Fetomaternal hemorrhage Archives - Revista Brasileira de Ginecologia e Obstetrícia

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    Why do we waste anti-D immunoglobulin in early miscarriage?

    Revista Brasileira de Ginecologia e Obstetrícia. 08-04-2004;26(5):363-367

    Summary

    Trabalhos Originais

    Why do we waste anti-D immunoglobulin in early miscarriage?

    Revista Brasileira de Ginecologia e Obstetrícia. 08-04-2004;26(5):363-367

    DOI 10.1590/S0100-72032004000500004

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    OBJECTIVE: evaluation of fetomaternal hemorrhage (FMH) in patients who would need Rh alloimmunization with anti-D immunoglobulin (300 mug) prophylaxis after early miscarriage. METHOD: we included in the study Rh (D) negative blood group patients with positive or unknown Rh (D) partners, who had had a miscarriage up to 12 weeks of gestation, and had been admitted to hospital for uterine curettage. After this procedure 5 ml of venous blood was collected from the patients and the rosette test was applied to screen which patients would need quantitative determination of fetal blood transferred to the maternal circulation, by the Kleihauer-Betke test (K-B). RESULTS: out of 26 patients evaluated the rosette test was positive in one , who showed an FMH of 1.5 ml in the K-B test. CONCLUSIONS: the dose of anti-D immunoglobulin used in cases of miscarriage up to 12 weeks of gestation should be substantially reduced. The availability of preparations of 50 mug is recommended, for a more inexpensive and rational treatment.

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    This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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