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Original Article05-16-2019
Assessment of Metalloproteinase Matrix 9 (MMP9) Gene Polymorphisms Risk Factors for Pelvic Organ Prolapse in the Brazilian Population
- Frederico Rezende Ghersel
, - Ricardo Peres Souto,
- Ester Wilma Pacheco Gonzales,
- Denise Souza Paulo,
- César Eduardo Fernandes, [ ... ],
- Emerson Oliveira
Abstract
Original ArticleAssessment of Metalloproteinase Matrix 9 (MMP9) Gene Polymorphisms Risk Factors for Pelvic Organ Prolapse in the Brazilian Population
Revista Brasileira de Ginecologia e Obstetrícia. 2019;41(3):164-169
- Frederico Rezende Ghersel ,
- Ricardo Peres Souto,
- Ester Wilma Pacheco Gonzales,
- Denise Souza Paulo,
- César Eduardo Fernandes,
- Emerson Oliveira
Views224See moreAbstract
Objective
To evaluate the C-1562T matrix metalloproteinase 9 (MMP9) gene polymorphisms as risk factors related to the occurrence of pelvic organ prolapse (POP) and to identifytheclinicalvariablesassociatedwith theoccurrenceof thedisease.Epidemiological studies of risk factors for POP do not explain why nulliparous women with no known risk factors also develop POP. Therefore, genetic factors may be involved.
Methods
Cohort study with 86 women with symptomatic POP (cases), and 158 women withoutapriororcurrentdiagnosisof thisdisorder(controls).Thegroupswereanalyzedfor the presence of MMP9 gene polymorphisms. Genotyping was performed using polymerase chainreaction(PCR)with DNA obtained froma peripheral venouspuncture ofboth groups.
Results
There were no differences between the cases and controls even when we grouped the mutant homozygous and heterozygous genotypes. The analysis of patients with a complete absence of POP versus patients with total POP also showed no statistically significant differences. Ageand home birth were found to be independent risk factors for POP.
Conclusions
There were no statistically significant differences in the C-1562T MMP9 polymorphisms between the cases and controls in Brazilian women.
Views224
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
Original ArticleAssessment of Metalloproteinase Matrix 9 (MMP9) Gene Polymorphisms Risk Factors for Pelvic Organ Prolapse in the Brazilian Population
Revista Brasileira de Ginecologia e Obstetrícia. 2019;41(3):164-169
- Frederico Rezende Ghersel ,
- Ricardo Peres Souto,
- Ester Wilma Pacheco Gonzales,
- Denise Souza Paulo,
- César Eduardo Fernandes,
- Emerson Oliveira
Views224See moreAbstract
Objective
To evaluate the C-1562T matrix metalloproteinase 9 (MMP9) gene polymorphisms as risk factors related to the occurrence of pelvic organ prolapse (POP) and to identifytheclinicalvariablesassociatedwith theoccurrenceof thedisease.Epidemiological studies of risk factors for POP do not explain why nulliparous women with no known risk factors also develop POP. Therefore, genetic factors may be involved.
Methods
Cohort study with 86 women with symptomatic POP (cases), and 158 women withoutapriororcurrentdiagnosisof thisdisorder(controls).Thegroupswereanalyzedfor the presence of MMP9 gene polymorphisms. Genotyping was performed using polymerase chainreaction(PCR)with DNA obtained froma peripheral venouspuncture ofboth groups.
Results
There were no differences between the cases and controls even when we grouped the mutant homozygous and heterozygous genotypes. The analysis of patients with a complete absence of POP versus patients with total POP also showed no statistically significant differences. Ageand home birth were found to be independent risk factors for POP.
Conclusions
There were no statistically significant differences in the C-1562T MMP9 polymorphisms between the cases and controls in Brazilian women.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Frederico Rezende Ghersel
matrix metalloproteinase Archives - Revista Brasileira de Ginecologia e Obstetrícia
