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Original Article09-30-2019
Progesterone’s Serum Level and a New Ultrasonographic Parameter in the First Trimester Pregnancy – Prognostic Factors for Embryonic Demise
- Carmen Elena Bucuri
, - Razvan Ciortea,
- Andrei Mihai Malutan,
- Costin Berceanu,
- Maria Patricia Rada, [ ... ],
- Dan Mihu
Abstract
Original ArticleProgesterone’s Serum Level and a New Ultrasonographic Parameter in the First Trimester Pregnancy – Prognostic Factors for Embryonic Demise
Revista Brasileira de Ginecologia e Obstetrícia. 2019;41(9):525-530
- Carmen Elena Bucuri ,
- Razvan Ciortea,
- Andrei Mihai Malutan,
- Costin Berceanu,
- Maria Patricia Rada,
- Dan Mihu
Views231See moreAbstract
Objective
The etiology of embryonic demise is multifactorial, with chromosomal abnormalities being the most common (40%). The purpose of the present study is to evaluate the correlation between a serum biomarker, progesterone, and an ultrasonographic parameter, the distance between yolk sac and embryo (DYSE) in assessing the prognosis of pregnancy outcome in the 1st trimester.
Methods
The present study is a prospective case-control analysis that includes 2 groups of patients: 81 patients with first-trimester normal evolutive pregnancy and 89 patients with embryonic demise, all of the patients having between 6 and 11 weeks of amenorrhea. Endovaginal ultrasonographic exploration was performed to evaluate the distance between the lower pole of the embryo and the yolk sac. From each subject enrolled in the study, 20ml of blood was collected for progesterone serum level measurement.
Results
Regarding the DYSE in the case group, lower values were observed compared with the control group, the difference being statistically significant. In the statistical analysis of serum progesterone values, statistically significant differences were observed between the 2 groups (p<0.05).
Conclusion
The DYSE has a high positive predictive value in identifying pregnancies with potentially reserved outcome, with the present study demonstrating that a DYSE<3mm causes an unfavorable evolution of the pregnancy. Low serum levels of progesterone are associated with an increased rate of nonviable embryos. The correlation between these two parameters increases the effectiveness of screening methods in prenatal monitoring and improves the diagnostic methods for the firsttrimester pregnancies whose outcome potential can be reserved.
Views231
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
Original ArticleProgesterone’s Serum Level and a New Ultrasonographic Parameter in the First Trimester Pregnancy – Prognostic Factors for Embryonic Demise
Revista Brasileira de Ginecologia e Obstetrícia. 2019;41(9):525-530
- Carmen Elena Bucuri ,
- Razvan Ciortea,
- Andrei Mihai Malutan,
- Costin Berceanu,
- Maria Patricia Rada,
- Dan Mihu
Views231See moreAbstract
Objective
The etiology of embryonic demise is multifactorial, with chromosomal abnormalities being the most common (40%). The purpose of the present study is to evaluate the correlation between a serum biomarker, progesterone, and an ultrasonographic parameter, the distance between yolk sac and embryo (DYSE) in assessing the prognosis of pregnancy outcome in the 1st trimester.
Methods
The present study is a prospective case-control analysis that includes 2 groups of patients: 81 patients with first-trimester normal evolutive pregnancy and 89 patients with embryonic demise, all of the patients having between 6 and 11 weeks of amenorrhea. Endovaginal ultrasonographic exploration was performed to evaluate the distance between the lower pole of the embryo and the yolk sac. From each subject enrolled in the study, 20ml of blood was collected for progesterone serum level measurement.
Results
Regarding the DYSE in the case group, lower values were observed compared with the control group, the difference being statistically significant. In the statistical analysis of serum progesterone values, statistically significant differences were observed between the 2 groups (p<0.05).
Conclusion
The DYSE has a high positive predictive value in identifying pregnancies with potentially reserved outcome, with the present study demonstrating that a DYSE<3mm causes an unfavorable evolution of the pregnancy. Low serum levels of progesterone are associated with an increased rate of nonviable embryos. The correlation between these two parameters increases the effectiveness of screening methods in prenatal monitoring and improves the diagnostic methods for the firsttrimester pregnancies whose outcome potential can be reserved.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. - Carmen Elena Bucuri
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Review Article05-17-2011
Obstetric ultrasound between the 11th and 14th weeks: beyond the screening for chromosomal abnormalities
Revista Brasileira de Ginecologia e Obstetrícia. 2011;33(1):49-57
Abstract
Review ArticleObstetric ultrasound between the 11th and 14th weeks: beyond the screening for chromosomal abnormalities
Revista Brasileira de Ginecologia e Obstetrícia. 2011;33(1):49-57
DOI 10.1590/S0100-72032011000100008
Views160This is a traditional (narrative) review with the objective of highlighting the contribution of obstetric ultrasonography (US) between the 11th and 14th week of pregnancy, commonly called first trimester anomaly scan. In addition to being used for the screening of chromosomal anomalies, US can be employed during this period to confirm or determine gestational age, evaluate fetal anatomy, diagnose malformations, screen major structural abnormalities and genetic syndromes, define the prognosis of pregnancy, diagnose and characterize multiple pregnancies, and screen preeclampsia and intrauterine growth restriction. The most important studies about this subject published between 1990 and 2010 in the Cochrane and PubMed libraries were included. The selected studies can be classified with scientific levels I to III.
Key-words Chromosome aberrationsFetal malformationFirst trimesterHeart defects, congenitalNuchal translucency measurementObstetric ultrasonographyPre-eclampsiaPregnancy, multipleSee moreViews160This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract
Review ArticleObstetric ultrasound between the 11th and 14th weeks: beyond the screening for chromosomal abnormalities
Revista Brasileira de Ginecologia e Obstetrícia. 2011;33(1):49-57
DOI 10.1590/S0100-72032011000100008
Views160This is a traditional (narrative) review with the objective of highlighting the contribution of obstetric ultrasonography (US) between the 11th and 14th week of pregnancy, commonly called first trimester anomaly scan. In addition to being used for the screening of chromosomal anomalies, US can be employed during this period to confirm or determine gestational age, evaluate fetal anatomy, diagnose malformations, screen major structural abnormalities and genetic syndromes, define the prognosis of pregnancy, diagnose and characterize multiple pregnancies, and screen preeclampsia and intrauterine growth restriction. The most important studies about this subject published between 1990 and 2010 in the Cochrane and PubMed libraries were included. The selected studies can be classified with scientific levels I to III.
Key-words Chromosome aberrationsFetal malformationFirst trimesterHeart defects, congenitalNuchal translucency measurementObstetric ultrasonographyPre-eclampsiaPregnancy, multipleSee moreThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
First trimester Archives - Revista Brasileira de Ginecologia e Obstetrícia
