Estrogens/therapeutic use Archives - Revista Brasileira de Ginecologia e Obstetrícia

  • Original Article05-01-2015

    Effects of tibolone on the breast parenchyma: experimental study

    Revista Brasileira de Ginecologia e Obstetrícia. 2015;37(5):233-240

    Abstract

    Original Article

    Effects of tibolone on the breast parenchyma: experimental study

    Revista Brasileira de Ginecologia e Obstetrícia. 2015;37(5):233-240

    DOI 10.1590/SO100-720320150005333

    Views109

    OBJECTIVE:

    To assess the effect of tibolone on mammary tissue of castrated rats over 3
    different periods of time.

    METHODS:

    Sixty virgin female Wistar rats were submitted to oophorectomy. Twenty-one days
    after surgery, with hypoestrogenism confirmed, the experimental rats were randomly
    assigned to six groups: Tibolone 1 (n=10) received tibolone 1 mg/day for 23 days,
    tibolone 2 (n=10) for 59 days and tibolone 3 (n=10) for 118 days. The groups
    control 1 (n=8), control 2 (n=7) and control 2 (n=10) received distilled water for
    23, 59 and 118 days, respectively. After treatment, all six pairs of mammary
    glands were removed and stained with hematoxylin and eosin (HE) for histological
    analysis after euthanasia. The histological parameters evaluated were: epithelial
    cell proliferation and secretory activity. The variables were analyzed
    statistically, with the level of significance set at 0.05.

    RESULTS:

    Histological changes were observed in 20/55 rats, mild epithelial hyperplasia in
    7/55, moderate epithelial hyperplasia in 5/55, alveolar-nodular hyperplasia in
    7/55, atypia without epithelial proliferation in 1/55, and no cases of severe
    epithelial hyperplasia were found. Secretory activity was observed in 31/55 rats.
    The secretory activity was significantly higher in the tibolone groups compared to
    control at all the time points assessed (p=0,001). The histological changes were
    did not show significance when the control and tibolone groups were compared. The
    time of exposure to tibolone did not show significance when the three different
    periods of evaluation were compared.

    CONCLUSION:

    No relation between histological modification and tibolone treatment was verified
    after short-, medium- and long-term treatment.

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    This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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