Papillomavirus humano Archives - Revista Brasileira de Ginecologia e Obstetrícia

  • Review Article

    HPV and coronary diseases in menopausal women: an integrative review

    Revista Brasileira de Ginecologia e Obstetrícia. 07-26-2024;46:e-rbgo57

    Summary

    Review Article

    HPV and coronary diseases in menopausal women: an integrative review

    Revista Brasileira de Ginecologia e Obstetrícia. 07-26-2024;46:e-rbgo57

    DOI 10.61622/rbgo/2024rbgo57

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    Abstract

    High-risk human papillomavirus (HPV) infection is associated with cervical cancer while low-risk HPV strains mostly cause benign lesions. Multiple studies have also associated HPV with coronary artery (CAD) disease in women. Furthermore, the climacteric period in women, triggers chronic inflammation and has major implications for CAD and associated lipid disorders. The association of HPV with coronary artery disease in climacteric women has few studies, and the objective of this review is to gather and analyse scientific data on the subject. This is an integrative review performed on PubMed and Google Scholar using the keywords “HPV”, “coronary heart disease” and “climacteric”, among these keywords the boolean operator AND and the publication date filter. (2018 onwards). Five articles were found, whose main results show presence of high-risk vaginal HPV in climacteric women. Climacterium and HPV were associated with a three-fold increased risk of CAD, as well as with factors related to menopause that promote atheroma formation, lipid disorders and chronic inflammation. Thus, these results support the association between HPV infection and CAD in climacteric women, possibly via chronic inflammation, hormonal factors related to menopause and dyslipidemia.

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    This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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