Labor, obstetric Archives - Revista Brasileira de Ginecologia e Obstetrícia

  • Artigos Originais

    Impact of vaginal delivery after a previous cesarean section on perinatal outcomes

    Revista Brasileira de Ginecologia e Obstetrícia. 2013;35(11):516-522

    Summary

    Artigos Originais

    Impact of vaginal delivery after a previous cesarean section on perinatal outcomes

    Revista Brasileira de Ginecologia e Obstetrícia. 2013;35(11):516-522

    DOI 10.1590/S0100-72032013001100007

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    PURPOSE: To analyze the impact of vaginal delivery after a previous cesarean section on perinatal outcomes. METHODS: Case-control study with selection of incident cases and consecutive controls. Maternal and perinatal variables were analyzed. We compared secundiparas who had a vaginal delivery after a previous cesarean delivery (VBAC) (n=375) with secundiparas who had a second cesarean section (CS) (n=375). Inclusion criteria were: secundiparas who underwent a cesarean section in the previous pregnancy; singleton and term pregnancy; fetus in vertex presentation, with no congenital malformation; absence of placenta previa or any kind of bleeding in the third quarter of pregnancy. RESULTS: The rate of vaginal delivery was 45.6%, and 20 (5.3%) women had forceps deliveries. We found a significant association between VBAC and mothers younger than 19 years (p<0.01), Caucasian ethnicity (p<0.05), mean number of prenatal care visits (p<0.001), time of premature rupture of membranes (p<0.01), labor duration shorter than 12 hours (p<0.04), Apgar score lower than seven at 5th minute (p<0.05), fetal birth trauma (p<0.01), and anoxia (p<0.006). In the group of newborns delivered by cesarean section, we found a higher frequency of transient tachypnea (p<0.014), respiratory disorders (p<0.048), and longer time of stay in the neonatal intensive care unit (p<0.016). There was only one case of uterine rupture in the VBAC group. The rate of neonatal mortality was similar in both groups. CONCLUSIONS: Vaginal delivery in secundiparas who had previous cesarean sections was associated with a significant increase in neonatal morbidity. Further studies are needed to develop strategies aimed at improving perinatal results and professional guidelines, so that health care professionals will be able to provide their patients with better counseling regarding the choice of the most appropriate route of delivery.

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  • Artigos Originais

    Low dose of sublingual misoprostol (12.5 µg) for labor induction

    Revista Brasileira de Ginecologia e Obstetrícia. 2012;34(4):164-169

    Summary

    Artigos Originais

    Low dose of sublingual misoprostol (12.5 µg) for labor induction

    Revista Brasileira de Ginecologia e Obstetrícia. 2012;34(4):164-169

    DOI 10.1590/S0100-72032012000400005

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    PURPOSE: To describe the maternal and perinatal outcomes after the use of 12.5 µg of sublingual misoprostol for labor induction in women with term pregnancy and a live fetus. METHODS: We conducted a multicenter, open and non-randomized clinical trial during the period from July to December 2009. We included 30 pregnant women with an indication for labor induction at term, carrying a live fetus, with a Bishop score of six or less, cephalic presentation, estimated fetal weight of less than 4,000 g and an amniotic fluid index greater than five. We excluded women with a previous uterine scar, non-reassuring fetal status, congenital anomalies, multiple pregnancy, intrauterine growth restriction, genital bleeding, and contraindications of vaginal delivery. A tablet of 12.5 µg sublingual misoprostol was administered every six hours, until the beginning of labor, with the maximum of eight doses. RESULTS: Labor was successfully induced in 90% of pregnant women. The mean interval between the first dose and the onset of uterine contractions and delivery was 14.3±11.7 hours and 25.4±13 hours, respectively. The frequency of vaginal delivery was 60%. Uterine tachysystole occurred in two pregnant women, being reversed in both cases without the need for cesarean section. Meconium-stained amniotic fluid was observed in four patients, and an Apgar score of less than 7 at five minutes in only one newborn. CONCLUSION: Maternal and perinatal outcomes were favorable after induction of labor with sublingual misoprostol at a dose of 12.5 µg every six hours. However, controlled trials are needed to compare this regimen with other doses and routes of administration.

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  • Artigos Originais

    Cervical Foley catheter versus vaginal misoprostol for cervical ripening and induction of labor: a randomized clinical trial

    Revista Brasileira de Ginecologia e Obstetrícia. 2010;32(7):346-351

    Summary

    Artigos Originais

    Cervical Foley catheter versus vaginal misoprostol for cervical ripening and induction of labor: a randomized clinical trial

    Revista Brasileira de Ginecologia e Obstetrícia. 2010;32(7):346-351

    DOI 10.1590/S0100-72032010000700007

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    PURPOSE: to compare the effectiveness of the Foley balloon with vaginal misoprostol for cervical ripening and labor induction. METHODS: randomized clinical trial, not blind, conducted from January 2006 to January 2008. A total of 160 pregnant women with indication for induction of labor were included and divided into two groups, 80 for Foley and 80 for vaginal misoprostol. Inclusion criteria were: gestational age of 37 weeks or more, a live single fetus with cephalic presentation and a Bishop score of four or less. We excluded patients with a uterine scar, ruptured membranes, estimated fetal weight greater than 4000 g, placenta previa, chorioamnionitis and conditions that imposed the immediate termination of pregnancy. Statistical tests employed were Mann-Whitney, χ2 test or Fisher's exact test, and p value was significant if less than 0.005. RESULTS: misoprostol triggered more frequently spontaneous delivery (50.0 versus 15.0% for Foley, p<0.001) and required less use of oxytocin (41.2 versus 76.2%), and this group presented more tachysystole (21.2 versus 5.0%). The Foley catheter caused more discomfort to the patient (28.7 versus 1.2%). There were no differences in the time required for development of the Bishop score (20.69 versus 21.36 hours), for triggering delivery (36.42 versus 29.57 hours) or in rates of cesarean delivery (51.2 versus 42.5%). There were no significant differences in perinatal performance, with similar rates of abnormal cardiotocography (20.0 versus 21.2%), presence of meconium (13.7 versus 17.5%) and need for neonatal intensive care unit (3.7 versus 6.2%). CONCLUSIONS: the use of the Foley catheter was as effective as misoprostol for cervical ripening, but less effective in triggering spontaneous labor. Our results support the recommendation of its use for cervical ripening, especially in patients with cesarean scar.

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  • Artigos Originais

    Titrated oral solution of misoprostol for labour induction: a pilot study

    Revista Brasileira de Ginecologia e Obstetrícia. 2010;32(5):208-213

    Summary

    Artigos Originais

    Titrated oral solution of misoprostol for labour induction: a pilot study

    Revista Brasileira de Ginecologia e Obstetrícia. 2010;32(5):208-213

    DOI 10.1590/S0100-72032010000500002

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    PURPOSE: to test effectiveness and safety of the oral administration of a new misoprostol formulation in titrated doses for the induction of delivery of a live fetus at term. METHODS: an open pilot multicenter, non-randomized clinical trial was conducted from July to December 2008. A total of 30 patients with indications for induction of labor were included. The patients had a live fetus, Bishop score <6, vertex presentation, fetal weight <4,000g estimated by ultrasonography and amniotic fluid index >5. Exclusion criteria were previous uterine scar, non-reassuring fetal heart rate tracing, multiple pregnancy, fetal growth restriction, genital hemorrhage and presence of genital tumors, ulcerations or malformations. An initial dose of 20µg/hour of the oral misoprostol solution was used in the first 6 hours, and was increased progressively to 20µg/hour every 6 hours if labor did not start, up to a maximum dose of 80µg/h in the first 24 hours, maintained for additional 24 hours if necessary. RESULTS: labor was satisfactorily induced in 96.7% of patients. The interval between the first dose and the beginning of uterine contractions was 3.8±1.8 hours. The interval between the initial dose and delivery varied from 6 to 24 hours. The frequency of vaginal delivery was 80% (24 cases). Most of the patients (60%; n=18) initiated labor with a dose of 20mg/hour. Tachysystole occurred in 13.3% of women and meconium-stained fluid was detected in 20% of cases. There were two cases of Apgar scores <7 in the first minute and no Apgar score <7 in the fifth minute. CONCLUSIONS: the oral solution of misoprostol was effective and safe for the induction of labor. However, further randomized controlled trials are needed to compare this new formulation with misoprostol administered by the vaginal route.

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  • Artigos Originais

    Combined spinal-epidural block versus continuous epidural block in labor analgesia for primiparous women: newborns and women outcomes

    Revista Brasileira de Ginecologia e Obstetrícia. 2009;31(10):485-491

    Summary

    Artigos Originais

    Combined spinal-epidural block versus continuous epidural block in labor analgesia for primiparous women: newborns and women outcomes

    Revista Brasileira de Ginecologia e Obstetrícia. 2009;31(10):485-491

    DOI 10.1590/S0100-72032009001000003

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    PURPOSE: to compare maternal and perinatal results, after the use of continuous peridural versus combined rachidian and peridural analgesia in primiparous parturients. METHODS: randomized clinical trial with 128 primiparous pregnant women in labor, divided into two groups: peridural analgesia (CPA) with 65 women, and combined continuous rachidian and peridural analgesia (CRPA) with 63, all of them admitted in the pre-labor period at two maternities in Jundiai, in the state of São Paulo. The variables studied were: latency of analgesia onset, pain intensity, total time until complete dilation, Apgar index at the first and fifth minutes, labor duration, degree of motor blockade, adverse effects such as vomiting, pruritus, arterial hypotension and degree of maternal fulfillment. Inclusion criteria were: primiparous, physical condition ASA 1 and 2, an only foetus, cephalic presentation, term delivery, 3 to 6 cm cervical dilation, and analgesia required by the obstetritian. Women with morbidity, membrane rupture, fetal abnormality and use of opioids up to four hours before were excluded. The Mann-Whitney test was used for the statistical analysis of non-parametric continuous variables, and Fisher's exact and Pearson's χ2 tests, for the categoric variables. RESULTS: there was no difference between the groups concerning the length of cervical dilation, labor duration, maternal hemodynamic parameters, newborn vitality, analgesic complementation during labor and type of delivery. Analgesia onset was quicker in the CRPA group, and the CPA group presented less motor blockade. Differences concerning adverse effects such as nausea, vomiting, pruritus and hypotension have not been observed, but hypotension was more frequent in the CPA group (6.3 versus 3.1%). CONCLUSIONS: both techniques have proved to be safe and efficient, but CRP has provided an earlier onset, with quicker pain relief. The lesser motor blockade in the CPA group has allowed the parturients more active movements in bed and more effective collaboration during the expulsion period. Most women were pleased with the analgesia they got. The doses of local anesthetics and opioids used in both analgesic techniques and the complementary doses, equal in both groups, neither had any significant adverse effect nor affected newborn vitality.

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    Combined spinal-epidural block versus continuous epidural block in labor analgesia for primiparous women: newborns and women outcomes
  • Artigos Originais

    The macrophages in the placenta during labor

    Revista Brasileira de Ginecologia e Obstetrícia. 2009;31(2):90-93

    Summary

    Artigos Originais

    The macrophages in the placenta during labor

    Revista Brasileira de Ginecologia e Obstetrícia. 2009;31(2):90-93

    DOI 10.1590/S0100-72032009000200007

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    PURPOSE: to verify the amount of CD68+ cells in chorionic villosities in placentae from gestations submitted or not to labor. METHODS: transversal study with healthy near-term pregnant women, among whose placentae, 31 have been examined by immunohistochemical technique. Twenty placentae were obtained after vaginal delivery (VAGG) and eleven after elective cesarean sections (CESG). Slides were prepared with chorionic villosities samples and labeled with anti-CD68 antibody, specific for macrophages. Labeled and nonlabeled cells were counted inside the villosities. Non-parametric statistical tests were used for the analysis. RESULTS: among the 6,424 cells counted in the villosities' stroma from the 31 placentae, 1,135 cells (17.6%) were stained by the CD68+. The mean of cells labeled by the anti-CD68 was 22±18 for the VAGG group and 20±16 for the CESG, in each placentary sample. CONCLUSIONS: there were no significant differences in the percentage of macrophages (CD68+) in association with labor.

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    The macrophages in the placenta during labor
  • Artigos Originais

    Low-dose vaginal misoprostol (12.5 versus 25 µg) for induction of labor at term

    Revista Brasileira de Ginecologia e Obstetrícia. 2007;29(12):639-646

    Summary

    Artigos Originais

    Low-dose vaginal misoprostol (12.5 versus 25 µg) for induction of labor at term

    Revista Brasileira de Ginecologia e Obstetrícia. 2007;29(12):639-646

    DOI 10.1590/S0100-72032007001200007

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    PURPOSE: to compare the effectiveness of low doses of vaginal misoprostol (12.5 versus 25 µg) for induction of labor. METHODS: a double-blind, randomized, controlled clinical trial was performed in Santa Casa de Misericórdia de Sobral, from May 2005 to April 2006. Sixty-two term pregnant women, with intact membranes and with indication for labor induction, were included. They randomly received 25 µg (32) or 12.5 µg (30) of vaginal misoprostol each four hours, until the maximum of eight doses. Mode of delivery, time between induction and delivery, perinatal complications, and maternal side effects were studied. The control variables were maternal and gestational ages, parity and Bishop score. The statistical tests used were average calculations, shunting line-standards and Student t-test (numerical continuous variables), chi2 (categorical variables) and Mann-Whitney test (discrete variables). RESULTS: the two groups, 12.5 and 25 µg, did not differ in relation to the interval of time between the induction onset and delivery (1524 versus 1212 min, p=0.333), in the frequency of vaginal delivery (70 versus 71.8%, p=0.720), Apgar scores below seven at the fifth minute (3,3 versus 6,25%, p=0.533) and tachysystole frequency (3.3 versus 9.3%, p=0.533). The average of total dose administered was significantly higher in the 25 µg group (40 versus 61.2 µg, p=0.03). CONCLUSIONS: vaginal misoprostol in the dose of 12.5 µg was efficient, with collateral effects similar, to the 25 µg of vaginal misoprostol, for induction of labor at term.

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  • Artigos Originais

    Influence of maternal mobility on duration of the active phase of labor

    Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(11):671-679

    Summary

    Artigos Originais

    Influence of maternal mobility on duration of the active phase of labor

    Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(11):671-679

    DOI 10.1590/S0100-72032006001100007

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    PURPOSE: to investigate the influence of the maternal mobility during the active phase of labor. METHODS: a prospective clinical trial was conducted through comparative analysis among a treatment group (n=50) and a control group (n=50), in the Obstetric Center of the Hospital Universitário da Universidade de São Paulo (USP). The inclusion criteria were: primigravidae with a single fetus on cephalic presentation, with 37 to 42 weeks of pregnancy, with two uterine contractions every ten minutes and with cervical dilatation until 4 cm, besides the agreement to sign the free and informed consent term. The evolution of labor for cesarean section was the exclusion criteria. The patients were assisted during the active phase of labor by the physiotherapist and encouraged for staying in vertical position and movement, according to each dilatation stage and fetus head progression. The control group had obstetric support without the presence of the physiotherapist; it was selected retrospectively, according to the same inclusion and exclusion criteria. RESULTS: 58 primigravidae between 15 and 37 years old were accompanied; 50 of them (86.2%) evolved to vaginal birth and eight (13.7%) evolved to cesarean section and were excluded. Among the patients who were accompanied, the mean of active phase was five hours and 16 minutes, while in the control group it was eight hours and 28 minutes (p<0.001). This difference was maintained in relation to the amniotic sac either whole or ragged. As for the cervix uterine evanescence, the treatment group showed a smaller period of active phase in association to a thin uterine cervix (p<0.001). In the treatment group, none of the patients used analgesics during the active phase, against 62% of the control group (p<0.001). In this group, all the patients used some kind of anesthesia for delivery; in the treatment group, among those who used anesthesia, 76% did it while the dilatation was 9 or 10 cm and 12% did not use any kind of anesthesia (p<0.05). The average weight of the newborns and the apgar did not show significant difference rates between the two groups. CONCLUSIONS: the good performance of maternal mobility has positive influences on the labor process: it increases the tolerance to pain, avoids the use of drugs during labor, improves the evolution of dilatation and reduces the duration of the active phase.

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    Influence of maternal mobility on duration of the active phase of labor

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