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Case Report
High-Grade Transformation in Adenoid Cystic Carcinoma of the Bartholin Gland: Case Report
- Aline Evangelista Santiago
, - Nicky Teunissen ,
- Bernardo Ferreira de Paula Ricardo ,
- Eduardo Batista Cândido ,
- Rafaela de Souza Furtado , [ ... ],
- Agnaldo Lopes da Silva Filho
01-24-2021
Summary
Case ReportHigh-Grade Transformation in Adenoid Cystic Carcinoma of the Bartholin Gland: Case Report
Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(12):980-984
01-24-2021- Aline Evangelista Santiago ,
- Nicky Teunissen ,
- Bernardo Ferreira de Paula Ricardo ,
- Eduardo Batista Cândido ,
- Rafaela de Souza Furtado ,
- Agnaldo Lopes da Silva Filho
Views115See moreAbstract
Introduction
In the present study, we report a case of primary adenoid cystic carcinoma (ACC) of the Bartholin gland with high-grade transformation (HGT). Adenoid cystic carcinoma of the Bartholin gland is a rare tumor and HGT has only been reported in head and neck tumors.
Case Report
A 77-year-old woman with a non-ulcerated vulvar lesion on the topography of the right Bartholin gland. The patient was submitted to tumor resection followed by V–Y island flap and adjuvant radiotherapy. The histopathological examination revealed primary ACC of the Bartholin gland, with areas of HGT and extensive perineural invasion. The immunohistochemical study with p53 showed a diffuse and strong positive reaction in areas with HGT. After 24 months of follow-up, the patient presented distant metastases and died, despite having undergone to chemotherapy.
Conclusion
As far as we know, this case is the first description in the literature of HGT in ACC of the Bartholin gland, and HGT appears to be associated with tumor aggressiveness.
Views115
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Case ReportHigh-Grade Transformation in Adenoid Cystic Carcinoma of the Bartholin Gland: Case Report
Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(12):980-984
01-24-2021- Aline Evangelista Santiago ,
- Nicky Teunissen ,
- Bernardo Ferreira de Paula Ricardo ,
- Eduardo Batista Cândido ,
- Rafaela de Souza Furtado ,
- Agnaldo Lopes da Silva Filho
Views115See moreAbstract
Introduction
In the present study, we report a case of primary adenoid cystic carcinoma (ACC) of the Bartholin gland with high-grade transformation (HGT). Adenoid cystic carcinoma of the Bartholin gland is a rare tumor and HGT has only been reported in head and neck tumors.
Case Report
A 77-year-old woman with a non-ulcerated vulvar lesion on the topography of the right Bartholin gland. The patient was submitted to tumor resection followed by V–Y island flap and adjuvant radiotherapy. The histopathological examination revealed primary ACC of the Bartholin gland, with areas of HGT and extensive perineural invasion. The immunohistochemical study with p53 showed a diffuse and strong positive reaction in areas with HGT. After 24 months of follow-up, the patient presented distant metastases and died, despite having undergone to chemotherapy.
Conclusion
As far as we know, this case is the first description in the literature of HGT in ACC of the Bartholin gland, and HGT appears to be associated with tumor aggressiveness.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 
- Aline Evangelista Santiago
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Case Report
Differential Diagnosis between Bartholin Cyst and Vulvar Leiomyoma: Case Report
Revista Brasileira de Ginecologia e Obstetrícia. 2017;39(8):433-435
08-01-2017
Summary
Case ReportDifferential Diagnosis between Bartholin Cyst and Vulvar Leiomyoma: Case Report
Revista Brasileira de Ginecologia e Obstetrícia. 2017;39(8):433-435
08-01-2017Views137See moreAbstract
Genital leiomyomas are rare tumors that can often be misdiagnosed as Bartholin cyst. We report a case of a 32-year-old patient who had a cystic nodulation in the left labium majus that was suggestive of Bartholin cyst. A resection surgery was performed, and the definitive histopathology diagnosis was vulvar leiomyoma. The macroscopic features of cystic lesions difficult the differential diagnosis between leiomyoma and Bartholin cyst; therefore, a histopathologic examination is often recommended.
Views137This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Summary
Case ReportDifferential Diagnosis between Bartholin Cyst and Vulvar Leiomyoma: Case Report
Revista Brasileira de Ginecologia e Obstetrícia. 2017;39(8):433-435
08-01-2017Views137See moreAbstract
Genital leiomyomas are rare tumors that can often be misdiagnosed as Bartholin cyst. We report a case of a 32-year-old patient who had a cystic nodulation in the left labium majus that was suggestive of Bartholin cyst. A resection surgery was performed, and the definitive histopathology diagnosis was vulvar leiomyoma. The macroscopic features of cystic lesions difficult the differential diagnosis between leiomyoma and Bartholin cyst; therefore, a histopathologic examination is often recommended.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Bartholin gland Archives - Revista Brasileira de Ginecologia e Obstetrícia
