Você pesquisou por y - Revista Brasileira de Ginecologia e Obstetrícia

PURPOSE:

To evaluate pregnancy outcome and thrombophilia frequency in women with recurrent
fetal death.

METHODS:

Evaluation of obstetric outcomes in a retrospective cohort of pregnant women with
recurrent stillbirth after the 20^th week, from 2001 to 2013.
Antithrombin activity, protein C and S activity, factor V Leiden, prothrombin gene
mutation and antiphospholipid syndrome were analyzed.

RESULTS:

We included 20 patients who had recurrent fetal death. Thrombophilia were found
in 11 of them, 7 diagnosed with antiphospholipid syndrome, 3 with protein S
deficiency and 1 with prothrombin gene mutation. All of them were treated with
subcutaneous heparin (unfractionated heparin or enoxaparina) and 14 of them with
acetylsalicylic acid (AAS) during pregnancy. Obstetric complications occurred in
15 patients and included: intrauterine fetal growth restriction (25%), placenta
previa (15%), reduced amniotic fluid index (25%), severe preeclampsia (10%), fetal
distress (5%), and stillbirth (5%). The mean gestational age at delivery was
35.8±3.7 weeks and newborn weight averaged 2,417.3±666.2 g.

CONCLUSION:

Thrombophilia screening should be performed in all pregnant women with recurrent
fetal death after the 20^th week as a way to identify possible causal
factors suitable for treatment.