesterone receptor gene was detected by polymerase chain reaction and analyzed on 2% agarose gel stained with ethidium bromide. ANOVA analysis was performed in order to make comparisons between among the studied groups. RESULTS: the groups of women with endometriosis stages I-II (EndoI group) and stages III-IV (EndoII group) showed statistically significant increased incidence of PROGINS polymorphic allele as compared with the control group: 27% in the EndoI group, 38% in EndoII and 18% in the control group (p < 0.001. In the analyses, a high frequency of the PROGINS insertion was observed in women with endometriosis as compared to healthy women, disregarding the clinical stage of the disease (p = 0.0385). CONCLUSION: there is a significant statistical association between the PROGINS polymorphism and pelvic endometriosis.
Views115This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Trabalhos OriginaisProgesterone receptor gene polymorphism (PROGINS) in women with pelvic endometriosis
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(8):613-617
11-23-2004DOI 10.1590/S0100-72032004000800004
Views115See moreOBJECTIVE: the aim of the present study was to verify whether there is a correlation between the prevalence of the polymorphism in the progesterone receptor gene named PROGINS and pelvic endometriosis at different stages. METHODS: a case-control study carried out from November 2003 to May 2004. The genotypes of 104 women were analyzed 66 women had had surgically confirmed endometriosis (26 women at stages I-II and 40 at stages III-IV), and 38 were healthy women. The 306-base pair Alu insertion polymorphism in the intron G of the progesterone receptor gene was detected by polymerase chain reaction and analyzed on 2% agarose gel stained with ethidium bromide. ANOVA analysis was performed in order to make comparisons between among the studied groups. RESULTS: the groups of women with endometriosis stages I-II (EndoI group) and stages III-IV (EndoII group) showed statistically significant increased incidence of PROGINS polymorphic allele as compared with the control group: 27% in the EndoI group, 38% in EndoII and 18% in the control group (p < 0.001. In the analyses, a high frequency of the PROGINS insertion was observed in women with endometriosis as compared to healthy women, disregarding the clinical stage of the disease (p = 0.0385). CONCLUSION: there is a significant statistical association between the PROGINS polymorphism and pelvic endometriosis.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Progesterone receptor Archives - Revista Brasileira de Ginecologia e Obstetrícia
