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  • Artigos Originais

    Hysteroscopic evaluation in patients with infertility

    Revista Brasileira de Ginecologia e Obstetrícia. 2010;32(8):393-397

    Summary

    Artigos Originais

    Hysteroscopic evaluation in patients with infertility

    Revista Brasileira de Ginecologia e Obstetrícia. 2010;32(8):393-397

    DOI 10.1590/S0100-72032010000800006

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    PURPOSE: to describe hysteroscopy findings in infertile patients. METHODS: this was a retrospective series of 953 patients with diagnosis of infertility evaluated by hysteroscopy. A total of 957 patients investigated for infertility were subjected to hysteroscopy, preferentially during the first phase of the menstrual cycle. When necessary, directed biopsies (under direct visualization during the exam) or guided biopsies were obtained using a Novak curette after defining the site to be biopsied during the hysteroscopic examination. Outcome frequencies were determined as percentages, and the χ2 test was used for the correlations. The statistical software EpiInfo 2000 (CDC) was used for data analysis. RESULTS: a normal uterine cavity was detected in 436 cases (45.8%). This was the most frequent diagnosis for women with primary infertility and for women with one or no abortion (p<0.05). Abnormal findings were obtained in 517 of 953 cases (54.2%), including intrauterine synechiae in 185 patients (19.4%), endometrial polyps in 115 (12.1%), endocervical polyps in 66 (6.0%), submucosal myomas in 47 (4.9%), endometrial hyperplasia in 39 (4.1%), adenomyosis in five (0.5%), endometritis (with histopathological confirmation) in four (0.4%), endometrial bone metaplasia in two (0.4%), and cancer of the endometrium in one case (0.1%). Morphological and functional changes of the uterus were detected in 5.6% of the cases, including uterine malformations in 32 (3.4%) and isthmus-cervical incompetence in 21 (2.2%). CONCLUSIONS: intrauterine synechiae were the most frequent abnormal findings in patients evaluated for infertility. Patients with a history of abortion and infertility should be submitted to hysteroscopy in order to rule out intrauterine synechiae as a possible cause of infertility.

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  • Artigos Originais

    Effect of treatment with raloxifene on mammographic breast density in postmenopausa

    Revista Brasileira de Ginecologia e Obstetrícia. 2007;29(10):525-531

    Summary

    Artigos Originais

    Effect of treatment with raloxifene on mammographic breast density in postmenopausa

    Revista Brasileira de Ginecologia e Obstetrícia. 2007;29(10):525-531

    DOI 10.1590/S0100-72032007001000006

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    PURPOSE: to evaluate changes in mammographic breast density in postmenopausal women using raloxifene. METHODS: in this clinical trial, 80 women (mean age=61.1 years) were studied prospectively. Forty patients received 60 mg/day raloxifene, and 40 women comprised the non-treated group (control), paired by age and time of menopause. The treated group was composed of patients with osteoporosis of the lumbar spine. Those with history of breast surgery and users of hormone therapy up to six months prior to the study were excluded. The breast density was assessed qualitatively (subjective) and quantitatively (objective) in two moments, initial and final, after a 6-month follow-up. The 320 mammograms (craniocaudal and oblique) were interpreted qualitatively by the Breast Imaging Reporting and Data System (BI-RADS) classification and quantitatively by digital scanning and computer-assisted segmentation. For statistical analysis t-test, Wilcoxon Mann-Whitney, Spearman correlation and the kappa index were used. RESULTS: on the initial statistical comparison, the groups were considered homogenous for the variables: analyzed age, time of menopause, parity, breast feeding, previous hormonal therapy and body mass index. Baseline breast density, by qualitative and quantitative methods, correlated negatively with the age in both groups (p<0.05). Concerning the other variables, there was no correlation. After six months, no alteration was observed in the mammographic breast density in 38 women of raloxifene group and 38 of the control group, by qualitative method. However, by quantitative method, no alteration was observed in 30 women of the raloxifene group and 27 controls (p>0.05). It was observed a weak agreement rate (kappa=0.25) between the BI-RADS classification and digital scanning/computer-assisted segmentation. CONCLUSIONS: in post-menopausal women with osteoporosis, submitted to raloxifene treatment for six months, no alterations were observed on the mammographic breast density.

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  • Trabalhos Originais

    Post-tubal sterilization syndrome: evaluation of the psychological and clinical disturbances in tubal ligation syndrome

    Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(4):199-205

    Summary

    Trabalhos Originais

    Post-tubal sterilization syndrome: evaluation of the psychological and clinical disturbances in tubal ligation syndrome

    Revista Brasileira de Ginecologia e Obstetrícia. 1998;20(4):199-205

    DOI 10.1590/S0100-72031998000400005

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    The purpose of the present study was to investigate the menstrual disturbances and the psychological effects of post-tubal sterilization - the so-called post-tubal sterilization syndrome. Does it exist? The authors followed-up prospectively 300 women from the Gynecological Endoscopy and Family Planning Section, Department of Obstetrics and Gynecology, Botucatu Medical School, Universidade Estadual Paulista (UNESP) during one, three and five years after tubal sterilization surgery. Different parameters such as menstrual cycle length, duration of menstrual flow, dysmenorrhea, pelvic pain, regret rates etc, after tubal ligation, were analyzed. Each woman served as her own control. In conclusion, our findings suggest that most women reported no menstrual changes subsequent to sterilization. These findings do not deny or diminish the importance or benefits of tubal sterilization, but serve as a focus for further investigation.

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    Post-tubal sterilization syndrome: evaluation of the psychological and clinical disturbances in tubal ligation syndrome
  • Trabalhos Originais

    Experimental hypertension and pregnancy in rats: use of Goldblatt I (one kidney — one clip model)

    Revista Brasileira de Ginecologia e Obstetrícia. 1999;21(4):209-214

    Summary

    Trabalhos Originais

    Experimental hypertension and pregnancy in rats: use of Goldblatt I (one kidney — one clip model)

    Revista Brasileira de Ginecologia e Obstetrícia. 1999;21(4):209-214

    DOI 10.1590/S0100-72031999000400005

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    Purpose: to develop an experimental model in rats to study the interaction between hypertension and pregnancy. Methods: the present experiment was divided into 5 periods: adaptation (2 weeks), surgical procedures (1 week), hypertension development (6 weeks), mating and blood pressure stabilization (6 weeks), and gestational period (3 weeks). A total of 82 animals in reproductive age, weighing from 180 to 240 g, were used. They were randomly assigned to the 4 different groups (control, handled, nephrectomy and hypertension) and renal hypertension was produced by a controlled constriction of the main left renal artery, according to the technique described by Goldblatt, and contralateral nephrectomy (Goldblatt I - one kidney, one clip hypertension). They were studied at 15 precise moments. Afterwards, periodic blood pressure determinations were made by the tail plethysmographic method. Results: pregnancy caused a fall in blood pressure levels in the rat. Conclusion: the experimental model was adequate for the purposes of the study, since it proved to be efficient in producing hypertension.

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    Experimental hypertension and pregnancy in rats: use of Goldblatt I (one kidney — one clip model)
  • Artigos Originais

    Comparative study of female surgery contraception access: microlaparoscopy versus minilaparotomy

    Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(7):403-409

    Summary

    Artigos Originais

    Comparative study of female surgery contraception access: microlaparoscopy versus minilaparotomy

    Revista Brasileira de Ginecologia e Obstetrícia. 2006;28(7):403-409

    DOI 10.1590/S0100-72032006000700005

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    PURPOSE: to compare in a retrospective way, 51 women who underwent tubal ligation, 30 through microlaparoascopy (Gmicrol) and 21 through minilaparotomy (Gminil). METHODS: the analyzed parameters were: total time for accomplishment of the procedure and the surgical technique, time of hospital stay and return to the habitual activities after the surgery, postoperative pain, morbidity, satisfaction degree and esthetic effect, considering values of p<0,05 as significant, and also standard cost. RESULTS: Gmicrol took less time to accomplish the surgery than the Gminil (43 against 57 minutes respectively, p<0,05), less time to accomplish the surgical technique (6.48 against 30.32 minutes respectively, p<0,05), and lower hospital stay (9,90 hours as against 41,7 hours respectively, p <0,05). There was no significant difference between the two groups regarding time to return to the habitual activities after surgery. To evaluate postoperative pain, a scale of 0-10 it was applied. Gmicrol present a lower pain score on the 1st and 2nd postoperative days (1.13 and 0.26 to Gmicrol and 4.52 and 1.14 to Gminil, respectively, p<0,05). There was no significant difference between immediate postoperative the most common complaint being pain at the site of pain and that on the 3rd postoperative day. Gminil presented a higher morbidity rate incision. To evaluate the satisfaction degree and esthetic effect, numeric values were attributed to as good, regular, poor and very bad as answered by the patiets. Gmicrol presented a higher satisfaction degree (p<0,05) and better esthetic effect as compared to Gminil (p <0,05). The microlaparoscopy standard cost was R$ 109.30 being lower than that of minilaparotomy. CONCLUSIONS: tubal ligation by microlaparoscopy, under local anesthesia and conscious sedation presented some advantages compared to minilaparotomy.

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  • Técnica e Equipamentos

    Endometrial Ablation Using a Thermal Balloon: Preliminary Results

    Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(4):235-238

    Summary

    Técnica e Equipamentos

    Endometrial Ablation Using a Thermal Balloon: Preliminary Results

    Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(4):235-238

    DOI 10.1590/S0100-72032000000400008

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    Purpose: to evaluate thermal balloon endometrial ablation in the management of menorrhagia. Study design: twenty patients were submitted to endometrial ablation using the thermal balloon device, between June 1996 and June 1997. Local anesthesia was used in 16 patients. The device was introduced into the uterine cavity. The duration of the procedure was 8 minutes and 30 seconds. Results: two patients (10%) did not show improvement of the symptons. Eighteen patients (90%) referred improvement of symptoms. There was no complication during and after the procedure. Conclusions: The thermal balloon seems to be safe and efficient in the management of menorrhagia.

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  • Trabalhos Originais

    Office Microlaparoscopy in Patients with Chronic Pelvic Pain

    Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(2):95-100

    Summary

    Trabalhos Originais

    Office Microlaparoscopy in Patients with Chronic Pelvic Pain

    Revista Brasileira de Ginecologia e Obstetrícia. 2000;22(2):95-100

    DOI 10.1590/S0100-72032000000200006

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    SUMMARY Purpose: to study the usefulness of minilaparoscopy in diagnosing the cause of pelvic pain. Methods: women with pelvic pain were prospectively analyzed and underwent an office video-microlaparoscopy. We analyzed the data regarding procedure time, stay in the recovery room, acceptance of anesthesia, and morbidity. Results: the average procedure time of the office video-microlaparoscopy was 19 min, the average stay for recovery was 43 min, and the technical quality of the image was excellent or good in 100% of the selected patients. The following laparoscopic findings were reported: 34.4% endometriosis, 28.1% pelvic adhesion, 12.5% pelvic varices, and 25% normal. Based on Bordhal et al.'s¹ criteria, a low frequency of pain manifestation during local anesthesia (12.5%) and discomfort on pneumoperitoneum (46.9%) were noticed. It could also be observed that, according to Milki and Tazuke's² criteria, the tolerance to the method was excellent and good (96.9%). Twenty-four hours after the procedure the morbidity rate was in accordance with Chung et al.'s³ criteria, showing a high frequency of pain at the incision area (59.4%) and sleepiness (43.8%). Only 3.1% reported they felt pain during the procedure, which shows the acceptance of the method by the patients. Conclusions: the acceptance of anesthesia and of the surgical procedure and the low morbidity allow the use of minilaparoscopy as a very important method in investigating patients with pelvic pain.

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    Office Microlaparoscopy in Patients with Chronic Pelvic Pain
  • Trabalhos Originais

    Submucous fibroids: presurgical classification to evaluate the viability of hysteroscopic surgical treatment

    Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(4):305-309

    Summary

    Trabalhos Originais

    Submucous fibroids: presurgical classification to evaluate the viability of hysteroscopic surgical treatment

    Revista Brasileira de Ginecologia e Obstetrícia. 2004;26(4):305-309

    DOI 10.1590/S0100-72032004000400007

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    OBJECTIVE: to develop a new preoperative classification of submucous myomas to evaluate the viability and the degree of difficulty of hysteroscopic myomectomy. METHODS: forty-four patients were submitted to hysteroscopic resection of submucous myomas. The possibility of total resection of the myoma, the surgery duration, the fluid deficit, and the incidence of complications were evaluated. The myomas were classified by the Classification of the European Society of Endoscopic Surgery (CESES) and by the classification proposed (CP) by our group, that besides the degree of penetration of the myoma in the myometrium, adds the parameters: extent of the base of the myoma as related to the uterine wall, the size of the myoma in centimeters and its topography at the uterine cavity. For statistical analysis the Fisher test, the Student t test and the analysis of variance were used. Statistic significance was considered when the p-value was smaller than 0.05 in the bicaudal test. RESULTS: in 47 myomas the hysteroscopic surgery was considered complete. There was no significant difference among the three levels (0, 1 and 2) by CESES. By CP, the difference among the number of complete surgeries was significant (p=0.001) between the two levels (groups I and II). The difference between the surgery duration was significant when the two classifications were compared. In relation to the fluid deficit, just CP presented significant differences among the levels (p=0,02). CONCLUSIONS: the proposed classification includes more clues about the difficulties of the hysteroscopic myomectomy than the standard classification. It should be noted that the number of hysteroscopic myomectomies used for that analysis was modest, being interesting to evaluate the performance of the proposed classification in larger series of cases.

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    Submucous fibroids: presurgical classification to evaluate the viability of hysteroscopic surgical treatment

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