HIV infection Archives - Revista Brasileira de Ginecologia e Obstetrícia

  • Original Article06-27-2001

    Histopathology accuracy for the diagnosis of HPV in cervical lesions of HIV-seropositive women

    Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(6):355-364

    Abstract

    Original Article

    Histopathology accuracy for the diagnosis of HPV in cervical lesions of HIV-seropositive women

    Revista Brasileira de Ginecologia e Obstetrícia. 2001;23(6):355-364

    DOI 10.1590/S0100-72032001000600003

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    Purpose: to compare histopathology and polymerase chain reaction (PCR) for the diagnosis of human papillomavirus (HPV) in cervical lesions of human immunodeficiency virus (HIV)-seropositive women. Methods: fifty-two HIV-seropositive women with suspected HPV cervical lesions were studied. Cervical scrapes were collected for PCR and colposcopy-guided biopsy was made for the histopathologic study. Three samples were disqualified for PCR, leaving a study population of 49 women. Results: the prevalence of HPV was 53% by histopathology and 85.7% by PCR. Among the 42 patients in whom HPV was detected by PCR, 26 were confirmed by histopathology (sensitivity = 61.9%). This method gave no false-positives (specificity = 100%), with 100% of positive prediction. Compared to PCR, the histopathology had: positive predcitive value = 100% and negative predcitive value = 30.4%. Among the 26 patients with HPV-positive biopsy, 15 (57.7%) had cervical intraepithelial neoplasia (CIN); relative risk = 13.3. Conclusion: histopathology was 100% correct for HPV-infection diagnosis. It means that when the biopsy is positive, HPV will be present, confirming the clinical suspicion. However, the low sensitivity excludes histopathology as a screening examination in this group of women.

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    This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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