Anemia, sickle cell Archives - Revista Brasileira de Ginecologia e Obstetrícia
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2010;32(11):525-529
DOI 10.1590/S0100-72032010001100002
PURPOSE: to evaluate the characteristics of the menstrual cycle and to identify the occurrence of ovulation in nulliparous young women with sickle cell anemia (SCA). METHODS: we conducted a case-control study including 26 nulliparous women of reproductive age, divided into two groups: "cases", consisting of 13 women with SCA, and "Control" Group, consisting of 13 healthy women with the same interval since menarche. The characteristics of the menstrual cycle were reported by the participants, who were also submitted to measurements of serum progesterone, basal body temperature curves and transabdominal ultrasound in three consecutive cycles (total: 78 cycles) in order to identify the occurrence of ovulation. The results were compared between groups using the nonparametric Mann-Whitney or Kruskal Wallis tests, and the differences were considered significant when p-value < 0.05. RESULTS: no significant difference was found in mean chronological age between the two groups (p = 0.2) in the pattern of the menstrual cycle when duration of flow (p = 0.4) and interval between cycles (p = 0.3) were compared. There was no difference between groups in age at menarche (p = 0.05). Mean hemoglobin value was 8.4 g/dL (± 0.9) in the group of women with SCA and 12.6 g/dL (± 0.8) in the control group (p < 0.01). The frequency of ovulatory cycles was similar for cases (76.9%) and controls (92.3%) (p = 0.5), with a predominance of individuals with three ovulatory cycles in the control group (84.6%) compared to 23.1% in the case group (p = 0.04). CONCLUSION: the findings justify the need for effective guidance for patients with SCA regarding sexual activity, the possibility of pregnancy and the alternatives for contraception.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2010;32(11):525-529
DOI 10.1590/S0100-72032010001100002
PURPOSE: to evaluate the characteristics of the menstrual cycle and to identify the occurrence of ovulation in nulliparous young women with sickle cell anemia (SCA). METHODS: we conducted a case-control study including 26 nulliparous women of reproductive age, divided into two groups: "cases", consisting of 13 women with SCA, and "Control" Group, consisting of 13 healthy women with the same interval since menarche. The characteristics of the menstrual cycle were reported by the participants, who were also submitted to measurements of serum progesterone, basal body temperature curves and transabdominal ultrasound in three consecutive cycles (total: 78 cycles) in order to identify the occurrence of ovulation. The results were compared between groups using the nonparametric Mann-Whitney or Kruskal Wallis tests, and the differences were considered significant when p-value < 0.05. RESULTS: no significant difference was found in mean chronological age between the two groups (p = 0.2) in the pattern of the menstrual cycle when duration of flow (p = 0.4) and interval between cycles (p = 0.3) were compared. There was no difference between groups in age at menarche (p = 0.05). Mean hemoglobin value was 8.4 g/dL (± 0.9) in the group of women with SCA and 12.6 g/dL (± 0.8) in the control group (p < 0.01). The frequency of ovulatory cycles was similar for cases (76.9%) and controls (92.3%) (p = 0.5), with a predominance of individuals with three ovulatory cycles in the control group (84.6%) compared to 23.1% in the case group (p = 0.04). CONCLUSION: the findings justify the need for effective guidance for patients with SCA regarding sexual activity, the possibility of pregnancy and the alternatives for contraception.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(2):122-125
DOI 10.1590/S0100-72032006000200008
PURPOSE: to evaluate the prevalence of hemoglobin S (HbS) in newborns, through clinical investigation and laboratory data. METHODS: a protocol established the drawing of 10 mL blood from the umbilical cord after its ligature and section, immediately after birth. The samples were kept in a tube with 5% EDTA and then submitted to high-performance liquid chromatography. The study included a clinical record taken from an interview with the mother, her physical and biochemical condition, as well as that of her newborn. Main criteria were newborn's weight, sex, first minute Apgar, and the mother's color. Statistical analysis was based on the Epi-Info 6.0 program and performed by Student's t test, with the level of significance set at p<0.05. RESULTS: from August 2001 to September 2002, 389 umbilical cord blood samples showed HbS in 16 newborn babies (4.1%). Fifteen of these presented sickle-cell traits (HbS) and the other had a diagnostic hypothesis of sickle-cell anemia (HbSS). Hemoglobinopathy prevailed among male babies. No significant difference was observed between newborns with or without HbS regarding averages of weight and Apgar scores; the same occurred regarding the mother's skin color (Caucasians, mulattos and blacks). CONCLUSION: searching for hemoglobin diseases in newborns should be considered because of the possibility of 25% sickle-cell anemia in the offspring of couples with sickle-cell traits. Screening for abnormal hemoglobin is important in the population at risk. Thus, the creation of programs with these aims is recommended to be included in hospital routines.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(2):122-125
DOI 10.1590/S0100-72032006000200008
PURPOSE: to evaluate the prevalence of hemoglobin S (HbS) in newborns, through clinical investigation and laboratory data. METHODS: a protocol established the drawing of 10 mL blood from the umbilical cord after its ligature and section, immediately after birth. The samples were kept in a tube with 5% EDTA and then submitted to high-performance liquid chromatography. The study included a clinical record taken from an interview with the mother, her physical and biochemical condition, as well as that of her newborn. Main criteria were newborn's weight, sex, first minute Apgar, and the mother's color. Statistical analysis was based on the Epi-Info 6.0 program and performed by Student's t test, with the level of significance set at p<0.05. RESULTS: from August 2001 to September 2002, 389 umbilical cord blood samples showed HbS in 16 newborn babies (4.1%). Fifteen of these presented sickle-cell traits (HbS) and the other had a diagnostic hypothesis of sickle-cell anemia (HbSS). Hemoglobinopathy prevailed among male babies. No significant difference was observed between newborns with or without HbS regarding averages of weight and Apgar scores; the same occurred regarding the mother's skin color (Caucasians, mulattos and blacks). CONCLUSION: searching for hemoglobin diseases in newborns should be considered because of the possibility of 25% sickle-cell anemia in the offspring of couples with sickle-cell traits. Screening for abnormal hemoglobin is important in the population at risk. Thus, the creation of programs with these aims is recommended to be included in hospital routines.