Neoplasm recurrence, local Archives - Revista Brasileira de Ginecologia e Obstetrícia

  • Original Article01-18-2006

    Risk factors for cervical intraepithelial lesions after loop electrosurgical excision procedure in HIV-infected and non-infected women

    Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(9):536-544

    Abstract

    Original Article

    Risk factors for cervical intraepithelial lesions after loop electrosurgical excision procedure in HIV-infected and non-infected women

    Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(9):536-544

    DOI 10.1590/S0100-72032006000900006

    Views111

    PURPOSE: to evaluate risk factors associated with cervical intraepithelial lesion recurrence after LEEP conization. METHODS: nested case-control study in a cohort of 201 patients with cervical intraepithelial lesion, that were submitted to LEEP conization. Average follow-up of these patients was 2 years. Ninety-four HIV-infected women and 107 non-infected were enrolled. Cervical conization was achieved by the Loop Electrosurgical Excision Procedure (LEEP). Evaluated surgical biopsy histopathological characteristics were lesion grade, lesion borders and glandular involvement. After surgery all patients were submitted to a colposcopy and cytological evaluation every six months. Recurrent lesions were defined it confirmed by biopsy after surgery. Cases were patients with and controls patients without recurrence. chi2 test and multivariable analysis by logistic regression were used for group comparisons. Kaplan Meier's method was performed for the survival analyses (log-rank test). RESULTS: 40 patients had lesion recurrence. Initially, significant variables were: partner number, HIV-infection, lesion borders and glandular involvement. The most frequent recurrence occurred when there were simultaneous association between positive margins and glandular involvement as indicator for recurrence risk. After logistic regression analysis the main factors associated with lesion recurrence were: glandular involvement (OR-9.1; 95% CI:13.0- 27.5); HIV-infection (OR-4.6; 95% IC:1.1-6.3); compromised margins (OR-2.6; 95% IC:1.9-11.2). CONCLUSIONS: risk factors associated with cervical intraepitelial lesion recurrence were HIV-infection, glandular involvement and compromised margins.

    See more
    This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Search

Search in:

Article type
Article type
abstract
book-review
brief-report
case-report
correction
editorial
letter
other
rapid-communication
research-article
review-article
Section
Section
Autors' Reply
Case Report
Clinical Consensus Recommendation
Editor's Note
Editorial
Equipments and Methods
Erratum
FEBRASGO POSITION STATEMENT
FIGO Statement
GUIDELINES
Integrative Review
Letter to the Editor
Nominata 2024
Original Article
Original Article/Contraception
Original Article/Infertility
Original Article/Obstetrics
Original Article/Oncology
Original Article/Sexual Violence/Pediatric and Adolescent Gynecology
Original Article/Teaching and Training
Previous Note
Reply to the Letter to the Editor
Resumos dos Trabalhos Premiados no 50º Congresso Brasileiro de Ginecologia e Obstetrícia
Review Article
Short Communication
Special Article
Systematic Review
Thesis Abstract
Year / Volume
Year / Volume
2025; v.47
2025; v.46
2024; v.46
2023; v.45
2022; v.44
2021; v.43
2020; v.42
2019; v.41
2018; v.40
2017; v.39
2016; v.38
2015; v.37
2014; v.36
2013; v.35
2012; v.34
2011; v.33
2010; v.32
2009; v.31
2008; v.30
2007; v.29
2006; v.28
2005; v.27
2004; v.26
2003; v.25
2002; v.24
2001; v.23
2000; v.22
1999; v.21
1998; v.20
ISSUE
ISSUE