Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2009;31(5):264-264
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2009;31(5):264-264
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(4):264-264
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2011;33(9):264-269
DOI 10.1590/S0100-72032011000900008
PURPOSE: to evaluate the effects of high doses of genistein on the mammary glands of adult female rats. METHODS: Twenty-eight days after oophorectomy, 50 adult female rats were divided into five groups, as follows: a control group (Ctrl), three rats that received genistein (GEN) at the doses of 46 mg/kg (GEN46;), 125 mg/kg (GEN125) and 250 mg/kg (GEN250); one group received conjugated equine estrogen at the dose of 50 µg/g (ECE50). The substances were administered daily for 30 consecutive days by gavage and in the last week of the period of treatment, colpocytological exams were carried out for seven consecutive days. After treatment, the animals were anesthetized, blood samples were collected for estradiol and progesterone determination and the first pair of inguinal mammary glands was removed and processed for histomorphometric analysis. Collected data were subjected to analysis of variance supplemented by the Tukey-Kramer test (p<0.05). RESULTS: the ctrl group and the ones treated with different doses of GEN showed atrophic mammary glands, whereas the glands were more developed in the ECE group, where numerous mammary ducts and alveoli were observed. Morphometry showed a larger area of mammary parenchyma in the ECE group (98.870.1±550.4 µm²* per mm²; p<0.05) compared with other groups (Ctrl=36.875.6±443.4; GEN46=37.001.7±557.4; GEN125=36.480.8±658.3 and GEN250=37.502.8±669.3). The same occurred in the number of alveoli in the ECE group (33.2±6.9* per mm²; p<0.05) compared to the other groups (Ctrl=10.4±2.1, GEN46=11.2±3.1; GEN125=11.6±2.1 and GEN250=12.3±2.3). The estradiol level was higher in the ECE group compared to the other groups (9.4±1.7 pg/mL; p<0.05), whereas serum levels of progesterone were similar in all groups. CONCLUSION: the administration of genistein at high doses had no trophic effect on the mammary glands of rats.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2021;43(4):264-274
To evaluate the applicability and usefulness of second-trimester TUCL to predict PTB in a cohort of Portuguese pregnant women.
Retrospective cross-sectional cohort study including all singleton pregnant women who performed their second-trimester ultrasound (between weeks 18 and 22þ6 days) from January 2013 to October 2017 at Centro Hospitalar Universitário São João.
Our cohort included 4,481 women. The prevalence of spontaneous PTB was of 4.0%, with 0.7% occurring before the 34th week of gestation. The mean TUCL was of 33.8mm,and percentiles 3, 5 and 10 corresponded toTUCLs of 25.0mm, 27.0mmand 29.0mmrespectively. The multiple logistic regression analysis, including maternal age, previous PTB and cervical surgery showed a significant negative association between TUCL and PTB, with an odds ratio (OR) of 0.92 (95% confidence interval [95%CI]: 0.90-0.95; p<0.001). The use of a TUCL of 20mm is the best cut-off, when compared with the 25-mm cut-off, improving the prediction of risk.
The present study showed an inverse association between TUCL and PTB, and that the inclusion of other risk factors like maternal age, previous PTB and cervical surgery can improve the screening algorithm. Furthermore, it emphasizes that the TUCL cut-off that defines short cervix can differ according to the population.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2017;39(6):265-272
To evaluate maternal-fetal surveillance and follow-up of infants at risk for congenital syphilis (CS).
Retrospective cohort study in a Portuguese Tertiary Referral Hospital. The main inclusion criterion was a positive syphilis serology. The study included all pregnant women that delivered in our hospital between January 2004 and December 2013. The neonates were classified according to their probability of infection based on the Centers for Disease Control and Prevention guidelines.
Among the 27 pregnancies at risk for CS, 48.2% (n = 13) of the women had a diagnosis during the 1st trimester, and the median gestational age at the end of the treatment was 28 weeks. Inadequate treatment was noted in 44.4% (n = 12) of the women. Adverse pregnancy outcomes were observed in 30.8% of the cases (n = 8), 5 of which had been adequately treated. We found 2 (7.7%) cases with “proven or highly probable CS,” 10 (38.5%) with “possible CS,” 12 (46.1%) with “less likely CS,” and 2 (7.7%) with “unlikely CS.”Among the infants, the treatment was successful, except for 1 neurosyphilis case.
This study highlights many of the difficulties/concerns encountered in the maternal-neonatal management of syphilis. We highlight the importance of assuring the early detection of the infection as a way of guaranteeing the timely treatment, as well as a good compliance to the treatment and follow-up through a more efficient pregnant women surveillance network.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(5):265-274
DOI 10.1590/S0100-72032000000500003
Purpose: this study, using verapamil, a slow calcium channel blocker, was a randomized, clinical, double blind and placebo controlled trial, whose objective was to observe if there was a uteroplacental and fetoplacental flow variation during its chronic oral use. Methods: 123 patients were accompanied: study group (n = 61), submitted to verapamil 240 mg/day and control group (n = 62), submitted to placebo. These patients were randomized into groups of four women and treatment or placebo was given for thirty days. A flow examination of the uterine arteries and umbilical artery through doppler-velocimetry was recorded. The values of resistance (RI) and pulsatility index (PI) and of the systole/diastole ratio (S/D) of the arteries were compared after the drug administration calculating means and standard deviations. Results: the verapamil group showed RI = 0.82 (0.28), PI = 1.06 (0.12) and S/D = 2.42 (0.51) in the uterine arteries. The placebo group showed RI = 0.75 (0.35), PI = 1.00 (0.18) and S/D = 2.30 (0.38). When we analyzed the umbilical artery, the verapamil group showed RI = 0.73 (0.12), PI = 1.04 (0.13) and S/D = 2.94 (0.32). The placebo group showed RI = 0.70 (0.14), PI = 1.03 (0.07) and S/D = 3.02 (0.78). The statistical analysis of the differences of the means by the F ratio showed that there was no difference between these two groups. Conclusion: this study indicates the use of verapamil for chronic hypertensive pregnants since it does not provoke damage to the uterine and fetal blood flow.