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Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(10):436-441
DOI 10.1590/SO100-720320140005105
Pregnant women have a 2-3 fold higher probability of developing restless legs syndrome (RLS – sleep-related movement disorders) than general population. This study aims to evaluate the behavior and locomotion of rats during pregnancy in order to verify if part of these animals exhibit some RLS-like features.
We used 14 female 80-day-old Wistar rats that weighed between 200 and 250 g. The rats were distributed into control (CTRL) and pregnant (PN) groups. After a baseline evaluation of their behavior and locomotor activity in an open-field environment, the PN group was inducted into pregnancy, and their behavior and locomotor activity were evaluated on days 3, 10 and 19 of pregnancy and in the post-lactation period in parallel with the CTRL group. The serum iron and transferrin levels in the CTRL and PN groups were analyzed in blood collected after euthanasia by decapitation.
There were no significant differences in the total ambulation, grooming events, fecal boli or urine pools between the CTRL and PN groups. However, the PN group exhibited fewer rearing events, increased grooming time and reduced immobilization time than the CTRL group (ANOVA, p<0.05).
These results suggest that pregnant rats show behavioral and locomotor alterations similar to those observed in animal models of RLS, demonstrating to be a possible animal model of this sleep disorder.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(10):436-441
DOI 10.1590/SO100-720320140005105
Pregnant women have a 2-3 fold higher probability of developing restless legs syndrome (RLS – sleep-related movement disorders) than general population. This study aims to evaluate the behavior and locomotion of rats during pregnancy in order to verify if part of these animals exhibit some RLS-like features.
We used 14 female 80-day-old Wistar rats that weighed between 200 and 250 g. The rats were distributed into control (CTRL) and pregnant (PN) groups. After a baseline evaluation of their behavior and locomotor activity in an open-field environment, the PN group was inducted into pregnancy, and their behavior and locomotor activity were evaluated on days 3, 10 and 19 of pregnancy and in the post-lactation period in parallel with the CTRL group. The serum iron and transferrin levels in the CTRL and PN groups were analyzed in blood collected after euthanasia by decapitation.
There were no significant differences in the total ambulation, grooming events, fecal boli or urine pools between the CTRL and PN groups. However, the PN group exhibited fewer rearing events, increased grooming time and reduced immobilization time than the CTRL group (ANOVA, p<0.05).
These results suggest that pregnant rats show behavioral and locomotor alterations similar to those observed in animal models of RLS, demonstrating to be a possible animal model of this sleep disorder.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(2):90-96
DOI 10.1590/S0100-72032014000200008
To evaluate the frequency of sleep disorders, such as obstructive sleep apnea,
restless leg syndrome and insomnia in overweight/obese postmenopausal women seen
in a climacteric sleep disorders clinic.
Thirty-four postmenopausal women were selected using the following inclusion
criteria: age between 50 and 70 years; at least 12 months of amenorrhea; body mass
index (BMI) greater than or equal to 25 kg/m2; and sleep-related
complaints with at least one previous polysomnography. Patients provided responses
to 6 questionnaires related to sleep characteristics and menopausal symptoms.
Weight and height were measured using standardized scales, and abdomen and hip
circumferences were also measured. The statistical analyses were performed using
the χ2 test for qualitative variables and using Student's t-test for
quantitative variables.
Patients' characteristics were as follows: mean age of 60.35 years; mean BMI of
31.62; an average of 11.61 postmenopausal years and an average Kupperman Index of
19. A total of 85.2% of the patients had a waist/hip ratio of less than 0.8. The
Epworth Scale score was greater than or equal to 9 in 50% of patients; 68% had
sleep disturbances according to the Pittsburgh Index, and 68% were classified as
high-risk for sleep apnea by the Berlin Questionnaire. On polysomnography, 70.58%
of the patients had a sleep efficiency lower than 85%; 79.41% had a sleep latency
of less than 30 min; 58.82% had a REM sleep latency of less than 90 min, and
44.11% had mild apnea. When the groups were compared, a linear association was
identified between BMI and the AHI average, and a relationship between high BMI
and use of drugs for thyroid treatment was found.
There was a high prevalence of sleep-disordered breathing, initial insomnia,
fragmented sleep, and thyroid disorders in the group with higher BMI.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2014;36(2):90-96
DOI 10.1590/S0100-72032014000200008
To evaluate the frequency of sleep disorders, such as obstructive sleep apnea,
restless leg syndrome and insomnia in overweight/obese postmenopausal women seen
in a climacteric sleep disorders clinic.
Thirty-four postmenopausal women were selected using the following inclusion
criteria: age between 50 and 70 years; at least 12 months of amenorrhea; body mass
index (BMI) greater than or equal to 25 kg/m2; and sleep-related
complaints with at least one previous polysomnography. Patients provided responses
to 6 questionnaires related to sleep characteristics and menopausal symptoms.
Weight and height were measured using standardized scales, and abdomen and hip
circumferences were also measured. The statistical analyses were performed using
the χ2 test for qualitative variables and using Student's t-test for
quantitative variables.
Patients' characteristics were as follows: mean age of 60.35 years; mean BMI of
31.62; an average of 11.61 postmenopausal years and an average Kupperman Index of
19. A total of 85.2% of the patients had a waist/hip ratio of less than 0.8. The
Epworth Scale score was greater than or equal to 9 in 50% of patients; 68% had
sleep disturbances according to the Pittsburgh Index, and 68% were classified as
high-risk for sleep apnea by the Berlin Questionnaire. On polysomnography, 70.58%
of the patients had a sleep efficiency lower than 85%; 79.41% had a sleep latency
of less than 30 min; 58.82% had a REM sleep latency of less than 90 min, and
44.11% had mild apnea. When the groups were compared, a linear association was
identified between BMI and the AHI average, and a relationship between high BMI
and use of drugs for thyroid treatment was found.
There was a high prevalence of sleep-disordered breathing, initial insomnia,
fragmented sleep, and thyroid disorders in the group with higher BMI.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(12):731-736
DOI 10.1590/S0100-72032005001200005
PURPOSE: to evaluate the prevalence of reported sleep disturbances through polysomnographic recording (PSG) in a sample of postmenopausal women. METHODS: thirty-three postmenopausal women with a mean age of 56 years, a mean body mass index (BMI) of 27 kg/m², with 7.7 years of recognized postmenopausal period, and a mean Kupperman index of 17, were selected. The inclusion criteria were: age range from 50 to 65 years, at least one year of amenorrhea and an FSH which equaled or exceeded 30 mU/ml; they should not be undergoing hormone therapy, and should display normal laboratory test results. The patients with severe clinical diseases and/or decompensated were excluded; also the ones with suspicion of carcinoma of endometrium and/or breast cancer, a BMI over 30 kg/m² and those who ingested hypnotic drugs. The patients followed a routine climacteric check-up, answered a questionnaire about sleep and underwent an all-night PSG recording. Frequencies in percentage of emerging sleep complaints based on the questionnaire and those pertaining to PSG diagnosis were then calculated separately. RESULTS: the subjective prevalence of insomnia was 61% against 83% in the PSG recordings. The prevalence of apnea reported was 23% against 27% in the PSG. The subjective restless legs syndrome prevalence was 45%, and the objective, 27%. CONCLUSION: there was a high prevalence of sleep disturbances in postmenopausal patients, specially insomnia, apnea and restless legs.
Summary
Revista Brasileira de Ginecologia e Obstetrícia. 2005;27(12):731-736
DOI 10.1590/S0100-72032005001200005
PURPOSE: to evaluate the prevalence of reported sleep disturbances through polysomnographic recording (PSG) in a sample of postmenopausal women. METHODS: thirty-three postmenopausal women with a mean age of 56 years, a mean body mass index (BMI) of 27 kg/m², with 7.7 years of recognized postmenopausal period, and a mean Kupperman index of 17, were selected. The inclusion criteria were: age range from 50 to 65 years, at least one year of amenorrhea and an FSH which equaled or exceeded 30 mU/ml; they should not be undergoing hormone therapy, and should display normal laboratory test results. The patients with severe clinical diseases and/or decompensated were excluded; also the ones with suspicion of carcinoma of endometrium and/or breast cancer, a BMI over 30 kg/m² and those who ingested hypnotic drugs. The patients followed a routine climacteric check-up, answered a questionnaire about sleep and underwent an all-night PSG recording. Frequencies in percentage of emerging sleep complaints based on the questionnaire and those pertaining to PSG diagnosis were then calculated separately. RESULTS: the subjective prevalence of insomnia was 61% against 83% in the PSG recordings. The prevalence of apnea reported was 23% against 27% in the PSG. The subjective restless legs syndrome prevalence was 45%, and the objective, 27%. CONCLUSION: there was a high prevalence of sleep disturbances in postmenopausal patients, specially insomnia, apnea and restless legs.
