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Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo81
To verify the prevalence and factors associated with Non-Alcoholic Fatty Liver Disease (NAFLD) among women with Polycystic Ovary Syndrome (PCOS).
A cross-sectional study was conducted with 53 patients with PCOS. The diagnosis of PCOS followed the Rotterdam criteria. The diagnosis of NAFLD was made through US showing hepatic steatosis, excluding significant alcohol consumption and chronic liver disease. The following variables were compared between the groups of women with and without NAFLD: age, race, anthropometric data, blood pressure levels, liver enzymes, glycemic and lipid profiles, total testosterone, presence of hirsutism, and metabolic syndrome (MS). Variables were compared between the groups using T-test, Mann-Whitney, and Chi-square tests.
Among 53 patients with PCOS, 50.9% had NAFLD. The NAFLD group had higher weight (p=0.003), BMI (p=0.001), waist circumference (p≤0.001), fasting glucose (p=0.021), HbA1C% (p=0.028), triglycerides (p=0.023), AST (p=0.004), ALT (p=0.001), higher prevalence of MS (p=0.004), and lower levels of HDL cholesterol (p=0.043). The other variables did not differ between the groups. Both groups were predominantly of caucasian race, and there was no significant difference in age.
The prevalence of NAFLD among patients with PCOS was 50.9%. Metabolic and hepatic enzyme abnormalities were more prevalent in this group compared to the group without the disease. Obesity tripled the prevalence of NAFLD.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2024;46:e-rbgo81
To verify the prevalence and factors associated with Non-Alcoholic Fatty Liver Disease (NAFLD) among women with Polycystic Ovary Syndrome (PCOS).
A cross-sectional study was conducted with 53 patients with PCOS. The diagnosis of PCOS followed the Rotterdam criteria. The diagnosis of NAFLD was made through US showing hepatic steatosis, excluding significant alcohol consumption and chronic liver disease. The following variables were compared between the groups of women with and without NAFLD: age, race, anthropometric data, blood pressure levels, liver enzymes, glycemic and lipid profiles, total testosterone, presence of hirsutism, and metabolic syndrome (MS). Variables were compared between the groups using T-test, Mann-Whitney, and Chi-square tests.
Among 53 patients with PCOS, 50.9% had NAFLD. The NAFLD group had higher weight (p=0.003), BMI (p=0.001), waist circumference (p≤0.001), fasting glucose (p=0.021), HbA1C% (p=0.028), triglycerides (p=0.023), AST (p=0.004), ALT (p=0.001), higher prevalence of MS (p=0.004), and lower levels of HDL cholesterol (p=0.043). The other variables did not differ between the groups. Both groups were predominantly of caucasian race, and there was no significant difference in age.
The prevalence of NAFLD among patients with PCOS was 50.9%. Metabolic and hepatic enzyme abnormalities were more prevalent in this group compared to the group without the disease. Obesity tripled the prevalence of NAFLD.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2009;31(7):335-341
DOI 10.1590/S0100-72032009000700003
PURPOSE: to describe alcohol and tobacco use in adult pregnant women and determine its association with the obstetric outcome. METHODS: analytical transversal study, in which 433 adult pregnant women and their newborns have been included, attended at a public maternity hospital in Rio de Janeiro, from 1999 to 2006. Information on the mother and the newborn was collected at the moment of delivery and during puerperium through an interview and inspection of the medical records. "Use of alcohol during gestation" and "use of cigarette during gestation" have been considered when detected at any gestational age and written down on the medical record. RESULTS: it was observed that 5.5 and 7.7% of the pregnant women reported cigarette and alcohol use during gestation, respectively. Maternal features related to tobacco use during pregnancy were marital status (p=0.005), age (p=0.01) and pre-natal nutritional guidance (p=0.003). Tobacco use during pregnancy has been strongly associated with alcohol use, 31.3% of the women reporting concomitant use of both substances (p<0.05). No association between alcohol or tobacco use during gestation and obstetric outcome (gestational age, newborn weight at birth and newborn medical conditions; p>0.05) has been detected. CONCLUSIONS: these results suggest that tobacco and alcohol use should be investigated during pre-natal care among all women, particularly single women, over 35 years old, with history of miscarriage, and with unwanted pregnancy. Nutritional guidance had a protective effect against tobacco use during gestation, and thus pregnant women should be informed as to the harmful effects of substance use to ensure better obstetric outcome.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2009;31(7):335-341
DOI 10.1590/S0100-72032009000700003
PURPOSE: to describe alcohol and tobacco use in adult pregnant women and determine its association with the obstetric outcome. METHODS: analytical transversal study, in which 433 adult pregnant women and their newborns have been included, attended at a public maternity hospital in Rio de Janeiro, from 1999 to 2006. Information on the mother and the newborn was collected at the moment of delivery and during puerperium through an interview and inspection of the medical records. "Use of alcohol during gestation" and "use of cigarette during gestation" have been considered when detected at any gestational age and written down on the medical record. RESULTS: it was observed that 5.5 and 7.7% of the pregnant women reported cigarette and alcohol use during gestation, respectively. Maternal features related to tobacco use during pregnancy were marital status (p=0.005), age (p=0.01) and pre-natal nutritional guidance (p=0.003). Tobacco use during pregnancy has been strongly associated with alcohol use, 31.3% of the women reporting concomitant use of both substances (p<0.05). No association between alcohol or tobacco use during gestation and obstetric outcome (gestational age, newborn weight at birth and newborn medical conditions; p>0.05) has been detected. CONCLUSIONS: these results suggest that tobacco and alcohol use should be investigated during pre-natal care among all women, particularly single women, over 35 years old, with history of miscarriage, and with unwanted pregnancy. Nutritional guidance had a protective effect against tobacco use during gestation, and thus pregnant women should be informed as to the harmful effects of substance use to ensure better obstetric outcome.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(7):376-381
DOI 10.1590/S0100-72032005000700002
PURPOSE: to check alcohol consumption during pregnancy and to estimate teratogenic effects on the fetus. METHODS: the T-ACE questionnaire was applied to 150 women who had just given birth in a maternity hospital in Ribeirão Preto/SP, from April to November 2004. The patients were divided into those who consumed and those did not consume alcohol during gestation. The newborns of these women were evaluated regarding weight, length and head circumference at birth. These anthropometric measurements were compared with the alcoholic beverage consumption by the women. The data analysis was performed by Student's t test, Mann-Whitney U-test and chi2 test, with the level of significance set at 5%. RESULTS: among the interviewed women, 79.3% (119) were not identified as alcohol consumers by the T-ACE questionnaire and 20.7% (31) were considered consumers by this questionnaire. The newborns whose mothers did not consume alcohol had a mean length of 48.2 cm. On the other hand, those whose mothers used alcohol were 46.7 cm long, and such difference was statistically significant. A mean decrease of 109 g in weight and 0.42 cm in head circumference was observed in the children whose mothers had consumed alcohol. In the female fetuses the weight decrease was more pronounced (186 g). CONCLUSION: the T-ACE questionnaire was an effective screening instrument for detecting alcohol consumption during pregnancy. The use of alcohol during pregnancy was associated with fetal growth restriction. Apparently, the female fetuses were more susceptible to the effects of the use of alcohol during pregnancy.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(7):376-381
DOI 10.1590/S0100-72032005000700002
PURPOSE: to check alcohol consumption during pregnancy and to estimate teratogenic effects on the fetus. METHODS: the T-ACE questionnaire was applied to 150 women who had just given birth in a maternity hospital in Ribeirão Preto/SP, from April to November 2004. The patients were divided into those who consumed and those did not consume alcohol during gestation. The newborns of these women were evaluated regarding weight, length and head circumference at birth. These anthropometric measurements were compared with the alcoholic beverage consumption by the women. The data analysis was performed by Student's t test, Mann-Whitney U-test and chi2 test, with the level of significance set at 5%. RESULTS: among the interviewed women, 79.3% (119) were not identified as alcohol consumers by the T-ACE questionnaire and 20.7% (31) were considered consumers by this questionnaire. The newborns whose mothers did not consume alcohol had a mean length of 48.2 cm. On the other hand, those whose mothers used alcohol were 46.7 cm long, and such difference was statistically significant. A mean decrease of 109 g in weight and 0.42 cm in head circumference was observed in the children whose mothers had consumed alcohol. In the female fetuses the weight decrease was more pronounced (186 g). CONCLUSION: the T-ACE questionnaire was an effective screening instrument for detecting alcohol consumption during pregnancy. The use of alcohol during pregnancy was associated with fetal growth restriction. Apparently, the female fetuses were more susceptible to the effects of the use of alcohol during pregnancy.
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