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Artigos Originais
Association between viral load and CD4+ T lymphocyte count and cervical intraepithelial lesions in HIV-infected women
- Angela Cristina Labanca de Araújo,
- Victor Hugo de Melo,
- Lúcia Porto Fonseca de Castro,
- Mark Drew Crosland Guimarães,
- Agdemir Waléria Aleixo, [ ... ],
- Maria Luiza Silva
03-06-2005
Summary
Artigos OriginaisAssociation between viral load and CD4+ T lymphocyte count and cervical intraepithelial lesions in HIV-infected women
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(3):106-111
03-06-2005DOI 10.1590/S0100-72032005000300002
- Angela Cristina Labanca de Araújo,
- Victor Hugo de Melo,
- Lúcia Porto Fonseca de Castro,
- Mark Drew Crosland Guimarães,
- Agdemir Waléria Aleixo,
- Maria Luiza Silva
Views151PURPOSE: to evaluate CD4+ T lymphocyte cell count and HIV viral load influence on the presence of cervical squamous intraepithelial lesions (SIL). METHODS: cross-sectional study of 134 HIV-infected women submitted to uterine cervical biopsy, HIV viral load quantification and CD4+ T lymphocyte cell count. Viral load and CD4+ T lymphocyte cell count were performed before biopsy timing. Three different levels of viral load (<400 copies/mL; 401 to 50,000 copies/mL; >50,000 copies/mL) and CD4+ T lymphocyte count (<200 cells/mm³; 200 to 350 cells/mm³; >350 cells/mm³) were defined. Data were statistically analyzed by the chi2 test, linear tendency chi2 test, Mantel-Haenszel test, and analysis of variance, with level of significance set at p<0.05 and 95% confidence interval. RESULTS: there was no risk tendency for HIV-infected women to show SIL with viral load level increase or CD4+ T lymphocyte reduction. Comparing viral load with the presence or absence of SIL, stratified by quantification timing, there was a significant difference for values over 400 copies/mL (p=0.048; OR: 3.17; 95% CI: 1,02-9.93). No association was found between CD4+ T lymphocyte cell count and SIL. CONCLUSION: patients with HIV viral load higher than 400 copies/mL, performed before uterine cervical biopsy, showed a 3.17 times greater chance to develop SIL. CD4+ T lymphocyte count had no influence on the development of SIL.
Key-words Cervical intraepithelial neoplasiaCervix uteryHIV Acquired immunodeficiency syndromeLymphocytesViral loadSee moreViews151This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Artigos OriginaisAssociation between viral load and CD4+ T lymphocyte count and cervical intraepithelial lesions in HIV-infected women
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(3):106-111
03-06-2005DOI 10.1590/S0100-72032005000300002
- Angela Cristina Labanca de Araújo,
- Victor Hugo de Melo,
- Lúcia Porto Fonseca de Castro,
- Mark Drew Crosland Guimarães,
- Agdemir Waléria Aleixo,
- Maria Luiza Silva
Views151PURPOSE: to evaluate CD4+ T lymphocyte cell count and HIV viral load influence on the presence of cervical squamous intraepithelial lesions (SIL). METHODS: cross-sectional study of 134 HIV-infected women submitted to uterine cervical biopsy, HIV viral load quantification and CD4+ T lymphocyte cell count. Viral load and CD4+ T lymphocyte cell count were performed before biopsy timing. Three different levels of viral load (<400 copies/mL; 401 to 50,000 copies/mL; >50,000 copies/mL) and CD4+ T lymphocyte count (<200 cells/mm³; 200 to 350 cells/mm³; >350 cells/mm³) were defined. Data were statistically analyzed by the chi2 test, linear tendency chi2 test, Mantel-Haenszel test, and analysis of variance, with level of significance set at p<0.05 and 95% confidence interval. RESULTS: there was no risk tendency for HIV-infected women to show SIL with viral load level increase or CD4+ T lymphocyte reduction. Comparing viral load with the presence or absence of SIL, stratified by quantification timing, there was a significant difference for values over 400 copies/mL (p=0.048; OR: 3.17; 95% CI: 1,02-9.93). No association was found between CD4+ T lymphocyte cell count and SIL. CONCLUSION: patients with HIV viral load higher than 400 copies/mL, performed before uterine cervical biopsy, showed a 3.17 times greater chance to develop SIL. CD4+ T lymphocyte count had no influence on the development of SIL.
Key-words Cervical intraepithelial neoplasiaCervix uteryHIV Acquired immunodeficiency syndromeLymphocytesViral loadSee moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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