You searched for:"Antonio Braga"
We found (19) results for your search.Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(6):483-488
DOI 10.1590/S0100-72032004000600010
OBJECTIVE: to determine whether the clinical presentation of hydatidiform mole has changed in the recent years (1992-1998) when compared with historic controls (1960-1981). METHODS: medical records of 80 patients with hydatidiform mole attended in the 1960-1981 period (Group I) were reviewed and compared to data from 801 patients followed in the 1992-1998 period (Group II). The clinical signals and symptoms analyzed were: age distribution, number of pregnancies, vaginal bleeding, hyperemesis, edema, hypertension, large uterus for gestation date and theca lutein cysts of the ovaries. Statistical analyses employed chi-square tests and odds ratio (OR) estimate with the confidence interval (CI) of 95%. RESULTS: concerning age, the disease occurred more frequently in group II than in group I, in patients under 15 and over 40 years old. As to the number of pregnancies, there was no statistical difference only in those patients who were in their third or fourth pregnancies. Arterial hypertension was the only symptom that occurred with similar frequency in both groups. Enlarged uterus was more frequent in group II (41.4 X 31.2% - p <0.05; OR: 1.5; IC: 1.0-2.3). Bleeding remained the most common symptom, occurring in 76.9% of patients (Group II), although it has occurred in 98.7% of the historic controls (p<0.05; OR: 0.04; IC: 0.03 0.04). The following symptoms were also less frequent in group II as compared to group I: hyperemesis (36.5% X 45% - p<0.05; OR: 0.7; IC: 0.4 0.9), edema (12.7% X 20% - p<0.05, OR: 0.5, IC: 0.3 0.8), enlarged uterus for gestational age (41.4% x 31.2% - p<0.05; OR: 1.5; IC: 1.0 2.3) and theca lutein cysts (16.4% X 41.2% - p<0.05; OR: 0.3; IC: 0.2 0.4). Ultrasound has become the commonest method of diagnosis (89.2% - p<0.05), allowing early detection of hydatidiform moles. CONCLUSION: there was a decrease of the traditional symptoms in current patients with hydatidiform mole as compared to historic controls, due to early diagnosis through ultrasonography.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(7):503-506
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2003;25(1):61-66
DOI 10.1590/S0100-72032003000100009
PURPOSE: to study the frequency of recurrent gestational trophoblastic neoplasm and to analyze whether the features and the outcome of the repetitive disease lead to a higher risk of invasion or of malignization and the need for more courses of chemotherapy and more aggressive regimens. METHODS: twenty-nine patients with recurrent hydatidiform mole were followed up at the Santa Casa da Misericórdia Trophoblastic Disease Center (Rio de Janeiro, Brazil) between 1960 and 2001, showing an incidence of 1.28% (29/2262). The medical charts were examined to determine the patient's age, number of pregnancies, parity, clinical presentation and chemotherapy. A total of fifty-eight trophoblastic neoplasm episodes occurred in these 29 patients and all were reviewed regarding their pathology. Statistical data were determined by the chi2 test with Yates correction and analysis was performed using Epi-Info software for Windows 2000. RESULTS: invasive mole or choriocarcinoma occurred at the first event of hydatidiform mole in only one patient (1/29 - 3.44%), whereas invasion or malignization occurred in the second event in seven patients (7/29 - 24,13%) [OR: 8.9; CI 95%: 1.5 - 41; p<0.05]. CONCLUSION: recurrent molar pregnancy was associated with histological worsening and an increase in the incidence of proliferative trophoblastic sequelae in the consecutive episodes of hydatidiform mole, more frequent and aggressive chemotherapy being necessary.